Dentin HypersensitivityNCT07431736
Laser Therapy for Dentin Hypersensitivity
A study testing Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD and Remin Pro (VOCO, Cuxhaven, Germany) in people with Dentin Hypersensitivity, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
This split-mouth randomized controlled clinical trial compared the effectiveness of Er,Cr:YSGG laser irradiation, a hydroxyapatite- and fluoride-containing agent (Remin Pro), and their combined application in the treatment of dentin hypersensitivity over 3 months, and evaluated changes in oral health-related quality… Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Dentin Hypersensitivity
- What is being tested?
- Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD and Remin Pro (VOCO, Cuxhaven, Germany)
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 11 Nov 2025to 18 Feb 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18 and 70 years
- Voluntary agreement to participate in the study and written informed consent
- Not receiving any analgesic therapy
- No systemic disease that could interfere with the treatment outcomes
- Not pregnant or breastfeeding
- At least three teeth with a Visual Analog Scale (VAS) score of 4 or higher
Show all 10Show fewer
- No tooth substance loss of sufficient depth to require restorative treatment
- No extensive or defective restorations or caries in the sensitive teeth
- No pulpitis
- No hypersensitivity associated with periodontal procedures
Who cannot join
- Age younger than 18 years or older than 70 years
- Unwillingness to participate in the study voluntarily
- Receiving any analgesic therapy
- Systemic disease that could interfere with the treatment outcomes
- Pregnancy or breastfeeding
- Tooth substance loss of sufficient depth to require restorative treatment, or enamel fracture
Show all 10Show fewer
- Extensive or defective restorations or caries in the sensitive teeth
- Pulpitis
- Periodontal treatment within the previous 3 months with persistent hypersensitivity related to that treatment
- Use of a desensitizing dentifrice or mouthrinse within the previous 3 months
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Clinical Evaluation of Laser Therapy for Dentin Hypersensitivity
This split-mouth randomized controlled clinical trial compared the effectiveness of Er,Cr:YSGG laser irradiation, a hydroxyapatite- and fluoride-containing agent (Remin Pro), and their combined application in the treatment of dentin hypersensitivity over 3 months, and evaluated changes in oral health-related quality of life using the OHIP-14 questionnaire.
Read the detailed description
This single-center, split-mouth randomized controlled clinical trial was conducted at the Department of Restorative Dentistry, Faculty of Dentistry, Hacettepe University. Twenty-five patients aged 18-70 years with at least three hypersensitive teeth (baseline visual analog scale [VAS] score of 4 or higher) were enrolled, and a total of 90 teeth were included. In each patient, eligible teeth were grouped into sets of three and randomly allocated to the three treatment protocols using a computer-generated random number table (www.randomizer.org), so that every patient received all three treatments. All treatments were performed in a single session by one operator, and sensitivity assessments and questionnaires were carried out by a second examiner who was blinded to the treatment assigned to each tooth. Participants were instructed not to use dentifrices or other oral-care products with desensitizing ingredients throughout the study. In Group I (Remin Pro), after cotton-roll isolation, a pea-sized amount of Remin Pro (VOCO GmbH, Cuxhaven, Germany; hydroxyapatite, sodium fluoride and xylitol) was applied to the exposed cervical surface with a disposable microbrush, left in place for 3 minutes in accordance with the manufacturer's instructions, and the excess was removed with a cotton pellet. In Group II (Er,Cr:YSGG laser), teeth were irradiated with an Er,Cr:YSGG laser (Waterlase, Biolase, Irvine, CA, USA; 2780 nm, 20 Hz, 140 microseconds pulse duration, 0% water and 10% air) using an MZ6 sapphire tip in non-contact mode at a distance of 1-2 mm with continuous scanning movements, and the output power was increased stepwise from 0.10 W for 30 seconds to 0.25 W for a further 30 seconds (total irradiation time 60 seconds). In Group III (combination), the laser protocol of Group II was performed first, immediately followed by the application of Remin Pro as described for Group I. Dentin hypersensitivity was assessed in response to a 1-second evaporative air stimulus using the VAS (primary outcome) and the Schiff Cold Air Sensitivity Scale (secondary outcome) at baseline, immediately after treatment, and at 1 week, 1 month and 3 months, and the response to a tactile stimulus was recorded as present or absent. Oral health-related quality of life was evaluated with the Oral Health Impact Profile-14 (OHIP-14) questionnaire at baseline, 1 month and 3 months.
