Total Knee AnthroplastyGNB-FNBNCT07478783
Genicular Nerve Block Added to Femoral Nerve Block for Analgesia After Total Knee Arthroplasty
A study testing Ultrasound-guided Femoral Nerve Block and ltrasound-guided Genicular Nerve Block in people with Total Knee Anthroplasty, run by Ankara City Hospital Bilkent at 2 sites in Turkey (Türkiye).
Trial summary
Total knee arthroplasty (TKA) is a common orthopedic procedure in which effective postoperative pain management is important for early mobilization and rehabilitation. Various regional anesthesia techniques are used as part of multimodal analgesia protocols to improve postoperative pain control. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Total Knee Anthroplasty
- What is being tested?
- Ultrasound-guided Femoral Nerve Block and ltrasound-guided Genicular Nerve Block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 1 Nov 2021to 28 Feb 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged ≥18 years
- Scheduled for elective total knee replacement surgery
- American Society of Anesthesiologists (ASA) physical status I-III
- Planned to receive femoral nerve block with or without genicular nerve block
- Ability to provide written informed consent
Who cannot join
- Refusal to participate
- Contraindication to regional anesthesia
- Coagulopathy or ongoing anticoagulant therapy incompatible with nerve block
- Infection at the injection site
- Known allergy to local anesthetics
- Severe hepatic or renal insufficiency
- Cognitive impairment preventing pain assessment
- Chronic opioid use or opioid dependency
Trial locations and contacts
2 sites in 1 country.
Turkey (Türkiye)2 sites
Ankara Bilkent City Hospital
Ankara, Turkey
Ankara Bilkent City Hospital
Etimesgut, Ankara, 06790
About this study
Official title: Addition Of Genicular Nerve Block To Femoral Nerve Block Improves Early Postoperative Analgesia After Total Knee Replacement: A Randomized Controlled Trial
Total knee arthroplasty (TKA) is a common orthopedic procedure in which effective postoperative pain management is important for early mobilization and rehabilitation. Various regional anesthesia techniques are used as part of multimodal analgesia protocols to improve postoperative pain control. Genicular nerve block has recently been introduced as a potential motor-sparing technique that may enhance postoperative analgesia when used alone or in combination with other regional blocks.
The aim of this randomized controlled study is to evaluate whether the addition of ultrasound-guided genicular nerve block to femoral nerve block improves early postoperative analgesia in patients undergoing primary unilateral total knee arthroplasty under combined spinal-epidural anesthesia.
A total of 80 patients aged 18-80 years scheduled for elective primary unilateral TKA will be included and randomly assigned to two groups using sealed envelopes. One group will receive femoral nerve block alone (Group F), while the other group will receive femoral nerve block combined with genicular nerve block (Group FG). Postoperative pain scores using the visual analog scale (VAS), epidural patient-controlled analgesia consumption during the first 24 hours, and the time to additional analgesic requirement will be recorded and compared between the groups.
Read the detailed description
The aim of this prospective, randomized controlled study is to evaluate whether the addition of an ultrasound-guided (USG) genicular nerve block (GNB) to a standard femoral nerve block (FNB) improves postoperative analgesia compared with FNB alone in patients undergoing primary unilateral total knee arthroplasty (TKA).
All patients will undergo surgery under combined spinal-epidural anesthesia. After administration of the spinal block and placement of the epidural catheter, participants will be randomly assigned to one of two groups.
Group F (Control): Participants will receive an ultrasound-guided femoral nerve block using 20 mL of 0.25% bupivacaine.
Group FG (Intervention): Participants will receive an ultrasound-guided femoral nerve block (20 mL of 0.25% bupivacaine) combined with a four-point ultrasound-guided genicular nerve block targeting the superomedial, superolateral, inferomedial, and inferolateral genicular nerve branches. Each branch will receive 5 mL of 0.25% bupivacaine.
Postoperative analgesia will be standardized in both groups using an epidural patient-controlled analgesia (PCA) device operating in bolus-only mode (5 mL bolus, 20-minute lockout interval) containing fentanyl (3 µg/mL) and bupivacaine (0.5 mg/mL).
