Endurance ExerciseREDNCT07504003
Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise
A study testing Long sessions and Short sessions in people with Endurance Exercise and Healthy Volunteers, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
Trial summary
During prolonged endurance exercise, certain physiological variables deteriorate depending on the duration of the exercise. Physiological resilience has therefore been defined as the ability to resist these changes and appears to be an important performance factor in endurance sports. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Endurance Exercise, Healthy Volunteers
- What is being tested?
- Long sessions and Short sessions
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteFrance
- Study dates
- 8 Apr 2026to 28 Feb 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Subjects who engage in rigorous cardiovascular activity (e.g., endurance sports, team sports, combat sports, etc.) for a maximum of two hours per week
- Ability to understand, speak, read, and write French
- Affiliated with or beneficiaries of a social security system
- Having freely given their written consent after being informed of the purpose, procedure, and potential risks involved
Who cannot join
- Subjects with chronic joint conditions (e.g., recurrent sprains, patellar or ligament problems).
- Subjects with one or more heart conditions, including ischemic, valvular, arrhythmic, hypertensive, congenital, or hypertrophic heart disease.
- Participants under guardianship or conservatorship.
- Subjects with chronic or central neurological conditions.
- Subjects who report having taken products prohibited by the World Anti-Doping Agency.
- Pregnant or breastfeeding women.
- Subjects who are unable to understand the purpose and conditions of the study and unable to give their consent.
- Persons deprived of their liberty by judicial or administrative decision, persons receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of Article L. 1121-8, and persons admitted to a health or social care facility for purposes other than research.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Service de physiologie clinique et de l'exercice
Saint-Etienne, 42055
Léonard FEASSON, PHD, (0)477120383 ext. +33, leonard.feasson@chu-st-etienne.fr
About this study
During prolonged endurance exercise, certain physiological variables deteriorate depending on the duration of the exercise. Physiological resilience has therefore been defined as the ability to resist these changes and appears to be an important performance factor in endurance sports. For example, most studies in this field have investigated changes in cycling power output associated with the first ventilatory threshold (VT1), a marker of an individual's endurance capacity, after prolonged endurance exercise. To date, only two studies have examined the effects of training on resilience. The first compared the effectiveness of two training programs, one with low-intensity sessions and the other with high-intensity sessions, with no difference between the conditions. The second study showed that incorporating strength training into a running training program was more effective at improving resilience than running alone. However, the influence of training session duration on resilience remains unknown. Only one observational study has shown that in a group of runners of similar ability, those who were used to doing long sessions had better resilience than those who only did short sessions.
Read the detailed description
We hypothesize that at equal intensity and volume, a less frequent training consisting of long sessions would be more effective in improving physiological resilience than a more frequent training composed of short sessions.
- Conditions
- Endurance Exercise, Healthy Volunteers
- Being tested
- Long sessions, Short sessions
- Keywords
- physiological resilience, endurance exercise, training session
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Long sessionsOther
Training frequency of 2 long sessions per week
Short sessionsOther
Training frequency of 5 short sessions per week
| Study group | Role | What they receive |
|---|---|---|
| Long sessions group | Experimental | Group benefiting from long sessions, twice a week Receives: Other: Long sessions |
| Short sessions group | Active comparator | Group benefiting from short sessions, 5 times a week Receives: Other: Short sessions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Power (watt) output at ventilatory threshold 1 (VT1)
the power (Watt) output at the VT1 measured by the difference of the power output (% decrease after 4 hours of cycling) between measurements taken before and after a training program. The results will be compared between group benefiting from long sessions and group from short sessions
Measured: At inclusion, Day 80.
