StrokeDAC-SNNCT07507383
Dynamic Auditory Cueing for Spatial Neglect in Stroke
A study testing Dynamic Auditory Cueing and Conventional Rehabilitation in people with Stroke and Perceptual Disorders, run by Gazi University at 1 site in Turkey (Türkiye).
Trial summary
Spatial neglect is a common condition after stroke and can make it difficult for people to pay attention to one side of space. This problem can negatively affect daily activities and functional independence. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stroke, Perceptual Disorders, Spatial Neglect
- What is being tested?
- Dynamic Auditory Cueing and Conventional Rehabilitation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 21 Aug 2024to 10 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older
- Subacute or chronic stroke
- Clinical diagnosis of left-sided spatial neglect confirmed by standardized tests (e.g., Line Bisection Test (LBT), Star Cancellation Test (SCT))
- Normal or corrected visual acuity
- Absence of auditory extinction
- Ability to understand and comply with study procedures
- Provision of written informed consent
Who cannot join
- Hearing impairment (Hearing Handicap Inventory score ≥26)
- Presence of hemianopia
- Impaired visual acuity due to ocular pathology (e.g., cataract, glaucoma)
- History of neurological disease (e.g., dementia, Parkinson's disease)
- Structural brain lesions unrelated to stroke
- Inability to participate in rehabilitation sessions or assessments
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Gazi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation
Ankara, Ankara, 06560
About this study
Official title: The Effect of Dynamic Auditory Cueing on Spatial Neglect in Patients With Stroke: A Randomized Controlled Trial
Spatial neglect is a common condition after stroke and can make it difficult for people to pay attention to one side of space. This problem can negatively affect daily activities and functional independence. This study aims to evaluate whether dynamic auditory cueing for spatial neglect (DAC-SN) can improve spatial neglect in people with stroke. Participants are randomly assigned to one of two groups. One group receives conventional rehabilitation, while the other group receives conventional rehabilitation combined with dynamic auditory cueing. Dynamic auditory cueing uses moving sounds to guide attention toward the affected side. The intervention is applied for about ten minutes per day, five days a week, for four weeks. Spatial neglect and functional outcomes are assessed using standardized clinical tests and scales at baseline and at predefined time points during and after the intervention. The results of this study may provide evidence for the use of auditory-based approaches in the rehabilitation of spatial neglect after stroke.
Read the detailed description
Spatial neglect is a common and disabling condition following stroke, characterized by reduced awareness of stimuli on one side of space. It is associated with impaired functional recovery and decreased independence in daily activities. Despite conventional rehabilitation approaches, spatial neglect may persist and continues to be a significant challenge in stroke rehabilitation. Dynamic auditory cueing for spatial neglect (DAC-SN) has been proposed as a method to facilitate attentional orientation by providing external sensory input directed toward the affected side. This approach may enhance spatial exploration and support recovery by promoting engagement with the neglected hemispace. The aim of this randomized controlled trial is to investigate the effect of dynamic auditory cueing in patients with stroke and spatial neglect. Participants are randomly assigned to receive either conventional rehabilitation alone or conventional rehabilitation combined with dynamic auditory cueing. The intervention is delivered in addition to standard rehabilitation in structured sessions over a four-week period. The control group receives conventional rehabilitation according to standard clinical practice. Spatial neglect severity and functional outcomes are assessed using standardized clinical measures at baseline and at predefined time points during and after the intervention period. The findings of this study are expected to provide evidence on the potential role of auditory-based interventions as an adjunct to conventional rehabilitation in improving spatial neglect and functional outcomes in patients with stroke.
- Being tested
- Dynamic Auditory Cueing, Conventional Rehabilitation
- Keywords
- Spatial Neglect, Hemispatial Neglect, Stroke Rehabilitation, Dynamic Auditory Cueing, Auditory Stimulation, Spatial Attention, Unilateral Neglect, Visual Scanning, Neurorehabilitation, Cognitive Rehabilitation
- Medical subject headings
- Stroke, Perceptual Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dynamic Auditory CueingOther
The intervention consists of structured 10-minute sessions using digitized environmental sounds (e.g., animal sounds, moving vehicles, or sirens) as auditory cues. Dynamic auditory cueing for spatial neglect (DAC-SN) is applied using sounds presented with a dynamic spatial movement pattern across the horizontal plane. The auditory stimulus is designed to move from the intact hemispace toward the neglected hemispace or to follow a continuous scanning trajectory to guide attention toward the affected side. Stimuli are delivered through a stereo headset to ensure clear perception of directional movement. The intervention is administered in standardized sessions over a four-week period (5 sessions per week). This approach aims to promote active spatial attention and scanning behavior and differs from conventional static auditory stimulation.