- Conditions
- Dentin Hypersensitivity
- Being tested
- Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD, Remin Pro (VOCO, Cuxhaven, Germany)
- Keywords
- Remin Pro, Er,Cr:YSGG
- Medical subject headings
- Dentin Sensitivity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABDDevice
Er,Cr;YSGG Laser
Remin Pro (VOCO, Cuxhaven, Germany)Device
a hydroxyapatite-containing remineralizing agent
| Study group | Role | What they receive |
|---|---|---|
| Er,Cr:YSGG Laser | Experimental | Teeth allocated to this arm were irradiated in a single session with an Er,Cr:YSGG laser (2780 nm; Waterlase, Biolase Technology Inc., Irvine, CA, USA) at 20 Hz, 140 microseconds pulse duration, 0% water and 10% air, using an MZ6 sapphire tip in non-contact mode at a distance of 1-2 mm with continuous scanning movements. The output power was increased stepwise from 0.10 W for 30 seconds to 0.25 W for a further 30 seconds (total irradiation time 60 seconds). Receives: Device: Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD |
| Remin Pro, a hydroxyapatite-containing remineralizing agent | Experimental | Remin Pro (VOCO, Cuxhaven, Germany) is a desensitizing paste containing hydroxyapatite, sodium fluoride and xylitol. Teeth allocated to this arm were isolated with cotton rolls, and a pea-sized amount of Remin Pro was applied to the exposed cervical surface with a disposable microbrush in a single session, left in place for 3 minutes in accordance with the manufacturer's instructions, and the excess was removed with a cotton pellet. Receives: Device: Remin Pro (VOCO, Cuxhaven, Germany) |
| Combined Therapy: Er,Cr:YSGG Laser + Remin Pro | Experimental | The laser protocol described for the Er,Cr:YSGG laser arm was performed first, immediately followed by the application of Remin Pro as described for the Remin Pro arm, in a single session. Receives: Device: Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD; Device: Remin Pro (VOCO, Cuxhaven, Germany) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Visual Analog Scale
Subjective pain intensity was evaluated with a 10-cm horizontal Visual Analog Scale (VAS) anchored by 0 (no pain) and 10 (unbearable pain). Immediately after a 1-second air stimulus applied to the exposed cervical dentin, participants marked their perceived pain intensity on the scale; scores range from 0 to 10, with higher values indicating greater pain.
Measured: Baseline, immediately after treatment, 1 week, 1 month and 3 months
Secondary outcomes (2)
Schiff Cold Air Sensitivity Scale
Examiner-rated sensitivity was evaluated using the Schiff Cold Air Sensitivity Scale (0-3) in response to a 1-second air stimulus: 0, no response; 1, response without discomfort; 2, response with discomfort or a request to discontinue the stimulus; 3, severe pain with withdrawal of the head or body. Higher scores indicate greater dentin hypersensitivity.
Measured: Baseline, immediately after treatment, 1 week, 1 month and 3 months
Oral Health Impact Profile-14 (OHIP-14) score
Oral health-related quality of life was evaluated at the patient level with the 14-item Oral Health Impact Profile (OHIP-14) questionnaire. The total score ranges from 0 to 56, with higher scores indicating poorer oral health-related quality of life.
Measured: Baseline, 1 month and 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Feb 2026
- Study start11 Nov 2025
- Primary completion18 Feb 2026
- Study completion18 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Dentin HypersensitivityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Split-mouth design: in each patient, eligible teeth were allocated in sets of three to the three treatment protocols, so that every patient received all three treatments.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 25 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ezgi Yesim Aybek Firat, Hacettepe University
- Investigators
- Ayse Ruya Yazici, Prof., Study director, Hacettepe UniversityEzgi Yesim Aybek Firat, Principal investigator, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07431736
- Sponsor's protocol ID
- E-61749811-000-4041535
- Status last verified
- Oct 2026
- First submitted
- 19 Feb 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
AlHabdan A, AlAhmari F. Phototherapy Using Er,Cr:YSGG Laser as a Definitive Treatment for Dentin Hypersensitivity: A Systematic Review. Int J Gen Med. 2022 May 11;15:4871-4880. doi: 10.2147/IJGM.S355890. eCollection 2022.
