Alcohol Use DisorderIDEAS-AUDNCT07475988
Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania
A study testing IDEAS-AUD in people with Alcohol Use Disorder and Suicide Prevention, run by Duke University.
Trial summary
Together, alcohol use and suicide account for approximately 4 million deaths per year, with a considerable burden on low and middle-income countries. Tanzania is among the world's most underserved nations for mental health treatment, with very little capacity to treat suicidality or alcohol use disorders. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alcohol Use Disorder, Suicide Prevention
- What is being tested?
- IDEAS-AUD
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- No sites listed yet
- Study dates
- Aug 2027to Mar 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 18 years of age or older
- screen positive for alcohol use disorder (AUDIT >=8)
- have had suicidal thinking (C-SSRS item indicating "actual thoughts of suicide") in last 30 days
- clinically sober
- medically stable
- have the physical and cognitive capacity to provide consent and complete study procedures
- able to communicate in Swahili or English
Who cannot join
- prisoners
- decline or unable to complete informed consent
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania: IDEAS-AUD
Together, alcohol use and suicide account for approximately 4 million deaths per year, with a considerable burden on low and middle-income countries. Tanzania is among the world's most underserved nations for mental health treatment, with very little capacity to treat suicidality or alcohol use disorders. In this study, the researchers will adapt an evidence-based intervention for suicide prevention to address the unique needs of people with alcohol use disorders in Tanzania, and rigorously pilot test the intervention to assess its feasibility and acceptability in a Tanzanian emergency department.
Read the detailed description
Globally, alcohol use disorders (AUD) cause 3.3 million deaths each year and account for nearly 100 million disability-adjusted life years (DALYs). Alcohol use is also one of the most prominent risk factors for death by suicide, as people with AUD have a lifetime risk of suicide more than 7 times higher than the general population. In preliminary studies at Kilimanjaro Christian Medical Centre (KCMC) in Tanzania, 7% of patients with AUD met criteria for comorbid depression, 7% were experiencing suicidal thoughts or behavior, and nearly half reported challenges in social support. Unfortunately, Tanzania is also among the most underserved nations in the world for mental health treatment, with fewer than 1 psychologist or psychiatrist per 1 million people and very little capacity to intervene for suicide risk or AUD. Given this shortage in treatment, there is a critical need for innovative, resource-efficient treatments for suicide prevention among people with AUD. In Tanzania, 91% of the population owns a cellular phone and nearly 50% use mobile internet, yet telehealth interventions have been largely unexplored, representing a major missed opportunity for delivering evidence-based interventions. By adapting an evidence-based Motivational Interviewing intervention, MI-SafeCope, the team developed IDEAS for Hope, a telehealth intervention for suicide prevention in HIV care in Tanzania. In the current grant, the researchers propose to revisit this process by adapting MI-SafeCope, with lessons learned from the HIV study, to reduce suicide risk among people with AUD who are presenting for care in the KCMC Emergency Department (ED). The resulting intervention, IDEAS-AUD, will address suicide risk with a four-pillared approach: reducing alcohol-related harm, building social support, enhancing emotional health, and addressing social determinants of health. The pillars are integrated with Motivational Interviewing-enhanced safety planning and referral for local psychiatric care as appropriate. The long-term goal is to create evidence-based, accessible, and cost-effective treatments for mental health and substance use treatment in low-resource settings. The objectives of this proposal are to: 1) adapt IDEAS-AUD for the AUD population in Kilimanjaro, Tanzania; 2) rigorously evaluate the acceptability and feasibility of IDEAS-AUD; and 3) develop the intervention package, along with a trialability evaluation, for a future implementation evaluation and clinical trial. In Aim 1 of the current study, the researchers will identify drivers of suicide risk and desired intervention characteristics to prevent suicide in the AUD population at KCMC. In Aim 2, the study team will adapt an evidence-based suicide prevention intervention to existing AUD care, guided by a community coalition. In Aim 3, the investigators will pilot test the telehealth intervention to assess its feasibility and acceptability for reducing suicide risk in the KCMC AUD population. By the end of this proposed project, the researchers will have a framework-guided, culturally- and resource-adapted, piloted protocol for IDEAS-AUD, including screening tools, programmatic, and implementation components.
