Parkinson Disease (PD)NCT07495462
Effect of Motor Imagery Added to Rehabilitation on Balance and Kinesiophobia in Patients With Parkinson's Disease
A study testing Conventional Rehabilitation and Motor Imagery Training in people with Parkinson Disease (PD), run by Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
Parkinson's Disease (PD) is a progressive brain disorder that affects movement and balance. It can cause slowed movements, stiffness, tremor, balance problems, and an increased risk of falling. Many individuals with PD develop fear of movement, also referred to as kinesiophobia, and fear of falling. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Parkinson Disease (PD)
- What is being tested?
- Conventional Rehabilitation and Motor Imagery Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 2 Jan 2026to 17 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of Parkinson's Disease (PD)
- Age 40 years or older
- Modified Hoehn and Yahr scale stage between 1 and 3
- Mini-Mental State Examination (MMSE) score of 22 or higher
Who cannot join
- Presence of an additional neurological disorder
- Movement impairment or nerve damage due to orthopedic pathology
- Cardiopulmonary conditions that contraindicate exercise participation
- Presence of severe dyskinesia
- Visual or vestibular impairments that may affect balance
- Presence of motor fluctuations (on-off periods)
- Deep brain stimulation for Parkinson's Disease
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Istanbul, Istanbul, 34785
About this study
Official title: The Effect of Motor Imagery Added to Conventional Rehabilitation on Balance and Kinesiophobia in Patients With Parkinson's Disease: A Randomized Controlled Trial
Parkinson's Disease (PD) is a progressive brain disorder that affects movement and balance. It can cause slowed movements, stiffness, tremor, balance problems, and an increased risk of falling. Many individuals with PD develop fear of movement, also referred to as kinesiophobia, and fear of falling. This condition may lead to avoidance of physical activity, which can further worsen balance and movement abilities.
This study aims to determine whether adding Motor Imagery (MI) to a standard rehabilitation program can improve balance and reduce fear of movement in individuals with PD. MI is a mental practice technique in which an individual rehearses movements cognitively without actual physical execution. For example, a person may imagine standing up, walking, or climbing stairs. Although the movement is not physically performed, the brain regions involved in movement are activated. MI is safe, does not require special equipment, and may help improve motor control.
Read more
Eligible participants will be randomly assigned to one of two groups. One group will receive standard physical therapy and rehabilitation exercises, while the other group will receive the same therapy combined with additional MI training. The rehabilitation program will last six weeks.
The study will primarily evaluate whether this combined approach improves balance and reduces fear of movement. In addition, the potential effects of the intervention on fall risk, functional mobility and performance, fear of falling, activities of daily living, and motor function will also be examined. Assessments will be performed at the beginning of the study, at the end of treatment, and again at 12 weeks.
Researchers hope to determine whether combining MI with conventional rehabilitation provides greater benefits than conventional rehabilitation alone and may help improve rehabilitation strategies for people living with PD.
Read the detailed description
Parkinson's Disease (PD) is a progressive neurological disorder that affects movement control due to the gradual loss of dopamine-producing neurons. Over time, individuals may experience motor symptoms such as bradykinesia, rigidity, tremor, and impaired postural control. Among these symptoms, balance impairment and postural instability are major contributors to falls and increased fall risk. Falls are common in people with PD and may lead to injury and limitations in safe mobility.
In addition to motor symptoms, psychological factors may influence movement performance. One important factor is kinesiophobia, defined as an excessive fear of movement due to the belief that physical activity may cause falling or injury. Fear of falling may lead individuals to avoid movement and reduce participation in physical activities and rehabilitation programs. Reduced activity levels may contribute to muscle weakness, further balance deterioration, decline in functional performance, and worsening motor abilities. Therefore, rehabilitation strategies that address both motor impairments and movement-related fear are essential.
Conventional rehabilitation programs for PD typically include balance training, gait training, strengthening exercises, and functional mobility tasks. These interventions aim to improve postural control, reduce fall risk, and enhance motor performance. However, the effectiveness of rehabilitation may vary depending on patient engagement, motivation, and psychological readiness for movement.
Motor Imagery (MI) is a technique that involves mentally rehearsing a movement without physically performing it. Neurophysiological research indicates that MI activates neural pathways similar to those involved in actual movement execution. This activation may facilitate motor learning, improve coordination, and enhance balance control. Because MI does not require physical exertion, it may be particularly beneficial for individuals whose participation in physical exercise is limited by balance deficits or fear of falling.
