Tooth Impaction, Impacted Canine, Dental AnomaliesPCINCT07509320
This Systematic Review Aims to Synthesize Available Evidence Regarding the Prevalence, Anatomical Distribution, Etiological Determinants, and Diagnostic Assessment of Permanent Canine Impaction. A Systematic Search of PubMed, PubMed Central, and ScienceDirect Was Conducted for Studies Published Betw
An observational study of Tooth Impaction, Impacted Canine, Dental Anomalies, run by Dimitrie Cantemir University at 1 site in Romania.
Trial summary
This systematic review aimed to synthesize current evidence regarding the prevalence, anatomical distribution, etiological determinants, and diagnostic assessment of permanent canine impaction. Read more about this study
- Who is it for?
- Ages 10 to 30 years
- Conditions the study is for
- Tooth Impaction, Impacted Canine, Dental Anomalies
- How many people
- 0 participants
- Where
- 1 siteRomania
- Study dates
- 15 Sep 2025to 10 Feb 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 10 to 30 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Published observational and clinical studies evaluating patients with permanent canine impaction. The review includes studies reporting prevalence, anatomical distribution, etiological factors, and diagnostic imaging characteristics.
Who may be able to join
None listed.
Who cannot join
- - Case reports and small case series
- Studies focused exclusively on syndromic or systemic conditions
- Studies lacking quantitative epidemiological data
- Studies investigating exclusively third molar impaction
- Narrative reviews, editorials, and expert opinions
- Non-English publications
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Permanent Canine Impaction: A Systematic Review That Aims to Synthesize Available Evidence Regarding the Prevalence, Anatomical Distribution, Etiological Determinants, and Diagnostic Assessment of Permanent Canine Impaction. A Systematic Search of PubMed, PubMed Central, and ScienceDirect Was Conducted for Studies Published Between December 2009 and December 2025. Study Selection Followed PRISMA 2020 Guidelines. Thirty-one Studies Were Included in the Qualitative Synthesis. Outcomes Included Prevalence Patterns, Positional Distribution, Etiological Factors, and Imaging Modalities.
This systematic review aimed to synthesize current evidence regarding the prevalence, anatomical distribution, etiological determinants, and diagnostic assessment of permanent canine impaction. A comprehensive literature search was conducted in PubMed, PubMed Central, and ScienceDirect for studies published between December 2009 and December 2025. Study selection followed PRISMA 2020 guidelines. Two independent reviewers screened titles, abstracts, and full texts, and methodological quality was assessed using the Joanna Briggs Institute critical appraisal tools.
Thirty-one studies met the inclusion criteria and were included in the qualitative synthesis. Reported prevalence of maxillary canine impaction ranged from approximately 0.97% to 7.10%, with mandibular impaction occurring less frequently. Palatal displacement represented the most common positional pattern. Major etiological factors included retained deciduous canines, dental arch constriction, supernumerary teeth, odontomas, and genetic anomalies. Cone-Beam Computed Tomography demonstrated superior diagnostic accuracy compared with conventional radiographic methods.
The review provides a comprehensive synthesis of epidemiological patterns, etiological mechanisms, and imaging considerations associated with permanent canine impaction, highlighting the importance of early diagnosis and appropriate radiographic assessment.
Read the detailed description
This study was designed as a systematic review to evaluate the prevalence, anatomical distribution, etiological determinants, and diagnostic assessment of permanent canine impaction. The review was conducted in accordance with PRISMA 2020 guidelines. A comprehensive electronic search was performed in PubMed, PubMed Central, and ScienceDirect databases for studies published between December 2009 and December 2025. Manual searches of relevant orthodontic and oral radiology journals were also conducted.
Studies were eligible if they investigated permanent canine impaction and reported prevalence data, anatomical positioning, etiological factors, or imaging characteristics. Case reports, syndromic populations, and studies lacking quantitative data were excluded. Two independent reviewers screened titles, abstracts, and full texts, and disagreements were resolved by consensus. Methodological quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools appropriate for observational study designs.
Data extracted from eligible studies included sample size, prevalence rates, anatomical positioning, gender distribution, etiological factors, imaging modalities, and presence of root resorption. Due to methodological heterogeneity, quantitative meta-analysis was not feasible, and a qualitative synthesis approach was adopted.
Thirty-one studies met the inclusion criteria and were included in the qualitative synthesis. The review evaluated epidemiological patterns, positional distribution, local and genetic etiological factors, and diagnostic imaging approaches. The findings emphasize the multifactorial nature of permanent canine impaction and the importance of early detection and appropriate imaging evaluation.
- Keywords
- canine impaction, maxillary canine, mandibular canine, dental anomalies, prevalence, etiology, CBCT, transmigration, root resorption, systematic review
- Medical subject headings
- Tooth, Impacted, Tooth Abnormalities, Root Resorption
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of permanent canine impaction
Assessment of reported prevalence rates of permanent canine impaction across included studies.
