AzTrials
AzTrials

Cardiovascular Disease and Lipoprotein(a)Phase 3NCT07517263

An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

A Phase 3 study testing Pelacarsen (TQJ230) in people with Cardiovascular Disease and Lipoprotein(a), run by Novartis Pharmaceuticals at 646 sites in 40 countries.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

This open-label extension study provides post-trial access to pelacarsen (TQJ230) to participants who have successfully completed the double-blind parent study (CTQJ230A12301). Study has been terminated by sponsor following the outcome of the Lp(a)HORIZON study (NCT04023552), which did not meet its primary endpoint. Read more about this study

Who is it for?
Ages 18 to 100 years
What is being tested?
Pelacarsen (TQJ230)
Could I receive a placebo?
No, everyone receives an active treatment
How many people
5,700 participants
Where
646 sitesin 40 countries
Study dates
11 May 2026to 9 Jan 2030
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 100 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Participants who have provided informed consent prior to initiation of any study-specific activities/procedures.
  • Participants who have completed the parent study EOS visit while still on assigned investigational product.

Who cannot join

  • Participants who for any reason permanently discontinued or have interrupted the investigational product for continuous 6 months at EOS during the parent study.
  • Participants who have a history or evidence of any clinically significant disorder, condition, or disease that in the opinion of the investigator or Novartis physician (if consulted), would put the participant at risk or interfere with the study participation, including, but not restricted to conditions outlined in Table 6-3 and Table 6-5.
  • Participants are receiving another investigational drug or device before the open-label treatment period.
  • Participants have a known sensitivity to the study drug and are deemed as unsuited for the study by the Investigator at Screening visit.
  • Other protocol-defined inclusion/exclusion criteria may apply.

Trial locations and contacts

646 sites in 40 countries.

