Creatine SupplementationHIITCRECOGNCT07534293
Effects of 7-Day Creatine Supplementation on Cognitive Function After High-Intensity Interval Training in Active Young Men
A study testing Creatine Monohydrate and High Intensity Interval Training in people with Creatine Supplementation and Exercise Ergogenics, run by Universitas Negeri Malang at 1 site in Indonesia.
Trial summary
This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or… Read more about this study
- Who is it for?
- Ages 19 to 25 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Creatine Supplementation, Exercise Ergogenics
- What is being tested?
- Creatine Monohydrate and High Intensity Interval Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 20 participants
- Where
- 1 siteIndonesia
- Study dates
- 7 Feb 2026to 14 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 25 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male sport science students aged 19 to 25 years
- Physically active and accustomed to high-intensity exercise
- Healthy volunteers
- Willing to participate and provide written informed consent
- Willing to complete the 7-day intervention and cognitive testing procedures
Who cannot join
- History of cardiovascular disease
- History of kidney disease
- Current use of creatine supplements
- Current use of pre-workout supplements, steroids, or diuretics
- Any musculoskeletal, neurological, or medical condition that could interfere with exercise participation or cognitive testing
- Refusal or inability to complete the study procedures
Trial locations and contacts
1 site in 1 country.
Indonesia1 site
Laboratory Sports Science Universitas Negeri Malang
Malang, East Java, 65145
About this study
Official title: Creatine Monohydrate Supplementation Preserves Cognitive Function in Student Athletes Following High Intensity Interval Training: Implications for Academic Performance
This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.
Read the detailed description
This study used a controlled pretest-posttest, four-arm interventional design to examine the effects of short-term creatine monohydrate supplementation on cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were allocated into four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise. The intervention lasted 7 days.
Participants in the exercise groups completed a bodyweight HIIT protocol consisting of two rounds. Round 1 used 40 seconds of work and 20 seconds of rest, and round 2 used 30 seconds of work and 15 seconds of rest, with 30 seconds of rest between rounds. The session included 14 sequential movements and was preceded by a 5-minute warm-up and followed by a 5-minute cool-down.
Cognitive performance was assessed before and after the intervention using visual reaction time (VRT), go/no-go visual reaction time (GNGVRT), and Trail Making Test Parts A and B. These measures were selected to capture processing speed, inhibitory control, attention, and executive function. The study was approved by the ethics committee of Universitas Negeri Malang, and written informed consent was obtained from all participants.
- Conditions
- Creatine Supplementation, Exercise Ergogenics
- Being tested
- Creatine Monohydrate, Placebo, High Intensity Interval Training
- Keywords
- creatine monohydrate, High Intensity Interval Training, Cognitive, Reaction Time, Executive Function
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Creatine MonohydrateDrug
Creatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days.
Creatine MonohydrateDrug
Creatine monohydrate supplementation at a dose of 0,3 g/KgBW/day for 7 days.
PlaceboDrug
Placebo supplementation for 7 days
High Intensity Interval TrainingBehavioural
A bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds.
| Study group | Role | What they receive |
|---|---|---|
| Placebo + Exercise | Placebo comparator | Participants received placebo supplementation using maltodextrin for 7 days and performed high-intensity interval training. Receives: Drug: Placebo; Behavioral: High Intensity Interval Training |
| Placebo Without Exercise | Placebo comparator | Participants received placebo supplementation using maltodextrin for 7 days without exercise intervention. Receives: Drug: Placebo |
| Creatine 0,1 g/KgBW/day + Exercise | Experimental | Participants received creatine monohydrate supplementation at 0,1 g/KgBW/day for 7 days and performed high-intensity interval training. Receives: Drug: Creatine Monohydrate; Behavioral: High Intensity Interval Training |
| Creatine 0,3 g/KgBW/day + Exercise | Experimental | Participants received creatine monohydrate supplementation at 0,3 g/KgBW/day for 7 days and performed high-intensity interval training. Receives: Drug: Creatine Monohydrate; Behavioral: High Intensity Interval Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Go/No-Go Visual Reaction Time False Alarm Errors
Number of false alarm (commission) errors recorded during the Go/No-Go Visual Reaction Time test. Lower values indicate better inhibitory control.
Measured: Baseline and Day 7
Secondary outcomes (4)
Go/No-Go Visual Reaction Time
Average response time for correct go trials during the Go/No-Go Visual Reaction Time test, expressed in milliseconds. Lower values indicate faster processing speed.
Measured: Baseline and Day 7
Trail Making Test Part B Completion Time
Trail Making Test Part B Completion Time
Measured: Baseline and Day 7
Visual Reaction Time
Simple visual reaction time measured in milliseconds. Lower values indicate faster processing speed.
Measured: Baseline and Day 7
Trail Making Test Part A Completion Time
Trail Making Test Part A Completion Time
Measured: Baseline and Day 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Apr 2026
- Study start7 Feb 2026
- Primary completion14 Feb 2026
- Study completion14 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Creatine SupplementationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were assigned to one of four parallel groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise.
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universitas Negeri Malang
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gosy Endra Vigriawan, Universitas Negeri Malang
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07534293
- Sponsor's protocol ID
- 12.02.01/UN32.14.2.8/LT2032
- Other IDs
- 4309/B3/DT.03.08/2025
- Acronym
- HIITCRECOG
- Status last verified
- Apr 2026
- First submitted
- 9 Apr 2026
- Last updated
- 16 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: The plan for sharing individual participant data has not yet been finalized.
