Dynamic Strength Exercise SessionCOMBAT-HNCT07470450
Acute and Chronic Effects of Combined Training on BP in Hypertensives
A study testing Combined strength training, Dynamic strength training and Acute Isometric Exercise Session. in people with Dynamic Strength Exercise Session and Isometric Strength Exercise Session, run by Federal University of Rio Grande do Sul at 1 site in Brazil.
Trial summary
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy. It is currently endorsed by treatment and prevention guidelines for systemic arterial hypertension (SAH) due to its significant effect on lowering blood pressure (BP). Read more about this study
- Who is it for?
- Ages 30 to 60 years
- Conditions the study is for
- Dynamic Strength Exercise Session, Isometric Strength Exercise Session, Combined Exercise Session
- What is being tested?
- Combined strength training, Dynamic strength training and Acute Isometric Exercise Session.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteBrazil
- Study dates
- 26 Jul 2025to 23 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Clinical diagnosis of stage 1 or stage 2 hypertension, according to current guidelines.
- Sedentary lifestyle (no participation in structured exercise training for at least 6 months).
- Age between 18 and 60 years. Stable antihypertensive pharmacological treatment for at least 4 weeks before enrollment.
- Ability to perform resistance exercise.
Who cannot join
- Symptomatic cardiovascular disease. Heart failure. Unstable angina. Uncontrolled diabetes mellitus (HbA1c > 8%). Renal insufficiency. Musculoskeletal disorders or physical limitations that contraindicate resistance exercise.
- Changes in antihypertensive medication within the 4 weeks prior to enrollment or during the study protocol.
- Current smoking. Excessive alcohol consumption.
Trial locations and contacts
1 site in 1 country.
Brazil1 site
Universidade Federal do Rio Grande do Sul
Porto Alegre, Rio Grande do Sul, 91420-550
About this study
Official title: Acute And Chronic Effects Of Combined Strength Training On Regulatory Variables Of Ambulatory Blood Pressure In Medicated Hypertensive Patients
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy. It is currently endorsed by treatment and prevention guidelines for systemic arterial hypertension (SAH) due to its significant effect on lowering blood pressure (BP). However, when comparing BP reduction values, isometric strength training (IST) stands out with greater magnitudes of BP reduction, although without the neuromuscular adaptations seen in DST. Given their similarities, a combination of these strategies through combined strength training (CST) is possible but has not yet been evaluated. The researchers hypothesized that CST may have an additive effect compared with DST and IST alone in reducing ambulatory BP. Therefore, the objective of the present thesis was to evaluate and compare the effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients. This thesis is structured in two parts: (1) a crossover study with medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses related to ambulatory BP after a single session of CST, DST, and IST; and (2) a randomized clinical trial to assess the chronic effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients.
Read the detailed description
"This thesis is structured in two sequential stages:
A randomized crossover trial involving medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses on ambulatory blood pressure following a single session of Combined Strength Training (CST), Dynamic Strength Training (DST), and Isometric Strength Training (IST), compared to a control session.
A randomized controlled trial to assess the chronic effects (8 weeks) of CST and DST on the regulatory variables of ambulatory blood pressure in medicated middle-aged hypertensive patients, compared to a non-exercising control group."
- Conditions
- Dynamic Strength Exercise Session, Isometric Strength Exercise Session, Combined Exercise Session, Control Session (CON), Dynamic Strength Training, Combined Strength Training
- Being tested
- Combined strength training, Dynamic strength training, Acute Isometric Exercise Session., Control Session and Follow-up
- Keywords
- Ambulatory Blood Pressure Monitoring, Resistence training, Isometric exercise, Post-Exercise hypotension, Endothelial Function
- Medical subject headings
- Post-Exercise Hypotension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined strength trainingOther
Participants in this group undergo two phases. Phase 1: A single acute exercise session consisting of 8 resistance exercises (3 sets of 11 repetitions with a 10-second isometric hold at the end of each set; 1s concentric/2s eccentric phases). Phase 2: An 8-week chronic intervention period, performing the same combined protocol 3 times a week, with intensity progressing from 50% to 65% of 1RM.
Dynamic strength trainingOther
Participants in this group go through two phases.
Phase 1: A single acute exercise session consisting of 8 resistance exercises (3 sets of 14 repetitions, 1 second concentric phase and 2 seconds eccentric phase, 30 seconds of rest between sets and 90 seconds between exercises) at 50% of 1RM.
Phase 2: An 8-week chronic intervention period, performing the same dynamic resistance protocol 3 times a week, with intensity progressing from 50% to 65% of 1RM.
