Periodontitis, AggressiveNCT07526883
The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis
A study testing Non-surgical periodontal treatment in people with Periodontitis, Aggressive, run by Istanbul University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. Read more about this study
- Who is it for?
- Ages 19 to 36 yearsHealthy volunteers can take part
- Conditions the study is for
- Periodontitis, Aggressive
- What is being tested?
- Non-surgical periodontal treatment
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jul 2006to 1 Jun 2010
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 36 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Young adults aged 19 to 36 years
- At least 20 teeth present
- Clinical attachment loss of at least 5 mm affecting at least 8 teeth
- Bone loss around at least 3 teeth other than incisors and first molars
Who cannot join
- Systemic disease
- Pregnancy or lactation
- Current or former smoking
- Systemic conditions that could alter the host response
- Medical conditions requiring antibiotic prophylaxis during routine dental procedures
- Antibiotic therapy within the previous 6 months
- Previous periodontal treatment
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istanbul University, Faculty of Dentistry, Department of Periodontology
Istanbul
About this study
The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were:
Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis?
Read more
Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment?
Researchers compared participants with severe periodontitis to healthy participants without periodontitis.
Participants with severe periodontitis:
- Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved
- Had full-mouth gum examinations
- Provided blood samples at the start of the study and again at 2 and 6 months after treatment
Healthy participants:
- Had gum examinations
- Provided blood samples for comparison at the start of the study
- Conditions
- Periodontitis, Aggressive
- Being tested
- Non-surgical periodontal treatment
- Keywords
- Inflammation, Periodontal Debridement, Periodontitis, Systemic Biomarkers
- Medical subject headings
- Aggressive Periodontitis, Inflammation, Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Non-surgical periodontal treatmentProcedure or surgery
Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment.
| Study group | Role | What they receive |
|---|---|---|
| Healthy Group | No intervention | The healthy control arm included systemically and periodontally healthy young adults with no periodontal or systemic disease who met the same exclusion criteria as the periodontitis group. Participants did not receive periodontal treatment. They underwent baseline full-mouth periodontal examination and blood sampling to provide healthy reference values. |
| Periodontitis Group | Active comparator | The periodontitis arm included systemically healthy young adults with severe periodontitis. Participants underwent baseline full-mouth periodontal examination and blood sampling, received non-surgical periodontal treatment, and were re-evaluated at 2 and 6 months after treatment. Receives: Procedure: Non-surgical periodontal treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
The change in serum high-sensitivity C-reactive protein (hs-CRP) concentration after periodontal treatment
This change is measured in serum, as mg/dl, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. The study was powered on the change in this parameter from baseline to 6 months after treatment.
Measured: 6 months
The change in HDL cholesterol concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in LDL cholesterol concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in total cholesterol concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in triglyceride concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in albumin concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in von Willebrand factor (vWf) level after periodontal treatment
This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in creatinine concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in fibrinogen concentration after periodontal treatment
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in Factor VII level after periodontal treatment
This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in interleukin-1 receptor (IL-1ra) antagonist concentration after periodontal treatment
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in interleukin-6 (IL-6) level after periodontal treatment
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in soluble tumor necrosis factor receptor I (sTNFRI) concentration after periodontal treatment
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in soluble tumor necrosis factor receptor II concentration (sTNFRII) after periodontal treatment
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
The change in tissue plasminogen activator (tPA) concentration after periodontal treatment
This parameter is measured in blood samples, as ng/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
Measured: 6 months
Secondary outcomes (5)
The change in sulcus bleeding index (SBI) after periodontal treatment
This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.
Measured: 6 months
The change in plaque index (PI) after periodontal treatment
This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.
Measured: 6 months
The change in clinical attachment level (CAL) after periodontal treatment
This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.
Measured: 6 months
The change in probing pocket depth (PPD) after periodontal treatment
This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.
Measured: 6 months
The change in level of gingival margin (LGM) after periodontal treatment
This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2026
- Study start1 Jul 2006
- Primary completion1 Dec 2009
- Study completion1 Jun 2010
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Periodontitis, AggressiveStudies of the same condition, open and under way.
