Ankle SprainsLAS-PFPSNCT07508163
Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders
An observational study of Ankle Sprains and Patellofemoral Pain Syndrome, run by Cairo University.
Trial summary
Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Read more about this study
- Who is it for?
- Ages 20 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Ankle Sprains, Patellofemoral Pain Syndrome
- What is being tested?
- diagnosis of APSI, MLSI, OASI
- How many people
- 90 participants
- Where
- No sites listed yet
- Study dates
- 30 Mar 2026to 27 Apr 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: a total of 90 participants (30 per group) will be required to participate in the study taking into consideration 10% drop out. Participants of both sexes with ages of 20 to 30 years will be recruited and assigned into three groups: individuals with lateral ankle sprain (LAS), individuals with patellofemoral pain syndrome (PFPS), and healthy control participants. All participants will have normal cognitive function and the ability to understand and follow instructions required for balance assessment.
Who may be able to join
- Inclusion criteria for the lateral ankle sprain group will include participants with a clinically confirmed history of unilateral lateral ankle sprain, who are at least three months post-injury to avoid acute inflammatory effects, and who report residual symptoms such as pain or functional limitation. Participants in the patellofemoral pain syndrome group will have a clinical diagnosis of patellofemoral pain syndrome characterized by anterior or retropatellar knee pain aggravated by functional activities such as stair climbing, squatting, or prolonged sitting, with symptoms persisting for at least three months. Healthy control participants will have no history of lower limb musculoskeletal injury, pain, or functional impairment within the past three months and will be matched to the patient groups based on age and sex. All participants across groups will be able to stand independently without assistive devices and will demonstrate sufficient cognitive ability to understand and follow study instructions
Who cannot join
- Exclusion criteria for all groups will include a history of lower limb fracture or surgery, neurological or vestibular disorders that may affect balance or postural control, uncorrected visual impairments, systemic inflammatory or rheumatological diseases, and metabolic or neurological conditions known to influence neuromuscular performance. Participants currently engaged in structured balance, proprioceptive, or neuromuscular training programs, as well as those taking medications that may affect balance or postural stability, will also be excluded from the study.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders: Evidence From Lateral Ankle Sprain and Patellofemoral Pain Syndrome
Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Therefore, the aim of this study is to compare overall, mediolateral, and anteroposterior postural stability indices among individuals with LAS, PFPS, and healthy controls using the Biodex Balance System
- Conditions
- Ankle Sprains, Patellofemoral Pain Syndrome
- Being tested
- diagnosis of APSI, MLSI, OASI
- Keywords
- Postural stability, APSI, MLSI, OASI, LAS, PFPS
- Medical subject headings
- Ankle Injuries, Patellofemoral Pain Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
diagnosis of APSI, MLSI, OASIDiagnostic test
To compare overall, antero-posterior and mediolateral postural stability indices among individuals with lateral ankle sprain, patellofemoral pain syndrome, and healthy controls using the Biodex Balance System.
| Study group | Role | What they receive |
|---|---|---|
| healthy control group | 30 healthy matched participants of both sexes with ages from 20 to 30 years Receives: Diagnostic Test: diagnosis of APSI, MLSI, OASI | |
| group of lateral ankle sprain (LAS) | 30 patients with LAS of both sexes with ages from 20 to 30 years Receives: Diagnostic Test: diagnosis of APSI, MLSI, OASI | |
| group of patellofemoral pain syndrome (PFPS) | 30 patients with PFPS of both sexes with ages from 20 to 30 years Receives: Diagnostic Test: diagnosis of APSI, MLSI, OASI |
What is being measured
The primary outcome is the main question the study is designed to answer.