Previous studies in neurological rehabilitation suggest that Motor Imagery (MI) may support improvements in motor performance and balance. However, limited evidence exists regarding its effectiveness in simultaneously improving balance and reducing movement-related fear in individuals with PD.
This study is designed to evaluate whether integrating structured MI sessions into a conventional rehabilitation program provides additional clinical benefits. The primary objective is to determine its effectiveness in improving balance and reducing kinesiophobia. Secondary objectives include examining the effects of the intervention on fall risk, functional performance, fear of falling, activities of daily living, and motor function.
The intervention focuses on functional, everyday movements that are directly associated with balance control and fall prevention. These movements include weight shifting, sit-to-stand transitions, walking, stair negotiation, trunk rotation, reciprocal movements, object retrieval from the floor, as well as rhythmic and coordinated activities such as dance-based movements and step exercises.
MI sessions will follow a structured format. Participants will observe standardized demonstrations of correctly performed functional movements and will then be guided to mentally rehearse these movements using visual imagery and kinesthetic imagery techniques. Immediately after the imagery phase, participants will physically perform the same activities under professional supervision. Exercise difficulty will be progressively adjusted according to individual performance levels to promote improvements in balance, functional mobility, and motor performance.
The rationale for combining mental rehearsal with physical execution is based on principles of motor learning and neuroplasticity. Repeated activation of motor-related neural circuits through both mental and physical practice may enhance postural control, coordination, and movement confidence. Addressing both motor control and movement-related fear may contribute to safer mobility and improved functional performance.
The study is conducted in a clinical rehabilitation setting and follows a randomized controlled parallel-group design. Participants will receive a structured rehabilitation program over a defined treatment period. Follow-up assessments will be conducted immediately after the intervention and at 12 weeks to evaluate the persistence of intervention effects.
The anticipated contribution of this study is to clarify whether Motor Imagery (MI) provides additional benefits beyond conventional rehabilitation in improving balance and reducing movement-related fear in individuals with PD. If proven effective, MI may represent a safe and easily implementable approach to enhance rehabilitation strategies.
- Conditions
- Parkinson Disease (PD)
- Being tested
- Conventional Rehabilitation, Motor Imagery Training
- Keywords
- Rehabilitation, Kinesiophobia, Balance, Motor Imagery (MI)
- Medical subject headings
- Parkinson Disease, Kinesiophobia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional RehabilitationBehavioural
Also called Control
A structured physiotherapy program focusing on balance, gait, strength, and functional mobility training
Motor Imagery TrainingBehavioural
A structured motor imagery program including guided visual and kinesthetic mental rehearsal of functional movements, applied in addition to conventional rehabilitation.
| Study group | Role | What they receive |
|---|---|---|
| Conventional Rehabilitation Group | Active comparator | Participants will receive a structured conventional rehabilitation program including balance training, gait training, strengthening exercises, and functional mobility exercises Receives: Behavioral: Conventional Rehabilitation |
| Motor Imagery + Conventional Rehabilitation Group | Experimental | Participants will receive traditional rehabilitation along with motor imagery training. Receives: Behavioral: Conventional Rehabilitation; Behavioral: Motor Imagery Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from baseline in kinesiophobia
Kinesiophobia will be assessed using the Tampa Scale for Kinesiophobia (TSK-17). The TSK-17 is a self-reported questionnaire used to evaluate fear of movement or re-injury. Higher scores indicate greater levels of kinesiophobia.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in balance performance
Balance performance will be assessed using the Berg Balance Scale (BBS). The BBS is a widely used clinical scale consisting of 14 functional tasks that evaluate static and dynamic balance abilities. Higher scores indicate better balance performance.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Secondary outcomes (5)
Change from baseline in motor function
Motor function will be assessed using Part III of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS Part III), which evaluates motor symptoms including tremor, rigidity, and bradykinesia in individuals with Parkinson's Disease.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in fall risk and functional mobility
Fall risk and functional mobility will be assessed using the Timed Up and Go (TUG) test, which measures the time required for a participant to stand up from a chair, walk three meters, turn, walk back, and sit down.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in fear of falling
Fear of falling will be assessed using the Falls Efficacy Scale-International (FES-I). The FES-I is a self-reported questionnaire that evaluates concern about falling during 16 daily activities. Scores range from 16 to 64, with higher scores indicating greater fear of falling.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in non-motor experiences of daily living
Non-motor experiences of daily living will be assessed using Part I of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS Part I). This scale evaluates non-motor symptoms including cognitive impairment, hallucinations, depressed mood, anxious mood, and apathy. Scores range from 0 to 52, with higher scores indicating greater non-motor symptom burden.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in motor experiences of daily living
Motor experiences of daily living will be assessed using Part II of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS Part II). This scale evaluates the impact of motor symptoms on daily activities including speech, eating, dressing, hygiene, handwriting, and walking. Scores range from 0 to 52, with higher scores indicating greater functional impairment in daily living activities.
