Missing Maxillary Anterior TeethLiDi-VFDPNCT07434700
Clinical Performance of Lithium Disilicate Veneer-Fixed Dental Prostheses for Incisor Tooth Replacement
An observational study of Missing Maxillary Anterior Teeth, run by Damascus University.
Trial summary
This study evaluated a conservative treatment approach for replacing a missing upper front tooth (maxillary incisor). The treatment involved an all-ceramic, resin-bonded fixed dental prosthesis designed as a minimally invasive alternative to conventional bridges. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Missing Maxillary Anterior Teeth
- What is being tested?
- Lithium disilicate double retainer veneer bridge and Lithium disilicate single retainer veneer bridge
- Type of treatment
- Medical device
- How many people
- 23 participants
- Where
- No sites listed yet
- Study dates
- 3 Oct 2011to 1 Dec 2014
- How long will I take part?
- 12 Months
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Group of people > 18 years old with no parafunctional habit
Who may be able to join
- Patients with a missing maxillary incisor replaced with a veneer fixed dental prosthesis
- Intact adjacent teeth suitable to serve as abutments
- Adequate periodontal health and bone support of adjacent teeth
- Age 18 years or older
- Minimum of 12 months clinical follow-up available
Who cannot join
- Patients younger than 18 years
- Adjacent teeth with extensive restorations, structural compromise, or inadequate enamel for bonding
- Active periodontal disease affecting abutment teeth
- Presence of parafunctional habits (e.g., bruxism or clenching)
- Insufficient follow-up (< 12 months)
- Incomplete clinical records
About this study
Official title: Lithium Disilicate Veneer-Fixed Dental Prostheses for Anterior Tooth Replacement: Clinical Case Series
This study evaluated a conservative treatment approach for replacing a missing upper front tooth (maxillary incisor). The treatment involved an all-ceramic, resin-bonded fixed dental prosthesis designed as a minimally invasive alternative to conventional bridges.
The prostheses were fabricated from lithium disilicate glass-ceramic and were designed either with a single retainer (bonded to one adjacent tooth) or with two retainers (bonded to two adjacent teeth). All restorations were bonded using light-curing resin cement.
The study assessed the clinical performance of these prostheses over a follow-up period of at least 12 months. Clinical evaluation included assessment of prosthesis integrity and function during the observation period.
Read the detailed description
This retrospective case series evaluated the short-term clinical performance of veneer fixed dental prostheses used to replace a missing maxillary incisor. The prostheses were fabricated from lithium disilicate glass-ceramic (IPS e.max Press).
The retainers consisted of labial ceramic veneers bonded to the enamel surfaces of adjacent teeth. Two prosthetic designs were included: a single-retainer (cantilever) design and a two-retainer design. All veneer retainers were cemented using a light-curing resin cement according to standard adhesive clinical procedures.
Existing patient records were reviewed to assess prosthesis survival and clinical success during follow-up visits. Survival was defined as the prosthesis remaining in situ during the observation period. Clinical success was evaluated based on prosthesis integrity, maintenance of function, and absence of technical complications such as fracture or loss of retention. Follow-up duration was at least 12 months after cementation.
- Conditions
- Missing Maxillary Anterior Teeth
- Being tested
- Lithium disilicate double retainer veneer bridge, Lithium disilicate single retainer veneer bridge
- Keywords
- Resin-bonded fixed partial dentures, Resin-bonded bridge, veneer bridge, Lithium disilicate glass ceramic, All-ceramic resin-bonded bridge, All-ceramic veneer bridge
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lithium disilicate double retainer veneer bridgeDevice
Replacing missing maxillary incisor with single retainer lithium disilicate veneer bridge
Lithium disilicate single retainer veneer bridgeDevice
Replacing missing maxillary incisor with double retainer lithium disilicate veneer bridge
| Study group | Role | What they receive |
|---|---|---|
| Patient with missing maxillary incisor | Adult patients that have missing an incisor which needs replacement Receives: Device: Lithium disilicate double retainer veneer bridge; Device: Lithium disilicate single retainer veneer bridge |
What is being measured
The primary outcome is the main question the study is designed to answer.
Success rate
The percentage of successful emax veneer briges
Measured: 12 months
Success rate
The percentage of clinically successful bridge after the observation time
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Feb 2026
- Study start3 Oct 2011
- Primary completion1 Dec 2014
- Study completion1 Dec 2014
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Missing Maxillary Anterior TeethStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Other
- Enrolment
- 23 participants (actual)
- Target duration
- 12 Months
Sponsor and investigators
- Lead sponsor
- Damascus University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Nabil Alhouri, PhD, Study director, Damascus University, Faculty of Dentistry
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07434700
- Sponsor's protocol ID
- UDDS-Prosth-2025-10
- Acronym
- LiDi-VFDP
- Status last verified
- Feb 2026
- First submitted
- 15 Feb 2026
- Last updated
- 25 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No: Study was done from 2011 to 2015
Publications
Al-Bermani ASA, Quigley NP, Ha WN. Do zirconia single-retainer resin-bonded fixed dental prostheses present a viable treatment option for the replacement of missing anterior teeth? A systematic review and meta-analysis. J Prosthet Dent. 2023 Oct;130(4):533-542. doi: 10.1016/j.prosdent.2021.10.015. Epub 2021 Dec 7.
