Chronic Ulnar Nerve InjuryNCT07434999
Tendon Transfer for Correction of Pinch in Chronic Ulnar Nerve Injury
A study testing Combined ECRB and APL Tendon Transfer in people with Chronic Ulnar Nerve Injury, run by Sohag University at 1 site in Egypt.
Trial summary
This prospective study evaluates the outcomes of combined ECRB and APL tendon transfer for restoring pinch function in patients with chronic ulnar nerve injury. Patients will be followed postoperatively to assess improvement in hand function, strength, and daily activity performance. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Chronic Ulnar Nerve Injury
- What is being tested?
- Combined ECRB and APL Tendon Transfer
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 17 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Nov 2025to 20 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with chronic ulnar nerve injury (more than 1 year duration).
- Age between 18 and 60 years.
- Patients with stable joints and good passive range of motion of the hand and fingers.
- Absence of active infection or severe contracture.
Who cannot join
- • Patients with combined median or radial nerve injury.
- Patients with severe soft-tissue loss or fixed deformities precluding tendon transfer.
- Uncooperative patients or those with systemic diseases affecting muscle power or healing (e.g., diabetes mellitus, peripheral vascular disease).
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of Combined ECRB and APL Tendon Transfer for Pinch Restoration in Chronic Ulnar Nerve Injury
This prospective study evaluates the outcomes of combined ECRB and APL tendon transfer for restoring pinch function in patients with chronic ulnar nerve injury. Patients will be followed postoperatively to assess improvement in hand function, strength, and daily activity performance. Participation is voluntary and all standard care procedures will be maintained
Read the detailed description
The study is a prospective, single-center interventional trial including adult patients diagnosed with chronic ulnar nerve injury affecting pinch function. Eligible participants will undergo combined ECRB (Extensor Carpi Radialis Brevis) tendon transfer to adductor pollicis tendon and APL (Abductor Pollicis Longus) tendon transfer to 1st dorsal interosseous tendon that performed by experienced surgeons. Preoperative evaluation includes baseline hand function, pinch strength, and disability assessment. Postoperative follow-up will occur at 4, 6, 12, and 24 weeks to measure functional improvement using standardized hand assessment tools. Adverse events will be monitored and recorded. Inclusion criteria: adults ≥18 years, chronic ulnar nerve injury >6 months, and consent to participate. Exclusion criteria: prior tendon transfer, coexisting neuromuscular disorder, or inability to provide consent. Data will be anonymized to maintain confidentiality, and all ethical approvals will be in place.
- Conditions
- Chronic Ulnar Nerve Injury
- Being tested
- Combined ECRB and APL Tendon Transfer
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Combined ECRB and APL Tendon TransferProcedure or surgery
This surgical procedure involves transferring the Extensor Carpi Radialis Brevis (ECRB) and Abductor Pollicis Longus (APL) tendons to restore pinch function in patients with chronic ulnar nerve injury. Standard postoperative physiotherapy will follow, with assessments at 4, 6, and 12 weeks to monitor pinch strength, thumb mobility, and any complications
| Study group | Role | What they receive |
|---|---|---|
| ECRB and APL Tendon Transfer | Experimental | ECRB transfer transfer to adductor pollicis and APL tendon transfer to 1st dorsal interosseous muscle for pinch restoration in chronic ulnar nerve injury Receives: Procedure: Combined ECRB and APL Tendon Transfer |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean Grip Strength of the Operated Hand Measured Using a Hand Dynamometer (kg)
Grip strength of the operated hand will be assessed using a calibrated hand dynamometer. Three consecutive measurements will be obtained during the same session, and the average value will be calculated and reported in kilograms.
Measured: 6 months postoperatively
Secondary outcomes (1)
DASH Score (Disabilities of the Arm, Shoulder and Hand Questionnaire)
Functional outcome will be assessed using the DASH questionnaire. The total score ranges from 0 to 100, with higher scores indicating greater disability. The overall total score will be reported.