PubMed 35592535Shukla K, Saxena A, Joshi J, Jain D. A Comparative Study of the Effect of Tooth Mousse Plus Remin Pro and Fluor Protector Gel on Enamel Erosion: An In Vitro Study. Int J Clin Pediatr Dent. 2023 Aug;16(Suppl 1):S57-S62. doi: 10.5005/jp-journals-10005-2602.
PubMed 37663219
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Evaluation of Laser Therapy for Dentin Hypersensitivity
- ClinicalTrials.gov ID
- NCT07431736
- Acronym / sponsor ID
- E-61749811-000-4041535
- Conditions
- Dentin Hypersensitivity
- Keywords
- Remin Pro, Er,Cr:YSGG
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 25 participants (actual)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 11 Nov 2025 (actual)
- Primary completion
- 18 Feb 2026 (actual)
- Study completion
- 18 Feb 2026 (actual)
- First posted
- 25 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This split-mouth randomized controlled clinical trial compared the effectiveness of Er,Cr:YSGG laser irradiation, a hydroxyapatite- and fluoride-containing agent (Remin Pro), and their combined application in the treatment of dentin hypersensitivity over 3 months, and evaluated changes in oral health-related quality of life using the OHIP-14 questionnaire.
Detailed description
This single-center, split-mouth randomized controlled clinical trial was conducted at the Department of Restorative Dentistry, Faculty of Dentistry, Hacettepe University. Twenty-five patients aged 18-70 years with at least three hypersensitive teeth (baseline visual analog scale [VAS] score of 4 or higher) were enrolled, and a total of 90 teeth were included. In each patient, eligible teeth were grouped into sets of three and randomly allocated to the three treatment protocols using a computer-generated random number table (www.randomizer.org), so that every patient received all three treatments. All treatments were performed in a single session by one operator, and sensitivity assessments and questionnaires were carried out by a second examiner who was blinded to the treatment assigned to each tooth. Participants were instructed not to use dentifrices or other oral-care products with desensitizing ingredients throughout the study. In Group I (Remin Pro), after cotton-roll isolation, a pea-sized amount of Remin Pro (VOCO GmbH, Cuxhaven, Germany; hydroxyapatite, sodium fluoride and xylitol) was applied to the exposed cervical surface with a disposable microbrush, left in place for 3 minutes in accordance with the manufacturer's instructions, and the excess was removed with a cotton pellet. In Group II (Er,Cr:YSGG laser), teeth were irradiated with an Er,Cr:YSGG laser (Waterlase, Biolase, Irvine, CA, USA; 2780 nm, 20 Hz, 140 microseconds pulse duration, 0% water and 10% air) using an MZ6 sapphire tip in non-contact mode at a distance of 1-2 mm with continuous scanning movements, and the output power was increased stepwise from 0.10 W for 30 seconds to 0.25 W for a further 30 seconds (total irradiation time 60 seconds). In Group III (combination), the laser protocol of Group II was performed first, immediately followed by the application of Remin Pro as described for Group I. Dentin hypersensitivity was assessed in response to a 1-second evaporative air stimulus using the VAS (primary outcome) and the Schiff Cold Air Sensitivity Scale (secondary outcome) at baseline, immediately after treatment, and at 1 week, 1 month and 3 months, and the response to a tactile stimulus was recorded as present or absent. Oral health-related quality of life was evaluated with the Oral Health Impact Profile-14 (OHIP-14) questionnaire at baseline, 1 month and 3 months.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- Split-mouth design: in each patient, eligible teeth were allocated in sets of three to the three treatment protocols, so that every patient received all three treatments.