Conventional RehabilitationOther
Participants receive standard stroke rehabilitation, including physical and occupational therapy focused on motor function, mobility, and activities of daily living. This group follows the same rehabilitation schedule as the experimental group but does not receive dynamic auditory cueing for spatial neglect (DAC-SN).
| Study group | Role | What they receive |
|---|---|---|
| Dynamic Auditory Cueing Group | Experimental | Participants in this group receive dynamic auditory cueing for spatial neglect (DAC-SN) in addition to their standard conventional rehabilitation program. The intervention involves exposure to moving environmental sounds (such as animal or transportation noises) designed to redirect attention toward the neglected hemispace. The intervention is administered for 10 minutes per day, 5 days per week, over a total period of 4 weeks. Receives: Other: Dynamic Auditory Cueing; Other: Conventional Rehabilitation |
| Conventional Rehabilitation Group | Active comparator | Participants in this group receive only the standard conventional rehabilitation program provided by the clinic. This group does not receive dynamic auditory cueing for spatial neglect (DAC-SN). The frequency and duration of the standard therapy are matched to those of the experimental group to ensure a fair comparison of the additional effects of auditory cueing. Receives: Other: Conventional Rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Line Bisection Test (LBT) deviation score
The Line Bisection Test (LBT) is used to assess spatial bias by measuring deviation from the true midpoint of horizontal lines. Deviation toward the right side indicates more severe left-sided spatial neglect.
Measured: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)
Catherine Bergego Scale (CBS) score
The Catherine Bergego Scale (CBS) is used to assess the impact of spatial neglect on daily activities. Higher scores indicate greater severity of neglect in functional tasks.
Measured: Baseline and after 20 sessions (end of treatment)
Secondary outcomes (4)
Star Cancellation Test (SCT) score
The Star Cancellation Test (SCT) is used to assess spatial neglect by measuring the number and spatial distribution of correctly identified targets. Omission of targets on the left side indicates more severe left-sided spatial neglect.
Measured: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)
Line Cancellation Test (LCT) score
The Line Cancellation Test (LCT) evaluates spatial neglect by assessing the ability to detect and cancel target lines. Omission of lines on the left side indicates more severe left-sided spatial neglect.
Measured: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)
Functional Independence Measure (FIM) score
The Functional Independence Measure (FIM) assesses functional independence in activities of daily living. Higher scores indicate greater functional independence.
Measured: Baseline and after 20 sessions
Center of Cancellation (CoC) value
The Center of Cancellation (CoC) quantifies spatial bias based on cancellation task performance. Higher absolute values indicate more severe spatial neglect.
Measured: Baseline, after 1 session, after 10 sessions, and after 20 sessions
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study start21 Aug 2024
- Primary completion10 Apr 2026
- Study completion10 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants are randomly assigned to one of two parallel groups. The experimental group receives dynamic auditory cueing in addition to conventional rehabilitation, while the control group receives conventional rehabilitation alone.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- Gazi University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elif Ezgi Kurtul, MD, Gazi University
- Investigators
- Gulcin Kaymak Karatas, MD, Principal investigator, Gazi University Faculty of Medicine, Department of Physical Medicine and RehabilitationElif E Kurtul, MD, Study director, Gazi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07507383
- Sponsor's protocol ID
- GAZI-DAC-2026-01
- Acronym
- DAC-SN
- Status last verified
- Jul 2026
- First submitted
- 27 Mar 2026
- Last updated
- 23 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Kaufmann BC, Cazzoli D, Bartolomeo P, Frey J, Pflugshaupt T, Knobel SEJ, Nef T, Muri RM, Nyffeler T. Auditory spatial cueing reduces neglect after right-hemispheric stroke: A proof of concept study. Cortex. 2022 Mar;148:152-167. doi: 10.1016/j.cortex.2021.12.009. Epub 2022 Jan 19.
PubMed 35176552Golay L, Hauert CA, Greber C, Schnider A, Ptak R. Dynamic modulation of visual detection by auditory cues in spatial neglect. Neuropsychologia. 2005;43(9):1258-65. doi: 10.1016/j.neuropsychologia.2004.12.006. Epub 2005 Feb 5.
PubMed 15949510Barrett AM, Burkholder S. Monocular patching in subjects with right-hemisphere stroke affects perceptual-attentional bias. J Rehabil Res Dev. 2006 May-Jun;43(3):337-46. doi: 10.1682/jrrd.2005.01.0015.