The primary outcome measure will be the total volume of epidural analgesic solution consumed during the first 24 hours after surgery. Secondary outcome measures will include postoperative pain intensity assessed using the Visual Analog Scale (VAS) at predefined time points (0, 2, 8, 12, and 24 hours), time to first additional analgesic requirement, and the incidence of postoperative side effects such as nausea or dizziness.
- Conditions
- Total Knee Anthroplasty
- Being tested
- Ultrasound-guided Femoral Nerve Block, ltrasound-guided Genicular Nerve Block
- Keywords
- Postoperative analgesia, total knee replacemenet, femoral nerve block, controlled study, prospective
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-guided Femoral Nerve BlockProcedure or surgery
Administration of 20 ml of 0.25% bupivacaine to the femoral nerve under ultrasound guidance. This procedure was performed on patients in both Group F and Group FG
ltrasound-guided Genicular Nerve BlockProcedure or surgery
Administration of 5 ml of 0.25% bupivacaine to each of the four genicular nerve branches (superomedial, superolateral, inferomedial, and inferolateral) under ultrasound guidance. This procedure was performed only on patients in Group FG
| Study group | Role | What they receive |
|---|---|---|
| Group F (Femoral Block Only) | Active comparator | Patients in this group received an ultrasound-guided femoral nerve block administered with 20 ml of 0.25% bupivacaine. All patients also received standardized multimodal analgesia, including epidural patient-controlled analgesia (PCA) Receives: Procedure: Ultrasound-guided Femoral Nerve Block |
| Group FG (Combined Block) | Experimental | Patients in this group received a combination of an ultrasound-guided femoral nerve block (20 ml of 0.25% bupivacaine) and an ultrasound-guided genicular nerve block. The genicular nerve block targeted the superomedial, superolateral, inferomedial, and inferolateral genicular nerves, with 5 ml of 0.25% bupivacaine administered at each site. All patients also received standardized multimodal analgesia, including epidural patient-controlled analgesia (PCA). Receives: Procedure: ltrasound-guided Genicular Nerve Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Title: 24-hour postoperative epidural analgesic consumption.Description: The total dose (in ml) of epidural analgesic consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours following total knee arthroplasty su
Total volume (in ml) of the epidural analgesic solution (fentanyl and bupivacaine) consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours post-surgery.
Measured: First 24 hours following the total knee arthroplasty (TKA) procedure
24-hour postoperative epidural analgesic consumption.
Total volume (in ml) of epidural analgesic solution (fentanyl and bupivacaine) consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours post-surgery
Measured: First 24 hours following the total knee arthroplasty (TKA) procedure.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2026
- Study start1 Nov 2021
- Primary completion1 Nov 2021
- Study completion28 Feb 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (13)Papers the sponsor has linked to this study.
- Other trials for Total Knee AnthroplastyStudies of the same condition, open and under way.
- More trials run by Ankara City Hospital BilkentThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned to two parallel groups. One group received ultrasound-guided femoral nerve block only (Group F), while the other group received a combination of femoral nerve block and genicular nerve block (Group FG). Postoperative pain scores and analgesic consumption were compared between the groups within the first 24 hours following total knee arthroplasty.
- Masking
- None (open label)
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara City Hospital Bilkent
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, semih başkan, Ankara City Hospital Bilkent
- Investigators
- Semih Baskan, Proffesor, Principal investigator, Ankara City Hospital Bilkent
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07478783
- Sponsor's protocol ID
- E1-21-2105
- Other IDs
- E1-21-2105
- Acronym
- GNB-FNB
- Status last verified
- Mar 2026
- First submitted
- 8 Mar 2026
- Last updated
- 25 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: he researchers will share de-identified individual participant data (IPD) underlying the results reported in this study, including demographic data (age, gender, BMI) and primary/secondary outcomes (24-hour epidural consumption and VAS scores). Data will be available to researchers who provide a methodologically sound research proposal approved by the principal investigator. Supporting documents, including the Study Protocol, Statistical Analysis Plan (SAP), and Informed Consent Form (ICF), will also be available. Access will be granted starting 9 months after publication and ending 36 months after the publication date. Data sharing is subject to a signed data access agreement and confirmation of institutional ethics committee approval for the requester's secondary analysis. Requests should be directed to the corresponding author.