PubMed 34893319Chen J, Cai H, Ren X, Suo L, Pei X, Wan Q. A Systematic Review of the Survival and Complication Rates of All-Ceramic Resin-Bonded Fixed Dental Prostheses. J Prosthodont. 2018 Jul;27(6):535-543. doi: 10.1111/jopr.12678. Epub 2017 Oct 6.
PubMed 28985448
Study at a glance
From the registry record, last updated by the sponsor on 25 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Lithium Disilicate Veneer-Fixed Dental Prostheses for Anterior Tooth Replacement: Clinical Case Series
- ClinicalTrials.gov ID
- NCT07434700
- Acronym / sponsor ID
- LiDi-VFDP / UDDS-Prosth-2025-10
- Conditions
- Missing Maxillary Anterior Teeth
- Keywords
- Resin-bonded fixed partial dentures, Resin-bonded bridge, veneer bridge, Lithium disilicate glass ceramic, All-ceramic resin-bonded bridge, All-ceramic veneer bridge
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 23 participants (actual)
- Lead sponsor
- Damascus UniversityUniversity, hospital or other
- Study start
- 3 Oct 2011 (actual)
- Primary completion
- 1 Dec 2014 (actual)
- Study completion
- 1 Dec 2014 (actual)
- First posted
- 25 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated a conservative treatment approach for replacing a missing upper front tooth (maxillary incisor). The treatment involved an all-ceramic, resin-bonded fixed dental prosthesis designed as a minimally invasive alternative to conventional bridges.
The prostheses were fabricated from lithium disilicate glass-ceramic and were designed either with a single retainer (bonded to one adjacent tooth) or with two retainers (bonded to two adjacent teeth). All restorations were bonded using light-curing resin cement.
The study assessed the clinical performance of these prostheses over a follow-up period of at least 12 months. Clinical evaluation included assessment of prosthesis integrity and function during the observation period.
Detailed description
This retrospective case series evaluated the short-term clinical performance of veneer fixed dental prostheses used to replace a missing maxillary incisor. The prostheses were fabricated from lithium disilicate glass-ceramic (IPS e.max Press).
The retainers consisted of labial ceramic veneers bonded to the enamel surfaces of adjacent teeth. Two prosthetic designs were included: a single-retainer (cantilever) design and a two-retainer design. All veneer retainers were cemented using a light-curing resin cement according to standard adhesive clinical procedures.
Existing patient records were reviewed to assess prosthesis survival and clinical success during follow-up visits. Survival was defined as the prosthesis remaining in situ during the observation period. Clinical success was evaluated based on prosthesis integrity, maintenance of function, and absence of technical complications such as fracture or loss of retention. Follow-up duration was at least 12 months after cementation.
Study design
- Observational model
- Case-control
- Time perspective
- Other
- Target follow-up
- 12 Months
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patient with missing maxillary incisor | – | Device: Lithium disilicate double retainer veneer bridge, Device: Lithium disilicate single retainer veneer bridgeAdult patients that have missing an incisor which needs replacement |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Group of people > 18 years old with no parafunctional habit
Key inclusion criteria (5 listed)
- Patients with a missing maxillary incisor replaced with a veneer fixed dental prosthesis
- Intact adjacent teeth suitable to serve as abutments
- Adequate periodontal health and bone support of adjacent teeth
- Age 18 years or older
- Minimum of 12 months clinical follow-up available
Key exclusion criteria (6 listed)
- Patients younger than 18 years
- Adjacent teeth with extensive restorations, structural compromise, or inadequate enamel for bonding
- Active periodontal disease affecting abutment teeth
- Presence of parafunctional habits (e.g., bruxism or clenching)
- Insufficient follow-up (< 12 months)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Lithium disilicate double retainer veneer bridgeReplacing missing maxillary incisor with single retainer lithium disilicate veneer bridge | Device | Patient with missing maxillary incisor |
| Lithium disilicate single retainer veneer bridgeReplacing missing maxillary incisor with double retainer lithium disilicate veneer bridge | Device | Patient with missing maxillary incisor |
Primary outcome
Success rate
Time frame: 12 months
The percentage of successful emax veneer briges
Success rate
Time frame: 12 months
The percentage of clinically successful bridge after the observation time
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Feb 2026.
- Background: PubMed 34893319Al-Bermani ASA, Quigley NP, Ha WN. Do zirconia single-retainer resin-bonded fixed dental prostheses present a viable treatment option for the replacement of missing anterior teeth? A systematic review and meta-analysis. J Prosthet Dent. 2023 Oct;130(4):533-542. doi: 10.1016/j.prosdent.2021.10.015. Epub 2021 Dec 7.
- Background: PubMed 28985448Chen J, Cai H, Ren X, Suo L, Pei X, Wan Q. A Systematic Review of the Survival and Complication Rates of All-Ceramic Resin-Bonded Fixed Dental Prostheses. J Prosthodont. 2018 Jul;27(6):535-543. doi: 10.1111/jopr.12678. Epub 2017 Oct 6.
- Individual participant dataSharing planned: No. Study was done from 2011 to 2015
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Nabil Alhouri, PhD study director
Damascus University, Faculty of Dentistry
Questions about this trial
What is this clinical trial studying?
An observational study of Missing Maxillary Anterior Teeth, run by Damascus University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Success rate (time frame: 12 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07434700, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2026.