Substrate MetabolismNCT07503990
Effects of Food Intake Sequence on Substrate Utilisation and Endurance Performance
A study testing Carbohydrate-last meal pattern and Carbohydrate-first meal pattern in people with Substrate Metabolism and Healthy Participants, run by Universidade do Porto at 1 site in Portugal.
Trial summary
The goal of this clinical trial is to understand how consuming a pre-exercise meal in different food intake sequences affects substrate utilisation and endurance exercise performance in healthy trained athletes. Read more about this study
- Who is it for?
- Ages 18 to 64 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Substrate Metabolism, Healthy Participants, Endurance Exercise
- What is being tested?
- Carbohydrate-last meal pattern and Carbohydrate-first meal pattern
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 sitePortugal
- Study dates
- 1 Apr 2026to 9 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 64 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Adult (18-64 years old)
- Men
- Endurance-trained athletes (meeting training and performance caliber criteria ≥Tier 2; McKay et al., 2022)
- Healthy (meeting the exclusion criteria for medical conditions)
- Normal glucose tolerant according to the latest criteria established by the American Diabetes Association (2024): HbA1c <5.7%, fasting plasma glucose <5.6 mmol/L (100 mg/dL) or 2-h plasma glucose <7.8 mmol/L (140 mg/dL) during a 75-g OGTT
- Able and willing to provide informed consent and safely comply with study procedures
Who cannot join
- Any medical condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias into the experiment (e.g. cardiovascular disease; alcohol or substance abuse; any condition affecting the glucose or lipid metabolism, reviewed on a case by case basis)
- Any reported medication or supplementation that may interfere with the glucose metabolism (e.g., acarbose, insulin, metformin, semaglutide, thiazolidinediones, sulfonylureas, corticosteroids, thiazide diuretics) or lipid metabolism (e.g., statins, nicotinic acid, colestyramine anhydrous, ezetimibe, fibrates, L-carnitine). Other medication and supplementation will be reviewed on a case by case basis.
- Known food allergy, intolerance or hypersensitivity to any of the test meal ingredients
- Recent change in body mass (± 2 kg in the last 2 months)
- Smoking
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Manipulating Food Intake Sequence in the Pre-exercise Meal on Substrate Utilisation and Endurance Performance in Athletes
The goal of this clinical trial is to understand how consuming a pre-exercise meal in different food intake sequences affects substrate utilisation and endurance exercise performance in healthy trained athletes. Specifically, the main questions it aims to answer are:
- Does consuming the pre-exercise meal in different food intake sequences alter the whole-body utilisation of fat and CHO at rest and during prolonged exercise at moderate to heavy intensities?
- Does consuming the pre-execise meal in different food intake sequences alter time-trial performance?
- Does consuming the pre-exercise meal in different food intake sequences alter other metabolic and physiological responses before, during or after exercise (i.e., blood glucose, blood lactate, heart rate (HR), ratings of perceived exertion (RPE), appetite)?
Read more
To address these questions, researchers will compare eating the dietary sources of rapidly absorbed CHO at the end (CHO-last meal pattern) or at the start (CHO-first meal pattern) of a standardised pre-exercise meal, in a randomised, counterbalanced, crossover design. Two hours after starting the pre-exercise meal, participants will perform a 60-min submaximal test on a cycling ergometer at two different intensities (30 min at 90% of the ventilatory threshold (VT) 1 and 30 min at 50% VT1-VT2), followed by a 10-km cycling time trial (TT).
In the screening visit participants will:
- Be screened for cardiometabolic conditions
- Perform an 8-12-min graded exercise test to determine their maximal pulmonary oxygen uptake (VO2max) and non-invasive submaximal anchors of performance (VT 1 and VT 2)
- Be familiarised to the experimental procedures
In experimental visits participants will:
- Follow guidelines pertaining to dietary intake, exercise and sleep in the previous 24 hours
- Have a standardised test meal in either the CHO-last or CHO-first food intake sequence
- Have 3 drops of capillary blood (0,9 µL in total) collected to measure glucose and lactate pre-meal, 15, 30, 45, 60, 90 and 120 min post-meal, every 15 min during submaximal exercise and post-TT
- Breathe into an indirect calorimetry mask for 5 min pre-meal, 15, 30, 45, 60, 90 and 120 min post-meal, every 15 min during submaximal exercise and post-TT
- Wear a HR monitor continuously during submaximal exercise and the TT
- Rate their appetite on visual analogue scales pre-meal, 15, 30, 45, 60, 90 and 120 min post-meal, and 30 min post-TT
- Rate their perceived exertion on RPE scales every 15 min during submaximal exercise, post-TT and 30 min post-TT.