646 sites in 40 countries

United States120 sites

  • Akron Hospital Summa Health System

    Akron, Ohio, 44309

  • SEC Clinical Research LLC

    Andalusia, Alabama, 36420

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309

  • Emory University

    Atlanta, Georgia, 30322

  • Univ Of Color Anschutz Med Center

    Aurora, Colorado, 80045

  • University of Maryland

    Baltimore, Maryland, 21201

  • Sinai Ct for Throm Res and Drug Dev

    Baltimore, Maryland, 21209

  • Johns Hopkins Univ School of Med

    Baltimore, Maryland, 21287

  • Belzoni Clinical Research

    Belzoni, Mississippi, 39038

  • Cardiovascular Res Found

    Beverly Hills, California, 90210

  • National Heart Institute

    Beverly Hills, California, 90211

  • Excel Medical Clinical Trials LLC

    Boca Raton, Florida, 33434

  • MGH

    Boston, Massachusetts, 02114-2696

  • Brigham and Womens Hosp Harvard Med School

    Boston, Massachusetts, 02115

  • Progressive Clinical Research

    Bountiful, Utah, 84010

  • Bay Area Cardiology Assoc

    Brandon, Florida, 33511

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610

  • Aultman Hospital

    Canton, Ohio, 44710

  • Novant Health Heart Vas Inst

    Charlotte, North Carolina, 28204

  • Rush University Medical Center

    Chicago, Illinois, 60612

  • Lindner Ctr At The Christ Hosp

    Cincinnati, Ohio, 45219

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195

  • Johns Hopkins University

    Columbia, Maryland, 21044

  • Ohio State University

    Columbus, Ohio, 43210

  • Valley Clinical Trials Inc

    Covina, California, 91723

  • Cardiovascular Associates Research

    Covington, Louisiana, 70433

  • Louisiana Heart Center Research

    Covington, Louisiana, 70433

  • Soltero Cardiovascular Research Center

    Dallas, Texas, 75226

  • North Texas Endocrine Center

    Dallas, Texas, 75231

  • SW Family Medicine Associates

    Dallas, Texas, 75235

  • Wayne State University

    Detroit, Michigan, 48201

  • Henry Ford Hospital

    Detroit, Michigan, 48202

  • Inova Fairfax Hospital

    Falls Church, Virginia, 22042

  • Virginia Heart

    Falls Church, Virginia, 22042

  • AA Medical Research Center

    Flint, Michigan, 48504

  • Anderson Medical Research

    Ft. Washington, Maryland, 20744

  • The Stern Cardiovascular Foundation

    Germantown, Tennessee, 38138

  • Mercy Gilbert Medical Center

    Gilbert, Arizona, 85297

  • Medication Management LLC

    Greensboro, North Carolina, 27405

  • Hartford Hospital

    Hartford, Connecticut, 06102

  • CV Institute of the South

    Houma, Louisiana, 70360

  • Baylor College Of Medicine

    Houston, Texas, 77030

  • Diabetes Lipid Management Center

    Huntington Beach, California, 92648

  • Heart Center Research Llc

    Huntsville, Alabama, 35801

  • Krannert Institute of Cardiology

    Indianapolis, Indiana, 46202-4800

  • Uni Of Iowa Hospitals And Clinics

    Iowa City, Iowa, 52242

  • University of Calif Irvine Med Cntr

    Irvine, California, 92660

  • Apex Cardiology Research Associates of Jackson

    Jackson, Tennessee, 38301

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

  • Western Michigan University

    Kalamazoo, Michigan, 49008

  • University of Kansas Hospital

    Kansas City, Kansas, 66160

  • Lancaster General Health

    Lancaster, Pennsylvania, 17603

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03756

  • Cardiology and Medicine Clinic PA

    Little Rock, Arkansas, 72204

  • Memorial Care Health System

    Long Beach, California, 90806

  • Keck Medical Center USC

    Los Angeles, California, 90033

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

  • Northwell Health

    Manhasset, New York, 11030

  • Saint Johns Hospital

    Maplewood, Minnesota, 55109

  • Rama Research LLC

    Marion, Ohio, 43302

  • Grace Research

    Marshall, Texas, 75670

  • Omega Clinical Research

    Metairie, Louisiana, 70006

  • St Luke s Medical Center Aurora

    Milwaukee, Wisconsin, 53215

  • Minneapolis Heart Institute

    Minneapolis, Minnesota, 55407

  • University Of Minnesota

    Minneapolis, Minnesota, 55455

  • Mobile Heart Specialists

    Mobile, Alabama, 36608

  • West Virginia University Hospital

    Morgantown, West Virginia, 26506

  • Intermountain Medical Center

    Murray, Utah, 84107

  • Advanced Research for Health Improvement LLC

    Naples, Florida, 34102

  • Vanderbilt Univ Medi Cen

    Nashville, Tennessee, 37232

  • Tulane Center for Clinical Research

    New Orleans, Louisiana, 70112

  • Weill Cornell Medical Center

    New York, New York, 10021

  • Icahn School of Med at Mt Sinai

    New York, New York, 10029

  • Lenox Hill Hospital

    New York, New York, 43210

  • Valley Clinical Trials

    Northridge, California, 91325

  • Quality Clinical Research

    Omaha, Nebraska, 68114

  • CV Ins of the South

    Opelousas, Louisiana, 70570

  • Stanford University Medical Center

    Palo Alto, California, 94304

  • Advocate Lutheran General Childrens Hospital

    Park Ridge, Illinois, 60068

  • McLaren Ctr Research Innovation

    Petoskey, Michigan, 49770

  • Perelman School of Medicine

    Philadelphia, Pennsylvania, 19104

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212

  • Peace River Cardiovascular Center

    Port Charlotte, Florida, 33952

  • Progressive Medical Research

    Port Orange, Florida, 32127

  • Cardiovascular Res of Knoxville LLC

    Powell, Tennessee, 37849

  • Accellacare US Inc

    Raleigh, North Carolina, 27609

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

  • Dominion Medical Associates

    Richmond, Virginia, 23219

  • The Valley Hospital

    Ridgewood, New Jersey, 07450

  • Northwell Health Physician Peconic

    Riverhead, New York, 11901

  • Adventist HealthCare Shady Grove Medical Center

    Rockville, Maryland, 20850

  • Central Michigan University

