Adolescent Idiopathic Scoliosis (AIS)SPRE-AISNCT07481279
Effect of Scoliosis and Progressive Resistance Exercises on Clinical and Pulmonary Parameters in Adolescents With Idiopathic Scoliosis
A study testing Scoliosis Exercises and Progressive Resistance Exercises in people with Adolescent Idiopathic Scoliosis (AIS), run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
Trial summary
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that may affect physical function and pulmonary capacity during adolescence. Exercise-based rehabilitation programs are frequently used in the conservative management of scoliosis. Read more about this study
- Who is it for?
- Ages 12 to 18 years
- Conditions the study is for
- Adolescent Idiopathic Scoliosis (AIS)
- What is being tested?
- Scoliosis Exercises and Progressive Resistance Exercises
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2025to 30 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- Adolescents aged between 12 and 18 years diagnosed with adolescent idiopathic scoliosis (AIS)
- Cobb angle between 10° and 25° confirmed by radiological evaluation
- C-type scoliosis curve pattern
Who cannot join
- Presence of congenital scoliosis
- Presence of chromosomal abnormalities
- Presence of skeletal dysplasia
- Presence of connective tissue disease
- Presence of neuromuscular disease
- Presence of metabolic diseases affecting bone metabolism
Show all 13Show fewer
- Calcium metabolism disorders
- Severe autoimmune diseases
- Severe endocrine diseases
- Severe cognitive impairment
- Orthopedic conditions preventing participation in exercise
- History of spinal surgery
- History of excisional procedure or surgery involving paravertebral muscles
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Scoliosis Exercises and Upper and Lower Extremity Progressive Resistance Exercises on Anthropometric, Clinical, and Pulmonary Parameters in Adolescents With Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that may affect physical function and pulmonary capacity during adolescence. Exercise-based rehabilitation programs are frequently used in the conservative management of scoliosis.
The aim of this study is to investigate the effects of scoliosis-specific exercises combined with upper and lower extremity progressive resistance exercises on anthropometric, clinical, and pulmonary parameters in adolescents with idiopathic scoliosis.
Read more
Participants diagnosed with adolescent idiopathic scoliosis will participate in an exercise program including scoliosis-specific exercises and progressive resistance exercises targeting upper and lower extremities. Anthropometric measurements, clinical assessments, and pulmonary function parameters will be evaluated before and after the intervention.
The results of this study are expected to provide evidence regarding the effectiveness of combined exercise interventions on physical and respiratory outcomes in adolescents with idiopathic scoliosis.
Read the detailed description
Adolescent idiopathic scoliosis (AIS) is characterized by a three-dimensional spinal deformity that can influence posture, musculoskeletal balance, and respiratory function. Conservative treatment approaches often include physiotherapy-based exercise programs aimed at improving spinal alignment, muscle strength, and overall functional capacity.
In this study, adolescents diagnosed with idiopathic scoliosis will undergo an exercise intervention consisting of scoliosis-specific exercises combined with progressive resistance exercises targeting upper and lower extremity muscle groups. The intervention program aims to improve musculoskeletal strength, posture, and respiratory function.
Anthropometric measurements, clinical parameters, and pulmonary function values will be assessed before and after the exercise program. These outcomes will help evaluate the effectiveness of the intervention in improving physical and respiratory parameters in adolescents with idiopathic scoliosis.
The findings of this study may contribute to the development of effective rehabilitation strategies for adolescents with idiopathic scoliosis and support evidence-based physiotherapy practices.
- Conditions
- Adolescent Idiopathic Scoliosis (AIS)
- Being tested
- Scoliosis Exercises, Progressive Resistance Exercises
- Keywords
- Scoliosis, Scoliosis Exercises, Progressive Resistance Exercise, Pulmonary Function, Musculoskeletal Ultrasonography
- Medical subject headings
- Scoliosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scoliosis ExercisesBehavioural
Scoliosis-specific exercise program designed to improve spinal alignment, posture, and respiratory function in adolescents with idiopathic scoliosis. The program includes supervised therapeutic exercises performed under physiotherapist guidance.
Progressive Resistance ExercisesBehavioural
Progressive resistance exercise program targeting upper and lower extremity muscle groups including biceps, triceps, pectoral, back, quadriceps, and hamstring muscles.
| Study group | Role | What they receive |
|---|---|---|
| Scoliosis Exercise Program | Experimental | Participants perform scoliosis-specific exercises designed to improve spinal alignment, posture, and respiratory function. Receives: Behavioral: Scoliosis Exercises |
| Progressive Resistance Exercise Program | Experimental | Participants perform upper and lower extremity progressive resistance exercises targeting major muscle groups. Receives: Behavioral: Progressive Resistance Exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscle Thickness Measured by Ultrasonography
Changes in diaphragm, lumbar multifidus and pectoralis major muscle thickness measured by ultrasonography.
Measured: Baseline (Week 0), Week 4, and Week 8
Secondary outcomes (4)
Sit and Reach Flexibility Test
Flexibility assessment using the sit and reach test to evaluate hamstring and lower back flexibility before and after the intervention.
Measured: Baseline (Week 0), Week 4, and Week 8
Back Scratch Test
Shoulder flexibility assessment using the back scratch test before and after the intervention.
Measured: Baseline (Week 0), Week 4, and Week 8
Hand Grip Strength
Upper extremity muscle strength measured using a hand dynamometer.
Measured: Baseline (Week 0), Week 4, and Week 8
Pulmonary Function Test
Pulmonary function parameters including FVC and FEV1 measured using spirometry.
Measured: Baseline (Week 0), Week 4, and Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2026
- Study start1 Jun 2025
- Primary completion30 Jan 2026
- Study completion30 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Adolescent Idiopathic Scoliosis (AIS)Studies of the same condition, open and under way.
