Knee Pain ChronicNCT07474597
Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individuals With Knee Pain.
A study testing Myofascial Release in people with Knee Pain Chronic, run by Istanbul Rumeli University at 1 site in Turkey (Türkiye).
Trial summary
This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Knee Pain Chronic
- What is being tested?
- Myofascial Release
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Oct 2025to 2 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Being between 18-70 years of age
- Being able to communicate in Turkish
- Being literate
- Having a diagnosis of non-specific knee pain, Patellafemoral pain syndrome, or Knee Osteoarthritis
- Volunteering to participate in the study
Who cannot join
- Having undergone surgery on the knee joint
- Having a diagnosis of inflammatory rheumatism
- Having a significant clinical infection
- Having a fracture in the bones forming the knee joint
- Having received cortisol treatment within the last 6 months
- Having a disease that prevents the patient from lying prone
Show all 9Show fewer
- Having a history of deep vein thrombosis
- Having severe varicose vein disease
- Being an active cancer patient
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
İstanbul Fatih Sultan Mehmet Eğitim ve Araştırma Hastahanesi
Istanbul
About this study
This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain.
Read the detailed description
This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain. Sixty patients presenting with knee pain were assessed according to inclusion and exclusion criteria, and 45 eligible participants were enrolled. Participants were allocated into two groups: the popliteus group (23) and the control group (22). Assessments were performed before treatment and after treatment. Both groups received a standard PTR program consisting of heat therapy (20 min), transcutaneous electrical nerve stimulation (TENS) (20 min), therapeutic ultrasound (US) (4 min), and exercises, administered 5 days per week for a total of 10 sessions. In addition, popliteus muscle-targeted MFR techniques were applied to the popliteus group. Outcome measures included pain (visual analog scale, VAS), functional status (Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC), quality of life (Short Form-12 Health Survey, SF-12), range of motion (ROM), limb circumference measurement, and balance tests (single-leg stance test, SLST).
- Conditions
- Knee Pain Chronic
- Being tested
- Myofascial Release
- Keywords
- Knee pain; Popliteus; Myofascial release; Manual therapy; Physical therapy and rehabilitation; WOMAC
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Myofascial ReleaseOther
Classical Myofascial Release
| Study group | Role | What they receive |
|---|---|---|
| Popliteus | Active comparator | Myofascial Release Techniques Applied to the Popliteus Muscle Receives: Other: Myofascial Release |
| Kontrol Grubu | No intervention | Myofascial Release uygulanmadı |
What is being measured
The primary outcome is the main question the study is designed to answer.
Myofascial Release Techniques AppliMeasurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle.
Measurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle. The SF-12 scale was used as the measurement. Patella circumference measurements were also taken.
Measured: 5 days 10 sessions
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Mar 2026
- Study start1 Oct 2025
- Primary completion2 Jan 2026
- Study completion2 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Knee Pain ChronicStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Rumeli University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Aysegul Kutsal, Istanbul Rumeli University
- Investigators
- Ali CIMBIZ, Study director, Istanbul Rumeli Universitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07474597
- Sponsor's protocol ID
- IRU-FTR-AK-01
- Status last verified
- Mar 2026
- First submitted
- 29 Jan 2026
- Last updated
- 17 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Publications
Flandry F, Hommel G. Normal anatomy and biomechanics of the knee. Sports Med Arthrosc Rev. 2011 Jun;19(2):82-92. doi: 10.1097/JSA.0b013e318210c0aa.
PubMed 21540705
Study at a glance
From the registry record, last updated by the sponsor on 17 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effectiveness of Myofascial Release Techniques Applied to the Popliteus Muscle in Individuals With Knee Pain.
- ClinicalTrials.gov ID
- NCT07474597
- Acronym / sponsor ID
- IRU-FTR-AK-01
- Conditions
- Knee Pain Chronic
- Keywords
- Knee pain; Popliteus; Myofascial release; Manual therapy; Physical therapy and rehabilitation; WOMAC
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Istanbul Rumeli UniversityUniversity, hospital or other
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- 2 Jan 2026 (actual)
- Study completion
- 2 Jan 2026 (actual)
- First posted
- 16 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain.
Detailed description
This study aimed to evaluate the effectiveness of popliteus muscle-targeted myofascial release techniques (MFR) when added to conventional physical therapy and rehabilitation (PTR) and exercise protocols in patients with knee pain. Sixty patients presenting with knee pain were assessed according to inclusion and exclusion criteria, and 45 eligible participants were enrolled. Participants were allocated into two groups: the popliteus group (23) and the control group (22). Assessments were performed before treatment and after treatment. Both groups received a standard PTR program consisting of heat therapy (20 min), transcutaneous electrical nerve stimulation (TENS) (20 min), therapeutic ultrasound (US) (4 min), and exercises, administered 5 days per week for a total of 10 sessions. In addition, popliteus muscle-targeted MFR techniques were applied to the popliteus group. Outcome measures included pain (visual analog scale, VAS), functional status (Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC), quality of life (Short Form-12 Health Survey, SF-12), range of motion (ROM), limb circumference measurement, and balance tests (single-leg stance test, SLST).
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Popliteus | Active comparator | Other: Myofascial ReleaseMyofascial Release Techniques Applied to the Popliteus Muscle |
| Kontrol Grubu | No intervention | –Myofascial Release uygulanmadı |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Being between 18-70 years of age
- Being able to communicate in Turkish
- Being literate
- Having a diagnosis of non-specific knee pain, Patellafemoral pain syndrome, or Knee Osteoarthritis
- Volunteering to participate in the study
Key exclusion criteria (9 listed)
- Having undergone surgery on the knee joint
- Having a diagnosis of inflammatory rheumatism
- Having a significant clinical infection
- Having a fracture in the bones forming the knee joint
- Having received cortisol treatment within the last 6 months
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Myofascial ReleaseClassical Myofascial Release | Other | Popliteus |
Primary outcome
Myofascial Release Techniques AppliMeasurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle.
Time frame: 5 days 10 sessions
Measurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle. The SF-12 scale was used as the measurement. Patella circumference measurements were also taken.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Mar 2026.
- Results publication: PubMed 21540705Flandry F, Hommel G. Normal anatomy and biomechanics of the knee. Sports Med Arthrosc Rev. 2011 Jun;19(2):82-92. doi: 10.1097/JSA.0b013e318210c0aa.
- Individual participant dataSharing planned: Yes
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A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ali CIMBIZ study director
Istanbul Rumeli Universitesi
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Myofascial Release in people with Knee Pain Chronic, run by Istanbul Rumeli University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Myofascial Release Techniques AppliMeasurement of quality of life in individuals with knee pain following myofascial release techniques applied to the popliteus muscle. (time frame: 5 days 10 sessions). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07474597, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Mar 2026.