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PainNCT07505992

Acupressure for Pain, Injection Fear, and Satisfaction in Intramuscular Injection Patients

A study testing acupressure in people with Pain and Satisfaction, run by Istanbul University - Cerrahpasa at 1 site in Cyprus.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Background: Intramuscular (IM) injection-related pain and anxiety continue to be common problems in nursing practice. Non-pharmacological interventions such as acupressure are increasingly recognized for their potential to reduce procedure-related discomfort and enhance patient satisfaction. Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
Conditions the study is for
Pain, Satisfaction, Fear
What is being tested?
acupressure
Type of treatment
Injection or infusion
Could I receive a placebo?
No, everyone receives an active treatment
How many people
68 participants
Where
1 siteCyprus
Study dates
15 Nov 2024to 20 Feb 2025
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Were aged 18 years or older,
  • Possessed sufficient physical and cognitive abilities to assess pain using the VAS,
  • Had the ability to read and comprehend study instructions,
  • Were newly prescribed IM Diclofenac Sodium (without prior doses),
  • Had a body mass index within the normal or obese range ac- cording to WHO classification,
  • Had no scars, wounds,

Who cannot join

  • Patients who had taken any analgesic medications on the day of injection were excluded.

Trial locations and contacts

1 site in 1 country.

Cyprus1 site
  • Eastern Mediterranean University

    Famagusta, 34381

Other trials in Cyprus

About this study

Official title: Effect of Acupressure Therapy on Pain, Injection Fear, and Post-Injection Satisfaction in Patients Undergoing Intramuscular Injection: A Randomized Controlled Trial

Background: Intramuscular (IM) injection-related pain and anxiety continue to be common problems in nursing practice. Non-pharmacological interventions such as acupressure are increasingly recognized for their potential to reduce procedure-related discomfort and enhance patient satisfaction.

Aim: This study is planned to evaluate the effects of acupressure therapy on pain, injection-related fear, and post-injection satisfaction among patients receiving IM injections.

Methods: This study is designed as a randomized controlled trial to be conducted with 68 patients presenting to the emergency department and requiring IM diclofenac sodium injection. Participants will be randomly assigned to either an intervention group (n = 34), which will receive acupressure at the GB30 (Huantiao) point prior to injection, or a control group (n = 34), which will receive standard care. Data will be collected using the Visual Analog Scale, Injection Fear Scale, and Post-Injection Satisfaction Scale.