Measured: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2026
- Study start2 Jan 2026
- Primary completion13 Jul 2026
- Study completion17 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson Disease (PD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to two parallel groups receiving either conventional rehabilitation alone or conventional rehabilitation combined with motor imagery training.
- Masking
- None (open label)
- Enrolment
- 42 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07495462
- Sponsor's protocol ID
- MI-PD-2026-01
- Status last verified
- Sep 2026
- First submitted
- 21 Mar 2026
- Last updated
- 9 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Motor Imagery Added to Conventional Rehabilitation on Balance and Kinesiophobia in Patients With Parkinson's Disease: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07495462
- Acronym / sponsor ID
- MI-PD-2026-01
- Conditions
- Parkinson Disease (PD)
- Keywords
- Rehabilitation, Kinesiophobia, Balance, Motor Imagery (MI)
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 42 participants (actual)
- Lead sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalUniversity, hospital or other
- Study start
- 2 Jan 2026 (actual)
- Primary completion
- 13 Jul 2026 (actual)
- Study completion
- 17 Jul 2026 (actual)
- First posted
- 27 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Parkinson's Disease (PD) is a progressive brain disorder that affects movement and balance. It can cause slowed movements, stiffness, tremor, balance problems, and an increased risk of falling. Many individuals with PD develop fear of movement, also referred to as kinesiophobia, and fear of falling. This condition may lead to avoidance of physical activity, which can further worsen balance and movement abilities.
This study aims to determine whether adding Motor Imagery (MI) to a standard rehabilitation program can improve balance and reduce fear of movement in individuals with PD. MI is a mental practice technique in which an individual rehearses movements cognitively without actual physical execution. For example, a person may imagine standing up, walking, or climbing stairs. Although the movement is not physically performed, the brain regions involved in movement are activated. MI is safe, does not require special equipment, and may help improve motor control.
Eligible participants will be randomly assigned to one of two groups. One group will receive standard physical therapy and rehabilitation exercises, while the other group will receive the same therapy combined with additional MI training. The rehabilitation program will last six weeks.
The study will primarily evaluate whether this combined approach improves balance and reduces fear of movement. In addition, the potential effects of the intervention on fall risk, functional mobility and performance, fear of falling, activities of daily living, and motor function will also be examined. Assessments will be performed at the beginning of the study, at the end of treatment, and again at 12 weeks.
Researchers hope to determine whether combining MI with conventional rehabilitation provides greater benefits than conventional rehabilitation alone and may help improve rehabilitation strategies for people living with PD.
Detailed description
Parkinson's Disease (PD) is a progressive neurological disorder that affects movement control due to the gradual loss of dopamine-producing neurons. Over time, individuals may experience motor symptoms such as bradykinesia, rigidity, tremor, and impaired postural control. Among these symptoms, balance impairment and postural instability are major contributors to falls and increased fall risk. Falls are common in people with PD and may lead to injury and limitations in safe mobility.
In addition to motor symptoms, psychological factors may influence movement performance. One important factor is kinesiophobia, defined as an excessive fear of movement due to the belief that physical activity may cause falling or injury. Fear of falling may lead individuals to avoid movement and reduce participation in physical activities and rehabilitation programs. Reduced activity levels may contribute to muscle weakness, further balance deterioration, decline in functional performance, and worsening motor abilities. Therefore, rehabilitation strategies that address both motor impairments and movement-related fear are essential.
Conventional rehabilitation programs for PD typically include balance training, gait training, strengthening exercises, and functional mobility tasks. These interventions aim to improve postural control, reduce fall risk, and enhance motor performance. However, the effectiveness of rehabilitation may vary depending on patient engagement, motivation, and psychological readiness for movement.
Motor Imagery (MI) is a technique that involves mentally rehearsing a movement without physically performing it. Neurophysiological research indicates that MI activates neural pathways similar to those involved in actual movement execution. This activation may facilitate motor learning, improve coordination, and enhance balance control. Because MI does not require physical exertion, it may be particularly beneficial for individuals whose participation in physical exercise is limited by balance deficits or fear of falling.