Publications
Luo D, Fan Z, Yin W. Chronic post-surgical pain after total knee arthroplasty: a narrative review. Perioper Med (Lond). 2024 Nov 5;13(1):108. doi: 10.1186/s13741-024-00466-9.
PubMed 39501338Layera S, Aliste J, Bravo D, Saadawi M, Salinas FV, Tran Q. Motor-sparing nerve blocks for total knee replacement: A scoping review. J Clin Anesth. 2021 Feb;68:110076. doi: 10.1016/j.jclinane.2020.110076. Epub 2020 Oct 6.
PubMed 33035871Grape S, Kirkham KR, Baeriswyl M, Albrecht E. The analgesic efficacy of sciatic nerve block in addition to femoral nerve block in patients undergoing total knee arthroplasty: a systematic review and meta-analysis. Anaesthesia. 2016 Oct;71(10):1198-209. doi: 10.1111/anae.13568. Epub 2016 Jul 29.
PubMed 27469381Rambhia M, Chen A, Kumar AH, Bullock WM, Bolognesi M, Gadsden J. Ultrasound-guided genicular nerve blocks following total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Reg Anesth Pain Med. 2021 Oct;46(10):862-866. doi: 10.1136/rapm-2021-102667. Epub 2021 Jul 14.
PubMed 34261807Fonkoue L, Behets C, Kouassi JK, Coyette M, Detrembleur C, Thienpont E, Cornu O. Distribution of sensory nerves supplying the knee joint capsule and implications for genicular blockade and radiofrequency ablation: an anatomical study. Surg Radiol Anat. 2019 Dec;41(12):1461-1471. doi: 10.1007/s00276-019-02291-y. Epub 2019 Jul 23.
PubMed 31338537Akesen S, Akesen B, Atici T, Gurbet A, Ermutlu C, Ozyalcin A. Comparison of efficacy between the genicular nerve block and the popliteal artery and the capsule of the posterior knee (IPACK) block for total knee replacement surgery: A prospective randomized controlled study. Acta Orthop Traumatol Turc. 2021 Mar;55(2):134-140. doi: 10.5152/j.aott.2021.20187.
PubMed 33847575Sinha A, Arora D, Singh S, Das T, Biswas M. Evaluating Analgesic Efficacy of Single Femoral Nerve Block versus Combined Femoral-Sciatic Nerve Block Post Total Knee Arthroplasty. Anesth Essays Res. 2020 Apr-Jun;14(2):326-330. doi: 10.4103/aer.AER_78_20. Epub 2020 Oct 12.
PubMed 33487837Krishna Prasad GV. Post-operative analgesia techniques after total knee arthroplasty: A narrative review. Saudi J Anaesth. 2020 Jan-Mar;14(1):85-90. doi: 10.4103/sja.SJA_494_19. Epub 2020 Jan 6.
PubMed 31998025Kukreja P, Venter A, Mason L, Kofskey AM, Northern T, Naranje S, Ghanem E, Lawson PA, Kalagara H. Comparison of Genicular Nerve Block in Combination With Adductor Canal Block in Both Primary and Revision Total Knee Arthroplasty: A Retrospective Case Series. Cureus. 2021 Jul 29;13(7):e16712. doi: 10.7759/cureus.16712. eCollection 2021 Jul.
PubMed 34471571Liu Q, Wang A, Zhang J. The effects of local infiltration anesthesia and femoral nerve block analgesia after total knee arthroplasty: a systematic review and meta-analysis. Ann Transl Med. 2022 Feb;10(4):178. doi: 10.21037/atm-22-286.
PubMed 35280374Finkel KJ, Takata ET, Panza G, Stuart W, Kainkaryam P, Maffeo-Mitchell CL, Walker A. A Series of Peripheral Nerve Blocks Combined With Spinal Anesthesia Is Associated With Improved Outcomes Following Total Knee Arthroplasty: A Retrospective Study. Cureus. 2025 Apr 25;17(4):e83000. doi: 10.7759/cureus.83000. eCollection 2025 Apr.