    Saginaw, Michigan, 48601

  • East Coast Inst for Research LLC

    Saint Augustine, Florida, 32086

  • The University of Utah

    Salt Lake City, Utah, 84132-0001

  • University of California San Diego

    San Diego, California, 92103

  • UCSF

    San Francisco, California, 94115

  • Maine Health Cardiology

    Scarborough, Maine, 04074

  • Harborview Medical Center

    Seattle, Washington, 98104

  • Swedish Medical Center-Cardiovascular Research

    Seattle, Washington, 98122

  • Univ of Washington Medical Center

    Seattle, Washington, 98195

  • Grace Research Llc

    Shreveport, Louisiana, 71105

  • Louisiana Heart Center Research

    Slidell, Louisiana, 70458

  • Stern Cardiovascular Foundation Inc

    Southaven, Mississippi, 38671

  • Washington Univ School Of Medicine

    St Louis, Missouri, 63110

  • Mercy Hospital St Louis

    St Louis, Missouri, 63141

  • Manshadi Heart Institute

    Stockton, California, 95204

  • Overlook Medical Center

    Summit, New Jersey, 07901

  • Clinical Research Inst of Arizona

    Sun City West, Arizona, 85375

  • Cardiovascular Consultants of S GA

    Thomasville, Georgia, 31792

  • Northwest Houston Clinical Research PLLC

    Tomball, Texas, 77375

  • Cotton O Neil Clinical Res Center

    Topeka, Kansas, 66606

  • Eclipse Clinical Research

    Tucson, Arizona, 85745

  • Chase Medical Research LLC

    Waterbury, Connecticut, 06708

  • Cardiology Partners Clinical Research Institute

    Wellington, Florida, 33449

  • Interv Cardiology Med Grp

    West Hills, California, 91307

  • Wake Forest University Baptist Medical Center

    Winston-Salem, North Carolina, 27157

  • Metro Health Univ of MI Health

    Wyoming, Michigan, 49519

  • Cardiology Consultants of Philadelphia

    Yardley, Pennsylvania, 19067

  • Southern Clinical Research

    Zachary, Louisiana, 70791

Other trials in United States

Germany52 sites

  • Novartis Investigative Site

    Aachen, 52074

  • Novartis Investigative Site

    Bad Homburg, 61348

  • Novartis Investigative Site

    Bad Krozingen, 79189

  • Novartis Investigative Site

    Bad Oeynhausen, 32545

  • Novartis Investigative Site

    Bamberg, 96049

  • Novartis Investigative Site

    Berlin, 10367

  • Novartis Investigative Site

    Berlin, 10559

  • Novartis Investigative Site

    Berlin, 10787

  • Novartis Investigative Site

    Berlin, 10789

  • Novartis Investigative Site

    Berlin, 13347

  • Novartis Investigative Site

    Berlin, 13353

  • Novartis Investigative Site

    Bielefeld, 33604

  • Novartis Investigative Site

    Chemnitz, Saxony, 09113

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50733

  • Novartis Investigative Site

    Cologne, North Rhine-Westphalia, 50937

  • Novartis Investigative Site

    Dessau, 06846

  • Novartis Investigative Site

    Dortmund, 44137

  • Novartis Investigative Site

    Dresden, Saxony, 01099

  • Novartis Investigative Site

    Dresden, Saxony, 01307

  • Novartis Investigative Site

    Dresden, 01069

  • Novartis Investigative Site

    Dresden, 01277

  • Novartis Investigative Site

    Dresden, 01307

  • Novartis Investigative Site

    Essen, North Rhine-Westphalia, 45355

  • Novartis Investigative Site

    Essen, 45277

  • Novartis Investigative Site

    Essen, 45355

  • Novartis Investigative Site

    Essen, 45359

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60590

  • Novartis Investigative Site

    Frankfurt am Main, Hesse, 60594

  • Novartis Investigative Site

    Gelnhausen, 63571

  • Novartis Investigative Site

    Hamburg, 22041

  • Novartis Investigative Site

    Hamburg, 22607

  • Novartis Investigative Site

    Hanover, Lower Saxony, 30159

  • Novartis Investigative Site

    Jena, Thuringia, 07740

  • Novartis Investigative Site

    Kassel, 34121

  • Novartis Investigative Site

    Leipzig, Saxony, 04103

  • Novartis Investigative Site

    Löhne, North Rhine-Westphalia, 32584

  • Novartis Investigative Site

    Lüneburg, 21339

  • Novartis Investigative Site

    Magdeburg, 39120

  • Novartis Investigative Site

    Mannheim, Baden-Wurttemberg, 68305

  • Novartis Investigative Site

    Mannheim, 68165

  • Novartis Investigative Site

    Meissen, 01662

  • Novartis Investigative Site

    Muehldorf Am Inn, Bavaria, 84453

  • Novartis Investigative Site

    München, 80636

  • Novartis Investigative Site

    Munich, Bavaria, 81377

  • Novartis Investigative Site

    Münster, 48149

  • Novartis Investigative Site

    Potsdam, 14471

  • Novartis Investigative Site

    Rüdersdorf, 15562

  • Novartis Investigative Site

    Saint Ingbert, Saarland, 66386

  • Novartis Investigative Site

    Ulm, 89077

  • Novartis Investigative Site

    Warendorf, 48231

  • Novartis Investigative Site

    Weiden in Der Oberpfalz, Bavaria, 92637

  • Novartis Investigative Site

    Wittenberg, Saxony-Anhalt, 06886

Other trials in Germany

China36 sites

  • Novartis Investigative Site

    Baotou, Inner Mongolia, 014040

  • Novartis Investigative Site

    Beijing, Beijing Municipality, 100013

  • Novartis Investigative Site

    Beijing, 100050

  • Novartis Investigative Site

    Beijing, 100191

  • Novartis Investigative Site

    Beijing, 100730

  • Novartis Investigative Site

    Changchun, Jilin, 130021

  • Novartis Investigative Site

    Changsha, Hunan, 410003

  • Novartis Investigative Site

    Changsha, Hunan, 410008

  • Novartis Investigative Site

    Changsha, Hunan, 410011

  • Novartis Investigative Site

    Chengdu, Sichuan, 610041

  • Novartis Investigative Site

    Dalian, Liaoning, 116011

  • Novartis Investigative Site

    Foshan, Guangdong, 528000

  • Novartis Investigative Site

    Guangzhou, Guangdong, 510080

  • Novartis Investigative Site

    Hangzhou, Zhejiang, 310014

  • Novartis Investigative Site

    Hangzhou, Zhejiang, 310016