- Conditions
- Alcohol Use Disorder, Suicide Prevention
- Being tested
- IDEAS-AUD
- Keywords
- Telehealth, Nurse-delivered interventions, Stigma reduction, Care engagement, Suicide prevention, Health behavior, Alcohol use disorder, Harm reduction
- Medical subject headings
- Alcoholism, Suicide Prevention, Health Behavior, Harm Reduction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
IDEAS-AUDBehavioural
Telehealth-delivered counseling to reduce suicide risk among people with Alcohol Use Disorder (AUD) who are presenting for care in the KCMC Emergency Department (ED).
| Study group | Role | What they receive |
|---|---|---|
| IDEAS-AUD | Experimental | 3 sessions of telehealth-delivered counseling Receives: Behavioral: IDEAS-AUD |
What is being measured
The primary outcome is the main question the study is designed to answer.
Acceptability of intervention
Acceptability of Intervention Measure (AIM). Four items scored from 1-Completely disagree to 5-Completely agree. Scores are summed for a total score of 4 to 20, with higher scores indicating greater acceptability.
Measured: 3 months
Enrollment feasibility as measured by the percentage of ED patients with documented screening for study eligibility
Measured: up to 1 year
Enrollment feasibility as measured by the number of eligible participants who declined enrollment
Measured: up to 1 year
Enrollment feasibility as measured by the time needed to enroll 30 eligible participants
Measured: up to 1 year
Retention feasibility as measured by the number of participants retained for follow-up
Measured: session 2 (2 weeks), session 3 (4 weeks), and 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Mar 2026
- Study startAug 2027 (estimated)
- Primary completionMar 2029 (estimated)
- Study completionMar 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alcohol Use DisorderStudies of the same condition, open and under way.
- More trials run by Duke UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Duke University
- Sponsor type
- University, hospital or other
- Collaborators
- Kilimanjaro Christian Medical Centre, Tanzania
- Responsible party
- Sponsor
- Investigators
- Brandon Knettel, PhD, Principal investigator, Duke University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07475988
- Sponsor's protocol ID
- Pro00118645
- Acronym
- IDEAS-AUD
- Status last verified
- Mar 2026
- First submitted
- 12 Mar 2026
- Last updated
- 17 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 17 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania: IDEAS-AUD
- ClinicalTrials.gov ID
- NCT07475988
- Acronym / sponsor ID
- IDEAS-AUD / Pro00118645
- Conditions
- Alcohol Use Disorder, Suicide Prevention
- Keywords
- Telehealth, Nurse-delivered interventions, Stigma reduction, Care engagement, Suicide prevention, Health behavior, Alcohol use disorder, Harm reduction
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Duke UniversityUniversity, hospital or other
- Collaborators
- Kilimanjaro Christian Medical Centre, Tanzania
- Study start
- Aug 2027 (estimated)
- Primary completion
- Mar 2029 (estimated)
- Study completion
- Mar 2029 (estimated)
- First posted
- 17 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Together, alcohol use and suicide account for approximately 4 million deaths per year, with a considerable burden on low and middle-income countries. Tanzania is among the world's most underserved nations for mental health treatment, with very little capacity to treat suicidality or alcohol use disorders. In this study, the researchers will adapt an evidence-based intervention for suicide prevention to address the unique needs of people with alcohol use disorders in Tanzania, and rigorously pilot test the intervention to assess its feasibility and acceptability in a Tanzanian emergency department.