Data will be compared within-participant between food intake sequences using linear mixed-effects models with random intercepts, to account for repeated measurements, interindividual variability, and potential missing data.
- Being tested
- Carbohydrate-last meal pattern, Carbohydrate-first meal pattern
- Keywords
- food order, meal sequence, glucose metabolism, substrate utilisation, sport nutrition
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Carbohydrate-last meal patternOther
Also called CHO-last, CL
Skyr yoghurt, whey protein and almonds over ~5 min, immediately followed by white bread, strawberry jam, banana and pulp-free orange juice over ~10 min.
Carbohydrate-first meal patternOther
Also called CHO-first, CF
White bread, strawberry jam, banana and pulp-free orange juice over ~10 min, immediately followed by skyr yoghurt, whey protein and almonds over ~5 min.
| Study group | Role | What they receive |
|---|---|---|
| CL-CF | Experimental | The interventions (carbohydrate-last meal pattern (CL) or carbohydrate-first meal pattern (CF)) will be delivered in random order at two study visits, separated by a wash-out period of at least 7 days. If participants are allocated to this study arm, they will receive the CL on the first visit and the CF on the second visit. The nutritional composition of the test-meal will comply to the current sports nutrition guidelines for the pre-exercise meal (i.e., 1-4 g of CHO/kg of body mass, moderate amounts of protein, low-fat and fibre content, 5-10 mL/kg of body mass of fluids) (Thomas et al., 2016). Participants will be encouraged to consume the meal in full within 15 minutes, at a comfortable pace, to mimic real eating circumstances. Receives: Other: Carbohydrate-last meal pattern; Other: Carbohydrate-first meal pattern |
| CF-CL | Active comparator | The interventions (carbohydrate-last meal pattern (CL) or carbohydrate-first meal pattern (CF)) will be delivered in random order at two study visits, separated by a wash-out period of at least 7 days. If participants are allocated to this study arm, they will receive the CF on the first visit and the CL on the second visit. The test-meal will be identical and isocaloric in both interventions of the study. Receives: Other: Carbohydrate-last meal pattern; Other: Carbohydrate-first meal pattern |
What is being measured
The primary outcome is the main question the study is designed to answer.
Whole-body fat oxidation
Difference between CHO-last and CHO-first meal patterns in the whole-body fat oxidation rate (g/min) over time adjusted for baseline, measured by indirect calorimetry.
Measured: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Time-trial performance
Difference between CHO-last and CHO-first meal patterns in the time to complete (min:sec) a 10-km cycling TT, assessed using a validated cycle ergometer.
Measured: Immediately upon completion of the time trial subsequent to the post-meal resting period (0-120 minutes) and standardised exercise protocol (120-180 minutes)
Secondary outcomes (9)
Time-trial power output
Difference between CHO-last and CHO-first meal patterns in the average power output (W) during a 10-km cycling TT, assessed using a validated cycle ergometer.
Measured: Immediately upon completion of the time trial subsequent to the post-meal resting period (0-120 minutes) and standardised exercise protocol (120-180 minutes)
Whole-body CHO oxidation
Difference between CHO-last and CHO-first meal patterns in the whole-body CHO oxidation rate (g/min) over time adjusted for baseline, measured by indirect calorimetry.
Measured: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Respiratory exchange ratio (RER)
Difference between CHO-last and CHO-first meal patterns in the RER over time adjusted for baseline, measured by indirect calorimetry.