  • Novartis Investigative Site

    Harbin, Heilongjiang, 150000

  • Novartis Investigative Site

    Jinan, Shandong, 250013

  • Novartis Investigative Site

    Lanzhou, Gansu, 730030

  • Novartis Investigative Site

    Nanjing, Jiangsu, 210009

  • Novartis Investigative Site

    Nanjing, Jiangsu, 210029

  • Novartis Investigative Site

    Nanjing, Jiangsu, 211166

  • Novartis Investigative Site

    Shanghai, 200025

  • Novartis Investigative Site

    Shanghai, 200040

  • Novartis Investigative Site

    Shanghai, 200065

  • Novartis Investigative Site

    Shanghai, 200120

  • Novartis Investigative Site

    Shenyang, Liaoning, 110004

  • Novartis Investigative Site

    Shenyang, Liaoning, 110016

  • Novartis Investigative Site

    Suzhou, Jiangsu, 215004

  • Novartis Investigative Site

    Tianjin, 030045

  • Novartis Investigative Site

    Tianjin, 300052

  • Novartis Investigative Site

    Tianjin, 300121

  • Novartis Investigative Site

    Ürümqi, Xinjiang, 830054

  • Novartis Investigative Site

    Wenzhou, Zhejiang, 325000

  • Novartis Investigative Site

    Xiamen, 361004

  • Novartis Investigative Site

    Xian, Shanxi, 710061

  • Novartis Investigative Site

    Xuzhou, Jiangsu, 221003

Other trials in China

United Kingdom36 sites

  • Novartis Investigative Site

    Birmingham, B9 5SS

  • Novartis Investigative Site

    Bristol, BS2 8HW

  • Novartis Investigative Site

    Bromwich, B71 4HJ

  • Novartis Investigative Site

    Cardiff, Wales, CF5 4AD

  • Novartis Investigative Site

    Cardiff, CF64 2XX

  • Novartis Investigative Site

    Chertsey, Surrey, KT16 0PZ

  • Novartis Investigative Site

    Chesterfield, S40 4AA

  • Novartis Investigative Site

    Chichester, West Sussex, PO19 6SE

  • Novartis Investigative Site

    Dorchester, Dorset, DT1 2JY

  • Novartis Investigative Site

    Edinburgh, EH16 4SA

  • Novartis Investigative Site

    Glasgow, G20 7BE

  • Novartis Investigative Site

    Harrow, Middlesex, HA1 3UJ

  • Novartis Investigative Site

    Leicester, LE3 9QP

  • Novartis Investigative Site

    Liverpool, L7 8XP

  • Novartis Investigative Site

    London, GBR, EC1M 6BQ

  • Novartis Investigative Site

    London, Greater London, EN3 4GS

  • Novartis Investigative Site

    London, W12 0HS

  • Novartis Investigative Site

    Londonderry, BT47 6SB

  • Novartis Investigative Site

    Manchester, M13 9WL

  • Novartis Investigative Site

    Middlesbrough, TS4 3BW

  • Novartis Investigative Site

    Middlesex, UB9 6JH

  • Novartis Investigative Site

    Newcastle upon Tyne, Tyne and Wear, NE7 7DN

  • Novartis Investigative Site

    Newport, NP20 2UB

  • Novartis Investigative Site

    Norwich, NR4 7UY

  • Novartis Investigative Site

    Plymouth, PL6 8DH

  • Novartis Investigative Site

    Portadown, Nothern Ireland, BT63 5QQ

  • Novartis Investigative Site

    Preston, Lancashire, PR2 9QB

  • Novartis Investigative Site

    Rhyl, LL18 5UJ

  • Novartis Investigative Site

    Rochdale, North Manchester, OL11 4AU

  • Novartis Investigative Site

    Sheffield, S5 7AU

  • Novartis Investigative Site

    Sunderland, Tyne and Wear, SR4 7TP

  • Novartis Investigative Site

    Swansea, SA2 8QA

  • Novartis Investigative Site

    Taunton, Somerset, TA1 5DA

  • Novartis Investigative Site

    Tyne and Wear, NE29 8NH

  • Novartis Investigative Site

    Wiltshire, SN15 2SB

  • Novartis Investigative Site

    Wrexham, LL13 7TD

Other trials in United Kingdom

Russia34 sites

  • Novartis Investigative Site

    Chelyabinsk, 454047

  • Novartis Investigative Site

    Ivanovo, 153012

  • Novartis Investigative Site

    Izhevsk, 426061

  • Novartis Investigative Site

    Kemerovo, 650002

  • Novartis Investigative Site

    Kirov, 610035

  • Novartis Investigative Site

    Krasnodar, 350086

  • Novartis Investigative Site

    Moscow, 101990

  • Novartis Investigative Site

    Moscow, 117198

  • Novartis Investigative Site

    Moscow, 117997

  • Novartis Investigative Site

    Moscow, 121552

  • Novartis Investigative Site

    Moscow, 127473

  • Novartis Investigative Site

    Moscow, 141060

  • Novartis Investigative Site

    Novosibirsk, 630090

  • Novartis Investigative Site

    Perm, 614097

  • Novartis Investigative Site

    Rostov-on-Don, 344022

  • Novartis Investigative Site

    Ryazan, 390039

  • Novartis Investigative Site

    Saint Petersburg, Russia, 198328

  • Novartis Investigative Site

    Saint Petersburg, 191015

  • Novartis Investigative Site

    Saint Petersburg, 194354

  • Novartis Investigative Site

    Saint Petersburg, 195197

  • Novartis Investigative Site

    Saint Petersburg, 196143

  • Novartis Investigative Site

    Saint Petersburg, 197341

  • Novartis Investigative Site

    Saint Petersburg, 199178

  • Novartis Investigative Site

    Samara, 443070

  • Novartis Investigative Site

    Saratov, 410012

  • Novartis Investigative Site

    Saratov, 410028

  • Novartis Investigative Site

    Sochy, 354002

  • Novartis Investigative Site

    Tomsk, 634009

  • Novartis Investigative Site

    Ulyanovsk, 432063

  • Novartis Investigative Site

    Vsevolozhsk, 188643

  • Novartis Investigative Site

    Yaroslavl, 150062

  • Novartis Investigative Site

    Yekaterinburg, 620028

  • Novartis Investigative Site

    Yekaterinburg, 620137

  • Novartis Investigative Site

    Yekaterinburg, 620144

Other trials in Russia

Czechia33 sites

  • Novartis Investigative Site

    Brandýs nad Labem, 250 01

  • Novartis Investigative Site

    Brno, 602 00

  • Novartis Investigative Site

    Brno, 625 00

  • Novartis Investigative Site

    Broumov, 550 01

  • Novartis Investigative Site

    Český Krumlov, 381 01

  • Novartis Investigative Site

    Chlumec nad Cidlinou, 503 51

  • Novartis Investigative Site

    CZE, 110 00

  • Novartis Investigative Site

