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Postoperative AnalgesiaPhase 3NCT07469410

Comparison of Postoperative Analgesia in Erector Spinae Plane Block (ESPB) v/s Subcostal Transversus Abdominal Plane Block (STAP) in Adults Undergoing Laparoscopic Cholecystectomy.

A Phase 3 study testing Landmark guided Erector Spinae Block and Landmark guided Transversus Abdominis Plane Block in people with Postoperative Analgesia, run by Patel Hospital, Pakistan at 1 site in Pakistan.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Postoperative pain after laparoscopic cholecystectomy remains clinically relevant. This double-blinded randomized controlled trial compares the analgesic efficacy of landmark-guided Erector Spinae Plane Block (ESPB) and subcostal transversus abdominis plane (STAP) block in 60 adult patients. Read more about this study

Who is it for?
Ages 18 to 65 yearsHealthy volunteers can take part
Conditions the study is for
Postoperative Analgesia
What is being tested?
Landmark guided Erector Spinae Block and Landmark guided Transversus Abdominis Plane Block
Could I receive a placebo?
No, everyone receives an active treatment
How many people
60 participants
Where
1 sitePakistan
Study dates
1 Jun 2025to 15 Nov 2025
Phase
Phase 3
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 65 years
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Patients are both men and women.
  • Patients aged 18 to 65.
  • Patients are scheduled for a laparoscopic cholecystectomy.
  • Patients with ASA Physical Status I or II. Finally, III.
  • Give consent.

Who cannot join

  • Hypersensitivity to local anesthesia.
  • Infection at the block site.
  • Coagulation disorders.
  • BMI above 40kg/m2.
  • Patients with pregnancy.
  • Converted to open surgery.
Show all 9Show fewer
  • Drain placement.
  • Neurological or psychiatric disorders that impair cooperation.
  • Patients are unwilling to cooperate.

Trial locations and contacts

1 site in 1 country.

Pakistan1 site

  • Kulsoom Mehmood

    Karachi

Other trials in Pakistan

About this study

Official title: Comparison Of Postoperative Analgesia In Landmark Guided Erector Spinae Plane Block And Subcostal Transversus Abdominis Plane Block In Laparoscopic Cholecystectomy; A Randomized Controlled Trial

Postoperative pain after laparoscopic cholecystectomy remains clinically relevant. This double-blinded randomized controlled trial compares the analgesic efficacy of landmark-guided Erector Spinae Plane Block (ESPB) and subcostal transversus abdominis plane (STAP) block in 60 adult patients. Postoperative pain will be evaluated using the Visual Analogue Scale at multiple time points, along with rescue analgesic requirements and time to first analgesic request, to assess the effectiveness of these techniques in resource-limited settings.

Being tested
Landmark guided Erector Spinae Block, Landmark guided Transversus Abdominis Plane Block
Keywords
ESPB, STAP, landmark-guided blocl, laparoscopic cholecystectomy, post operative analgesia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Landmark guided Erector Spinae BlockDrug

    Patients will receive a landmark-guided Erector Spinae Plane Block on the right side at T9 level with 30 mL of 0.25% ropivacaine after induction of general anesthesia.

  • Landmark guided Transversus Abdominis Plane BlockDrug

    Patients will receive a landmark-guided Subcostal Transversus Abdominis Plane Block on the right side with 30 mL of 0.25% ropivacaine after induction of general anesthesia.

Study groups in NCT07469410
Study groupRoleWhat they receive
Experimental: Landmark-guided Erector Spinae Plane BlockExperimentalPatients will receive a landmark-guided erector spinae plane block on the right side at the T9 level with 30 mL of 0.25% ropivacaine after induction of general anesthesia.
Receives: Drug: Landmark guided Erector Spinae Block
landmark-guided Subcostal Transversus Abdominis Plane BlockActive comparatorPatients will receive a landmark-guided Subcostal Transversus Abdominis Plane Block on the right side with 30 mL of 0.25% ropivacaine after induction of general anesthesia.
Receives: Drug: Landmark guided Transversus Abdominis Plane Block

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. VAS score

    Postoperative pain intensity measured using the Visual Analog Scale (VAS), a 10-cm scale ranging from 0 to 10, where 0 = no pain and 10 = worst imaginable pain. Higher scores indicate worse pain.

    Measured: From arrival in the post-anesthesia care unit (PACU) through 24 hours postoperatively, assessed at 30 minutes in PACU, and at 6 hours, 12 hours, and 24 hours after surgery.

Secondary outcomes (1)

  1. need for rescue analgesia and time for first analgesic request.

    Proportion of patients requiring rescue analgesia during the postoperative period.

    Measured: From completion of surgery through 24 hours postoperatively.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Mar 2026
  2. Study start1 Jun 2025
  3. Primary completion15 Nov 2025
  4. Study completion15 Nov 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Who is masked
Participant
Enrolment
60 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07469410
Sponsor's protocol ID
PH/IRB/2025/023
Other IDs
PH/IRB/2025/023
Status last verified
Mar 2026
First submitted
22 Jan 2026
Last updated
13 Mar 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Publications

  • Vadera HK, Mistry T. Erector spinae plane block: Anatomical landmark-guided technique. Saudi J Anaesth. 2019 Jul-Sep;13(3):268-269. doi: 10.4103/sja.SJA_780_18. No abstract available.