PubMed 17041819Van Vleet TM, DeGutis JM. Cross-training in hemispatial neglect: auditory sustained attention training ameliorates visual attention deficits. Cortex. 2013 Mar;49(3):679-90. doi: 10.1016/j.cortex.2012.03.020. Epub 2012 Apr 9.
PubMed 22578712Long J, Zhang Y, Liu X, Gao Q, Pan M. Music-based interventions for unilateral spatial neglect: A systematic review. Neuropsychol Rehabil. 2023 Oct;33(9):1462-1487. doi: 10.1080/09602011.2022.2111314. Epub 2022 Aug 18.
PubMed 35980394
Study at a glance
From the registry record, last updated by the sponsor on 23 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Dynamic Auditory Cueing on Spatial Neglect in Patients With Stroke: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07507383
- Acronym / sponsor ID
- DAC-SN / GAZI-DAC-2026-01
- Keywords
- Spatial Neglect, Hemispatial Neglect, Stroke Rehabilitation, Dynamic Auditory Cueing, Auditory Stimulation, Spatial Attention, Unilateral Neglect, Visual Scanning
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- Gazi UniversityUniversity, hospital or other
- Study start
- 21 Aug 2024 (actual)
- Primary completion
- 10 Apr 2026 (actual)
- Study completion
- 10 Apr 2026 (actual)
- First posted
- 2 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Spatial neglect is a common condition after stroke and can make it difficult for people to pay attention to one side of space. This problem can negatively affect daily activities and functional independence. This study aims to evaluate whether dynamic auditory cueing for spatial neglect (DAC-SN) can improve spatial neglect in people with stroke. Participants are randomly assigned to one of two groups. One group receives conventional rehabilitation, while the other group receives conventional rehabilitation combined with dynamic auditory cueing. Dynamic auditory cueing uses moving sounds to guide attention toward the affected side. The intervention is applied for about ten minutes per day, five days a week, for four weeks. Spatial neglect and functional outcomes are assessed using standardized clinical tests and scales at baseline and at predefined time points during and after the intervention. The results of this study may provide evidence for the use of auditory-based approaches in the rehabilitation of spatial neglect after stroke.
Detailed description
Spatial neglect is a common and disabling condition following stroke, characterized by reduced awareness of stimuli on one side of space. It is associated with impaired functional recovery and decreased independence in daily activities. Despite conventional rehabilitation approaches, spatial neglect may persist and continues to be a significant challenge in stroke rehabilitation. Dynamic auditory cueing for spatial neglect (DAC-SN) has been proposed as a method to facilitate attentional orientation by providing external sensory input directed toward the affected side. This approach may enhance spatial exploration and support recovery by promoting engagement with the neglected hemispace. The aim of this randomized controlled trial is to investigate the effect of dynamic auditory cueing in patients with stroke and spatial neglect. Participants are randomly assigned to receive either conventional rehabilitation alone or conventional rehabilitation combined with dynamic auditory cueing. The intervention is delivered in addition to standard rehabilitation in structured sessions over a four-week period. The control group receives conventional rehabilitation according to standard clinical practice. Spatial neglect severity and functional outcomes are assessed using standardized clinical measures at baseline and at predefined time points during and after the intervention period. The findings of this study are expected to provide evidence on the potential role of auditory-based interventions as an adjunct to conventional rehabilitation in improving spatial neglect and functional outcomes in patients with stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants are randomly assigned to one of two parallel groups. The experimental group receives dynamic auditory cueing in addition to conventional rehabilitation, while the control group receives conventional rehabilitation alone.