Secondary outcomes (3)
a) Degree of change in heart rate (beats per minute),
Degree of changes in heart rate (beats per minute) during a 4-hour endurance cycling session, as measured by a heart rate monitor. The results will be compared between group benefiting from long sessions and group from short sessions
Measured: Day 7, Day 85
Rate of change in oxygen consumption (in L of O₂/min)
the rate of change in oxygen consumption (in L O₂/min) during a prolonged 4-hour endurance cycling exercise, quantified by measuring gas exchange (calculated using the equations of Jeukendrup and Wallis). The results will be compared between group benefiting from long sessions and group from short sessions
Measured: Day 7, Day 85
b) The Power (watt) output at ventilatory threshold 2 (VT2)
the power (Watt) output at the VT2 measured by the difference of the power output (% decrease after 4 hours of cycling) between measurements taken before and after a training program. The results will be compared between group benefiting from long sessions and group from short sessions
Measured: At inclusion, Day 80.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Mar 2026
- Study start8 Apr 2026
- Primary completion15 Nov 2028 (estimated)
- Study completion28 Feb 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Endurance ExerciseStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire de Saint EtienneThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Léonard FEASSON, PHD, Principal investigator, CHU de Saint-Etienne
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07504003
- Sponsor's protocol ID
- 25CH281
- Other IDs
- ANSM
- Acronym
- RED
- Status last verified
- Apr 2026
- First submitted
- 25 Mar 2026
- Last updated
- 14 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Training Session Duration on Improvements in Physiological Resilience to Exercise
- ClinicalTrials.gov ID
- NCT07504003
- Acronym / sponsor ID
- RED / 25CH281
- Conditions
- Endurance Exercise, Healthy Volunteers
- Keywords
- physiological resilience, endurance exercise, training session
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire de Saint EtienneUniversity, hospital or other
- Study start
- 8 Apr 2026 (actual)
- Primary completion
- 15 Nov 2028 (estimated)
- Study completion
- 28 Feb 2029 (estimated)
- First posted
- 31 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
During prolonged endurance exercise, certain physiological variables deteriorate depending on the duration of the exercise. Physiological resilience has therefore been defined as the ability to resist these changes and appears to be an important performance factor in endurance sports. For example, most studies in this field have investigated changes in cycling power output associated with the first ventilatory threshold (VT1), a marker of an individual's endurance capacity, after prolonged endurance exercise. To date, only two studies have examined the effects of training on resilience. The first compared the effectiveness of two training programs, one with low-intensity sessions and the other with high-intensity sessions, with no difference between the conditions. The second study showed that incorporating strength training into a running training program was more effective at improving resilience than running alone. However, the influence of training session duration on resilience remains unknown. Only one observational study has shown that in a group of runners of similar ability, those who were used to doing long sessions had better resilience than those who only did short sessions.
Detailed description
We hypothesize that at equal intensity and volume, a less frequent training consisting of long sessions would be more effective in improving physiological resilience than a more frequent training composed of short sessions.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Long sessions group | Experimental | Other: Long sessionsGroup benefiting from long sessions, twice a week |
| Short sessions group | Active comparator | Other: Short sessionsGroup benefiting from short sessions, 5 times a week |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Subjects who engage in rigorous cardiovascular activity (e.g., endurance sports, team sports, combat sports, etc.) for a maximum of two hours per week
- Ability to understand, speak, read, and write French
- Affiliated with or beneficiaries of a social security system
- Having freely given their written consent after being informed of the purpose, procedure, and potential risks involved
Key exclusion criteria (8 listed)
- Subjects with chronic joint conditions (e.g., recurrent sprains, patellar or ligament problems).
- Subjects with one or more heart conditions, including ischemic, valvular, arrhythmic, hypertensive, congenital, or hypertrophic heart disease.
- Participants under guardianship or conservatorship.
- Subjects with chronic or central neurological conditions.
- Subjects who report having taken products prohibited by the World Anti-Doping Agency.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Long sessionsTraining frequency of 2 long sessions per week | Other | Long sessions group |
| Short sessionsTraining frequency of 5 short sessions per week | Other | Short sessions group |
Primary outcome
Power (watt) output at ventilatory threshold 1 (VT1)
Time frame: At inclusion, Day 80.
the power (Watt) output at the VT1 measured by the difference of the power output (% decrease after 4 hours of cycling) between measurements taken before and after a training program. The results will be compared between group benefiting from long sessions and group from short sessions
3 secondary outcomes
a) Degree of change in heart rate (beats per minute),
Time frame: Day 7, Day 85
Rate of change in oxygen consumption (in L of O₂/min)
Time frame: Day 7, Day 85
b) The Power (watt) output at ventilatory threshold 2 (VT2)
Time frame: At inclusion, Day 80.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Apr 2026.
Related trials for Endurance Exercise
Recruiting
Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling
Athletic Performance, Hyperbaric Oxygenation
Recruiting
The Effect of Two Different Exercise Programs in Young Sailors
Healthy Volunteers
Active, not recruiting
Effects of Short-term Adaptation to Ketogenic Diet on Endurance Trained Athletes
Ketogenic Diet, Control Condition
Active, not recruiting
Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia
Hereditary Spastic Paraplegia
Recruiting
Effectivity of P1821, a Novel Tongue Strengthening and Endurance Enhancing Speech Flow Exercise
Ankyloglossia, Impairment of Speech
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Léonard FEASSON, PHD principal investigator
CHU de Saint-Etienne
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Long sessions and Short sessions in people with Endurance Exercise and Healthy Volunteers, run by Centre Hospitalier Universitaire de Saint Etienne at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 14 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Léonard FEASSON, PHD ((0)477120383 ext. +33, leonard.feasson@chu-st-etienne.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Power (watt) output at ventilatory threshold 1 (VT1) (time frame: At inclusion, Day 80.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Apr 2026.