    PubMed 31333385

  • Dey S, Mistry T, Mittapalli J, Neema PK. Landmark guided continuous erector spinae plane block: An adjunct for perioperative analgesia in a patient with difficult back operated for total hip arthroplasty. Saudi J Anaesth. 2020 Apr-Jun;14(2):276-277. doi: 10.4103/sja.SJA_46_20. Epub 2020 Mar 5. No abstract available.

    PubMed 32317901

  • Saadawi M, Layera S, Aliste J, Bravo D, Leurcharusmee P, Tran Q. Erector spinae plane block: A narrative review with systematic analysis of the evidence pertaining to clinical indications and alternative truncal blocks. J Clin Anesth. 2021 Feb;68:110063. doi: 10.1016/j.jclinane.2020.110063. Epub 2020 Oct 5.

    PubMed 33032124

  • Kot P, Rodriguez P, Granell M, Cano B, Rovira L, Morales J, Broseta A, Andres J. The erector spinae plane block: a narrative review. Korean J Anesthesiol. 2019 Jun;72(3):209-220. doi: 10.4097/kja.d.19.00012. Epub 2019 Mar 19.

    PubMed 30886130

  • Ozdemir H, Araz C, Karaca O, Turk E. Comparison of Ultrasound-Guided Erector Spinae Plane Block and Subcostal Transversus Abdominis Plane Block for Postoperative Analgesia after Laparoscopic Cholecystectomy: A Randomized, Controlled Trial. J Invest Surg. 2022 Apr;35(4):870-877. doi: 10.1080/08941939.2021.1931574. Epub 2021 Jun 4.

    PubMed 34085883

  • Altiparmak B, Korkmaz Toker M, Uysal AI, Kuscu Y, Gumus Demirbilek S. Ultrasound-guided erector spinae plane block versus oblique subcostal transversus abdominis plane block for postoperative analgesia of adult patients undergoing laparoscopic cholecystectomy: Randomized, controlled trial. J Clin Anesth. 2019 Nov;57:31-36. doi: 10.1016/j.jclinane.2019.03.012. Epub 2019 Mar 6.

    PubMed 30851501

  • Tulgar S, Kapakli MS, Senturk O, Selvi O, Serifsoy TE, Ozer Z. Evaluation of ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic cholecystectomy: A prospective, randomized, controlled clinical trial. J Clin Anesth. 2018 Sep;49:101-106. doi: 10.1016/j.jclinane.2018.06.019. Epub 2018 Jun 15.

    PubMed 29913392

  • Kapukaya F, Ekinci M, Ciftci B, Atalay YO, Golboyu BE, Kuyucu E, Demiraran Y. Erector spinae plane block vs interscalene brachial plexus block for postoperative analgesia management in patients who underwent shoulder arthroscopy. BMC Anesthesiol. 2022 May 12;22(1):142. doi: 10.1186/s12871-022-01687-5.

    PubMed 35550031

  • Chin KJ, Pawa A, Forero M, Adhikary S. Ultrasound-Guided Fascial Plane Blocks of the Thorax: Pectoral I and II, Serratus Anterior Plane, and Erector Spinae Plane Blocks. Adv Anesth. 2019 Dec;37:187-205. doi: 10.1016/j.aan.2019.08.007. Epub 2019 Sep 13. No abstract available.

    PubMed 31677656

  • Forero M, Adhikary SD, Lopez H, Tsui C, Chin KJ. The Erector Spinae Plane Block: A Novel Analgesic Technique in Thoracic Neuropathic Pain. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):621-7. doi: 10.1097/AAP.0000000000000451.

    PubMed 27501016

  • Ramkiran S, Jacob M, Honwad M, Vivekanand D, Krishnakumar M, Patrikar S. Ultrasound-guided Combined Fascial Plane Blocks as an Intervention for Pain Management after Laparoscopic Cholecystectomy: A Randomized Control Study. Anesth Essays Res. 2018 Jan-Mar;12(1):16-23. doi: 10.4103/aer.AER_157_17.

    PubMed 29628547

  • Canitez A, Kozanhan B, Aksoy N, Yildiz M, Tutar MS. Effect of erector spinae plane block on the postoperative quality of recovery after laparoscopic cholecystectomy: a prospective double-blind study. Br J Anaesth. 2021 Oct;127(4):629-635. doi: 10.1016/j.bja.2021.06.030. Epub 2021 Jul 31.

    PubMed 34340839

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Landmark guided Erector Spinae Block and Landmark guided Transversus Abdominis Plane Block in people with Postoperative Analgesia, run by Patel Hospital, Pakistan at 1 site in Pakistan.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

VAS score (time frame: From arrival in the post-anesthesia care unit (PACU) through 24 hours postoperatively, assessed at 30 minutes in PACU, and at 6 hours, 12 hours, and 24 hours after surgery.). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07469410, which also lists 12 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Mar 2026.

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