Measured: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Energy expenditure
Difference between CHO-last and CHO-first meal patterns in the energy expenditure rate (kcal/min) over time adjusted for baseline, measured by indirect calorimetry.
Measured: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Blood glucose concentrations
Difference between CHO-last and CHO-first meal patterns in the capillary blood glucose concentrations (mmol/L) over time adjusted for baseline, measured by a validated glucometer.
Measured: Every 15 minutes post-meal in the first hour (0-60 min), every 30 minutes in the second hour (60-120 min), every 15 minutes throughout the standardised exercise protocol (120-180 min) and immediately upon completion of the subsequent time trial
Blood lactate concentrations
Difference between CHO-last and CHO-first meal patterns in the capillary blood lactate concentrations (mmol/L) over time adjusted for baseline, measured by a validated lactate meter.
Measured: Every 15 minutes post-meal in the first hour (0-60 min), every 30 minutes in the second hour (60-120 min), every 15 minutes throughout the standardised exercise protocol (120-180 min) and immediately upon completion of the subsequent time trial
Heart Rate
Difference between CHO-last and CHO-first meal patterns in the heart rate (bpm) over time adjusted for baseline, assessed as 15-minute averages during exercise using a validated heart rate monitor.
Measured: Continuously throughout the standardised exercise protocol (120-180 minutes) and subsequent time trial
Ratings of perceived exertion (RPE)
Difference between CHO-last and CHO-first meal patterns in the absolute RPE over time, assessed during and after exercise using the validated modified Borg's 0-10 scale.
Measured: Every 15 minutes during the standardised exercise protocol (120-180 minutes), immediately upon completion of the subsequent time trial, 30 minutes after completion of the time trial
Subjective appetite ratings
Difference between CHO-last and CHO-first meal patterns in the appetite ratings (mm) over time adjusted for baseline, assessed at rest and after exercise using validated 100-mm visual analogue scales.
Measured: Every 15 minutes post-meal in the first hour (0-60 minutes), every 30 minutes in the second hour (60-120 minutes), and 30 minutes after completion of the time trial
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Mar 2026
- Study start1 Apr 2026
- Primary completion9 Jun 2026
- Study completion9 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Substrate MetabolismStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study is designed as a randomised, counterbalanced, crossover, superiority trial with two groups. Block randomization will be performed by an external researcher with a 1:1 allocation ratio, and allocation concealment will be ensured through the use of sequentially numbered, opaque, sealed envelopes.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidade do Porto
- Sponsor type
- University, hospital or other
- Collaborators
- Portuguese Football Federation, Fundação para a Ciência e a Tecnologia
- Responsible party
- Sponsor
- Investigators
- Rita Giro, Principal investigator, FCNAUP, University of Porto; Federação Portuguesa de Futebol
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07503990
- Sponsor's protocol ID
- FOODSEQ-SUEP
- Other IDs
- 2022.12954.BD
- Status last verified
- Apr 2026
- First submitted
- 14 Nov 2025
- Last updated
- 10 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymised IPD will be made available upon reasonable request directed to the corresponding author.
Study at a glance
From the registry record, last updated by the sponsor on 10 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Manipulating Food Intake Sequence in the Pre-exercise Meal on Substrate Utilisation and Endurance Performance in Athletes
- ClinicalTrials.gov ID
- NCT07503990
- Acronym / sponsor ID
- FOODSEQ-SUEP
- Keywords
- food order, meal sequence, glucose metabolism, substrate utilisation, sport nutrition
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- Universidade do PortoUniversity, hospital or other
- Collaborators
- Portuguese Football Federation, Fundação para a Ciência e a Tecnologia
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- 9 Jun 2026 (actual)
- Study completion
- 9 Jun 2026 (actual)
- First posted
- 31 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to understand how consuming a pre-exercise meal in different food intake sequences affects substrate utilisation and endurance exercise performance in healthy trained athletes. Specifically, the main questions it aims to answer are:
- Does consuming the pre-exercise meal in different food intake sequences alter the whole-body utilisation of fat and CHO at rest and during prolonged exercise at moderate to heavy intensities?
