Chronic Migraine, HeadacheNCT07512219
Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine
A study testing Greater occiptal nerve block and Pulsed radiofrequency in people with Chronic Migraine, Headache, run by Sohag University.
Trial summary
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Chronic Migraine, Headache
- What is being tested?
- Greater occiptal nerve block and Pulsed radiofrequency
- Type of treatment
- Injection or infusion, Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- No sites listed yet
- Study dates
- 1 May 2026to 1 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- patient with Diagnosis of chronic migraine for > 3 months.
- migraine days ≥ 15 days/month.
- Failure or inadequate response to standard medical treatment.
Who cannot join
- Secondary headache disorders.
- Coagulopathy or anticoagulant therapy.
- Infection at injection site.
- History of cervical spine surgery.
- Pregnancy or breastfeeding.
- Previous PRF or occipital nerve surgery within last 3 months
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
- Conditions
- Chronic Migraine, Headache
- Being tested
- Greater occiptal nerve block, Pulsed radiofrequency
- Medical subject headings
- Headache
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Greater occiptal nerve blockDrug
Also called GONB
Injection Procedure:
- Local skin infiltration with 1-2 mL of 1% lidocaine at puncture site.
- GON block using 3-5 mL of local anesthetic, optionally combined with 20-40 mg triamcinolone ( Bilaterally )
- Needle placement confirmed by ultrasound visualization of the nerve and spread of injectate.
- Observe patient for 15-20 minutes post-injection for immediate adverse events.
Pulsed radiofrequencyDevice
Also called PRF
- Introduce RF cannula adjacent to GON under ultrasound guidance.
- Confirm sensory stimulation: paresthesia at occipital scalp at <0.5 V.
- PRF settings:
- Temperature: ≤42°C
- Pulse duration: 20 ms
- Frequency: 2 Hz
- Duration: 120 seconds per cycle, 2 cycles per side
- Continuous monitoring of patient comfort and vital signs.
| Study group | Role | What they receive |
|---|---|---|
| Group of Greater Occiptal nerve Block , GONB | Active comparator | Injection Procedure:
1. Local skin infiltration with 1-2 mL of 1% lidocaine at puncture site.
2. GON block using 3-5 mL of local anesthetic, optionally combined with 20-40 mg triamcinolone ( Bilaterally )
3. Needle placement confirmed by ultrasound visualization of the nerve and spread of injectate.
4. Observe patient for 15-20 minutes post-injection for immediate adverse events. Receives: Drug: Greater occiptal nerve block |
| Group of Pulsed Radiofrequency , PRF | Active comparator | 1. Introduce RF cannula adjacent to GON under ultrasound guidance.
2. Confirm sensory stimulation: paresthesia at occipital scalp at <0.5 V.
3. PRF settings:
* Temperature: ≤42°C
* Pulse duration: 20 ms
* Frequency: 2 Hz
* Duration: 120 seconds per cycle, 2 cycles per side
4. Continuous monitoring of patient comfort and vital signs. Receives: Device: Pulsed radiofrequency |
What is being measured
The primary outcome is the main question the study is designed to answer.
The change in the VAS score of Pain over period of follow up
after do GONB and Pulsed radio frequency we assess improvement of Episodic Pain over period of Follow up
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Apr 2026
- Study start1 May 2026 (estimated)
- Primary completion1 Nov 2026 (estimated)
- Study completion1 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Migraine, HeadacheStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Shehab Mahmoud Mohamed, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07512219
- Sponsor's protocol ID
- Soh-Med--26-3-1MD
- Status last verified
- Mar 2026
- First submitted
- 30 Mar 2026
- Last updated
- 6 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 6 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
- ClinicalTrials.gov ID
- NCT07512219
- Acronym / sponsor ID
- Soh-Med--26-3-1MD
- Conditions
- Chronic Migraine, Headache
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (estimated)
- Primary completion
- 1 Nov 2026 (estimated)
- Study completion
- 1 May 2027 (estimated)
- First posted
- 6 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group of Greater Occiptal nerve Block , GONB | Active comparator | Drug: Greater occiptal nerve blockInjection Procedure: 1. Local skin infiltration with 1-2 mL of 1% lidocaine at puncture site. 2. GON block using 3-5 mL of local anesthetic, optionally combined with 20-40 mg triamcinolone ( Bilaterally ) 3. Needle placement confirmed by ultrasound visualization of the nerve and spread of injectate. 4. Observe patient for 15-20 minutes post-injection for immediate adverse events. |
| Group of Pulsed Radiofrequency , PRF | Active comparator | Device: Pulsed radiofrequency1. Introduce RF cannula adjacent to GON under ultrasound guidance. 2. Confirm sensory stimulation: paresthesia at occipital scalp at <0.5 V. 3. PRF settings: * Temperature: ≤42°C * Pulse duration: 20 ms * Frequency: 2 Hz * Duration: 120 seconds per cycle, 2 cycles per side 4. Continuous monitoring of patient comfort and vital signs. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- patient with Diagnosis of chronic migraine for > 3 months.
- migraine days ≥ 15 days/month.
- Failure or inadequate response to standard medical treatment.
Key exclusion criteria (6 listed)
- Secondary headache disorders.
- Coagulopathy or anticoagulant therapy.
- Infection at injection site.
- History of cervical spine surgery.
- Pregnancy or breastfeeding.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Greater occiptal nerve blockAlso: GONBInjection Procedure: 1. Local skin infiltration with 1-2 mL of 1% lidocaine at puncture site. 2. GON block using 3-5 mL of local anesthetic, optionally combined with 20-40 mg triamcinolone ( Bilaterally ) 3. Needle placement confirmed by ultrasound visualization of the nerve and spread of injectate. 4. Observe patient for 15-20 minutes post-injection for immediate adverse events. | Drug | Group of Greater Occiptal nerve Block , GONB |
| Pulsed radiofrequencyAlso: PRF1. Introduce RF cannula adjacent to GON under ultrasound guidance. 2. Confirm sensory stimulation: paresthesia at occipital scalp at <0.5 V. 3. PRF settings: * Temperature: ≤42°C * Pulse duration: 20 ms * Frequency: 2 Hz * Duration: 120 seconds per cycle, 2 cycles per side 4. Continuous monitoring of patient comfort and vital signs. | Device | Group of Pulsed Radiofrequency , PRF |
Primary outcome
The change in the VAS score of Pain over period of follow up
Time frame: 6 months
after do GONB and Pulsed radio frequency we assess improvement of Episodic Pain over period of Follow up
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Apr 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Greater occiptal nerve block and Pulsed radiofrequency in people with Chronic Migraine, Headache, run by Sohag University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact shehab Mahmoud mohamed, assisstant lecturer (0201090442332, shehabmahmoud@med.sohag.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The change in the VAS score of Pain over period of follow up (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2026.