Study at a glance
From the registry record, last updated by the sponsor on 16 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Creatine Monohydrate Supplementation Preserves Cognitive Function in Student Athletes Following High Intensity Interval Training: Implications for Academic Performance
- ClinicalTrials.gov ID
- NCT07534293
- Acronym / sponsor ID
- HIITCRECOG / 12.02.01/UN32.14.2.8/LT2032
- Conditions
- Creatine Supplementation, Exercise Ergogenics
- Keywords
- creatine monohydrate, High Intensity Interval Training, Cognitive, Reaction Time, Executive Function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Universitas Negeri MalangUniversity, hospital or other
- Study start
- 7 Feb 2026 (actual)
- Primary completion
- 14 Feb 2026 (actual)
- Study completion
- 14 Feb 2026 (actual)
- First posted
- 16 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluates whether 7-day creatine monohydrate supplementation affects cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were assigned to one of four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, or creatine 0.3 g/KgBW/day plus exercise. Cognitive performance was measured before and after the intervention using visual reaction time, go/no-go visual reaction time, and Trail Making Tests A and B.
Detailed description
This study used a controlled pretest-posttest, four-arm interventional design to examine the effects of short-term creatine monohydrate supplementation on cognitive function after high-intensity interval training (HIIT) in active young men. Twenty participants were allocated into four groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise. The intervention lasted 7 days.
Participants in the exercise groups completed a bodyweight HIIT protocol consisting of two rounds. Round 1 used 40 seconds of work and 20 seconds of rest, and round 2 used 30 seconds of work and 15 seconds of rest, with 30 seconds of rest between rounds. The session included 14 sequential movements and was preceded by a 5-minute warm-up and followed by a 5-minute cool-down.
Cognitive performance was assessed before and after the intervention using visual reaction time (VRT), go/no-go visual reaction time (GNGVRT), and Trail Making Test Parts A and B. These measures were selected to capture processing speed, inhibitory control, attention, and executive function. The study was approved by the ethics committee of Universitas Negeri Malang, and written informed consent was obtained from all participants.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- Participants were assigned to one of four parallel groups: placebo plus exercise, placebo without exercise, creatine 0.1 g/KgBW/day plus exercise, and creatine 0.3 g/KgBW/day plus exercise.
| Arm | Type | Receives |
|---|---|---|
| Placebo + Exercise | Placebo comparator | Drug: Placebo, Behavioral: High Intensity Interval TrainingParticipants received placebo supplementation using maltodextrin for 7 days and performed high-intensity interval training. |
| Placebo Without Exercise | Placebo comparator | Drug: PlaceboParticipants received placebo supplementation using maltodextrin for 7 days without exercise intervention. |
| Creatine 0,1 g/KgBW/day + Exercise | Experimental | Drug: Creatine Monohydrate, Behavioral: High Intensity Interval TrainingParticipants received creatine monohydrate supplementation at 0,1 g/KgBW/day for 7 days and performed high-intensity interval training. |
| Creatine 0,3 g/KgBW/day + Exercise | Experimental | Drug: Creatine Monohydrate, Behavioral: High Intensity Interval TrainingParticipants received creatine monohydrate supplementation at 0,3 g/KgBW/day for 7 days and performed high-intensity interval training. |
Who may qualify
- Ages
- 19 to 25 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Male sport science students aged 19 to 25 years
- Physically active and accustomed to high-intensity exercise
- Healthy volunteers
- Willing to participate and provide written informed consent
- Willing to complete the 7-day intervention and cognitive testing procedures
Key exclusion criteria (6 listed)
- History of cardiovascular disease
- History of kidney disease
- Current use of creatine supplements
- Current use of pre-workout supplements, steroids, or diuretics
- Any musculoskeletal, neurological, or medical condition that could interfere with exercise participation or cognitive testing
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Creatine MonohydrateCreatine monohydrate supplementation at a dose of 0,1 g/KgBW/day for 7 days. | Drug | Creatine 0,1 g/KgBW/day + Exercise |
| Creatine MonohydrateCreatine monohydrate supplementation at a dose of 0,3 g/KgBW/day for 7 days. | Drug | Creatine 0,3 g/KgBW/day + Exercise |
| PlaceboPlacebo supplementation for 7 days | Drug | Placebo + Exercise, Placebo Without Exercise |
| High Intensity Interval TrainingA bodyweight high-intensity interval training program performed in 2 rounds with 40 seconds work and 20 seconds rest in round 1, and 30 seconds work and 15 seconds rest in round 2, with 30 seconds rest between rounds. | Behavioural | Creatine 0,1 g/KgBW/day + Exercise, Creatine 0,3 g/KgBW/day + Exercise, Placebo + Exercise |
Primary outcome
Go/No-Go Visual Reaction Time False Alarm Errors
Time frame: Baseline and Day 7
Number of false alarm (commission) errors recorded during the Go/No-Go Visual Reaction Time test. Lower values indicate better inhibitory control.
4 secondary outcomes
Go/No-Go Visual Reaction Time
Time frame: Baseline and Day 7
Trail Making Test Part B Completion Time
Time frame: Baseline and Day 7
Visual Reaction Time
Time frame: Baseline and Day 7
Trail Making Test Part A Completion Time
Time frame: Baseline and Day 7
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Apr 2026.
- Individual participant dataSharing planned: Undecided. The plan for sharing individual participant data has not yet been finalized.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Creatine Monohydrate and High Intensity Interval Training in people with Creatine Supplementation and Exercise Ergogenics, run by Universitas Negeri Malang at 1 site in Indonesia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Indonesia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Go/No-Go Visual Reaction Time False Alarm Errors (time frame: Baseline and Day 7). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Apr 2026.