Ridge PreservationNCT07530471
Autologous Blood Products in Ridge Preservation
A study testing Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application in people with Ridge Preservation, run by Çanakkale Onsekiz Mart University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Ridge Preservation
- What is being tested?
- Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Apr 2026to 1 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Systemically healthy individuals with no medical conditions that could interfere with periodontal treatment, tooth extraction, or wound healing
- Absence of systemic diseases affecting blood coagulation and no use of anticoagulant medications
- No history of blood-borne infectious diseases
- Non-smokers
- Age ≥18 years
- Patients requiring extraction of a single-rooted tooth in the maxilla or mandible
- Availability of a pre-existing CBCT scan of the planned extraction site
- Extraction site suitable for implant placement
Who cannot join
- Presence of systemic diseases that may affect periodontal treatment, tooth extraction, wound healing, or increase the risk of complications
- Presence of bleeding or coagulation disorders, or use of anticoagulant therapy
- Presence of blood-borne infectious diseases
- Smoking habit
- Age <18 years
- Psychological or mental conditions that may affect compliance with treatment or study participation
Show all 9Show fewer
- Extraction sites not suitable for implant placement
- History of previous surgical intervention or compromised healing in the extraction site
- Pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Clinical, Radiological, and Ultrasonographic Evaluation of Autologous Blood Products in Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction.
After tooth extraction, dimensional changes occur in both hard and soft tissues, which may negatively affect future implant or prosthetic treatments. This study investigates whether the application of Titanium Platelet-Rich Fibrin (T-PRF), combined with injectable Platelet-Rich Fibrin (i-PRF), can improve healing and reduce tissue changes.
Read more
In this study, tooth extraction will be performed under local anesthesia using minimally invasive techniques. Autologous blood will be collected from the patient and processed by centrifugation to obtain T-PRF and i-PRF. The prepared materials will be applied to the extraction socket and stabilized with sutures. Healing will be monitored through clinical examinations, radiographic imaging, and ultrasonographic evaluations over a 6-month follow-up period.
Possible risks include pain, bleeding, infection, and temporary discomfort, all of which are manageable with standard clinical care.
The study is expected to contribute to the development of biologically based, minimally invasive treatment approaches that enhance tissue healing and support future dental treatments.
- Conditions
- Ridge Preservation
- Being tested
- Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application
- Keywords
- Ridge Preservation, T-PRF, i-PRF, T-PRF Plus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Autologous Titanium Platelet-Rich Fibrin with Injectable PRF ApplicationProcedure or surgery
Following atraumatic tooth extraction under local anesthesia, autologous blood will be collected from the patient. Titanium platelet-rich fibrin (T-PRF) will be prepared by centrifugation of blood in titanium tubes, and injectable platelet-rich fibrin (i-PRF) will be obtained using a low-speed centrifugation protocol.
The prepared i-PRF will be injected into the T-PRF membrane to create a combined autologous fibrin construct. This material will then be placed into the extraction socket to support clot stability and tissue regeneration, and the site will be sutured for stabilization.
This approach combines the dense fibrin structure of T-PRF with the biological activity of i-PRF, aiming to enhance angiogenesis, soft and hard tissue healing, and preservation of alveolar ridge dimensions.
| Study group | Role | What they receive |
|---|---|---|
| control | No intervention | Not described |
| test | Active comparator | Not described Receives: Procedure: Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application |
What is being measured
The primary outcome is the main question the study is designed to answer.
Horizontal Bone Width Change (CBCT Analysis)
Evaluation of horizontal bone width in millimeters at standardized levels (1 mm, 3 mm, and 5 mm from the alveolar crest) using CBCT at baseline (immediately after extraction) and 6 months
Measured: 6 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Apr 2026
- Study start1 Apr 2026
- Primary completion1 Nov 2026 (estimated)
- Study completion1 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Ridge PreservationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Çanakkale Onsekiz Mart University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mustafa Tunali, Çanakkale Onsekiz Mart University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07530471
- Sponsor's protocol ID
- OGU-EC-07-25
- Other IDs
- 2024-KAEK-15
- Status last verified
- Apr 2026
- First submitted
- 1 Apr 2026
- Last updated
- 15 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x.