Measured: Studies published between December 2009 and December 2025
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2026
- Study start15 Sep 2025 (estimated)
- Primary completion16 Jan 2026 (estimated)
- Study completion10 Feb 2026 (estimated)
Why it stopped: Completion of data, being a Systematic Review
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth Impaction, Impacted Canine, Dental AnomaliesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dimitrie Cantemir University
- Sponsor type
- University, hospital or other
- Collaborators
- University of Oradea
- Responsible party
- Principal investigator, Sorana-Maria Bucur, Dimitrie Cantemir University
- Investigators
- Marina A Pop, PhD Student, Principal investigator, Doctoral School of Biomedical Sciences, University of Oradea, RomaniaSorana-Maria Bucur, Associate Professor, Study director, Department of Dentistry, Faculty of Medicine, Dimitrie Cantemir University of Târgu Mureș, 3-5 Bodoni San-dor Street, 540545 Târgu Mureș, RomaniaAnca Porumb, Professor, Study director, Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, Romania
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07509320
- Sponsor's protocol ID
- Permanent Canine Impaction
- Other IDs
- Impacted Canines
- Acronym
- PCI
- Status last verified
- Mar 2026
- First submitted
- 27 Mar 2026
- Last updated
- 3 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Permanent Canine Impaction: A Systematic Review That Aims to Synthesize Available Evidence Regarding the Prevalence, Anatomical Distribution, Etiological Determinants, and Diagnostic Assessment of Permanent Canine Impaction. A Systematic Search of PubMed, PubMed Central, and ScienceDirect Was Conducted for Studies Published Between December 2009 and December 2025. Study Selection Followed PRISMA 2020 Guidelines. Thirty-one Studies Were Included in the Qualitative Synthesis. Outcomes Included Prevalence Patterns, Positional Distribution, Etiological Factors, and Imaging Modalities.
- ClinicalTrials.gov ID
- NCT07509320
- Acronym / sponsor ID
- PCI / Permanent Canine Impaction
- Keywords
- canine impaction, maxillary canine, mandibular canine, dental anomalies, prevalence, etiology, CBCT, transmigration, root resorption, systematic review
- Study type
- Observational
- Recruitment status
- WithdrawnReason stopped: Completion of data, being a Systematic Review
- Enrolment
- 0 participants (actual)
- Lead sponsor
- Dimitrie Cantemir UniversityUniversity, hospital or other
- Collaborators
- University of Oradea
- Study start
- 15 Sep 2025 (estimated)
- Primary completion
- 16 Jan 2026 (estimated)
- Study completion
- 10 Feb 2026 (estimated)
- First posted
- 3 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This systematic review aimed to synthesize current evidence regarding the prevalence, anatomical distribution, etiological determinants, and diagnostic assessment of permanent canine impaction. A comprehensive literature search was conducted in PubMed, PubMed Central, and ScienceDirect for studies published between December 2009 and December 2025. Study selection followed PRISMA 2020 guidelines. Two independent reviewers screened titles, abstracts, and full texts, and methodological quality was assessed using the Joanna Briggs Institute critical appraisal tools.
Thirty-one studies met the inclusion criteria and were included in the qualitative synthesis. Reported prevalence of maxillary canine impaction ranged from approximately 0.97% to 7.10%, with mandibular impaction occurring less frequently. Palatal displacement represented the most common positional pattern. Major etiological factors included retained deciduous canines, dental arch constriction, supernumerary teeth, odontomas, and genetic anomalies. Cone-Beam Computed Tomography demonstrated superior diagnostic accuracy compared with conventional radiographic methods.
The review provides a comprehensive synthesis of epidemiological patterns, etiological mechanisms, and imaging considerations associated with permanent canine impaction, highlighting the importance of early diagnosis and appropriate radiographic assessment.
Detailed description
This study was designed as a systematic review to evaluate the prevalence, anatomical distribution, etiological determinants, and diagnostic assessment of permanent canine impaction. The review was conducted in accordance with PRISMA 2020 guidelines. A comprehensive electronic search was performed in PubMed, PubMed Central, and ScienceDirect databases for studies published between December 2009 and December 2025. Manual searches of relevant orthodontic and oral radiology journals were also conducted.
Studies were eligible if they investigated permanent canine impaction and reported prevalence data, anatomical positioning, etiological factors, or imaging characteristics. Case reports, syndromic populations, and studies lacking quantitative data were excluded. Two independent reviewers screened titles, abstracts, and full texts, and disagreements were resolved by consensus. Methodological quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools appropriate for observational study designs.
Data extracted from eligible studies included sample size, prevalence rates, anatomical positioning, gender distribution, etiological factors, imaging modalities, and presence of root resorption. Due to methodological heterogeneity, quantitative meta-analysis was not feasible, and a qualitative synthesis approach was adopted.
Thirty-one studies met the inclusion criteria and were included in the qualitative synthesis. The review evaluated epidemiological patterns, positional distribution, local and genetic etiological factors, and diagnostic imaging approaches. The findings emphasize the multifactorial nature of permanent canine impaction and the importance of early detection and appropriate imaging evaluation.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
Who may qualify
- Ages
- 10 to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Published observational and clinical studies evaluating patients with permanent canine impaction. The review includes studies reporting prevalence, anatomical distribution, etiological factors, and diagnostic imaging characteristics.
Key inclusion criteria (0 listed)
Key exclusion criteria (6 listed)
- - Case reports and small case series
- Studies focused exclusively on syndromic or systemic conditions
- Studies lacking quantitative epidemiological data
- Studies investigating exclusively third molar impaction
- Narrative reviews, editorials, and expert opinions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Prevalence of permanent canine impaction
Time frame: Studies published between December 2009 and December 2025
Assessment of reported prevalence rates of permanent canine impaction across included studies.
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marina A Pop, PhD Student principal investigator
Doctoral School of Biomedical Sciences, University of Oradea, Romania
Sorana-Maria Bucur, Associate Professor study director
Department of Dentistry, Faculty of Medicine, Dimitrie Cantemir University of Târgu Mureș, 3-5 Bodoni San-dor Street, 540545 Târgu Mureș, Romania
Anca Porumb, Professor study director
Department of Dentistry, Faculty of Medicine and Pharmacy, University of Oradea, Romania
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Tooth Impaction, Impacted Canine, Dental Anomalies, run by Dimitrie Cantemir University at 1 site in Romania.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 3 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Romania. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of permanent canine impaction (time frame: Studies published between December 2009 and December 2025). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2026.