DeQuervain's TenosynovitisNCT07484737
Combined Effects of MWM and Tendon Gliding Exercises in Smartphone Users With De Quervain's Tenosynovitis
A study testing MWM + Tendon Gliding Exercises and Conventional Treatment in people with DeQuervain's Tenosynovitis, run by Riphah International University at 1 site in Pakistan.
Trial summary
This randomized controlled trial aims to assesses the combined effects of MWM and tendon gliding exercises on hand function in smartphone users with De Quervain's Tenosynovitis, considering hand anthropometric variations. Read more about this study
- Who is it for?
- Ages 18 to 25 years
- Conditions the study is for
- DeQuervain's Tenosynovitis
- What is being tested?
- MWM + Tendon Gliding Exercises and Conventional Treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 sitePakistan
- Study dates
- 20 Feb 2026to 10 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patient diagnosed with De Quervain's Tenosynovitis (positive Finkelstein's test).
- Patient having persistent thumb/wrist pain and functional difficulties for a duration of at-least 2 weeks.
- Patient willing to participate and give informed consent.
Who cannot join
- Patient with history of trauma, fracture, or surgery in the affected wrist or thumb.
- Patient with neurological disorder affecting the upper limb.
- Patient with systemic conditions like rheumatoid arthritis or diabetes affecting tendon function.
- Any other co-morbidity.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Begum Akhtar Rukhsana Hospital (stroke and rehab centre)
Rawalpindi, Punjab Province
About this study
Official title: Combined Effects of Mulligan's Mobilization With Movement and Tendon Gliding Exercises in Smartphone Users With De Quervain's Tenosynovitis.
This randomized controlled trial aims to assesses the combined effects of MWM and tendon gliding exercises on hand function in smartphone users with De Quervain's Tenosynovitis, considering hand anthropometric variations.
Read the detailed description
De Quervain's Tenosynovitis (DQT) is a painful musculoskeletal condition characterized by inflammation of the abductor pollicis longus and extensor pollicis brevis tendons within the first dorsal compartment of the wrist. It is commonly associated with repetitive thumb and wrist movements, with smartphone overuse emerging as a significant contributing factor among young adults.
Mulligan's Mobilization with Movement (MWM) has been shown to correct minor joint malalignments and reduce compressive forces on inflamed tendons, thereby improving wrist kinematics and reducing pain. Tendon gliding exercises enhance tendon excursion, minimize adhesions, and improve synovial fluid circulation, which supports recovery of thumb and wrist function. When combined, these interventions address both mechanical and functional impairments associated with DQT.
- Conditions
- DeQuervain's Tenosynovitis
- Being tested
- MWM + Tendon Gliding Exercises, Conventional Treatment
- Keywords
- Mulligan's Mobilization with Movement, Tendon Gliding Exercises, Hand Anthropometry, Dequeverian tenosynovitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MWM + Tendon Gliding ExercisesOther
MWM: Radial glide of 1st MCP with active thumb extension (10 reps × 3 sets, progressed with resistance in weeks 3-4). 2- Tendon Gliding Exercises: Straight hand, hook fist, tabletop, full fist, straight fist (10 reps × 2 sets in weeks 1-2; 3 sets × 15 with resistance band in weeks 3-4).
Conventional TreatmentOther
1- Wrist ROM (flexion, extension, radial/ulnar deviation, pronation/supination). 2-Thumb ROM (abduction/adduction, flexion/extension, opposition/circumduction). 3-Isometric wrist/thumb strengthening. 4-Strengthening with soft ball, thumb abduction/adduction against resistance. 5-Postural and ergonomic education for smartphone usage
| Study group | Role | What they receive |
|---|---|---|
| Mulligan's Mobilization with Movement (MWM) + Tendon Gliding Exercises (combined effect) | Experimental | MWM: Radial glide of 1st MCP with active thumb extension (10 reps × 3 sets, progressed with resistance in weeks 3-4). 2- Tendon Gliding Exercises: Straight hand, hook fist, tabletop, full fist, straight fist (10 reps × 2 sets in weeks 1-2; 3 sets × 15 with resistance band in weeks 3 Receives: Other: MWM + Tendon Gliding Exercises |
| Conventional Treatment | Other | Wrist ROM (flexion, extension, radial/ulnar deviation, pronation/supination). 2-Thumb ROM (abduction/adduction, flexion/extension, opposition/circumduction). 3-Isometric wrist/thumb strengthening. 4-Strengthening with soft ball, thumb abduction/adduction against resistance. 5-Postural and ergonomic education for smartphone usage. Receives: Other: Conventional Treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Grip Strength Dynamometer
It is a valid and reliable tool used for measuring isometric hand grip strength. This objective tool will be used to assess hand muscular performance and functional status in patients with De Quervain's Tenosynovitis. The NOD digital dynamometer has been shown to provide consistent and reproducible readings. Reliability: 0.97 and Validity: 0.94.
Measured: 4 weeks
Patient-Rated Wrist Evaluation (PRWE) Questionnaire
It is a valid and reliable patient-reported outcome measure for assessing wrist pain and functional disability. This tool will be used to evaluate wrist-related limitations in activities of daily living in DQT patients. It includes two subscales: pain and function, making it responsive to clinical changes. Reliability: 0.96 and Validity: 0.88.
