Cerebral PalsyNCT07428928
Effects of Play Based Neural Mobilisation Activities on Hand Grip Strength and Dexterity in Cerebral Palsy Children
A study testing neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. and Regular physical therapy in people with Cerebral Palsy, run by Riphah International University at 1 site in Pakistan.
Trial summary
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Read more about this study
- Who is it for?
- Ages 6 to 12 years
- Conditions the study is for
- Cerebral Palsy
- What is being tested?
- neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. and Regular physical therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 sitePakistan
- Study dates
- 29 Oct 2025to 20 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 12 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Diplegic cerebral palsy patients
- Both Girls and boys included
- Age limit 6-12 years
- CP child with Gross Motor Function Classification System (GMFCS) level III and IV(20)
- CP child at MACS level II and III
Who cannot join
- • Patients with history of injury in 1 year.
- Patients who cannot obey commands
- CP children with associated scoliosis
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Acme Medical center, Liaqat medical center
Lahore, Punjab Province, 54000
IMRAN AMJAD, PhD, 9233224390125, imran.amjad@riphah.edu.pk
Muhammad Asif Javed, MS-PT, 923224209422, a.javed@riphah.edu.pk
About this study
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.
Read the detailed description
Examining the UL's hand grip strength is arguably the best method to determine its overall consistency. Everybody's everyday life depends on their upper limbs. For people to function at their best, a number of sensorimotor factors are required, including hand grip strength. Dexterity is a manual skill that requires quick synchronization of voluntary gross and fine movements. It is built on a number of abilities that are developed via education, practice, and experience. It is commonly known as the "ability to use the hand in daily activities based on the anatomical integrity, sensation, coordination, strength, and dexterity." Both manual dexterity and grip strength are necessary for work-related tasks as well as play, leisure, and self-care activities. Neural mobilization (NM), a treatment approach used to treat patients with musculoskeletal disorders, has demonstrated promise in lowering pain and enhancing functionality. Combinations of joint motions that facilitate the gliding or tensioning of neural tissue make up NM, which can be carried out actively by the patient or passively by the healthcare provider. It is thought to promote axoplasmic flow, neural vascularity, and nerve gliding in relation to surrounding tissues, all of which lead to better neural functioning and, ultimately, better motor and sensory performance. The aim of study is to determine the effects of play based neural mobilization activities on hand grip strength and dexterity in cerebral palsy.
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.
- Conditions
- Cerebral Palsy
- Being tested
- neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment., Regular physical therapy
- Keywords
- Cerebral palsy, Diplegic, Exercise, Hand strength, Spastic
- Medical subject headings
- Cerebral Palsy, Motor Activity, Muscle Spasticity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment.Other
treatment include muscle stretching, strengthening, gait training, Range of motion exercises for both upper and lower limbs. Group A will perform neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. Total 20 sessions will be performed (40 min, 3 days a week)
Regular physical therapyOther
Regular physical therapy was administered to the control group along with baseline care. These workouts included upper and lower limb range of motion activities, gait training, strengthening exercises, and stretching exercises.