    Hlučín, 748 01

  • Novartis Investigative Site

    Hodonín, 695 01

  • Novartis Investigative Site

    Jihlava, 586 01

  • Novartis Investigative Site

    Kolín, 280 20

  • Novartis Investigative Site

    Kroměříž, Czech Republic, 767 55

  • Novartis Investigative Site

    Liberec, 460 01

  • Novartis Investigative Site

    Liberec, 460 05

  • Novartis Investigative Site

    Louny, Czech Republic, 440 01

  • Novartis Investigative Site

    Mariánské Lázně, 353 01

  • Novartis Investigative Site

    Mělník, 276 01

  • Novartis Investigative Site

    Most, 434 01

  • Novartis Investigative Site

    Olomouc, 779 00

  • Novartis Investigative Site

    Ostrava, Czech Republic, 725 27

  • Novartis Investigative Site

    Ostrava, Zabreh, 700 30

  • Novartis Investigative Site

    Ostrava, 700 30

  • Novartis Investigative Site

    Pardubice, 532 03

  • Novartis Investigative Site

    Polička, 57201

  • Novartis Investigative Site

    Prague, 110 00

  • Novartis Investigative Site

    Prague, 128 08

  • Novartis Investigative Site

    Slaný, 274 01

  • Novartis Investigative Site

    Třebíč, 674 01

  • Novartis Investigative Site

    Trutnov, 460 63

  • Novartis Investigative Site

    Uherské Hradiště, 686 01

  • Novartis Investigative Site

    Ústí nad Labem, Czech Republic, 400 01

  • Novartis Investigative Site

    Valašské Meziříčí, 75742

  • Novartis Investigative Site

    Zlín, 760 01

Other trials in Czechia

India32 sites

  • Novartis Investigative Site

    Ahmedabad, Gujarat, 380054

  • Novartis Investigative Site

    Ahmedabad, Gujarat, 380060

  • Novartis Investigative Site

    Belagavi, Karnataka, 590010

  • Novartis Investigative Site

    Bikaner, Rajasthan, 334003

  • Novartis Investigative Site

    Chennai, Tamil Nadu, 600006

  • Novartis Investigative Site

    Coimbatore, Tamil Nadu, 641009

  • Novartis Investigative Site

    Coimbatore, Tamil Nadu, 641037

  • Novartis Investigative Site

    Dehradun, Uttarakhand, 248001

  • Novartis Investigative Site

    Ghaziabad, Uttar Pradesh, 201012

  • Novartis Investigative Site

    Guntur, Andhra Pradesh, 522001

  • Novartis Investigative Site

    Hyderabad, Telangana, 500034

  • Novartis Investigative Site

    Hyderabad, Telangana, 500082

  • Novartis Investigative Site

    Kochi, Kerala, 682018

  • Novartis Investigative Site

    Kochi, Kerala, 682027

  • Novartis Investigative Site

    Kochi, Kerala, 682041

  • Novartis Investigative Site

    Lucknow, Uttar Pradesh, 226003

  • Novartis Investigative Site

    Mangalore, Karnataka, 575018

  • Novartis Investigative Site

    Manipal, Karnataka, 576104

  • Novartis Investigative Site

    Mysore, 570015

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440008

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440012

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440025

  • Novartis Investigative Site

    Nagpur, Maharashtra, 440033

  • Novartis Investigative Site

    Nashik, Maharashtra, 422005

  • Novartis Investigative Site

    New Delhi, National Capital Territory of Delhi, 110060

  • Novartis Investigative Site

    New Delhi, National Capital Territory of Delhi, 110075

  • Novartis Investigative Site

    New Delhi, 110025

  • Novartis Investigative Site

    Pune, Maharashtra, 411004

  • Novartis Investigative Site

    Pune, Maharashtra, 411028

  • Novartis Investigative Site

    Pune, Maharashtra, 411045

  • Novartis Investigative Site

    Secunderabad, Telangana, 500003

  • Novartis Investigative Site

    Vadodara, Gujarat, 390022

Other trials in India

Japan27 sites

  • Novartis Investigative Site

    Asahi, Chiba, 2892511

  • Novartis Investigative Site

    Bunkyo Ku, Tokyo, 1138431

  • Novartis Investigative Site

    Chuo Ku, Tokyo, 1048560

  • Novartis Investigative Site

    Chuo-ku, Tokyo, 1030027

  • Novartis Investigative Site

    Funabashi, Chiba, 2738588

  • Novartis Investigative Site

    Hachiōji, Tokyo, 1920918

  • Novartis Investigative Site

    Hirosaki, Aomori, 0368563

  • Novartis Investigative Site

    Ishikawa, 9208641

  • Novartis Investigative Site

    Itabashi-ku, Tokyo, 1738610

  • Novartis Investigative Site

    Kawasaki, Kanagawa, 2120021

  • Novartis Investigative Site

    Kitakyushu, Fukuoka, 8028555

  • Novartis Investigative Site

    Komatsu, Ishikawa-ken, 9230961

  • Novartis Investigative Site

    Kure, Hiroshima, 7370023

  • Novartis Investigative Site

    Matsudo, Chiba, 2702251

  • Novartis Investigative Site

    Miyhazaki, Miyazaki, 8802102

  • Novartis Investigative Site

    Nagoya, Aichi-ken, 4538511

  • Novartis Investigative Site

    Ōgaki, Gifu, 5038502

  • Novartis Investigative Site

    Ōmihachiman, Shiga, 5230082

  • Novartis Investigative Site

    Osaka, Osaka, 5438922

  • Novartis Investigative Site

    Ōta-ku, Tokyo, 1438541

  • Novartis Investigative Site

    Sagamihara, Kanagawa, 2520375

  • Novartis Investigative Site

    Sayama, Saitama, 3501305

  • Novartis Investigative Site

    Sendai, Miyagi, 9810914

  • Novartis Investigative Site

    Seto, Aichi-ken, 4898642

  • Novartis Investigative Site

    Takamatsu, Kagawa-ken, 7608557

  • Novartis Investigative Site

    Tsuchiura, Ibaraki, 3000028

  • Novartis Investigative Site

    Yokohama, Kanagawa, 2320024

Other trials in Japan

Brazil26 sites

  • Novartis Investigative Site

    Aracaju, Sergipe, 49055-530

  • Novartis Investigative Site

    Belo Horizonte, Minas Gerais, 30150-270

  • Novartis Investigative Site

    Belo Horizonte, Minas Gerais, 30150-320

  • Novartis Investigative Site

    Blumenau, Santa Catarina, 89020-430

  • Novartis Investigative Site

    Brasília, Federal District, 70390-700

  • Novartis Investigative Site

    Campinas, São Paulo, 13060-080

  • Novartis Investigative Site

    Campinas, São Paulo, 13092133

  • Novartis Investigative Site