PubMed 40416271Lavand'homme PM, Kehlet H, Rawal N, Joshi GP; PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA). Pain management after total knee arthroplasty: PROcedure SPEcific Postoperative Pain ManagemenT recommendations. Eur J Anaesthesiol. 2022 Sep 1;39(9):743-757. doi: 10.1097/EJA.0000000000001691. Epub 2022 Jul 20.
PubMed 35852550Lebleu J, Pauwels A, Poilvache H, Anract P, Belbachir A. Severe Postoperative Pain in Total Knee Arthroplasty Patients: Risk Factors, Insights and Implications for Pain Management via a Digital Health Approach. J Clin Med. 2023 Dec 15;12(24):7695. doi: 10.3390/jcm12247695.
PubMed 38137764
Study at a glance
From the registry record, last updated by the sponsor on 25 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Addition Of Genicular Nerve Block To Femoral Nerve Block Improves Early Postoperative Analgesia After Total Knee Replacement: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07478783
- Acronym / sponsor ID
- GNB-FNB / E1-21-2105
- Conditions
- Total Knee Anthroplasty
- Keywords
- Postoperative analgesia, total knee replacemenet, femoral nerve block, controlled study, prospective
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Ankara City Hospital BilkentUniversity, hospital or other
- Study start
- 1 Nov 2021 (actual)
- Primary completion
- 1 Nov 2021 (actual)
- Study completion
- 28 Feb 2022 (actual)
- First posted
- 18 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Total knee arthroplasty (TKA) is a common orthopedic procedure in which effective postoperative pain management is important for early mobilization and rehabilitation. Various regional anesthesia techniques are used as part of multimodal analgesia protocols to improve postoperative pain control. Genicular nerve block has recently been introduced as a potential motor-sparing technique that may enhance postoperative analgesia when used alone or in combination with other regional blocks.
The aim of this randomized controlled study is to evaluate whether the addition of ultrasound-guided genicular nerve block to femoral nerve block improves early postoperative analgesia in patients undergoing primary unilateral total knee arthroplasty under combined spinal-epidural anesthesia.
A total of 80 patients aged 18-80 years scheduled for elective primary unilateral TKA will be included and randomly assigned to two groups using sealed envelopes. One group will receive femoral nerve block alone (Group F), while the other group will receive femoral nerve block combined with genicular nerve block (Group FG). Postoperative pain scores using the visual analog scale (VAS), epidural patient-controlled analgesia consumption during the first 24 hours, and the time to additional analgesic requirement will be recorded and compared between the groups.
Detailed description
The aim of this prospective, randomized controlled study is to evaluate whether the addition of an ultrasound-guided (USG) genicular nerve block (GNB) to a standard femoral nerve block (FNB) improves postoperative analgesia compared with FNB alone in patients undergoing primary unilateral total knee arthroplasty (TKA).
All patients will undergo surgery under combined spinal-epidural anesthesia. After administration of the spinal block and placement of the epidural catheter, participants will be randomly assigned to one of two groups.
Group F (Control): Participants will receive an ultrasound-guided femoral nerve block using 20 mL of 0.25% bupivacaine.
Group FG (Intervention): Participants will receive an ultrasound-guided femoral nerve block (20 mL of 0.25% bupivacaine) combined with a four-point ultrasound-guided genicular nerve block targeting the superomedial, superolateral, inferomedial, and inferolateral genicular nerve branches. Each branch will receive 5 mL of 0.25% bupivacaine.
Postoperative analgesia will be standardized in both groups using an epidural patient-controlled analgesia (PCA) device operating in bolus-only mode (5 mL bolus, 20-minute lockout interval) containing fentanyl (3 µg/mL) and bupivacaine (0.5 mg/mL).
The primary outcome measure will be the total volume of epidural analgesic solution consumed during the first 24 hours after surgery. Secondary outcome measures will include postoperative pain intensity assessed using the Visual Analog Scale (VAS) at predefined time points (0, 2, 8, 12, and 24 hours), time to first additional analgesic requirement, and the incidence of postoperative side effects such as nausea or dizziness.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants were randomly assigned to two parallel groups. One group received ultrasound-guided femoral nerve block only (Group F), while the other group received a combination of femoral nerve block and genicular nerve block (Group FG). Postoperative pain scores and analgesic consumption were compared between the groups within the first 24 hours following total knee arthroplasty.
