EpilepsiesNCT07470931
Role of High-Frequency Oscillations on Scalp EEG in Identifying Epileptogenic Activity in Patients With Epilepsy and Healthy Controls
An observational study of Epilepsies, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
Trial summary
This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Epilepsies
- How many people
- 80 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Mar 2023to 30 Sep 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adults with epilepsy and age- and sex-comparable healthy controls who underwent scalp EEG recording. The control group consisted of individuals referred to the EEG laboratory for syncope differential diagnosis and found suitable for inclusion as controls.
Who may be able to join
- Adults diagnosed with epilepsy
- Availability of routine awake scalp EEG recording suitable for analysis
- EEG recorded with the study protocol and technical specifications
- Adults without epilepsy
- Referred for EEG evaluation in the context of syncope differential diagnosis
- Scalp EEG recording suitable for analysis
Who cannot join
- EEG recordings with inadequate technical quality or excessive artifact burden preventing HFO analysis
- Individuals not meeting study group definitions
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Saglik Bilimleri University Izmir Faculty of Medicine Department of Neurology
Izmir
About this study
Official title: Evaluation of High-Frequency Oscillations Detected by a Novel Signal Analysis Algorithm on Scalp Electroencephalography for Differentiating Patients With Epilepsy From Healthy Controls
This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. A signal-processing algorithm was developed to identify HFO activity in scalp EEG recordings, with particular focus on ripple (80-250 Hz) and fast ripple (250-500 Hz) frequency bands. Scalp EEG recordings obtained from patients with epilepsy and healthy controls are analyzed after preprocessing and filtering steps. The main outcome is the mean residence time of HFO-related activity above a predefined threshold in the ripple and fast ripple bands. The study investigates whether this noninvasive EEG-based approach may provide a useful biomarker for epilepsy diagnosis.
- Conditions
- Epilepsies
- Medical subject headings
- Epilepsy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| epilepsy patients | epileptic patients with eeg | |
| normal control | non epileptic patients with eeg |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG
The mean duration for which the ripple-band signal envelope remains above the predefined threshold, compared between epilepsy and control groups.
Measured: At the time of EEG assessment / baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Mar 2026
- Study start1 Mar 2023
- Primary completion30 Sep 2023
- Study completion30 Sep 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EpilepsiesStudies of the same condition, open and under way.
- More trials run by Saglik Bilimleri UniversitesiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Saglik Bilimleri Universitesi
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07470931
- Sponsor's protocol ID
- 2020/11-26
- Status last verified
- Mar 2026
- First submitted
- 10 Mar 2026
- Last updated
- 13 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of High-Frequency Oscillations Detected by a Novel Signal Analysis Algorithm on Scalp Electroencephalography for Differentiating Patients With Epilepsy From Healthy Controls
- ClinicalTrials.gov ID
- NCT07470931
- Acronym / sponsor ID
- 2020/11-26
- Conditions
- Epilepsies
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Saglik Bilimleri UniversitesiUniversity, hospital or other
- Study start
- 1 Mar 2023 (actual)
- Primary completion
- 30 Sep 2023 (actual)
- Study completion
- 30 Sep 2023 (actual)
- First posted
- 13 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. A signal-processing algorithm was developed to identify HFO activity in scalp EEG recordings, with particular focus on ripple (80-250 Hz) and fast ripple (250-500 Hz) frequency bands. Scalp EEG recordings obtained from patients with epilepsy and healthy controls are analyzed after preprocessing and filtering steps. The main outcome is the mean residence time of HFO-related activity above a predefined threshold in the ripple and fast ripple bands. The study investigates whether this noninvasive EEG-based approach may provide a useful biomarker for epilepsy diagnosis.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| epilepsy patients | – | –epileptic patients with eeg |
| normal control | – | –non epileptic patients with eeg |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adults with epilepsy and age- and sex-comparable healthy controls who underwent scalp EEG recording. The control group consisted of individuals referred to the EEG laboratory for syncope differential diagnosis and found suitable for inclusion as controls.
Key inclusion criteria (6 listed)
- Adults diagnosed with epilepsy
- Availability of routine awake scalp EEG recording suitable for analysis
- EEG recorded with the study protocol and technical specifications
- Adults without epilepsy
- Referred for EEG evaluation in the context of syncope differential diagnosis
Key exclusion criteria (2 listed)
- EEG recordings with inadequate technical quality or excessive artifact burden preventing HFO analysis
- Individuals not meeting study group definitions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG
Time frame: At the time of EEG assessment / baseline
The mean duration for which the ripple-band signal envelope remains above the predefined threshold, compared between epilepsy and control groups.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Epilepsies, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG (time frame: At the time of EEG assessment / baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Mar 2026.