Detailed description
Globally, alcohol use disorders (AUD) cause 3.3 million deaths each year and account for nearly 100 million disability-adjusted life years (DALYs). Alcohol use is also one of the most prominent risk factors for death by suicide, as people with AUD have a lifetime risk of suicide more than 7 times higher than the general population. In preliminary studies at Kilimanjaro Christian Medical Centre (KCMC) in Tanzania, 7% of patients with AUD met criteria for comorbid depression, 7% were experiencing suicidal thoughts or behavior, and nearly half reported challenges in social support. Unfortunately, Tanzania is also among the most underserved nations in the world for mental health treatment, with fewer than 1 psychologist or psychiatrist per 1 million people and very little capacity to intervene for suicide risk or AUD. Given this shortage in treatment, there is a critical need for innovative, resource-efficient treatments for suicide prevention among people with AUD. In Tanzania, 91% of the population owns a cellular phone and nearly 50% use mobile internet, yet telehealth interventions have been largely unexplored, representing a major missed opportunity for delivering evidence-based interventions. By adapting an evidence-based Motivational Interviewing intervention, MI-SafeCope, the team developed IDEAS for Hope, a telehealth intervention for suicide prevention in HIV care in Tanzania. In the current grant, the researchers propose to revisit this process by adapting MI-SafeCope, with lessons learned from the HIV study, to reduce suicide risk among people with AUD who are presenting for care in the KCMC Emergency Department (ED). The resulting intervention, IDEAS-AUD, will address suicide risk with a four-pillared approach: reducing alcohol-related harm, building social support, enhancing emotional health, and addressing social determinants of health. The pillars are integrated with Motivational Interviewing-enhanced safety planning and referral for local psychiatric care as appropriate. The long-term goal is to create evidence-based, accessible, and cost-effective treatments for mental health and substance use treatment in low-resource settings. The objectives of this proposal are to: 1) adapt IDEAS-AUD for the AUD population in Kilimanjaro, Tanzania; 2) rigorously evaluate the acceptability and feasibility of IDEAS-AUD; and 3) develop the intervention package, along with a trialability evaluation, for a future implementation evaluation and clinical trial. In Aim 1 of the current study, the researchers will identify drivers of suicide risk and desired intervention characteristics to prevent suicide in the AUD population at KCMC. In Aim 2, the study team will adapt an evidence-based suicide prevention intervention to existing AUD care, guided by a community coalition. In Aim 3, the investigators will pilot test the telehealth intervention to assess its feasibility and acceptability for reducing suicide risk in the KCMC AUD population. By the end of this proposed project, the researchers will have a framework-guided, culturally- and resource-adapted, piloted protocol for IDEAS-AUD, including screening tools, programmatic, and implementation components.
Study design
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| IDEAS-AUD | Experimental | Behavioral: IDEAS-AUD3 sessions of telehealth-delivered counseling |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- 18 years of age or older
- screen positive for alcohol use disorder (AUDIT >=8)
- have had suicidal thinking (C-SSRS item indicating "actual thoughts of suicide") in last 30 days
- clinically sober
- medically stable
Key exclusion criteria (2 listed)
- prisoners
- decline or unable to complete informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| IDEAS-AUDTelehealth-delivered counseling to reduce suicide risk among people with Alcohol Use Disorder (AUD) who are presenting for care in the KCMC Emergency Department (ED). | Behavioural | IDEAS-AUD |
Primary outcome
Acceptability of intervention
Time frame: 3 months
Acceptability of Intervention Measure (AIM). Four items scored from 1-Completely disagree to 5-Completely agree. Scores are summed for a total score of 4 to 20, with higher scores indicating greater acceptability.
Enrollment feasibility as measured by the percentage of ED patients with documented screening for study eligibility
Time frame: up to 1 year
Enrollment feasibility as measured by the number of eligible participants who declined enrollment
Time frame: up to 1 year
Enrollment feasibility as measured by the time needed to enroll 30 eligible participants
Time frame: up to 1 year
Retention feasibility as measured by the number of participants retained for follow-up
Time frame: session 2 (2 weeks), session 3 (4 weeks), and 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Mar 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Brandon Knettel, PhD principal investigator
Duke University
Questions about this trial
What is this clinical trial studying?
A study testing IDEAS-AUD in people with Alcohol Use Disorder and Suicide Prevention, run by Duke University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 17 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Brandon Knettel, PhD (9196601218, brandon.knettel@duke.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Acceptability of intervention (time frame: 3 months). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Mar 2026.