PubMed 15691354
Study at a glance
From the registry record, last updated by the sponsor on 15 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical, Radiological, and Ultrasonographic Evaluation of Autologous Blood Products in Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07530471
- Acronym / sponsor ID
- OGU-EC-07-25
- Conditions
- Ridge Preservation
- Keywords
- Ridge Preservation, T-PRF, i-PRF, T-PRF Plus
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Çanakkale Onsekiz Mart UniversityUniversity, hospital or other
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- 1 Nov 2026 (estimated)
- Study completion
- 1 Jan 2027 (estimated)
- First posted
- 15 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction.
After tooth extraction, dimensional changes occur in both hard and soft tissues, which may negatively affect future implant or prosthetic treatments. This study investigates whether the application of Titanium Platelet-Rich Fibrin (T-PRF), combined with injectable Platelet-Rich Fibrin (i-PRF), can improve healing and reduce tissue changes.
In this study, tooth extraction will be performed under local anesthesia using minimally invasive techniques. Autologous blood will be collected from the patient and processed by centrifugation to obtain T-PRF and i-PRF. The prepared materials will be applied to the extraction socket and stabilized with sutures. Healing will be monitored through clinical examinations, radiographic imaging, and ultrasonographic evaluations over a 6-month follow-up period.
Possible risks include pain, bleeding, infection, and temporary discomfort, all of which are manageable with standard clinical care.
The study is expected to contribute to the development of biologically based, minimally invasive treatment approaches that enhance tissue healing and support future dental treatments.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| control | No intervention | – |
| test | Active comparator | Procedure: Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Systemically healthy individuals with no medical conditions that could interfere with periodontal treatment, tooth extraction, or wound healing
- Absence of systemic diseases affecting blood coagulation and no use of anticoagulant medications
- No history of blood-borne infectious diseases
- Non-smokers
- Age ≥18 years
Key exclusion criteria (9 listed)
- Presence of systemic diseases that may affect periodontal treatment, tooth extraction, wound healing, or increase the risk of complications
- Presence of bleeding or coagulation disorders, or use of anticoagulant therapy
- Presence of blood-borne infectious diseases
- Smoking habit
- Age <18 years
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Autologous Titanium Platelet-Rich Fibrin with Injectable PRF ApplicationFollowing atraumatic tooth extraction under local anesthesia, autologous blood will be collected from the patient. Titanium platelet-rich fibrin (T-PRF) will be prepared by centrifugation of blood in titanium tubes, and injectable platelet-rich fibrin (i-PRF) will be obtained using a low-speed centrifugation protocol. The prepared i-PRF will be injected into the T-PRF membrane to create a combined autologous fibrin construct. This material will then be placed into the extraction socket to support clot stability and tissue regeneration, and the site will be sutured for stabilization. This approach combines the dense fibrin structure of T-PRF with the biological activity of i-PRF, aiming to enhance angiogenesis, soft and hard tissue healing, and preservation of alveolar ridge dimensions. | Procedure or surgery | test |
Primary outcome
Horizontal Bone Width Change (CBCT Analysis)
Time frame: 6 month
Evaluation of horizontal bone width in millimeters at standardized levels (1 mm, 3 mm, and 5 mm from the alveolar crest) using CBCT at baseline (immediately after extraction) and 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Apr 2026.
- Background: PubMed 15691354Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x.
- Individual participant dataSharing planned: No
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Effect of Collagen Membrane on Ridge Preservation
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Alveolar Ridge Preservation (ARP) Study Using Alloplastic Biomaterial and a Resorbable Synthetic Membrane. A Digital Workflow (CBCT/Scanner) Evaluates Hard and Soft Tissue Volumetric Changes at 4 Months, Validating Support for the Gingival Phenotype and Buccal Bone Plate.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application in people with Ridge Preservation, run by Çanakkale Onsekiz Mart University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 15 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Horizontal Bone Width Change (CBCT Analysis) (time frame: 6 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07530471, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Apr 2026.