Acute Isometric Exercise Session.Other
Participants in this group undergo a single acute exercise session consisting of 8 resistance exercises performed isometrically. The protocol includes 3 sets per exercise, with each set consisting of a 10-second static contraction at 50% of 1RM, with 30 seconds of rest between sets and 90 seconds between exercises
Control Session and Follow-upOther
Participants in this group undergo two phases. Phase 1: A single acute control session consisting of quiet rest in a seated position for the same duration as the exercise sessions. Phase 2: An 8-week follow-up period where participants maintain their usual daily activities and pharmacological treatment without any structured exercise program.
| Study group | Role | What they receive |
|---|---|---|
| Dynamic strength training | Experimental | 8 dynamic strength exercises, with 14 repetitions, 3 sets, 1 second concentric phase and 2 seconds eccentric phase. 30 seconds of rest between sets and 1 minute and 30 seconds of rest between exercises. Receives: Other: Dynamic strength training |
| Isometric strength training | Experimental | 8 isometric strength exercises. 10 seconds of isometric strength. 3 sets, 1 second concentric and 2 eccentric. 30 seconds rest between sets and 1 minute and 30 seconds rest between exercises. Receives: Other: Acute Isometric Exercise Session. |
| Control group | Experimental | The control group consists of maintaining their habits for 8 weeks, without strength exercises. Receives: Other: Control Session and Follow-up |
| Combined strength training | Experimental | 8 resistance exercises combining dynamic repetitions with isometric components. Protocol: 3 sets of 11 repetitions, with a concentric phase of 1 second and an eccentric phase of 2 seconds combined with 10 seconds of isometric hold at the end of each set. Includes 30 seconds of rest between sets and 90 seconds between exercises. Receives: Other: Combined strength training |
What is being measured
The primary outcome is the main question the study is designed to answer.
24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
Average systolic blood pressure measured over a 24-hour period using an automated ambulatory monitor (ABPM). This measure assesses the chronic effect of the 8-week training protocols compared to baseline.
Measured: Baseline and 8 weeks
Secondary outcomes (10)
Acute 24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
Average systolic blood pressure measured over a 24-hour period following a single session of each intervention (Dynamic, Combined, Isometric, and Control) to evaluate post-exercise hypotension. This was conducted in a crossover design.
Measured: 24 hours post-intervention
Acute Post-Exercise Blood Pressure Response
Systolic and diastolic blood pressure measured at rest (pre-intervention) and at 30 and 60 minutes following a single exercise session to evaluate the immediate post-exercise hypotension (PEH).
Measured: Baseline, 30 minutes, and 60 minutes post-exercise.
Vascular Endothelial Function - Chronic (Flow-Mediated Dilation)
Percentage of brachial artery dilation measured via high-resolution ultrasound to evaluate the chronic adaptations of vascular endothelial function after the 8-week intervention.
Measured: Baseline and 8 weeks
Vascular Endothelial Function - Acute Response (Flow-Mediated Dilation)
Acute changes in the percentage of brachial artery dilation following a single session of exercise. This measure evaluates the transient endothelial response at different time points.
Measured: Baseline, 30 minutes, and 60 minutes post-exercise.
Cardiac Autonomic Modulation - Chronic (Heart Rate Variability)
Analysis of heart rate variability (HRV) parameters in both time and frequency domains (e.g., SDNN, RMSSD, LF, HF) to evaluate chronic adaptations in cardiac autonomic control after the 8-week intervention.
Measured: Baseline and 8 weeks.
Cardiac Autonomic Modulation - Acute Response (Heart Rate Variability)
Acute changes in heart rate variability parameters following a single session of exercise. This evaluates the immediate autonomic recovery and sympathetic-vagal balance at different time points.
Measured: Baseline, 30 minutes, and 60 minutes post-exercise.
Office Blood Pressure Adaptation (Weekly Progression)
Assessment of the progression of resting systolic and diastolic blood pressure measured before exercise sessions throughout the 8-week intervention to evaluate the time course of blood pressure adaptations.
Measured: Baseline and weekly for 8 weeks.
Blood-based Biomarkers of Cardiovascular Health
Analysis of blood samples to evaluate biochemical markers related to cardiovascular health, such as markers of inflammation, oxidative stress, or nitric oxide bioavailability, to investigate the mechanisms underlying blood pressure changes.
Measured: Baseline and 8 weeks
Acute Blood-based Biomarkers Response
Analysis of blood samples to evaluate the acute response of biochemical markers related to cardiovascular and endothelial health (e.g., nitric oxide metabolites, inflammatory cytokines, or oxidative stress markers) following a single session of exercise.
Measured: Baseline, 30 minutes, and 60 minutes post-exercise.
Body Composition (Skinfold Thickness)
Assessment of body composition using skinfold thickness measurements to estimate body fat percentage and lean body mass. This measure monitors physical changes and ensures that any observed blood pressure adaptations are not solely due to changes in body fat or weight.