Measured: 4 weeks
Hand Anthropometry (Caliper & Measuring Tape)
These are reliable and valid tools used to measure various hand dimensions, including palm width, thumb length, and wrist circumference. These measurements help understand the influence of hand morphology on grip strength and functional ability in smartphone users with DQT. Reliability: 0.88 and Validity: 0.71.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Mar 2026
- Study start20 Feb 2026
- Primary completion2 May 2026
- Study completion10 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DeQuervain's TenosynovitisStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Maria khalid, MSOMPT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07484737
- Sponsor's protocol ID
- REC/ Sadia Wajid 02281
- Status last verified
- Aug 2026
- First submitted
- 16 Mar 2026
- Last updated
- 6 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combined Effects of Mulligan's Mobilization With Movement and Tendon Gliding Exercises in Smartphone Users With De Quervain's Tenosynovitis.
- ClinicalTrials.gov ID
- NCT07484737
- Acronym / sponsor ID
- REC/ Sadia Wajid 02281
- Conditions
- DeQuervain's Tenosynovitis
- Keywords
- Mulligan's Mobilization with Movement, Tendon Gliding Exercises, Hand Anthropometry, Dequeverian tenosynovitis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 20 Feb 2026 (actual)
- Primary completion
- 2 May 2026 (actual)
- Study completion
- 10 Jun 2026 (actual)
- First posted
- 20 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial aims to assesses the combined effects of MWM and tendon gliding exercises on hand function in smartphone users with De Quervain's Tenosynovitis, considering hand anthropometric variations.
Detailed description
De Quervain's Tenosynovitis (DQT) is a painful musculoskeletal condition characterized by inflammation of the abductor pollicis longus and extensor pollicis brevis tendons within the first dorsal compartment of the wrist. It is commonly associated with repetitive thumb and wrist movements, with smartphone overuse emerging as a significant contributing factor among young adults.
Mulligan's Mobilization with Movement (MWM) has been shown to correct minor joint malalignments and reduce compressive forces on inflamed tendons, thereby improving wrist kinematics and reducing pain. Tendon gliding exercises enhance tendon excursion, minimize adhesions, and improve synovial fluid circulation, which supports recovery of thumb and wrist function. When combined, these interventions address both mechanical and functional impairments associated with DQT.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Mulligan's Mobilization with Movement (MWM) + Tendon Gliding Exercises (combined effect) | Experimental | Other: MWM + Tendon Gliding ExercisesMWM: Radial glide of 1st MCP with active thumb extension (10 reps × 3 sets, progressed with resistance in weeks 3-4). 2- Tendon Gliding Exercises: Straight hand, hook fist, tabletop, full fist, straight fist (10 reps × 2 sets in weeks 1-2; 3 sets × 15 with resistance band in weeks 3 |
| Conventional Treatment | Other | Other: Conventional TreatmentWrist ROM (flexion, extension, radial/ulnar deviation, pronation/supination). 2-Thumb ROM (abduction/adduction, flexion/extension, opposition/circumduction). 3-Isometric wrist/thumb strengthening. 4-Strengthening with soft ball, thumb abduction/adduction against resistance. 5-Postural and ergonomic education for smartphone usage. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Patient diagnosed with De Quervain's Tenosynovitis (positive Finkelstein's test).
- Patient having persistent thumb/wrist pain and functional difficulties for a duration of at-least 2 weeks.
- Patient willing to participate and give informed consent.
Key exclusion criteria (4 listed)
- Patient with history of trauma, fracture, or surgery in the affected wrist or thumb.
- Patient with neurological disorder affecting the upper limb.
- Patient with systemic conditions like rheumatoid arthritis or diabetes affecting tendon function.
- Any other co-morbidity.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MWM + Tendon Gliding ExercisesMWM: Radial glide of 1st MCP with active thumb extension (10 reps × 3 sets, progressed with resistance in weeks 3-4). 2- Tendon Gliding Exercises: Straight hand, hook fist, tabletop, full fist, straight fist (10 reps × 2 sets in weeks 1-2; 3 sets × 15 with resistance band in weeks 3-4). | Other | Mulligan's Mobilization with Movement (MWM) + Tendon Gliding Exercises (combined effect) |
| Conventional Treatment1- Wrist ROM (flexion, extension, radial/ulnar deviation, pronation/supination). 2-Thumb ROM (abduction/adduction, flexion/extension, opposition/circumduction). 3-Isometric wrist/thumb strengthening. 4-Strengthening with soft ball, thumb abduction/adduction against resistance. 5-Postural and ergonomic education for smartphone usage | Other | Conventional Treatment |
Primary outcome
Grip Strength Dynamometer
Time frame: 4 weeks
It is a valid and reliable tool used for measuring isometric hand grip strength. This objective tool will be used to assess hand muscular performance and functional status in patients with De Quervain's Tenosynovitis. The NOD digital dynamometer has been shown to provide consistent and reproducible readings. Reliability: 0.97 and Validity: 0.94.
Patient-Rated Wrist Evaluation (PRWE) Questionnaire
Time frame: 4 weeks
It is a valid and reliable patient-reported outcome measure for assessing wrist pain and functional disability. This tool will be used to evaluate wrist-related limitations in activities of daily living in DQT patients. It includes two subscales: pain and function, making it responsive to clinical changes. Reliability: 0.96 and Validity: 0.88.
Hand Anthropometry (Caliper & Measuring Tape)
Time frame: Baseline
These are reliable and valid tools used to measure various hand dimensions, including palm width, thumb length, and wrist circumference. These measurements help understand the influence of hand morphology on grip strength and functional ability in smartphone users with DQT. Reliability: 0.88 and Validity: 0.71.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Aug 2026.
- Individual participant dataSharing planned: No
Related trials for DeQuervain's Tenosynovitis
Not yet recruitingObservational study
Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System
Hand, Hand Therapy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Maria khalid, MSOMPT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MWM + Tendon Gliding Exercises and Conventional Treatment in people with DeQuervain's Tenosynovitis, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Grip Strength Dynamometer (time frame: 4 weeks). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Aug 2026.