    Canoas, Rio Grande do Sul, 92425-900

  • Novartis Investigative Site

    Curitiba, Paraná, 80730-150

  • Novartis Investigative Site

    Goiânia, Goiás, 74605-020

  • Novartis Investigative Site

    Porto Alegre, Rio Grande do Sul, 90160-093

  • Novartis Investigative Site

    Porto Alegre, Rio Grande do Sul, 90880-480

  • Novartis Investigative Site

    Ribeirão Preto, São Paulo, 14026-020

  • Novartis Investigative Site

    Rio de Janeiro, 20241-180

  • Novartis Investigative Site

    Salvador, Estado de Bahia, 40170-130

  • Novartis Investigative Site

    Santo André, São Paulo, 09060-870

  • Novartis Investigative Site

    Santo André, São Paulo, 09090-790

  • Novartis Investigative Site

    Sao Jose Rio Preto, São Paulo, 15015-750

  • Novartis Investigative Site

    Sao Jose Rio Preto, São Paulo, 15090-000

  • Novartis Investigative Site

    São Paulo, São Paulo, 01323-000

  • Novartis Investigative Site

    São Paulo, São Paulo, 04005-003

  • Novartis Investigative Site

    São Paulo, São Paulo, 04266-010

  • Novartis Investigative Site

    São Paulo, São Paulo, 05403-000

  • Novartis Investigative Site

    São Paulo, São Paulo, 05403-900

  • Novartis Investigative Site

    Uberlândia, Minas Gerais, 38400-500

  • Novartis Investigative Site

    Vitória, Espírito Santo, 29055-450

Other trials in Brazil

Netherlands22 sites

  • Novartis Investigative Site

    Alkmaar, North Holland, 1815 JD

  • Novartis Investigative Site

    Amersfoort, 3813 TZ

  • Novartis Investigative Site

    Amsterdam, North Holland, 1090 HM

  • Novartis Investigative Site

    Amsterdam, North Holland, 1105 AZ

  • Novartis Investigative Site

    Apeldoorn, Gelderland, 7334 DZ

  • Novartis Investigative Site

    Arnhem, Gelderland, 6815 AD

  • Novartis Investigative Site

    Deventer, Overijssel, 7416 SE

  • Novartis Investigative Site

    Gouda, 2803 HH

  • Novartis Investigative Site

    Groningen, Provincie Groningen, 9728 NZ

  • Novartis Investigative Site

    Hardenberg, 7770 SE

  • Novartis Investigative Site

    Heemstede, North Holland, 2035 RC

  • Novartis Investigative Site

    Heerlen, Limburg, 6419 PC

  • Novartis Investigative Site

    Leiden, South Holland, 2333 ZA

  • Novartis Investigative Site

    Leiderdorp, South Holland, 2353 GA

  • Novartis Investigative Site

    Nijmegen, 6525 GA

  • Novartis Investigative Site

    Sneek, Provincie Friesland, 8601 ZK

  • Novartis Investigative Site

    The Hague, South Holland, 2545 AA

  • Novartis Investigative Site

    Tiel, Gelderland, 4002 WP

  • Novartis Investigative Site

    Tilburg, North Brabant, 5042 AD

  • Novartis Investigative Site

    Utrecht, 3584 CX

  • Novartis Investigative Site

    Venlo, 5912 BL

  • Novartis Investigative Site

    Zwolle, Overijssel, 8025 AB

Other trials in Netherlands

Italy21 sites

  • Novartis Investigative Site

    Ancona, AN, 60128

  • Novartis Investigative Site

    Bergamo, BG, 24127

  • Novartis Investigative Site

    Bologna, BO, 40138

  • Novartis Investigative Site

    Brescia, BS, 25123

  • Novartis Investigative Site

    Cona, FE, 44124

  • Novartis Investigative Site

    Florence, FI, 50134

  • Novartis Investigative Site

    Milan, MI, 20132

  • Novartis Investigative Site

    Milan, MI, 20138

  • Novartis Investigative Site

    Milan, MI, 20149

  • Novartis Investigative Site

    Milan, MI, 20162

  • Novartis Investigative Site

    Naples, 80131

  • Novartis Investigative Site

    Palermo, PA, 90127

  • Novartis Investigative Site

    Perugia, PG, 06129

  • Novartis Investigative Site

    Pisa, PI, 56124

  • Novartis Investigative Site

    Pisa, PI, 56126

  • Novartis Investigative Site

    Pozzilli, IS, 86077

  • Novartis Investigative Site

    Roma, RM, 00161

  • Novartis Investigative Site

    Roma, RM, 00189

  • Novartis Investigative Site

    Rozzano, MI, 20089

  • Novartis Investigative Site

    Salerno, SA, 84131

  • Novartis Investigative Site

    Varese, VA, 21100

Other trials in Italy

Slovakia19 sites

  • Novartis Investigative Site

    Bardejov, 085 01

  • Novartis Investigative Site

    Bratislava, 821 07

  • Novartis Investigative Site

    Bratislava, 833 05

  • Novartis Investigative Site

    Bratislava, 833 48

  • Novartis Investigative Site

    Handlová, 972 51

  • Novartis Investigative Site

    Komárno, 945 01

  • Novartis Investigative Site

    Komárno, 945 05

  • Novartis Investigative Site

    Košice, 040 01

  • Novartis Investigative Site

    Lučenec, 984 01

  • Novartis Investigative Site

    Nitra, 949 01

  • Novartis Investigative Site

    Nitra, 949 11

  • Novartis Investigative Site

    Nitra, 950 01

  • Novartis Investigative Site

    Nové Zámky, 940 01

  • Novartis Investigative Site

    Piešťany, 921 01

  • Novartis Investigative Site

    Považská Bystrica, 017 01

  • Novartis Investigative Site

    Prešov, 080 01

  • Novartis Investigative Site

    Rimavská Sobota, 979 01

  • Novartis Investigative Site

    Svidník, 089 01

  • Novartis Investigative Site

    Trnava, Slovakia, 917 02

Other trials in Slovakia

Spain18 sites

  • Novartis Investigative Site

    A Coruña, 15001

  • Novartis Investigative Site

    Badalona, Barcelona, 08916

  • Novartis Investigative Site

    Barcelona, 08025

  • Novartis Investigative Site

    Barcelona, 08036

  • Novartis Investigative Site

    Cáceres, Extremadura, 10003

  • Novartis Investigative Site

    Córdoba, 14004

  • Novartis Investigative Site

    Huelva, 21080

  • Novartis Investigative Site

    L'Hospitalet de Llobregat, Barcelona, 08907

  • Novartis Investigative Site

    Madrid, 28040

  • Novartis Investigative Site

    Madrid, 28041

  • Novartis Investigative Site

    Málaga, 29010

  • Novartis Investigative Site

    Reus, Tarragona, 43204

  • Novartis Investigative Site

    Santander, Cantabria, 39008