Measured: Baseline and 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Mar 2026
- Study start26 Jul 2025
- Primary completion23 Dec 2025
- Study completion23 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dynamic Strength Exercise SessionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Model description
- "The study follows a sequential design divided into two distinct phases. In Phase 1 (Acute), a randomized crossover design is employed where all participants undergo four experimental sessions (Control, Dynamic Strength, Isometric Strength, and Combined Exercise) in a randomized order, with a minimum washout period of 48 to 72 hours between sessions to evaluate 24-hour post-exercise hypotension. In Phase 2 (Chronic), participants are then randomized into three parallel groups (Control, Dynamic Strength Training, and Combined Strength Training) for an 8-week intervention period. This phase aims to evaluate long-term cardiovascular adaptations, including 24-hour ambulatory blood pressure and endothelial function. Data collection for both phases has been completed."
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Federal University of Rio Grande do Sul
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Alvaro Reischak-Oliveira, Federal University of Rio Grande do Sul
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07470450
- Sponsor's protocol ID
- 84584824.4.0000.5347
- Acronym
- COMBAT-H
- Status last verified
- Jul 2026
- First submitted
- 9 Mar 2026
- Last updated
- 28 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared to ensure the privacy and confidentiality of the participants, in accordance with the local institutional review board and data protection regulations.
Study at a glance
From the registry record, last updated by the sponsor on 28 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute And Chronic Effects Of Combined Strength Training On Regulatory Variables Of Ambulatory Blood Pressure In Medicated Hypertensive Patients
- ClinicalTrials.gov ID
- NCT07470450
- Acronym / sponsor ID
- COMBAT-H / 84584824.4.0000.5347
- Conditions
- Dynamic Strength Exercise Session, Isometric Strength Exercise Session, Combined Exercise Session, Control Session (CON), Dynamic Strength Training, Combined Strength Training
- Keywords
- Ambulatory Blood Pressure Monitoring, Resistence training, Isometric exercise, Post-Exercise hypotension, Endothelial Function
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Federal University of Rio Grande do SulUniversity, hospital or other
- Study start
- 26 Jul 2025 (actual)
- Primary completion
- 23 Dec 2025 (actual)
- Study completion
- 23 Dec 2025 (actual)
- First posted
- 13 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy. It is currently endorsed by treatment and prevention guidelines for systemic arterial hypertension (SAH) due to its significant effect on lowering blood pressure (BP). However, when comparing BP reduction values, isometric strength training (IST) stands out with greater magnitudes of BP reduction, although without the neuromuscular adaptations seen in DST. Given their similarities, a combination of these strategies through combined strength training (CST) is possible but has not yet been evaluated. The researchers hypothesized that CST may have an additive effect compared with DST and IST alone in reducing ambulatory BP. Therefore, the objective of the present thesis was to evaluate and compare the effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients. This thesis is structured in two parts: (1) a crossover study with medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses related to ambulatory BP after a single session of CST, DST, and IST; and (2) a randomized clinical trial to assess the chronic effects of CST, DST, and IST on regulatory variables of ambulatory BP in medicated middle-aged hypertensive patients.
Detailed description
"This thesis is structured in two sequential stages:
A randomized crossover trial involving medicated middle-aged hypertensive patients to identify autonomic, endothelial, and vascular responses on ambulatory blood pressure following a single session of Combined Strength Training (CST), Dynamic Strength Training (DST), and Isometric Strength Training (IST), compared to a control session.
A randomized controlled trial to assess the chronic effects (8 weeks) of CST and DST on the regulatory variables of ambulatory blood pressure in medicated middle-aged hypertensive patients, compared to a non-exercising control group."
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Sequential
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 4
- Model description
- "The study follows a sequential design divided into two distinct phases. In Phase 1 (Acute), a randomized crossover design is employed where all participants undergo four experimental sessions (Control, Dynamic Strength, Isometric Strength, and Combined Exercise) in a randomized order, with a minimum washout period of 48 to 72 hours between sessions to evaluate 24-hour post-exercise hypotension. In Phase 2 (Chronic), participants are then randomized into three parallel groups (Control, Dynamic Strength Training, and Combined Strength Training) for an 8-week intervention period. This phase aims to evaluate long-term cardiovascular adaptations, including 24-hour ambulatory blood pressure and endothelial function. Data collection for both phases has been completed."