- Does consuming the pre-execise meal in different food intake sequences alter time-trial performance?
- Does consuming the pre-exercise meal in different food intake sequences alter other metabolic and physiological responses before, during or after exercise (i.e., blood glucose, blood lactate, heart rate (HR), ratings of perceived exertion (RPE), appetite)?
To address these questions, researchers will compare eating the dietary sources of rapidly absorbed CHO at the end (CHO-last meal pattern) or at the start (CHO-first meal pattern) of a standardised pre-exercise meal, in a randomised, counterbalanced, crossover design. Two hours after starting the pre-exercise meal, participants will perform a 60-min submaximal test on a cycling ergometer at two different intensities (30 min at 90% of the ventilatory threshold (VT) 1 and 30 min at 50% VT1-VT2), followed by a 10-km cycling time trial (TT).
In the screening visit participants will:
- Be screened for cardiometabolic conditions
- Perform an 8-12-min graded exercise test to determine their maximal pulmonary oxygen uptake (VO2max) and non-invasive submaximal anchors of performance (VT 1 and VT 2)
- Be familiarised to the experimental procedures
In experimental visits participants will:
- Follow guidelines pertaining to dietary intake, exercise and sleep in the previous 24 hours
- Have a standardised test meal in either the CHO-last or CHO-first food intake sequence
- Have 3 drops of capillary blood (0,9 µL in total) collected to measure glucose and lactate pre-meal, 15, 30, 45, 60, 90 and 120 min post-meal, every 15 min during submaximal exercise and post-TT
- Breathe into an indirect calorimetry mask for 5 min pre-meal, 15, 30, 45, 60, 90 and 120 min post-meal, every 15 min during submaximal exercise and post-TT
- Wear a HR monitor continuously during submaximal exercise and the TT
- Rate their appetite on visual analogue scales pre-meal, 15, 30, 45, 60, 90 and 120 min post-meal, and 30 min post-TT
- Rate their perceived exertion on RPE scales every 15 min during submaximal exercise, post-TT and 30 min post-TT.
Data will be compared within-participant between food intake sequences using linear mixed-effects models with random intercepts, to account for repeated measurements, interindividual variability, and potential missing data.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This study is designed as a randomised, counterbalanced, crossover, superiority trial with two groups. Block randomization will be performed by an external researcher with a 1:1 allocation ratio, and allocation concealment will be ensured through the use of sequentially numbered, opaque, sealed envelopes.
| Arm | Type | Receives |
|---|---|---|
| CL-CF | Experimental | Other: Carbohydrate-last meal pattern, Other: Carbohydrate-first meal patternThe interventions (carbohydrate-last meal pattern (CL) or carbohydrate-first meal pattern (CF)) will be delivered in random order at two study visits, separated by a wash-out period of at least 7 days. If participants are allocated to this study arm, they will receive the CL on the first visit and the CF on the second visit. The nutritional composition of the test-meal will comply to the current sports nutrition guidelines for the pre-exercise meal (i.e., 1-4 g of CHO/kg of body mass, moderate amounts of protein, low-fat and fibre content, 5-10 mL/kg of body mass of fluids) (Thomas et al., 2016). Participants will be encouraged to consume the meal in full within 15 minutes, at a comfortable pace, to mimic real eating circumstances. |
| CF-CL | Active comparator | Other: Carbohydrate-last meal pattern, Other: Carbohydrate-first meal patternThe interventions (carbohydrate-last meal pattern (CL) or carbohydrate-first meal pattern (CF)) will be delivered in random order at two study visits, separated by a wash-out period of at least 7 days. If participants are allocated to this study arm, they will receive the CF on the first visit and the CL on the second visit. The test-meal will be identical and isocaloric in both interventions of the study. |
Who may qualify
- Ages
- 18 to 64 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Adult (18-64 years old)
- Men
- Endurance-trained athletes (meeting training and performance caliber criteria ≥Tier 2; McKay et al., 2022)
- Healthy (meeting the exclusion criteria for medical conditions)
- Normal glucose tolerant according to the latest criteria established by the American Diabetes Association (2024): HbA1c <5.7%, fasting plasma glucose <5.6 mmol/L (100 mg/dL) or 2-h plasma glucose <7.8 mmol/L (140 mg/dL) during a 75-g OGTT
Key exclusion criteria (5 listed)
- Any medical condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias into the experiment (e.g. cardiovascular disease; alcohol or substance abuse; any condition affecting the glucose or lipid metabolism, reviewed on a case by case basis)
- Any reported medication or supplementation that may interfere with the glucose metabolism (e.g., acarbose, insulin, metformin, semaglutide, thiazolidinediones, sulfonylureas, corticosteroids, thiazide diuretics) or lipid metabolism (e.g., statins, nicotinic acid, colestyramine anhydrous, ezetimibe, fibrates, L-carnitine). Other medication and supplementation will be reviewed on a case by case basis.
