UveitisUV1NCT07518134
A Study of Uveitis in Children <18 Years of Age
An observational study of Uveitis, run by Jaeb Center for Health Research at 4 sites in United States.
Trial summary
The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis. The main questions it aims to answer are: What are the frequency of uveitis subtypes in children? What are clinical and demographic characteristics overall and within each… Read more about this study
- Who is it for?
- Ages Up to 17 years
- Conditions the study is for
- Uveitis
- How many people
- 300 participants
- Where
- 4 sitesUnited States
- Study dates
- 14 Apr 2026to 1 Apr 2028
- How long will I take part?
- 12 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 17 years
- All sexes
- No healthy volunteers
- Child
Study population: Children <18 years with active or inactive uveitis.
Who may be able to join
- Age:
- Incident cases (onset ≤ 6 months) <17 years
- Established cases (onset > 6 months) <18 years
- Diagnosis of any type of uveitis (infectious or noninfectious) in any location except traumatic and post-operative uveitis.
- Active or inactive uveitis with any treatment status (current / prior / none [but under surveillance]).
Who cannot join
- Bilateral uveitis with differing etiologies
- Traumatic uveitis
- Post-operative uveitis
- Immediate family member (spouse, biological or legal guardian, child, sibling, parent) who is an investigative site personnel directly affiliated with this study or who is an employee of JAEB Center for Health Research.
- Ocular disease related to Retinoblastoma, Coat's disease, retinitis pigmentosa, inherited retinal degeneration, Juvenile xanthogranuloma (JXG), or leukemia/malignancy within the eye.
Trial locations and contacts
4 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States4 sites, 4 recruiting
- Recruiting
Akron Children's Hospital
Akron, Ohio, 44308
Cassandra S Solis, O.D, 330-543-5150, csolis@akronchildrens.org
- Recruiting
Department of Ophthalmology, Boston University School of Medicine
Boston, Massachusetts, 02118
Kara C LaMattina, MD, 617-414-4020, Kara.LaMattina@bmc.org
- Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Virginia Miraldi Utz, MD, 513-636-4751, virginia.utz@cchmc.org
- Recruiting
Pediatric Ophthalmology Associates, Inc.
Columbus, Ohio, 43205
Catherine O Jordan, MD, (614) 224-6222, cateolsonjordan@gmail.com
About this study
The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis. The main questions it aims to answer are:
- What are the frequency of uveitis subtypes in children?
- What are clinical and demographic characteristics overall and within each type of uveitis?
Participants will complete one enrollment visit with their doctor. Participants with uveitis onset <6 months from enrollment date will also partake in a 12 month chart review.
- Conditions
- Uveitis
- Keywords
- pediatric, uveitis
- Medical subject headings
- Uveitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Children diagnosed with uveitis - established cases | Children diagnosed with uveitis (onset > 6 months), either active or inactive with or without current treatment at time of enrollment. | |
| Children diagnosed with uveitis - incident cases | Children diagnosed with uveitis (onset ≤ 6 months), either active or inactive with or without current treatment at time of enrollment. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Frequency of uveitis subtypes in children <18 years of age
Measured: Enrollment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start14 Apr 2026
- Primary completion1 Apr 2027 (estimated)
- Study completion1 Apr 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for UveitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 300 participants (estimated)
- Target duration
- 12 Months
Sponsor and investigators
- Lead sponsor
- Jaeb Center for Health Research
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Kara C LaMattina, MD, Study chair, Department of Ophthalmology, Boston University School of MedicineVirginia Miraldi Utz, MD, Study chair, Children's Hospital Medical Center, Cincinnati
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07518134
- Sponsor's protocol ID
- UV1
- Acronym
- UV1
- Status last verified
- May 2026
- First submitted
- 1 Apr 2026
- Last updated
- 2 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 2 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Study of Uveitis in Children <18 Years of Age
- ClinicalTrials.gov ID
- NCT07518134
- Acronym / sponsor ID
- UV1 / UV1
- Conditions
- Uveitis
- Keywords
- pediatric, uveitis
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Jaeb Center for Health ResearchUniversity, hospital or other
- Study start
- 14 Apr 2026 (actual)
- Primary completion
- 1 Apr 2027 (estimated)
- Study completion
- 1 Apr 2028 (estimated)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis. The main questions it aims to answer are:
- What are the frequency of uveitis subtypes in children?
- What are clinical and demographic characteristics overall and within each type of uveitis?
Participants will complete one enrollment visit with their doctor. Participants with uveitis onset <6 months from enrollment date will also partake in a 12 month chart review.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Target follow-up
- 12 Months
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Children diagnosed with uveitis - established cases | – | –Children diagnosed with uveitis (onset > 6 months), either active or inactive with or without current treatment at time of enrollment. |
| Children diagnosed with uveitis - incident cases | – | –Children diagnosed with uveitis (onset ≤ 6 months), either active or inactive with or without current treatment at time of enrollment. |
Who may qualify
- Ages
- Up to 17 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
- Study population
- Children <18 years with active or inactive uveitis.
Key inclusion criteria (5 listed)
- Age:
- Diagnosis of any type of uveitis (infectious or noninfectious) in any location except traumatic and post-operative uveitis.
- Active or inactive uveitis with any treatment status (current / prior / none [but under surveillance]).
Key exclusion criteria (5 listed)
- Bilateral uveitis with differing etiologies
- Traumatic uveitis
- Post-operative uveitis
- Immediate family member (spouse, biological or legal guardian, child, sibling, parent) who is an investigative site personnel directly affiliated with this study or who is an employee of JAEB Center for Health Research.
- Ocular disease related to Retinoblastoma, Coat's disease, retinitis pigmentosa, inherited retinal degeneration, Juvenile xanthogranuloma (JXG), or leukemia/malignancy within the eye.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Frequency of uveitis subtypes in children <18 years of age
Time frame: Enrollment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Nov 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Kara C LaMattina, MD study chair
Department of Ophthalmology, Boston University School of Medicine
Virginia Miraldi Utz, MD study chair
Children's Hospital Medical Center, Cincinnati
4 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Uveitis, run by Jaeb Center for Health Research at 4 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 2 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 4 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Julianne Zawadzki, MSPH (813-975-8690, jrobinson@jaeb.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Frequency of uveitis subtypes in children <18 years of age (time frame: Enrollment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Nov 2026.