| Arm | Type | Receives |
|---|---|---|
| Group F (Femoral Block Only) | Active comparator | Procedure: Ultrasound-guided Femoral Nerve BlockPatients in this group received an ultrasound-guided femoral nerve block administered with 20 ml of 0.25% bupivacaine. All patients also received standardized multimodal analgesia, including epidural patient-controlled analgesia (PCA) |
| Group FG (Combined Block) | Experimental | Procedure: ltrasound-guided Genicular Nerve BlockPatients in this group received a combination of an ultrasound-guided femoral nerve block (20 ml of 0.25% bupivacaine) and an ultrasound-guided genicular nerve block. The genicular nerve block targeted the superomedial, superolateral, inferomedial, and inferolateral genicular nerves, with 5 ml of 0.25% bupivacaine administered at each site. All patients also received standardized multimodal analgesia, including epidural patient-controlled analgesia (PCA). |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Patients aged ≥18 years
- Scheduled for elective total knee replacement surgery
- American Society of Anesthesiologists (ASA) physical status I-III
- Planned to receive femoral nerve block with or without genicular nerve block
- Ability to provide written informed consent
Key exclusion criteria (8 listed)
- Refusal to participate
- Contraindication to regional anesthesia
- Coagulopathy or ongoing anticoagulant therapy incompatible with nerve block
- Infection at the injection site
- Known allergy to local anesthetics
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-guided Femoral Nerve BlockAdministration of 20 ml of 0.25% bupivacaine to the femoral nerve under ultrasound guidance. This procedure was performed on patients in both Group F and Group FG | Procedure or surgery | Group F (Femoral Block Only) |
| ltrasound-guided Genicular Nerve BlockAdministration of 5 ml of 0.25% bupivacaine to each of the four genicular nerve branches (superomedial, superolateral, inferomedial, and inferolateral) under ultrasound guidance. This procedure was performed only on patients in Group FG | Procedure or surgery | Group FG (Combined Block) |
Primary outcome
Title: 24-hour postoperative epidural analgesic consumption.Description: The total dose (in ml) of epidural analgesic consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours following total knee arthroplasty su
Time frame: First 24 hours following the total knee arthroplasty (TKA) procedure
Total volume (in ml) of the epidural analgesic solution (fentanyl and bupivacaine) consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours post-surgery.
24-hour postoperative epidural analgesic consumption.
Time frame: First 24 hours following the total knee arthroplasty (TKA) procedure.
Total volume (in ml) of epidural analgesic solution (fentanyl and bupivacaine) consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours post-surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Mar 2026.
- Results publication: PubMed 39501338Luo D, Fan Z, Yin W. Chronic post-surgical pain after total knee arthroplasty: a narrative review. Perioper Med (Lond). 2024 Nov 5;13(1):108. doi: 10.1186/s13741-024-00466-9.
- Results publication: PubMed 33035871Layera S, Aliste J, Bravo D, Saadawi M, Salinas FV, Tran Q. Motor-sparing nerve blocks for total knee replacement: A scoping review. J Clin Anesth. 2021 Feb;68:110076. doi: 10.1016/j.jclinane.2020.110076. Epub 2020 Oct 6.
- Results publication: PubMed 27469381Grape S, Kirkham KR, Baeriswyl M, Albrecht E. The analgesic efficacy of sciatic nerve block in addition to femoral nerve block in patients undergoing total knee arthroplasty: a systematic review and meta-analysis. Anaesthesia. 2016 Oct;71(10):1198-209. doi: 10.1111/anae.13568. Epub 2016 Jul 29.
- Results publication: PubMed 34261807Rambhia M, Chen A, Kumar AH, Bullock WM, Bolognesi M, Gadsden J. Ultrasound-guided genicular nerve blocks following total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Reg Anesth Pain Med. 2021 Oct;46(10):862-866. doi: 10.1136/rapm-2021-102667. Epub 2021 Jul 14.
- Results publication: PubMed 31338537Fonkoue L, Behets C, Kouassi JK, Coyette M, Detrembleur C, Thienpont E, Cornu O. Distribution of sensory nerves supplying the knee joint capsule and implications for genicular blockade and radiofrequency ablation: an anatomical study. Surg Radiol Anat. 2019 Dec;41(12):1461-1471. doi: 10.1007/s00276-019-02291-y. Epub 2019 Jul 23.