| Arm | Type | Receives |
|---|---|---|
| Dynamic Auditory Cueing Group | Experimental | Other: Dynamic Auditory Cueing, Other: Conventional RehabilitationParticipants in this group receive dynamic auditory cueing for spatial neglect (DAC-SN) in addition to their standard conventional rehabilitation program. The intervention involves exposure to moving environmental sounds (such as animal or transportation noises) designed to redirect attention toward the neglected hemispace. The intervention is administered for 10 minutes per day, 5 days per week, over a total period of 4 weeks. |
| Conventional Rehabilitation Group | Active comparator | Other: Conventional RehabilitationParticipants in this group receive only the standard conventional rehabilitation program provided by the clinic. This group does not receive dynamic auditory cueing for spatial neglect (DAC-SN). The frequency and duration of the standard therapy are matched to those of the experimental group to ensure a fair comparison of the additional effects of auditory cueing. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Adults aged 18 years or older
- Subacute or chronic stroke
- Clinical diagnosis of left-sided spatial neglect confirmed by standardized tests (e.g., Line Bisection Test (LBT), Star Cancellation Test (SCT))
- Normal or corrected visual acuity
- Absence of auditory extinction
Key exclusion criteria (6 listed)
- Hearing impairment (Hearing Handicap Inventory score ≥26)
- Presence of hemianopia
- Impaired visual acuity due to ocular pathology (e.g., cataract, glaucoma)
- History of neurological disease (e.g., dementia, Parkinson's disease)
- Structural brain lesions unrelated to stroke
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dynamic Auditory CueingThe intervention consists of structured 10-minute sessions using digitized environmental sounds (e.g., animal sounds, moving vehicles, or sirens) as auditory cues. Dynamic auditory cueing for spatial neglect (DAC-SN) is applied using sounds presented with a dynamic spatial movement pattern across the horizontal plane. The auditory stimulus is designed to move from the intact hemispace toward the neglected hemispace or to follow a continuous scanning trajectory to guide attention toward the affected side. Stimuli are delivered through a stereo headset to ensure clear perception of directional movement. The intervention is administered in standardized sessions over a four-week period (5 sessions per week). This approach aims to promote active spatial attention and scanning behavior and differs from conventional static auditory stimulation. | Other | Dynamic Auditory Cueing Group |
| Conventional RehabilitationParticipants receive standard stroke rehabilitation, including physical and occupational therapy focused on motor function, mobility, and activities of daily living. This group follows the same rehabilitation schedule as the experimental group but does not receive dynamic auditory cueing for spatial neglect (DAC-SN). | Other | Conventional Rehabilitation Group, Dynamic Auditory Cueing Group |
Primary outcome
Line Bisection Test (LBT) deviation score
Time frame: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)
The Line Bisection Test (LBT) is used to assess spatial bias by measuring deviation from the true midpoint of horizontal lines. Deviation toward the right side indicates more severe left-sided spatial neglect.
Catherine Bergego Scale (CBS) score
Time frame: Baseline and after 20 sessions (end of treatment)
The Catherine Bergego Scale (CBS) is used to assess the impact of spatial neglect on daily activities. Higher scores indicate greater severity of neglect in functional tasks.
4 secondary outcomes
Star Cancellation Test (SCT) score
Time frame: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)
Line Cancellation Test (LCT) score
Time frame: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)
Functional Independence Measure (FIM) score
Time frame: Baseline and after 20 sessions
Center of Cancellation (CoC) value
Time frame: Baseline, after 1 session, after 10 sessions, and after 20 sessions
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Jul 2026.
- Background: PubMed 35176552Kaufmann BC, Cazzoli D, Bartolomeo P, Frey J, Pflugshaupt T, Knobel SEJ, Nef T, Muri RM, Nyffeler T. Auditory spatial cueing reduces neglect after right-hemispheric stroke: A proof of concept study. Cortex. 2022 Mar;148:152-167. doi: 10.1016/j.cortex.2021.12.009. Epub 2022 Jan 19.
- Background: PubMed 15949510Golay L, Hauert CA, Greber C, Schnider A, Ptak R. Dynamic modulation of visual detection by auditory cues in spatial neglect. Neuropsychologia. 2005;43(9):1258-65. doi: 10.1016/j.neuropsychologia.2004.12.006. Epub 2005 Feb 5.
- Background: PubMed 17041819Barrett AM, Burkholder S. Monocular patching in subjects with right-hemisphere stroke affects perceptual-attentional bias. J Rehabil Res Dev. 2006 May-Jun;43(3):337-46. doi: 10.1682/jrrd.2005.01.0015.
- Background: PubMed 22578712Van Vleet TM, DeGutis JM. Cross-training in hemispatial neglect: auditory sustained attention training ameliorates visual attention deficits. Cortex. 2013 Mar;49(3):679-90. doi: 10.1016/j.cortex.2012.03.020. Epub 2012 Apr 9.
- Background: PubMed 35980394Long J, Zhang Y, Liu X, Gao Q, Pan M. Music-based interventions for unilateral spatial neglect: A systematic review. Neuropsychol Rehabil. 2023 Oct;33(9):1462-1487. doi: 10.1080/09602011.2022.2111314. Epub 2022 Aug 18.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Gulcin Kaymak Karatas, MD principal investigator
Gazi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation
Elif E Kurtul, MD study director
Gazi University Faculty of Medicine, Department of Physical Medicine and Rehabilitation
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dynamic Auditory Cueing and Conventional Rehabilitation in people with Stroke and Perceptual Disorders, run by Gazi University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Line Bisection Test (LBT) deviation score (time frame: Baseline, after 1 session, after 10 sessions, and after 20 sessions (end of treatment)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07507383, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Jul 2026.