  • Novartis Investigative Site

    Santiago Compostela, A Coruna, 15706

  • Novartis Investigative Site

    Seville, Andalusia, 41014

  • Novartis Investigative Site

    Seville, 41009

  • Novartis Investigative Site

    Seville, 41013

  • Novartis Investigative Site

    Zaragoza, 50009

Other trials in Spain

Argentina17 sites

  • Novartis Investigative Site

    Buenos Aires, C1280AEB

  • Novartis Investigative Site

    Caba, C1427CCL

  • Novartis Investigative Site

    CABA, Buenos Aires, C1407FWE

  • Novartis Investigative Site

    CABA, Buenos Aires F.D., C1426ABP

  • Novartis Investigative Site

    Capital Federal, C1023AAB

  • Novartis Investigative Site

    Córdoba, Córdoba Province, X5016KET

  • Novartis Investigative Site

    Córdoba, X5002HWE

  • Novartis Investigative Site

    Corrientes, W3400CDS

  • Novartis Investigative Site

    Mar del Plata, Buenos Aires, B7600ENA

  • Novartis Investigative Site

    Mar del Plata, Buenos Aires, B7600JXA

  • Novartis Investigative Site

    Ramos Mejía, Buenos Aires, B1704ETD

  • Novartis Investigative Site

    Rosario, Santa Fe Province, S2000CVD

  • Novartis Investigative Site

    Rosario, Santa Fe Province, S2000DTB

  • Novartis Investigative Site

    San Luis, D5702JRS

  • Novartis Investigative Site

    San Miguel de Tucumán, San Miguel de Tucuman, T4000AAL

  • Novartis Investigative Site

    San Miguel de Tucumán, San Miguel de Tucuman, T4000ICL

  • Novartis Investigative Site

    Santa Fe, Santa Fe Province, S3000FWO

Other trials in Argentina

Canada14 sites

  • Novartis Investigative Site

    Lévis, Quebec, G6V 4Z5

  • Novartis Investigative Site

    Montreal, Quebec, H1T 1C8

  • Novartis Investigative Site

    Montreal, Quebec, H2X 1R9

  • Novartis Investigative Site

    Montreal, Quebec, H3T 1E2

  • Novartis Investigative Site

    Montreal, Quebec, H4A 3J1

  • Novartis Investigative Site

    Oakville, Ontario, L6K 3W7

  • Novartis Investigative Site

    Québec, Quebec, G1R 2J6

  • Novartis Investigative Site

    Québec, Quebec, G1V 4G5

  • Novartis Investigative Site

    Québec, Quebec, G1V 4W2

  • Novartis Investigative Site

    Toronto, Ontario, M9V 4B4

  • Novartis Investigative Site

    Vancouver, British Columbia, V5Z 1M9

  • Novartis Investigative Site

    Vancouver, British Columbia, V6Z 2H2

  • Novartis Investigative Site

    Victoria, British Columbia, V8R4R2

  • Novartis Investigative Site

    Victoria, British Columbia, V8T 5G4

Other trials in Canada

South Korea11 sites

  • Novartis Investigative Site

    Bundang Gu, Gyeonggi-do, 13620

  • Novartis Investigative Site

    Busan, 49201

  • Novartis Investigative Site

    Daegu, Dalseo gu, 42602

  • Novartis Investigative Site

    Gwangju, 61469

  • Novartis Investigative Site

    Incheon, Korea, 405 760

  • Novartis Investigative Site

    Seoul, Korea, 02841

  • Novartis Investigative Site

    Seoul, Seoul, 03080

  • Novartis Investigative Site

    Seoul, 03181

  • Novartis Investigative Site

    Seoul, 06591

  • Novartis Investigative Site

    Suwon, Gyeonggi-do, 16499

  • Novartis Investigative Site

    Wŏnju, Gangwon-do, 26426

Other trials in South Korea

France9 sites

  • Novartis Investigative Site

    Bron, 69677

  • Novartis Investigative Site

    Chambray-lès-Tours, 37170

  • Novartis Investigative Site

    Compiègne, 60321

  • Novartis Investigative Site

    Grenoble, 38043

  • Novartis Investigative Site

    Le Coudray, 28630

  • Novartis Investigative Site

    Nantes, 44093

  • Novartis Investigative Site

    Paris, 75018

  • Novartis Investigative Site

    Toulouse, 31054

  • Novartis Investigative Site

    Valenciennes, 59300

Other trials in France

Taiwan9 sites

  • Novartis Investigative Site

    Hsinchu, 30069

  • Novartis Investigative Site

    Kaohsiung City, 80756

  • Novartis Investigative Site

    Kaohsiung City, 833

  • Novartis Investigative Site

    Keelung, 20401

  • Novartis Investigative Site

    Taichung, Taiwan ROC, 40201

  • Novartis Investigative Site

    Tainan, 71004

  • Novartis Investigative Site

    Taipei, 11217

  • Novartis Investigative Site

    Taoyuan, 33305

  • Novartis Investigative Site

    Yilan, 26058

Other trials in Taiwan

Belgium8 sites

  • Novartis Investigative Site

    Aalst, Oost Vlaanderen, 9300

  • Novartis Investigative Site

    Bruges, 8000

  • Novartis Investigative Site

    Brussels, Brussels Capital, 1070

  • Novartis Investigative Site

    Dendermonde, 9200

  • Novartis Investigative Site

    Genk, Limburg, 3600

  • Novartis Investigative Site

    Huy, 4500

  • Novartis Investigative Site

    Kortrijk, West-Vlaanderen, 8500

  • Novartis Investigative Site

    Mechelen, 2800

Other trials in Belgium

Colombia8 sites

  • Novartis Investigative Site

    Barranquilla, Colombia, 080020

  • Novartis Investigative Site

    Bogotá, 111211

  • Novartis Investigative Site

    Bucaramanga, Santander Department, 681017

  • Novartis Investigative Site

    Cali, Valle del Cauca Department, 760001

  • Novartis Investigative Site

    Cali, Valle del Cauca Department, 760032

  • Novartis Investigative Site

    Medellín, Antioquia, 050001

  • Novartis Investigative Site

    Medellín, 050037

  • Novartis Investigative Site

    San Gil, 684031

Other trials in Colombia

Turkey (Türkiye)8 sites

  • Novartis Investigative Site

    Ankara, Bilkent-Cankaya, 06800

  • Novartis Investigative Site

    Eskişehir, Odunpazari, 26040

  • Novartis Investigative Site

    Istanbul, Fatih, 34098

  • Novartis Investigative Site

    Istanbul, Kadikoy, 34668

  • Novartis Investigative Site

    Izmir, Balcova, 35340

  • Novartis Investigative Site

    Izmir, 35100

  • Novartis Investigative Site

    Mersin, Yenisehir, 33110

  • Novartis Investigative Site

    Samsun, Samsun, 55080

Other trials in Turkey (Türkiye)