- Results publication: PubMed 33847575Akesen S, Akesen B, Atici T, Gurbet A, Ermutlu C, Ozyalcin A. Comparison of efficacy between the genicular nerve block and the popliteal artery and the capsule of the posterior knee (IPACK) block for total knee replacement surgery: A prospective randomized controlled study. Acta Orthop Traumatol Turc. 2021 Mar;55(2):134-140. doi: 10.5152/j.aott.2021.20187.
- Results publication: PubMed 33487837Sinha A, Arora D, Singh S, Das T, Biswas M. Evaluating Analgesic Efficacy of Single Femoral Nerve Block versus Combined Femoral-Sciatic Nerve Block Post Total Knee Arthroplasty. Anesth Essays Res. 2020 Apr-Jun;14(2):326-330. doi: 10.4103/aer.AER_78_20. Epub 2020 Oct 12.
- Results publication: PubMed 31998025Krishna Prasad GV. Post-operative analgesia techniques after total knee arthroplasty: A narrative review. Saudi J Anaesth. 2020 Jan-Mar;14(1):85-90. doi: 10.4103/sja.SJA_494_19. Epub 2020 Jan 6.
- Results publication: PubMed 34471571Kukreja P, Venter A, Mason L, Kofskey AM, Northern T, Naranje S, Ghanem E, Lawson PA, Kalagara H. Comparison of Genicular Nerve Block in Combination With Adductor Canal Block in Both Primary and Revision Total Knee Arthroplasty: A Retrospective Case Series. Cureus. 2021 Jul 29;13(7):e16712. doi: 10.7759/cureus.16712. eCollection 2021 Jul.
- Results publication: PubMed 35280374Liu Q, Wang A, Zhang J. The effects of local infiltration anesthesia and femoral nerve block analgesia after total knee arthroplasty: a systematic review and meta-analysis. Ann Transl Med. 2022 Feb;10(4):178. doi: 10.21037/atm-22-286.
- Results publication: PubMed 40416271Finkel KJ, Takata ET, Panza G, Stuart W, Kainkaryam P, Maffeo-Mitchell CL, Walker A. A Series of Peripheral Nerve Blocks Combined With Spinal Anesthesia Is Associated With Improved Outcomes Following Total Knee Arthroplasty: A Retrospective Study. Cureus. 2025 Apr 25;17(4):e83000. doi: 10.7759/cureus.83000. eCollection 2025 Apr.
- Results publication: PubMed 35852550Lavand'homme PM, Kehlet H, Rawal N, Joshi GP; PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA). Pain management after total knee arthroplasty: PROcedure SPEcific Postoperative Pain ManagemenT recommendations. Eur J Anaesthesiol. 2022 Sep 1;39(9):743-757. doi: 10.1097/EJA.0000000000001691. Epub 2022 Jul 20.
- Individual participant dataSharing planned: Yes. he researchers will share de-identified individual participant data (IPD) underlying the results reported in this study, including demographic data (age, gender, BMI) and primary/secondary outcomes (24-hour epidural consumption and VAS scores). Data will be available to researchers who provide a methodologically sound research proposal approved by the principal investigator. Supporting documents, including the Study Protocol, Statistical Analysis Plan (SAP), and Informed Consent Form (ICF), will also be available. Access will be granted starting 9 months after publication and ending 36 months after the publication date. Data sharing is subject to a signed data access agreement and confirmation of institutional ethics committee approval for the requester's secondary analysis. Requests should be directed to the corresponding author.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Semih Baskan, Proffesor principal investigator
Ankara City Hospital Bilkent
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ultrasound-guided Femoral Nerve Block and ltrasound-guided Genicular Nerve Block in people with Total Knee Anthroplasty, run by Ankara City Hospital Bilkent at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Title: 24-hour postoperative epidural analgesic consumption.Description: The total dose (in ml) of epidural analgesic consumed by the patient via the patient-controlled analgesia (PCA) device within the first 24 hours following total knee arthroplasty su (time frame: First 24 hours following the total knee arthroplasty (TKA) procedure). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07478783, which also lists 13 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Mar 2026.