| Arm | Type | Receives |
|---|---|---|
| Dynamic strength training | Experimental | Other: Dynamic strength training8 dynamic strength exercises, with 14 repetitions, 3 sets, 1 second concentric phase and 2 seconds eccentric phase. 30 seconds of rest between sets and 1 minute and 30 seconds of rest between exercises. |
| Isometric strength training | Experimental | Other: Acute Isometric Exercise Session.8 isometric strength exercises. 10 seconds of isometric strength. 3 sets, 1 second concentric and 2 eccentric. 30 seconds rest between sets and 1 minute and 30 seconds rest between exercises. |
| Control group | Experimental | Other: Control Session and Follow-upThe control group consists of maintaining their habits for 8 weeks, without strength exercises. |
| Combined strength training | Experimental | Other: Combined strength training8 resistance exercises combining dynamic repetitions with isometric components. Protocol: 3 sets of 11 repetitions, with a concentric phase of 1 second and an eccentric phase of 2 seconds combined with 10 seconds of isometric hold at the end of each set. Includes 30 seconds of rest between sets and 90 seconds between exercises. |
Who may qualify
- Ages
- 30 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Clinical diagnosis of stage 1 or stage 2 hypertension, according to current guidelines.
- Sedentary lifestyle (no participation in structured exercise training for at least 6 months).
- Age between 18 and 60 years. Stable antihypertensive pharmacological treatment for at least 4 weeks before enrollment.
- Ability to perform resistance exercise.
Key exclusion criteria (3 listed)
- Symptomatic cardiovascular disease. Heart failure. Unstable angina. Uncontrolled diabetes mellitus (HbA1c > 8%). Renal insufficiency. Musculoskeletal disorders or physical limitations that contraindicate resistance exercise.
- Changes in antihypertensive medication within the 4 weeks prior to enrollment or during the study protocol.
- Current smoking. Excessive alcohol consumption.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined strength trainingParticipants in this group undergo two phases. Phase 1: A single acute exercise session consisting of 8 resistance exercises (3 sets of 11 repetitions with a 10-second isometric hold at the end of each set; 1s concentric/2s eccentric phases). Phase 2: An 8-week chronic intervention period, performing the same combined protocol 3 times a week, with intensity progressing from 50% to 65% of 1RM. | Other | Combined strength training |
| Dynamic strength trainingParticipants in this group go through two phases. Phase 1: A single acute exercise session consisting of 8 resistance exercises (3 sets of 14 repetitions, 1 second concentric phase and 2 seconds eccentric phase, 30 seconds of rest between sets and 90 seconds between exercises) at 50% of 1RM. Phase 2: An 8-week chronic intervention period, performing the same dynamic resistance protocol 3 times a week, with intensity progressing from 50% to 65% of 1RM. | Other | Dynamic strength training |
| Acute Isometric Exercise Session.Participants in this group undergo a single acute exercise session consisting of 8 resistance exercises performed isometrically. The protocol includes 3 sets per exercise, with each set consisting of a 10-second static contraction at 50% of 1RM, with 30 seconds of rest between sets and 90 seconds between exercises | Other | Isometric strength training |
| Control Session and Follow-upParticipants in this group undergo two phases. Phase 1: A single acute control session consisting of quiet rest in a seated position for the same duration as the exercise sessions. Phase 2: An 8-week follow-up period where participants maintain their usual daily activities and pharmacological treatment without any structured exercise program. | Other | Control group |
Primary outcome
24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
Time frame: Baseline and 8 weeks
Average systolic blood pressure measured over a 24-hour period using an automated ambulatory monitor (ABPM). This measure assesses the chronic effect of the 8-week training protocols compared to baseline.
10 secondary outcomes
Acute 24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean)
Time frame: 24 hours post-intervention
Acute Post-Exercise Blood Pressure Response
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Vascular Endothelial Function - Chronic (Flow-Mediated Dilation)
Time frame: Baseline and 8 weeks
Vascular Endothelial Function - Acute Response (Flow-Mediated Dilation)
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Cardiac Autonomic Modulation - Chronic (Heart Rate Variability)
Time frame: Baseline and 8 weeks.
Cardiac Autonomic Modulation - Acute Response (Heart Rate Variability)
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Office Blood Pressure Adaptation (Weekly Progression)
Time frame: Baseline and weekly for 8 weeks.
Blood-based Biomarkers of Cardiovascular Health
Time frame: Baseline and 8 weeks
Acute Blood-based Biomarkers Response
Time frame: Baseline, 30 minutes, and 60 minutes post-exercise.
Body Composition (Skinfold Thickness)
Time frame: Baseline and 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jul 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared to ensure the privacy and confidentiality of the participants, in accordance with the local institutional review board and data protection regulations.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined strength training, Dynamic strength training and Acute Isometric Exercise Session. in people with Dynamic Strength Exercise Session and Isometric Strength Exercise Session, run by Federal University of Rio Grande do Sul at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
24-hour Ambulatory Blood Pressure (Systolic, Diastolic, and Mean) (time frame: Baseline and 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jul 2026.