Measured: 3 months postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study start18 Nov 2025
- Primary completion20 Dec 2025
- Study completion20 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Ulnar Nerve InjuryStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Participants will be assigned to intervention or control arms to evaluate functional improvement after ECRB and APL tendon transfer. Each participant will undergo baseline assessment of hand function, and post-operative follow-ups will assess pinch restoration, grip strength, and dexterity
- Masking
- None (open label)
- Enrolment
- 17 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mostafa Elsayed Mohamed, Sohag University
- Investigators
- Mostafa Elsayed, Principal investigator, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07434999
- Sponsor's protocol ID
- Soh_Med_26_2_5MS
- Status last verified
- Feb 2026
- First submitted
- 19 Feb 2026
- Last updated
- 27 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be made publicly available.
Study at a glance
From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Combined ECRB and APL Tendon Transfer for Pinch Restoration in Chronic Ulnar Nerve Injury
- ClinicalTrials.gov ID
- NCT07434999
- Acronym / sponsor ID
- Soh_Med_26_2_5MS
- Conditions
- Chronic Ulnar Nerve Injury
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 17 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 18 Nov 2025 (actual)
- Primary completion
- 20 Dec 2025 (actual)
- Study completion
- 20 Dec 2026 (estimated)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective study evaluates the outcomes of combined ECRB and APL tendon transfer for restoring pinch function in patients with chronic ulnar nerve injury. Patients will be followed postoperatively to assess improvement in hand function, strength, and daily activity performance. Participation is voluntary and all standard care procedures will be maintained
Detailed description
The study is a prospective, single-center interventional trial including adult patients diagnosed with chronic ulnar nerve injury affecting pinch function. Eligible participants will undergo combined ECRB (Extensor Carpi Radialis Brevis) tendon transfer to adductor pollicis tendon and APL (Abductor Pollicis Longus) tendon transfer to 1st dorsal interosseous tendon that performed by experienced surgeons. Preoperative evaluation includes baseline hand function, pinch strength, and disability assessment. Postoperative follow-up will occur at 4, 6, 12, and 24 weeks to measure functional improvement using standardized hand assessment tools. Adverse events will be monitored and recorded. Inclusion criteria: adults ≥18 years, chronic ulnar nerve injury >6 months, and consent to participate. Exclusion criteria: prior tendon transfer, coexisting neuromuscular disorder, or inability to provide consent. Data will be anonymized to maintain confidentiality, and all ethical approvals will be in place.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Participants will be assigned to intervention or control arms to evaluate functional improvement after ECRB and APL tendon transfer. Each participant will undergo baseline assessment of hand function, and post-operative follow-ups will assess pinch restoration, grip strength, and dexterity
| Arm | Type | Receives |
|---|---|---|
| ECRB and APL Tendon Transfer | Experimental | Procedure: Combined ECRB and APL Tendon TransferECRB transfer transfer to adductor pollicis and APL tendon transfer to 1st dorsal interosseous muscle for pinch restoration in chronic ulnar nerve injury |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients with chronic ulnar nerve injury (more than 1 year duration).
- Age between 18 and 60 years.
- Patients with stable joints and good passive range of motion of the hand and fingers.
- Absence of active infection or severe contracture.
Key exclusion criteria (3 listed)
- • Patients with combined median or radial nerve injury.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Combined ECRB and APL Tendon TransferThis surgical procedure involves transferring the Extensor Carpi Radialis Brevis (ECRB) and Abductor Pollicis Longus (APL) tendons to restore pinch function in patients with chronic ulnar nerve injury. Standard postoperative physiotherapy will follow, with assessments at 4, 6, and 12 weeks to monitor pinch strength, thumb mobility, and any complications | Procedure or surgery | ECRB and APL Tendon Transfer |
Primary outcome
Mean Grip Strength of the Operated Hand Measured Using a Hand Dynamometer (kg)
Time frame: 6 months postoperatively
Grip strength of the operated hand will be assessed using a calibrated hand dynamometer. Three consecutive measurements will be obtained during the same session, and the average value will be calculated and reported in kilograms.
1 secondary outcome
DASH Score (Disabilities of the Arm, Shoulder and Hand Questionnaire)
Time frame: 3 months postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be made publicly available.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mostafa Elsayed principal investigator
Sohag University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Combined ECRB and APL Tendon Transfer in people with Chronic Ulnar Nerve Injury, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean Grip Strength of the Operated Hand Measured Using a Hand Dynamometer (kg) (time frame: 6 months postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026.