| Study group | Role | What they receive |
|---|---|---|
| Group A: intervention group (routine physical therapy +play based neural mobilisation) | Active comparator | movements that are advantageous for neural mobility will be used to incorporate neural mobilization. Total 20 sessions will be performed (40 min, 3 days a week) Receives: Other: neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. |
| Group B:control Group( routine physical Therapy) | Active comparator | exercises will be stretching exercises, strengthening exercises, gait training, range of motion exercises of upper and lower limbs. Total 20 sessions will be performed (40 min, 3 days a week). Receives: Other: Regular physical therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hand Dynamometer for hand grip strength
Handgrip dynamometers are employed for a wide range of purposes. Assessing general strength is the most widely used method for comparing muscular function across groups, evaluating the course of wasting disorders such as sarcopenia, and even identifying prospective deficits. In order to quantify the strength of various muscles that are directly linked to a pathological condition, such as rotator cuff strength, handgrip dynamometers are also utilized as functional evaluation instruments. Handgrip dynamometers are mostly used for evaluation in the rehabilitation process, such as monitoring general rehabilitation progress or assessing the impact of a particular rehabilitation regimen aimed at a grip strength issue, such as shoulder impingement syndrome. Strong handgrips are essential for independent and fulfilling daily functioning
Measured: baseline, 16th weeks
Pegboard test for Dexterity
The functional dexterity test (FDT), a timed pegboard test that involves manipulating each peg, is appropriate for young children due to its ease of use and speed. The 16-hole wooden pegboard used for the FDT is set up in four rows of four, with each peg hole that is 2.5 cm in diameter, 3 cm deep, and 2 cm away from the neighboring peg holes. Every patient will be requested to take a seat in a chair facing the FDT pegboard on a table. The patients will be instructed to practice by flipping every peg on the board once. After the test will be completed, the examiner will note how long it take to complete the test
Measured: baseline, 16th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Feb 2026
- Study start29 Oct 2025
- Primary completion20 Feb 2026 (estimated)
- Study completion20 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cerebral PalsyStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 34 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Uzma Irshad, MS-PT, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07428928
- Sponsor's protocol ID
- REC/RCR&AHS/UZMAIRSHAD
- Status last verified
- Feb 2026
- First submitted
- 18 Nov 2025
- Last updated
- 24 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Baptista FM, Cruz EB, Afreixo V, Silva AG. Effectiveness of neural mobilization on pain intensity, disability, and physical performance in adults with musculoskeletal pain-A protocol for a systematic review of randomized and quasi-randomized controlled trials and planned meta-analysis. PLoS One. 2022 Mar 10;17(3):e0264230. doi: 10.1371/journal.pone.0264230. eCollection 2022.
PubMed 35271600
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Play Based Neural Mobilisation Activities on Hand Grip Strength and Dexterity in Cerebral Palsy Children
- ClinicalTrials.gov ID
- NCT07428928
- Acronym / sponsor ID
- REC/RCR&AHS/UZMAIRSHAD
- Conditions
- Cerebral Palsy
- Keywords
- Cerebral palsy, Diplegic, Exercise, Hand strength, Spastic
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 34 participants (estimated)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 29 Oct 2025 (actual)
- Primary completion
- 20 Feb 2026 (estimated)
- Study completion
- 20 Feb 2026 (estimated)
- First posted
- 24 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.
Detailed description
Examining the UL's hand grip strength is arguably the best method to determine its overall consistency. Everybody's everyday life depends on their upper limbs. For people to function at their best, a number of sensorimotor factors are required, including hand grip strength. Dexterity is a manual skill that requires quick synchronization of voluntary gross and fine movements. It is built on a number of abilities that are developed via education, practice, and experience. It is commonly known as the "ability to use the hand in daily activities based on the anatomical integrity, sensation, coordination, strength, and dexterity." Both manual dexterity and grip strength are necessary for work-related tasks as well as play, leisure, and self-care activities. Neural mobilization (NM), a treatment approach used to treat patients with musculoskeletal disorders, has demonstrated promise in lowering pain and enhancing functionality. Combinations of joint motions that facilitate the gliding or tensioning of neural tissue make up NM, which can be carried out actively by the patient or passively by the healthcare provider. It is thought to promote axoplasmic flow, neural vascularity, and nerve gliding in relation to surrounding tissues, all of which lead to better neural functioning and, ultimately, better motor and sensory performance. The aim of study is to determine the effects of play based neural mobilization activities on hand grip strength and dexterity in cerebral palsy.