- More trials run by Istanbul UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ülkü Başer, Istanbul University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07526883
- Sponsor's protocol ID
- 2006/1469
- Status last verified
- Apr 2026
- First submitted
- 13 Mar 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis
- ClinicalTrials.gov ID
- NCT07526883
- Acronym / sponsor ID
- 2006/1469
- Conditions
- Periodontitis, Aggressive
- Keywords
- Inflammation, Periodontal Debridement, Periodontitis, Systemic Biomarkers
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Istanbul UniversityUniversity, hospital or other
- Study start
- 1 Jul 2006 (actual)
- Primary completion
- 1 Dec 2009 (actual)
- Study completion
- 1 Jun 2010 (actual)
- First posted
- 13 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were:
Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis?
Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment?
Researchers compared participants with severe periodontitis to healthy participants without periodontitis.
Participants with severe periodontitis:
- Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved
- Had full-mouth gum examinations
- Provided blood samples at the start of the study and again at 2 and 6 months after treatment
Healthy participants:
- Had gum examinations
- Provided blood samples for comparison at the start of the study
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Healthy Group | No intervention | –The healthy control arm included systemically and periodontally healthy young adults with no periodontal or systemic disease who met the same exclusion criteria as the periodontitis group. Participants did not receive periodontal treatment. They underwent baseline full-mouth periodontal examination and blood sampling to provide healthy reference values. |
| Periodontitis Group | Active comparator | Procedure: Non-surgical periodontal treatmentThe periodontitis arm included systemically healthy young adults with severe periodontitis. Participants underwent baseline full-mouth periodontal examination and blood sampling, received non-surgical periodontal treatment, and were re-evaluated at 2 and 6 months after treatment. |
Who may qualify
- Ages
- 19 to 36 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Young adults aged 19 to 36 years
- At least 20 teeth present
- Clinical attachment loss of at least 5 mm affecting at least 8 teeth
- Bone loss around at least 3 teeth other than incisors and first molars
Key exclusion criteria (7 listed)
- Systemic disease
- Pregnancy or lactation
- Current or former smoking
- Systemic conditions that could alter the host response
- Medical conditions requiring antibiotic prophylaxis during routine dental procedures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Non-surgical periodontal treatmentNon-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment. | Procedure or surgery | Periodontitis Group |
Primary outcome
The change in serum high-sensitivity C-reactive protein (hs-CRP) concentration after periodontal treatment
Time frame: 6 months
This change is measured in serum, as mg/dl, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. The study was powered on the change in this parameter from baseline to 6 months after treatment.
The change in HDL cholesterol concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in LDL cholesterol concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in total cholesterol concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in triglyceride concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in albumin concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in von Willebrand factor (vWf) level after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in creatinine concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in fibrinogen concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in Factor VII level after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in interleukin-1 receptor (IL-1ra) antagonist concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in interleukin-6 (IL-6) level after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in soluble tumor necrosis factor receptor I (sTNFRI) concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in soluble tumor necrosis factor receptor II concentration (sTNFRII) after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
The change in tissue plasminogen activator (tPA) concentration after periodontal treatment
Time frame: 6 months
This parameter is measured in blood samples, as ng/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.
5 secondary outcomes
The change in sulcus bleeding index (SBI) after periodontal treatment
Time frame: 6 months
The change in plaque index (PI) after periodontal treatment
Time frame: 6 months
The change in clinical attachment level (CAL) after periodontal treatment
Time frame: 6 months
The change in probing pocket depth (PPD) after periodontal treatment
Time frame: 6 months
The change in level of gingival margin (LGM) after periodontal treatment
Time frame: 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Non-surgical periodontal treatment in people with Periodontitis, Aggressive, run by Istanbul University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The change in serum high-sensitivity C-reactive protein (hs-CRP) concentration after periodontal treatment (time frame: 6 months). The study lists 15 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.