Osteoarthritis of the HipNCT07458360
FRONT Block for Quality of Recovery After Total Hip Arthroplasty
A study testing FRONT Block (Femoral Rami and Obturator Nerve Trunk Block) and Standard Multimodal Analgesia in people with Osteoarthritis of the Hip and Postoperative Pain, run by Konya Meram State Hospital at 1 site in Turkey (Türkiye).
Trial summary
This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip arthroplasty. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Osteoarthritis of the Hip, Postoperative Pain, Quality of Recovery
- What is being tested?
- FRONT Block (Femoral Rami and Obturator Nerve Trunk Block) and Standard Multimodal Analgesia
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 25 Apr 2026to 5 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years
- Scheduled for total hip arthroplasty under spinal anesthesia
- American Society of Anesthesiologists (ASA) physical status I-III
- Ability to understand and complete the QoR-15 questionnaire
- Provided written informed consent
Who cannot join
- Refusal to participate
- Contraindication to spinal anesthesia or regional block
- Allergy to study medications
- Chronic opioid use (daily use for more than 3 months)
- Neurological or neuromuscular disorders affecting the lower extremities
- Infection at the injection site
- Coagulation disorders
- Cognitive impairment prevents questionnaire completion
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Betul Kozanhan
Konya
Betul Kozanhan, (0332) 310 50 00, betulkozanhan@gmail.com
About this study
Official title: Effect of Femoral Rami and Obturator Nerve Trunk (FRONT) Block on Postoperative Quality of Recovery After Total Hip Arthroplasty: A Prospective Randomized Controlled Trial
This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip arthroplasty.
Read the detailed description
Total hip arthroplasty (THA) is associated with significant postoperative pain that may impair early recovery. The Femoral Rami and Obturator Nerve Trunk (FRONT) block is a regional anesthesia technique targeting sensory innervation of the anterior hip capsule and may improve postoperative recovery while preserving motor function. This prospective randomized controlled trial aims to evaluate whether the addition of ultrasound-guided unilateral FRONT block to standard multimodal analgesia improves postoperative quality of recovery in patients undergoing THA.
- Being tested
- FRONT Block (Femoral Rami and Obturator Nerve Trunk Block), Standard Multimodal Analgesia
- Medical subject headings
- Osteoarthritis, Hip, Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
FRONT Block (Femoral Rami and Obturator Nerve Trunk Block)Procedure or surgery
Ultrasound-guided unilateral FRONT block targeting the femoral rami and obturator nerve trunk will be performed
Standard Multimodal AnalgesiaProcedure or surgery
Standardized postoperative multimodal analgesia including intravenous paracetamol, nonsteroidal anti-inflammatory drugs, and rescue opioid analgesia as required.
| Study group | Role | What they receive |
|---|---|---|
| FRONT Block Group | Experimental | Participants in this group will receive an ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block in addition to standardized multimodal postoperative analgesia. Receives: Procedure: FRONT Block (Femoral Rami and Obturator Nerve Trunk Block); Procedure: Standard Multimodal Analgesia |
| Control Group | Active comparator | Participants in this group will receive standardized multimodal postoperative analgesia without FRONT block. Receives: Procedure: Standard Multimodal Analgesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Quality of Recovery (QoR-15 Score)
Postoperative quality of recovery will be assessed using the validated Quality of Recovery-15 (QoR-15) questionnaire. The total score ranges from 0 to 150, with higher scores indicating better recovery.
Measured: 24 hours after surgery
Secondary outcomes (6)
Quality of Recovery (QoR-15) Score at 48 Hours
Quality of recovery will be assessed using the validated Quality of Recovery-15 (QoR-15) questionnaire (0-150, higher scores indicate better recovery).
Measured: 48 hours after surgery
Postoperative Pain Intensity
Pain intensity will be assessed using an 11-point Numeric Rating Scale (NRS), where 0 indicates no pain and 10 indicates the worst imaginable pain.
Measured: 2, 6, 12, 24, and 48 hours after surgery
Total Opioid Consumption
Total postoperative opioid consumption during the first 24 hours will be recorded and converted to intravenous morphine milligram equivalents (MME).
Measured: 0-24 hours after surgery
Time to First Rescue Analgesia
Time from the end of surgery to the first rescue opioid administration will be recorded
Measured: Within the first 24 hours after surgery
Time to First Mobilization
Time from the end of surgery to first assisted ambulation will be recorded
Measured: Within the first 48 hours after surgery
Quadriceps Motor Strength
Quadriceps muscle strength will be evaluated using the Medical Research Council (MRC) scale ranging from 0 (no contraction) to 5 (normal muscle strength).