Read the detailed description

Intramuscular (IM) injections are among the most frequently performed parenteral medication administration methods by nurses worldwide, with billions of injections administered each year ( World Health Organization [WHO]). Despite their widespread use, IM injections continue to represent a significant source of pain, fear, and discomfort for patients. Injection-related pain is not limited to transient physical discomfort; it may also contribute to the development of injection fear, anxiety, and avoidance of future medical procedures. Pain is a universal human experience; however, its perception and expression vary across individuals. Furthermore, preinjection anxiety and fear significantly influence the pain experience. The act of needle penetration itself may trigger anxiety and, in some cases, lead to persistent fear of future injections. This fear can result in patients delaying or refusing injections, potentially compromising treat- ment adherence and recovery. Injection fear may lead individuals to avoid healthcare services, reduce adherence to prescribed treatments, and cause delays in care processes. These consequences are in direct conflict with the fundamental principles of patient-centered and evidence-based nursing care. Furthermore, pain and fear experienced during injections can negatively affect patient satisfaction, thereby reducing the perceived quality of care. Therefore, nurses are expected to apply evidence-based, patient-centered interventions during medication administration to reduce pain and improve patient outcomes. Several techniques have been recommended in the literature to minimize pain associated with IM injections, including correct injection site selection, appropriate patient positioning, slow drug administration, use of the Z-track technique, air- lock technique, distraction strategies, and complementary therapies. However, current evidence predominantly addresses pain intensity, while injection-related fear and postinjection satisfaction, which are key indicators of patient experience, remain under explored. Acupressure is a noninvasive technique that involves apply- ing pressure to specific points on the body using the fingers to alleviate or prevent pain. It is a low-cost and easily applicable complementary intervention that has been shown to be effective in pain management across various clinical contexts. In acupressure therapy, it is assumed that vital energy, referred to as Chi , flows throughout the body along energy channels known as meridians, which are named according to internal organs. Pressure applied to specific points along these meridians is believed to reduce tension and muscle stiffness in various parts of the body, enhance endorphin release, and modulate pain trans- mission pathways, thereby decreasing pain perception. However, there is a notable lack of studies comprehensively examining the effects of acupressure therapy on IM injection-related pain, injection fear, and postinjection satisfaction. The American Society for Pain Management Nursing emphasizes the importance of tailored, effective interventions for pain, anxiety, and fear management before, during, and after invasive procedures to enhance patient satisfaction. In this context, acupressure therapy represents a promising intervention for reducing pain perception during IM injections, alleviating injection-related fear, and ultimately enhancing postinjection satisfaction. To the best of our knowledge, no randomized con- trolled study has simultaneously examined the effects of acupressure on pain, injection-related fear, and postinjection satisfaction in patients receiving IM injections. Although various techniques have been explored to manage IM injection-related discomfort, the number of studies evaluating the effects of acupressure therapy on pain, injection-related fear, and postinjection satisfaction remains limited. Addressing this gap is critically important to support nurses in delivering evidence-based, holistic, and patient-centered care during IM injection practices. Therefore, this randomized controlled study was conducted to comprehensively evaluate the effects of acupressure therapy on pain, injection-related fear, and postinjection satisfaction in patients undergoing IM injections.

Conditions
Pain, Satisfaction, Fear
Being tested
acupressure
Medical subject headings
Pain, Personal Satisfaction

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • acupressureOther

    Acupressure was applied to the GB30 point, which is anatomically located at the junction of the lateral one- third and medial two-thirds of the distance between the greater trochanter of the femur and the sacral hiatus. Pressure was applied using the thumb at an intensity sufficient to produce slight skin blanching without causing pain, consistent with previously published acupressure protocols. The pressure was applied continuously for 1 minute immediately prior to the IM injection. To ensure consistency and standardization, all acupressure applications were performed by the same researcher following a predefined protocol. Participants in the control group received routine IM injection care without acupressure intervention.

Study groups in NCT07505992
Study groupRoleWhat they receive
acupressure groupExperimentalacupressure
Receives: Other: acupressure
Control groupNo interventionStandard injection procedure was performed.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Visual Analog Scale

    There is a significant difference in visual analog scale pain scores between patients in the acupressure group and those in the control group. 1 represents the lowest level of pain, and 10 represents the highest level of pain. As the number increases, the intensity of the pain also increases.

    Measured: 1 day

  2. Fear Scale

    There is a significant difference in injection fear scale scores between patients in the acupressure group and those in the control group. The scale is calculated based on the average item score. The lowest possible score on the scale is 1, and the highest is 5. As the score on the scale increases, the level of fear increases.

    Measured: 1 day

  3. postinjection satisfaction scale

    There is a significant difference in postinjection satisfaction scale scores between patients in the acupressure group and those in the control group. The lowest possible score on the scale is 1, and the highest is 5. As the score on the scale increases, the level of satisfaction increases. The Post-Injection Satisfaction Scale consists of 9 items.

    Measured: 1 day

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Apr 2026
  2. Study start15 Nov 2024
  3. Primary completion20 Feb 2025
  4. Study completion20 Feb 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
68 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07505992
Sponsor's protocol ID
Doğu Akdeniz Üniversitesi
Status last verified
Apr 2026
First submitted
24 Mar 2026
Last updated
7 Apr 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing acupressure in people with Pain and Satisfaction, run by Istanbul University - Cerrahpasa at 1 site in Cyprus.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 7 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Cyprus. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Visual Analog Scale (time frame: 1 day). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Apr 2026.

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