| Arm | Type | Receives |
|---|---|---|
| Er,Cr:YSGG Laser | Experimental | Device: Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABDTeeth allocated to this arm were irradiated in a single session with an Er,Cr:YSGG laser (2780 nm; Waterlase, Biolase Technology Inc., Irvine, CA, USA) at 20 Hz, 140 microseconds pulse duration, 0% water and 10% air, using an MZ6 sapphire tip in non-contact mode at a distance of 1-2 mm with continuous scanning movements. The output power was increased stepwise from 0.10 W for 30 seconds to 0.25 W for a further 30 seconds (total irradiation time 60 seconds). |
| Remin Pro, a hydroxyapatite-containing remineralizing agent | Experimental | Device: Remin Pro (VOCO, Cuxhaven, Germany)Remin Pro (VOCO, Cuxhaven, Germany) is a desensitizing paste containing hydroxyapatite, sodium fluoride and xylitol. Teeth allocated to this arm were isolated with cotton rolls, and a pea-sized amount of Remin Pro was applied to the exposed cervical surface with a disposable microbrush in a single session, left in place for 3 minutes in accordance with the manufacturer's instructions, and the excess was removed with a cotton pellet. |
| Combined Therapy: Er,Cr:YSGG Laser + Remin Pro | Experimental | Device: Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD, Device: Remin Pro (VOCO, Cuxhaven, Germany)The laser protocol described for the Er,Cr:YSGG laser arm was performed first, immediately followed by the application of Remin Pro as described for the Remin Pro arm, in a single session. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- Age between 18 and 70 years
- Voluntary agreement to participate in the study and written informed consent
- Not receiving any analgesic therapy
- No systemic disease that could interfere with the treatment outcomes
- Not pregnant or breastfeeding
Key exclusion criteria (10 listed)
- Age younger than 18 years or older than 70 years
- Unwillingness to participate in the study voluntarily
- Receiving any analgesic therapy
- Systemic disease that could interfere with the treatment outcomes
- Pregnancy or breastfeeding
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABDEr,Cr;YSGG Laser | Device | Combined Therapy: Er,Cr:YSGG Laser + Remin Pro, Er,Cr:YSGG Laser |
| Remin Pro (VOCO, Cuxhaven, Germany)a hydroxyapatite-containing remineralizing agent | Device | Combined Therapy: Er,Cr:YSGG Laser + Remin Pro, Remin Pro, a hydroxyapatite-containing remineralizing agent |
Primary outcome
Visual Analog Scale
Time frame: Baseline, immediately after treatment, 1 week, 1 month and 3 months
Subjective pain intensity was evaluated with a 10-cm horizontal Visual Analog Scale (VAS) anchored by 0 (no pain) and 10 (unbearable pain). Immediately after a 1-second air stimulus applied to the exposed cervical dentin, participants marked their perceived pain intensity on the scale; scores range from 0 to 10, with higher values indicating greater pain.
2 secondary outcomes
Schiff Cold Air Sensitivity Scale
Time frame: Baseline, immediately after treatment, 1 week, 1 month and 3 months
Oral Health Impact Profile-14 (OHIP-14) score
Time frame: Baseline, 1 month and 3 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Background: PubMed 35592535AlHabdan A, AlAhmari F. Phototherapy Using Er,Cr:YSGG Laser as a Definitive Treatment for Dentin Hypersensitivity: A Systematic Review. Int J Gen Med. 2022 May 11;15:4871-4880. doi: 10.2147/IJGM.S355890. eCollection 2022.
- Background: PubMed 37663219Shukla K, Saxena A, Joshi J, Jain D. A Comparative Study of the Effect of Tooth Mousse Plus Remin Pro and Fluor Protector Gel on Enamel Erosion: An In Vitro Study. Int J Clin Pediatr Dent. 2023 Aug;16(Suppl 1):S57-S62. doi: 10.5005/jp-journals-10005-2602.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ayse Ruya Yazici, Prof. study director
Hacettepe University
Ezgi Yesim Aybek Firat principal investigator
Hacettepe University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Er,Cr;YSGG Laser, Waterlase, Biolase Technology Inc., Irvine, CA, ABD and Remin Pro (VOCO, Cuxhaven, Germany) in people with Dentin Hypersensitivity, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Visual Analog Scale (time frame: Baseline, immediately after treatment, 1 week, 1 month and 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07431736, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.