HealthyAPSI-MLSINCT07516197
From Global Balance Metrics to Plane-Specific Signatures: Identifying Postural Instability Phenotypes in Females
An observational study of Healthy, run by Cairo University at 1 site in Egypt.
Trial summary
The main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females. Read more about this study
- Who is it for?
- Ages 20 to 29 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- observational study, one group, one shot assessment
- How many people
- 111 participants
- Where
- 1 siteEgypt
- Study dates
- 12 May 2024to 25 Oct 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 29 years
- Women only
- Healthy volunteers accepted
- Adult
Study population: A total of 111 healthy female participants were recruited for this study, representing a homogeneous sample of young adults, aged 20-29 years, reflecting a population within early adulthood, a stage typically characterized by optimal neuromuscular function and postural control capacity.
Who may be able to join
- a relatively uniform and non-clinical population
Who cannot join
- any history of neurological disorders, vestibular dysfunction, musculoskeletal injuries affecting the lower limbs or spine within the preceding six months
- or any condition known to impair balance. Individuals with visual impairments not corrected by lenses
- taking medications that could influence neuromuscular performance or postural control
- those engaged in specialized balance training or high-level athletic activities were also excluded to minimize potential confounding effects.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Physical Therapy, Cairo University
Dokki, Giza Governorate, 11432
About this study
The main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females.
Read the detailed description
Postural stability is essential for functional performance and injury prevention, with directional control influenced by neuromuscular and anthropometric factors. Limited data exist on proportional stability patterns and their relationship with body mass index (BMI). Therefore, the main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females.
- Conditions
- Healthy
- Being tested
- observational study, one group, one shot assessment
- Keywords
- Postural stability, APSI, MLSI, Biodex Balance System, BMI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
observational study, one group, one shot assessmentDiagnostic test
This study employed a cross-sectional observational design to evaluate postural stability characteristics and their associations with anthropometric variables in a cohort of healthy young adult females. The cross-sectional approach was selected to provide a snapshot of directional stability profiles and interrelationships between variables without the influence of intervention or temporal changes.
What is being measured
The primary outcome is the main question the study is designed to answer.
APSI
anterior-posterior stability index
Measured: one month
MLSI
Mediolateral stability index
Measured: one month
Secondary outcomes (1)
BMI
body mass index
Measured: one months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Apr 2026
- Study start12 May 2024
- Primary completion25 Sep 2024
- Study completion25 Oct 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 111 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Azza Mohammed, Cairo University
- Investigators
- Azza M Abdelmohsen, professor, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07516197
- Sponsor's protocol ID
- approved from IRB
- Acronym
- APSI-MLSI
- Status last verified
- Apr 2026
- First submitted
- 27 Mar 2026
- Last updated
- 8 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Zhang X, Ruan B, Gao Q. Dynamic postural stability indices in athletes: a case-control study on chronic ankle instability during multi-directional landing assessments. BMC Musculoskelet Disord. 2025 Dec 12;26(1):1093. doi: 10.1186/s12891-025-09307-2.
PubMed 41388395
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- From Global Balance Metrics to Plane-Specific Signatures: Identifying Postural Instability Phenotypes in Females
- ClinicalTrials.gov ID
- NCT07516197
- Acronym / sponsor ID
- APSI-MLSI / approved from IRB
- Conditions
- Healthy
- Keywords
- Postural stability, APSI, MLSI, Biodex Balance System, BMI
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 111 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 12 May 2024 (actual)
- Primary completion
- 25 Sep 2024 (actual)
- Study completion
- 25 Oct 2024 (actual)
- First posted
- 7 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females.
Detailed description
Postural stability is essential for functional performance and injury prevention, with directional control influenced by neuromuscular and anthropometric factors. Limited data exist on proportional stability patterns and their relationship with body mass index (BMI). Therefore, the main aim of this study was to evaluate anterior-posterior (AP) and medial-lateral (ML) stability, examine proportional stability, and explore associations with BMI in healthy young adult females.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
Who may qualify
- Ages
- 20 to 29 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- A total of 111 healthy female participants were recruited for this study, representing a homogeneous sample of young adults, aged 20-29 years, reflecting a population within early adulthood, a stage typically characterized by optimal neuromuscular function and postural control capacity.
Key inclusion criteria (1 listed)
- a relatively uniform and non-clinical population
Key exclusion criteria (4 listed)
- any history of neurological disorders, vestibular dysfunction, musculoskeletal injuries affecting the lower limbs or spine within the preceding six months
- or any condition known to impair balance. Individuals with visual impairments not corrected by lenses
- taking medications that could influence neuromuscular performance or postural control
- those engaged in specialized balance training or high-level athletic activities were also excluded to minimize potential confounding effects.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| observational study, one group, one shot assessmentThis study employed a cross-sectional observational design to evaluate postural stability characteristics and their associations with anthropometric variables in a cohort of healthy young adult females. The cross-sectional approach was selected to provide a snapshot of directional stability profiles and interrelationships between variables without the influence of intervention or temporal changes. | Diagnostic test | – |
Primary outcome
APSI
Time frame: one month
anterior-posterior stability index
MLSI
Time frame: one month
Mediolateral stability index
1 secondary outcome
BMI
Time frame: one months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Background: PubMed 41388395Zhang X, Ruan B, Gao Q. Dynamic postural stability indices in athletes: a case-control study on chronic ankle instability during multi-directional landing assessments. BMC Musculoskelet Disord. 2025 Dec 12;26(1):1093. doi: 10.1186/s12891-025-09307-2.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Azza M Abdelmohsen, professor principal investigator
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
APSI (time frame: one month). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07516197, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.