Denmark7 sites

  • Novartis Investigative Site

    Aarhus N, 8200

  • Novartis Investigative Site

    Copenhagen, 2100

  • Novartis Investigative Site

    Esbjerg, 6700

  • Novartis Investigative Site

    Gistrup, 9260

  • Novartis Investigative Site

    Herlev, 2730

  • Novartis Investigative Site

    Roskilde, 4000

  • Novartis Investigative Site

    Viborg, 8800

Other trials in Denmark

Israel7 sites

  • Novartis Investigative Site

    Beersheba, 8457108

  • Novartis Investigative Site

    Haifa, 3104802

  • Novartis Investigative Site

    Haifa, 3436212

  • Novartis Investigative Site

    Holon, 5822012

  • Novartis Investigative Site

    Jerusalem, 9112001

  • Novartis Investigative Site

    Petah Tikva, 4941492

  • Novartis Investigative Site

    Ramat Gan, 5265601

Other trials in Israel

Poland7 sites

  • Novartis Investigative Site

    Bielsko-Biala, 43-316

  • Novartis Investigative Site

    Chrzanów, 32-500

  • Novartis Investigative Site

    Gdansk, 80-214

  • Novartis Investigative Site

    Gdynia, 81-157

  • Novartis Investigative Site

    Lodz, 91-347

  • Novartis Investigative Site

    Lodz, 93-338

  • Novartis Investigative Site

    Tarnów, 33-100

Other trials in Poland

Australia6 sites

  • Novartis Investigative Site

    Camperdown, New South Wales, 2050

  • Novartis Investigative Site

    Chemside, Queensland, 4032

  • Novartis Investigative Site

    Clayton, Victoria, 3168

  • Novartis Investigative Site

    Liverpool, New South Wales, 2170

  • Novartis Investigative Site

    Perth, Western Australia, 6000

  • Novartis Investigative Site

    Woolloongabba, Queensland, 4102

Other trials in Australia

Austria6 sites

  • Novartis Investigative Site

    Graz, 8036

  • Novartis Investigative Site

    Innsbruck, 6020

  • Novartis Investigative Site

    Linz, 4021

  • Novartis Investigative Site

    Salzburg, 5020

  • Novartis Investigative Site

    Vienna, 1090

  • Novartis Investigative Site

    Vienna, 1210

Other trials in Austria

Bulgaria6 sites

  • Novartis Investigative Site

    Burgas, 8001

  • Novartis Investigative Site

    Pernik, 2300

  • Novartis Investigative Site

    Pleven, 5800

  • Novartis Investigative Site

    Plovdiv, 4000

  • Novartis Investigative Site

    Rousse, 7002

  • Novartis Investigative Site

    Sofia, 1233

Other trials in Bulgaria

Greece6 sites

  • Novartis Investigative Site

    Athens, 115 21

  • Novartis Investigative Site

    Athens, 115 27

  • Novartis Investigative Site

    Athens, 142 33

  • Novartis Investigative Site

    Ioannina, 455 00

  • Novartis Investigative Site

    Larissa, 411 10

  • Novartis Investigative Site

    Thessaloniki, 54636

Other trials in Greece

Hungary6 sites

  • Novartis Investigative Site

    Baja, 6500

  • Novartis Investigative Site

    Budapest, 1083

  • Novartis Investigative Site

    Budapest, 1145

  • Novartis Investigative Site

    Budapest, 1211

  • Novartis Investigative Site

    Debrecen, Hajdu Bihar Megye, 4032

  • Novartis Investigative Site

    Szeged, 6725

Other trials in Hungary

Romania6 sites

  • Novartis Investigative Site

    Baia Mare, Maramureş, 430123

  • Novartis Investigative Site

    Baia Mare, Maramureş, 430222

  • Novartis Investigative Site

    Bucharest, 010192

  • Novartis Investigative Site

    Bucharest, 050098

  • Novartis Investigative Site

    Buzău, Buzău, 120133

  • Novartis Investigative Site

    Craiova, Dolj, 200513

Other trials in Romania

Switzerland6 sites

  • Novartis Investigative Site

    Basel, 4031

  • Novartis Investigative Site

    Bern, 3010

  • Novartis Investigative Site

    Geneva, 1211

  • Novartis Investigative Site

    Lausanne, 1010

  • Novartis Investigative Site

    Liestal, 4410

  • Novartis Investigative Site

    Zurich, 8091

Other trials in Switzerland

Mexico5 sites

  • Novartis Investigative Site

    Aguascalientes, Aguascalientes, 20230

  • Novartis Investigative Site

    Cuernavaca, Morelos, 62250

  • Novartis Investigative Site

    Culiacan Sinaloa, 80230

  • Novartis Investigative Site

    Distrito Federal, 14080

  • Novartis Investigative Site

    San Luis Potosí City, San Luis Potosí, 78200

Other trials in Mexico

South Africa4 sites

  • Novartis Investigative Site

    Cape Town, Western Cape, 7500

  • Novartis Investigative Site

    Cape Town, 6665

  • Novartis Investigative Site

    George, Western Cape, 6529

  • Novartis Investigative Site

    Johannesburg, Gauteng, 2013

Other trials in South Africa

Portugal3 sites

  • Novartis Investigative Site

    Coimbra, 3004-561

  • Novartis Investigative Site

    Guimarães, 4835-044

  • Novartis Investigative Site

    Setúbal, 2910-549

Other trials in Portugal

Sweden3 sites

  • Novartis Investigative Site

    Gothenburg, 413 46

  • Novartis Investigative Site

    Lund, 222 21

  • Novartis Investigative Site

    Stockholm, 14186

Other trials in Sweden

Hong Kong2 sites

  • Novartis Investigative Site

    Hong Kong, Hong Kong, 999077

  • Novartis Investigative Site

    Hong Kong, 999077

Other trials in Hong Kong

Norway2 sites

  • Novartis Investigative Site

    Oslo, 0514

  • Novartis Investigative Site

    Skedsmokorset, 2020

Other trials in Norway

Slovenia2 sites

  • Novartis Investigative Site

    Ljubljana, Ljubljana, 1000

  • Novartis Investigative Site

    Ljubljana, 1000

Other trials in Slovenia

Iceland1 site

  • Novartis Investigative Site

    Reykjavik, 101

Other trials in Iceland

Puerto Rico1 site

  • Research and Cardiovascular Corp

    Ponce, 00717-1322

Other trials in Puerto Rico

About this study

Official title: A Single Arm, Multicenter, Open-label Extension (OLE) Trial to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) in Participants Who Completed the Parent Lp(a)HORIZON Trial

This open-label extension study provides post-trial access to pelacarsen (TQJ230) to participants who have successfully completed the double-blind parent study (CTQJ230A12301). Study has been terminated by sponsor following the outcome of the Lp(a)HORIZON study (NCT04023552), which did not meet its primary endpoint.

Read the detailed description

This study will evaluate long-term safety and tolerability of pelacarsen (TQJ230) 80 mg Once a month (QM) in participants with established cardiovascular disease and elevated Lp(a) who completed the parent study (CTQJ230A12301).

Being tested
Pelacarsen (TQJ230)
Keywords
Lipoprotein(a),, Lp(a),, cardiovascular disease,, CVD,, myocardial infarction,, stroke,, OLE,, pelacarsen,, open-label
Medical subject headings
Cardiovascular Diseases, Myocardial Infarction, Stroke

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Pelacarsen (TQJ230)Drug

    Also called TQJ230

    pelacarsen 80mg s.c. monthly

Study groups in NCT07517263
Study groupRoleWhat they receive
Pelacarsen (TQJ230)Experimentalopen-label pelacarsen 80mg
Receives: Drug: Pelacarsen (TQJ230)

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of participants with Adverse events

    Number of participants with Treatment Emergent Adverse Events (TEAEs), Treatment Emergent Serious Adverse Events (TESAEs), TEAEs of special interest, including abnormal laboratory evaluations and vital signs. Number of participants discontinuing due to treatment emergent adverse events (TEAEs) or treatment emergent serious adverse events (TESAEs) will also be presented.

    Measured: Up to 36 months

Secondary outcomes (7)

  1. Time to first occurrence of 4 Point-Major Cardiovascular Event (4P-MACE) from parent study baseline

    Time to first occurrence of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) from the beginning of the parent study will be presented

    Measured: Up to 36 months

  2. Time to the first occurrence of 4P-MACE from open-label extension (OLE) study baseline

    Time to first occurrence of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) from the beginning of the OLE study will be presented

    Measured: Up to 36 months

  3. Cumulative number of 4P-MACE over time from OLE study baseline

    Cumulative number of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) over time from the beginning of the OLE study will be presented

    Measured: Up to 36 months

  4. Cumulative number of 4P-MACE over time from parent study baseline

    Cumulative number of 4P-MACE (cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularization requiring hospitalization) over time from the beginning of the parent study will be presented

    Measured: Up to 36 months

  5. Observed value of Lipoprotein(a) (Lp(a))

    Samples for Lp(a) assessment will be collected at the defined time points, analyzed and values reported.

    Measured: Baseline, Month 3, Month 12, Month 24, Month 36

  6. Change in Lp(a) compared to baseline of the OLE study

    Samples for Lp(a) assessment will be collected at defined time points and change will be calculated against baseline of the OLE study.

    Measured: Baseline, Month 3, Month 12, Month 24, Month 36

  7. Change in Lp(a) compared to baseline of the parent study

    Samples for Lp(a) assessment will be collected at defined time points and change will be calculated against baseline of the parent study.

    Measured: Baseline, Month 3, Month 12, Month 24, Month 36

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Apr 2026
  2. Study start11 May 2026
  3. Primary completion9 Jan 2030 (estimated)
  4. Study completion9 Jan 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Model description
Open-label extension (OLE) study
Masking
None (open label)
Enrolment
5,700 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07517263
Sponsor's protocol ID
CTQJ230A12301E1
Other IDs
2024-519870-38-00
Status last verified
Oct 2026
First submitted
1 Apr 2026
Last updated
14 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations. This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Pelacarsen (TQJ230) in people with Cardiovascular Disease and Lipoprotein(a), run by Novartis Pharmaceuticals at 646 sites in 40 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 646 sites in United States, Germany, China, United Kingdom, Russia and 35 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of participants with Adverse events (time frame: Up to 36 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07517263.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026.

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