- More trials run by Ankara City Hospital BilkentThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants are randomly assigned to two exercise interventions in a crossover design. One group performs scoliosis-specific exercises while the other performs progressive resistance exercises. After the first intervention period, the groups switch to the alternate intervention and outcomes are reassessed.
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara City Hospital Bilkent
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gökçe Doğrayıcı, Ankara City Hospital Bilkent
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07481279
- Sponsor's protocol ID
- 481360
- Acronym
- SPRE-AIS
- Status last verified
- Mar 2026
- First submitted
- 15 Mar 2026
- Last updated
- 6 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Scoliosis Exercises and Upper and Lower Extremity Progressive Resistance Exercises on Anthropometric, Clinical, and Pulmonary Parameters in Adolescents With Idiopathic Scoliosis
- ClinicalTrials.gov ID
- NCT07481279
- Acronym / sponsor ID
- SPRE-AIS / 481360
- Conditions
- Adolescent Idiopathic Scoliosis (AIS)
- Keywords
- Scoliosis, Scoliosis Exercises, Progressive Resistance Exercise, Pulmonary Function, Musculoskeletal Ultrasonography
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Ankara City Hospital BilkentUniversity, hospital or other
- Study start
- 1 Jun 2025 (actual)
- Primary completion
- 30 Jan 2026 (actual)
- Study completion
- 30 Jan 2026 (actual)
- First posted
- 18 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity that may affect physical function and pulmonary capacity during adolescence. Exercise-based rehabilitation programs are frequently used in the conservative management of scoliosis.
The aim of this study is to investigate the effects of scoliosis-specific exercises combined with upper and lower extremity progressive resistance exercises on anthropometric, clinical, and pulmonary parameters in adolescents with idiopathic scoliosis.
Participants diagnosed with adolescent idiopathic scoliosis will participate in an exercise program including scoliosis-specific exercises and progressive resistance exercises targeting upper and lower extremities. Anthropometric measurements, clinical assessments, and pulmonary function parameters will be evaluated before and after the intervention.
The results of this study are expected to provide evidence regarding the effectiveness of combined exercise interventions on physical and respiratory outcomes in adolescents with idiopathic scoliosis.
Detailed description
Adolescent idiopathic scoliosis (AIS) is characterized by a three-dimensional spinal deformity that can influence posture, musculoskeletal balance, and respiratory function. Conservative treatment approaches often include physiotherapy-based exercise programs aimed at improving spinal alignment, muscle strength, and overall functional capacity.
In this study, adolescents diagnosed with idiopathic scoliosis will undergo an exercise intervention consisting of scoliosis-specific exercises combined with progressive resistance exercises targeting upper and lower extremity muscle groups. The intervention program aims to improve musculoskeletal strength, posture, and respiratory function.
Anthropometric measurements, clinical parameters, and pulmonary function values will be assessed before and after the exercise program. These outcomes will help evaluate the effectiveness of the intervention in improving physical and respiratory parameters in adolescents with idiopathic scoliosis.
The findings of this study may contribute to the development of effective rehabilitation strategies for adolescents with idiopathic scoliosis and support evidence-based physiotherapy practices.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants are randomly assigned to two exercise interventions in a crossover design. One group performs scoliosis-specific exercises while the other performs progressive resistance exercises. After the first intervention period, the groups switch to the alternate intervention and outcomes are reassessed.
| Arm | Type | Receives |
|---|---|---|
| Scoliosis Exercise Program | Experimental | Behavioral: Scoliosis ExercisesParticipants perform scoliosis-specific exercises designed to improve spinal alignment, posture, and respiratory function. |
| Progressive Resistance Exercise Program | Experimental | Behavioral: Progressive Resistance ExercisesParticipants perform upper and lower extremity progressive resistance exercises targeting major muscle groups. |
Who may qualify
- Ages
- 12 to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (3 listed)
- Adolescents aged between 12 and 18 years diagnosed with adolescent idiopathic scoliosis (AIS)
- Cobb angle between 10° and 25° confirmed by radiological evaluation
- C-type scoliosis curve pattern
Key exclusion criteria (13 listed)
- Presence of congenital scoliosis
- Presence of chromosomal abnormalities
- Presence of skeletal dysplasia
- Presence of connective tissue disease
- Presence of neuromuscular disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scoliosis ExercisesScoliosis-specific exercise program designed to improve spinal alignment, posture, and respiratory function in adolescents with idiopathic scoliosis. The program includes supervised therapeutic exercises performed under physiotherapist guidance. | Behavioural | Scoliosis Exercise Program |
| Progressive Resistance ExercisesProgressive resistance exercise program targeting upper and lower extremity muscle groups including biceps, triceps, pectoral, back, quadriceps, and hamstring muscles. | Behavioural | Progressive Resistance Exercise Program |
Primary outcome
Muscle Thickness Measured by Ultrasonography
Time frame: Baseline (Week 0), Week 4, and Week 8
Changes in diaphragm, lumbar multifidus and pectoralis major muscle thickness measured by ultrasonography.
4 secondary outcomes
Sit and Reach Flexibility Test
Time frame: Baseline (Week 0), Week 4, and Week 8
Back Scratch Test
Time frame: Baseline (Week 0), Week 4, and Week 8
Hand Grip Strength
Time frame: Baseline (Week 0), Week 4, and Week 8
Pulmonary Function Test
Time frame: Baseline (Week 0), Week 4, and Week 8
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Scoliosis Exercises and Progressive Resistance Exercises in people with Adolescent Idiopathic Scoliosis (AIS), run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscle Thickness Measured by Ultrasonography (time frame: Baseline (Week 0), Week 4, and Week 8). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2026.