APSI
anterior-posterior stability index
Measured: one shot assessment within one week
MLSI
Medial-lateral stability index
Measured: one shot assessment within one week
OASI
overall stability index
Measured: one shot assessment within one week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study start30 Mar 2026 (estimated)
- Primary completion25 Apr 2026 (estimated)
- Study completion27 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ankle SprainsStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Azza Mohammed, Cairo University
- Investigators
- Azza Abdelmohsen, professor, Principal investigator, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07508163
- Sponsor's protocol ID
- Approved
- Acronym
- LAS-PFPS
- Status last verified
- Apr 2026
- First submitted
- 27 Mar 2026
- Last updated
- 9 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders: Evidence From Lateral Ankle Sprain and Patellofemoral Pain Syndrome
- ClinicalTrials.gov ID
- NCT07508163
- Acronym / sponsor ID
- LAS-PFPS / Approved
- Conditions
- Ankle Sprains, Patellofemoral Pain Syndrome
- Keywords
- Postural stability, APSI, MLSI, OASI, LAS, PFPS
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 30 Mar 2026 (estimated)
- Primary completion
- 25 Apr 2026 (estimated)
- Study completion
- 27 Apr 2026 (estimated)
- First posted
- 2 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Lateral ankle sprain (LAS) and patellofemoral pain syndrome (PFPS) are common musculoskeletal conditions associated with postural instability. However, the direction-specific nature of balance deficits and comparative patterns across these conditions remain unclear. Therefore, the aim of this study is to compare overall, mediolateral, and anteroposterior postural stability indices among individuals with LAS, PFPS, and healthy controls using the Biodex Balance System
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| healthy control group | – | Diagnostic Test: diagnosis of APSI, MLSI, OASI30 healthy matched participants of both sexes with ages from 20 to 30 years |
| group of lateral ankle sprain (LAS) | – | Diagnostic Test: diagnosis of APSI, MLSI, OASI30 patients with LAS of both sexes with ages from 20 to 30 years |
| group of patellofemoral pain syndrome (PFPS) | – | Diagnostic Test: diagnosis of APSI, MLSI, OASI30 patients with PFPS of both sexes with ages from 20 to 30 years |
Who may qualify
- Ages
- 20 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- a total of 90 participants (30 per group) will be required to participate in the study taking into consideration 10% drop out. Participants of both sexes with ages of 20 to 30 years will be recruited and assigned into three groups: individuals with lateral ankle sprain (LAS), individuals with patellofemoral pain syndrome (PFPS), and healthy control participants. All participants will have normal cognitive function and the ability to understand and follow instructions required for balance assessment.
Key inclusion criteria (1 listed)
- Inclusion criteria for the lateral ankle sprain group will include participants with a clinically confirmed history of unilateral lateral ankle sprain, who are at least three months post-injury to avoid acute inflammatory effects, and who report residual symptoms such as pain or functional limitation. Participants in the patellofemoral pain syndrome group will have a clinical diagnosis of patellofemoral pain syndrome characterized by anterior or retropatellar knee pain aggravated by functional activities such as stair climbing, squatting, or prolonged sitting, with symptoms persisting for at least three months. Healthy control participants will have no history of lower limb musculoskeletal injury, pain, or functional impairment within the past three months and will be matched to the patient groups based on age and sex. All participants across groups will be able to stand independently without assistive devices and will demonstrate sufficient cognitive ability to understand and follow study instructions
Key exclusion criteria (1 listed)
- Exclusion criteria for all groups will include a history of lower limb fracture or surgery, neurological or vestibular disorders that may affect balance or postural control, uncorrected visual impairments, systemic inflammatory or rheumatological diseases, and metabolic or neurological conditions known to influence neuromuscular performance. Participants currently engaged in structured balance, proprioceptive, or neuromuscular training programs, as well as those taking medications that may affect balance or postural stability, will also be excluded from the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| diagnosis of APSI, MLSI, OASITo compare overall, antero-posterior and mediolateral postural stability indices among individuals with lateral ankle sprain, patellofemoral pain syndrome, and healthy controls using the Biodex Balance System. | Diagnostic test | group of lateral ankle sprain (LAS), group of patellofemoral pain syndrome (PFPS), healthy control group |
Primary outcome
APSI
Time frame: one shot assessment within one week
anterior-posterior stability index
MLSI
Time frame: one shot assessment within one week
Medial-lateral stability index
OASI
Time frame: one shot assessment within one week
overall stability index
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Apr 2026.
- Individual participant dataSharing planned: No
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The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Amateur Athletes With Chronic Ankle Instability
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Azza Abdelmohsen, professor principal investigator
Cairo University
Questions about this trial
What is this clinical trial studying?
An observational study of Ankle Sprains and Patellofemoral Pain Syndrome, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Azza M Abdelmohsen, professor (01145046304, dr_azzamohammed@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
APSI (time frame: one shot assessment within one week). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Apr 2026.