The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- The study design will be a Randomized control trial. The data will be collected from Acme Medical complex and Rehab cure clinic. The study will be completed in 10 months after the approval of synopsis. The sampling technique will be non-probability convenient sampling. Sample size is 16 calculated by epitool. Group A will receive Routine Physical therapy with play based neural mobilization activity method and Group B will receive Routine Physical therapy with baseline treatment. Diplegic cerebral palsy girls and boys included with age limit 6-12 years and without history of injury 1 year, Patients who cannot obey commands will be excluded. Hand dynamometer and pegboard test will used as outcome tool. Single blinding will be used. Data Analysis will be done on Statistical Package for the Social Sciences (SPSS) version 23.00.
| Arm | Type | Receives |
|---|---|---|
| Group A: intervention group (routine physical therapy +play based neural mobilisation) | Active comparator | Other: neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment.movements that are advantageous for neural mobility will be used to incorporate neural mobilization. Total 20 sessions will be performed (40 min, 3 days a week) |
| Group B:control Group( routine physical Therapy) | Active comparator | Other: Regular physical therapyexercises will be stretching exercises, strengthening exercises, gait training, range of motion exercises of upper and lower limbs. Total 20 sessions will be performed (40 min, 3 days a week). |
Who may qualify
- Ages
- 6 to 12 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (5 listed)
Key exclusion criteria (3 listed)
- • Patients with history of injury in 1 year.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment.treatment include muscle stretching, strengthening, gait training, Range of motion exercises for both upper and lower limbs. Group A will perform neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. Total 20 sessions will be performed (40 min, 3 days a week) | Other | Group A: intervention group (routine physical therapy +play based neural mobilisation) |
| Regular physical therapyRegular physical therapy was administered to the control group along with baseline care. These workouts included upper and lower limb range of motion activities, gait training, strengthening exercises, and stretching exercises. | Other | Group B:control Group( routine physical Therapy) |
Primary outcome
Hand Dynamometer for hand grip strength
Time frame: baseline, 16th weeks
Handgrip dynamometers are employed for a wide range of purposes. Assessing general strength is the most widely used method for comparing muscular function across groups, evaluating the course of wasting disorders such as sarcopenia, and even identifying prospective deficits. In order to quantify the strength of various muscles that are directly linked to a pathological condition, such as rotator cuff strength, handgrip dynamometers are also utilized as functional evaluation instruments. Handgrip dynamometers are mostly used for evaluation in the rehabilitation process, such as monitoring general rehabilitation progress or assessing the impact of a particular rehabilitation regimen aimed at a grip strength issue, such as shoulder impingement syndrome. Strong handgrips are essential for independent and fulfilling daily functioning
Pegboard test for Dexterity
Time frame: baseline, 16th week
The functional dexterity test (FDT), a timed pegboard test that involves manipulating each peg, is appropriate for young children due to its ease of use and speed. The 16-hole wooden pegboard used for the FDT is set up in four rows of four, with each peg hole that is 2.5 cm in diameter, 3 cm deep, and 2 cm away from the neighboring peg holes. Every patient will be requested to take a seat in a chair facing the FDT pegboard on a table. The patients will be instructed to practice by flipping every peg on the board once. After the test will be completed, the examiner will note how long it take to complete the test
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2026.
- Background: PubMed 35271600Baptista FM, Cruz EB, Afreixo V, Silva AG. Effectiveness of neural mobilization on pain intensity, disability, and physical performance in adults with musculoskeletal pain-A protocol for a systematic review of randomized and quasi-randomized controlled trials and planned meta-analysis. PLoS One. 2022 Mar 10;17(3):e0264230. doi: 10.1371/journal.pone.0264230. eCollection 2022.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Uzma Irshad, MS-PT principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing neural mobilization which include ulnar, median and radial nerves mobilisation by a play activity called "Simon says" in addition to the routine physical therapy treatment. and Regular physical therapy in people with Cerebral Palsy, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact IMRAN AMJAD, PhD (9233224390125, imran.amjad@riphah.edu.pk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hand Dynamometer for hand grip strength (time frame: baseline, 16th weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07428928, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2026.