Measured: 0-48 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Mar 2026
- Study start25 Apr 2026
- Primary completion5 Dec 2026 (estimated)
- Study completion5 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoarthritis of the HipStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomized in a 1:1 ratio to receive either an ultrasound-guided unilateral FRONT block plus standard multimodal analgesia or standard multimodal analgesia alone. Outcomes will be compared between the two parallel groups.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Konya Meram State Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Betul Kozanhan, Konya Meram State Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07458360
- Sponsor's protocol ID
- FRONT BLOCK
- Status last verified
- Oct 2026
- First submitted
- 3 Mar 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Femoral Rami and Obturator Nerve Trunk (FRONT) Block on Postoperative Quality of Recovery After Total Hip Arthroplasty: A Prospective Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07458360
- Acronym / sponsor ID
- FRONT BLOCK
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Konya Meram State HospitalUniversity, hospital or other
- Study start
- 25 Apr 2026 (actual)
- Primary completion
- 5 Dec 2026 (estimated)
- Study completion
- 5 Dec 2026 (estimated)
- First posted
- 9 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective randomized controlled trial evaluates the effect of ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block on postoperative quality of recovery in patients undergoing elective total hip arthroplasty.
Detailed description
Total hip arthroplasty (THA) is associated with significant postoperative pain that may impair early recovery. The Femoral Rami and Obturator Nerve Trunk (FRONT) block is a regional anesthesia technique targeting sensory innervation of the anterior hip capsule and may improve postoperative recovery while preserving motor function. This prospective randomized controlled trial aims to evaluate whether the addition of ultrasound-guided unilateral FRONT block to standard multimodal analgesia improves postoperative quality of recovery in patients undergoing THA.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomized in a 1:1 ratio to receive either an ultrasound-guided unilateral FRONT block plus standard multimodal analgesia or standard multimodal analgesia alone. Outcomes will be compared between the two parallel groups.
| Arm | Type | Receives |
|---|---|---|
| FRONT Block Group | Experimental | Procedure: FRONT Block (Femoral Rami and Obturator Nerve Trunk Block), Procedure: Standard Multimodal AnalgesiaParticipants in this group will receive an ultrasound-guided unilateral Femoral Rami and Obturator Nerve Trunk (FRONT) block in addition to standardized multimodal postoperative analgesia. |
| Control Group | Active comparator | Procedure: Standard Multimodal AnalgesiaParticipants in this group will receive standardized multimodal postoperative analgesia without FRONT block. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Age ≥ 18 years
- Scheduled for total hip arthroplasty under spinal anesthesia
- American Society of Anesthesiologists (ASA) physical status I-III
- Ability to understand and complete the QoR-15 questionnaire
- Provided written informed consent
Key exclusion criteria (8 listed)
- Refusal to participate
- Contraindication to spinal anesthesia or regional block
- Allergy to study medications
- Chronic opioid use (daily use for more than 3 months)
- Neurological or neuromuscular disorders affecting the lower extremities
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| FRONT Block (Femoral Rami and Obturator Nerve Trunk Block)Ultrasound-guided unilateral FRONT block targeting the femoral rami and obturator nerve trunk will be performed | Procedure or surgery | FRONT Block Group |
| Standard Multimodal AnalgesiaStandardized postoperative multimodal analgesia including intravenous paracetamol, nonsteroidal anti-inflammatory drugs, and rescue opioid analgesia as required. | Procedure or surgery | Control Group, FRONT Block Group |
Primary outcome
Postoperative Quality of Recovery (QoR-15 Score)
Time frame: 24 hours after surgery
Postoperative quality of recovery will be assessed using the validated Quality of Recovery-15 (QoR-15) questionnaire. The total score ranges from 0 to 150, with higher scores indicating better recovery.
6 secondary outcomes
Quality of Recovery (QoR-15) Score at 48 Hours
Time frame: 48 hours after surgery
Postoperative Pain Intensity
Time frame: 2, 6, 12, 24, and 48 hours after surgery
Total Opioid Consumption
Time frame: 0-24 hours after surgery
Time to First Rescue Analgesia
Time frame: Within the first 24 hours after surgery
Time to First Mobilization
Time frame: Within the first 48 hours after surgery
Quadriceps Motor Strength
Time frame: 0-48 hours after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing FRONT Block (Femoral Rami and Obturator Nerve Trunk Block) and Standard Multimodal Analgesia in people with Osteoarthritis of the Hip and Postoperative Pain, run by Konya Meram State Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Betul Kozanhan, md (905055044808, betulkozanhan@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Quality of Recovery (QoR-15 Score) (time frame: 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.