- Known food allergy, intolerance or hypersensitivity to any of the test meal ingredients
- Recent change in body mass (± 2 kg in the last 2 months)
- Smoking
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Carbohydrate-last meal patternAlso: CHO-last, CLSkyr yoghurt, whey protein and almonds over ~5 min, immediately followed by white bread, strawberry jam, banana and pulp-free orange juice over ~10 min. | Other | CF-CL, CL-CF |
| Carbohydrate-first meal patternAlso: CHO-first, CFWhite bread, strawberry jam, banana and pulp-free orange juice over ~10 min, immediately followed by skyr yoghurt, whey protein and almonds over ~5 min. | Other | CF-CL, CL-CF |
Primary outcome
Whole-body fat oxidation
Time frame: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Difference between CHO-last and CHO-first meal patterns in the whole-body fat oxidation rate (g/min) over time adjusted for baseline, measured by indirect calorimetry.
Time-trial performance
Time frame: Immediately upon completion of the time trial subsequent to the post-meal resting period (0-120 minutes) and standardised exercise protocol (120-180 minutes)
Difference between CHO-last and CHO-first meal patterns in the time to complete (min:sec) a 10-km cycling TT, assessed using a validated cycle ergometer.
9 secondary outcomes
Time-trial power output
Time frame: Immediately upon completion of the time trial subsequent to the post-meal resting period (0-120 minutes) and standardised exercise protocol (120-180 minutes)
Whole-body CHO oxidation
Time frame: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Respiratory exchange ratio (RER)
Time frame: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Energy expenditure
Time frame: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)
Blood glucose concentrations
Time frame: Every 15 minutes post-meal in the first hour (0-60 min), every 30 minutes in the second hour (60-120 min), every 15 minutes throughout the standardised exercise protocol (120-180 min) and immediately upon completion of the subsequent time trial
Blood lactate concentrations
Time frame: Every 15 minutes post-meal in the first hour (0-60 min), every 30 minutes in the second hour (60-120 min), every 15 minutes throughout the standardised exercise protocol (120-180 min) and immediately upon completion of the subsequent time trial
Heart Rate
Time frame: Continuously throughout the standardised exercise protocol (120-180 minutes) and subsequent time trial
Ratings of perceived exertion (RPE)
Time frame: Every 15 minutes during the standardised exercise protocol (120-180 minutes), immediately upon completion of the subsequent time trial, 30 minutes after completion of the time trial
Subjective appetite ratings
Time frame: Every 15 minutes post-meal in the first hour (0-60 minutes), every 30 minutes in the second hour (60-120 minutes), and 30 minutes after completion of the time trial
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Jun 2026.
- Individual participant dataSharing planned: Yes. Anonymised IPD will be made available upon reasonable request directed to the corresponding author.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Rita Giro principal investigator
FCNAUP, University of Porto; Federação Portuguesa de Futebol
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Carbohydrate-last meal pattern and Carbohydrate-first meal pattern in people with Substrate Metabolism and Healthy Participants, run by Universidade do Porto at 1 site in Portugal.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Portugal. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Whole-body fat oxidation (time frame: Every 15 minutes post-meal (0-120 minutes), every 15 minutes throughout the subsequent standardised exercise protocol (120-180 minutes)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Jun 2026.