Previous studies in neurological rehabilitation suggest that Motor Imagery (MI) may support improvements in motor performance and balance. However, limited evidence exists regarding its effectiveness in simultaneously improving balance and reducing movement-related fear in individuals with PD.
This study is designed to evaluate whether integrating structured MI sessions into a conventional rehabilitation program provides additional clinical benefits. The primary objective is to determine its effectiveness in improving balance and reducing kinesiophobia. Secondary objectives include examining the effects of the intervention on fall risk, functional performance, fear of falling, activities of daily living, and motor function.
The intervention focuses on functional, everyday movements that are directly associated with balance control and fall prevention. These movements include weight shifting, sit-to-stand transitions, walking, stair negotiation, trunk rotation, reciprocal movements, object retrieval from the floor, as well as rhythmic and coordinated activities such as dance-based movements and step exercises.
MI sessions will follow a structured format. Participants will observe standardized demonstrations of correctly performed functional movements and will then be guided to mentally rehearse these movements using visual imagery and kinesthetic imagery techniques. Immediately after the imagery phase, participants will physically perform the same activities under professional supervision. Exercise difficulty will be progressively adjusted according to individual performance levels to promote improvements in balance, functional mobility, and motor performance.
The rationale for combining mental rehearsal with physical execution is based on principles of motor learning and neuroplasticity. Repeated activation of motor-related neural circuits through both mental and physical practice may enhance postural control, coordination, and movement confidence. Addressing both motor control and movement-related fear may contribute to safer mobility and improved functional performance.
The study is conducted in a clinical rehabilitation setting and follows a randomized controlled parallel-group design. Participants will receive a structured rehabilitation program over a defined treatment period. Follow-up assessments will be conducted immediately after the intervention and at 12 weeks to evaluate the persistence of intervention effects.
The anticipated contribution of this study is to clarify whether Motor Imagery (MI) provides additional benefits beyond conventional rehabilitation in improving balance and reducing movement-related fear in individuals with PD. If proven effective, MI may represent a safe and easily implementable approach to enhance rehabilitation strategies.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to two parallel groups receiving either conventional rehabilitation alone or conventional rehabilitation combined with motor imagery training.
| Arm | Type | Receives |
|---|---|---|
| Conventional Rehabilitation Group | Active comparator | Behavioral: Conventional RehabilitationParticipants will receive a structured conventional rehabilitation program including balance training, gait training, strengthening exercises, and functional mobility exercises |
| Motor Imagery + Conventional Rehabilitation Group | Experimental | Behavioral: Conventional Rehabilitation, Behavioral: Motor Imagery TrainingParticipants will receive traditional rehabilitation along with motor imagery training. |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Diagnosis of Parkinson's Disease (PD)
- Age 40 years or older
- Modified Hoehn and Yahr scale stage between 1 and 3
- Mini-Mental State Examination (MMSE) score of 22 or higher
Key exclusion criteria (7 listed)
- Presence of an additional neurological disorder
- Movement impairment or nerve damage due to orthopedic pathology
- Cardiopulmonary conditions that contraindicate exercise participation
- Presence of severe dyskinesia
- Visual or vestibular impairments that may affect balance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional RehabilitationAlso: ControlA structured physiotherapy program focusing on balance, gait, strength, and functional mobility training | Behavioural | Conventional Rehabilitation Group, Motor Imagery + Conventional Rehabilitation Group |
| Motor Imagery TrainingA structured motor imagery program including guided visual and kinesthetic mental rehearsal of functional movements, applied in addition to conventional rehabilitation. | Behavioural | Motor Imagery + Conventional Rehabilitation Group |
Primary outcome
Change from baseline in kinesiophobia
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Kinesiophobia will be assessed using the Tampa Scale for Kinesiophobia (TSK-17). The TSK-17 is a self-reported questionnaire used to evaluate fear of movement or re-injury. Higher scores indicate greater levels of kinesiophobia.
Change from baseline in balance performance
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Balance performance will be assessed using the Berg Balance Scale (BBS). The BBS is a widely used clinical scale consisting of 14 functional tasks that evaluate static and dynamic balance abilities. Higher scores indicate better balance performance.
5 secondary outcomes
Change from baseline in motor function
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in fall risk and functional mobility
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in fear of falling
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in non-motor experiences of daily living
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Change from baseline in motor experiences of daily living
Time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Rehabilitation and Motor Imagery Training in people with Parkinson Disease (PD), run by Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from baseline in kinesiophobia (time frame: Baseline, at 6 weeks (end of intervention), and at 12 weeks follow-up). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2026.