Ulcerative Colitis (UC)Phase 2EMERALD-3NCT07415044
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
A Phase 2 study testing LY4268989 in people with Ulcerative Colitis (UC) and Ulcerative Colitis, Active Moderate, run by Eli Lilly and Company at 258 sites in 28 countries.
Trial summary
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally. The study will last up to approximately 108 weeks, excluding screening. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe
- What is being tested?
- LY4268989
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 1,431 participants
- Where
- 258 sitesin 28 countries
- Study dates
- 26 Mar 2026to Jul 2031
- Phase
- Phase 2
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Have had an established diagnosis of ulcerative colitis (UC) for ≥3 months prior to randomization, which includes endoscopic evidence of UC
- Have moderately to severely active UC defined by a Modified Mayo Score (mMS) of 5 to 9 with an Endoscopic Score (ES)≥2 confirmed by central reader and rectal bleeding (RB)≥1
- Have evidence of UC extending proximal to the rectum
- Have documented evidence of having had a surveillance colonoscopy within 1 year, or according to local guidelines, to evaluate for polyps, dysplasia, or malignancy, prior to randomization, if the participant has a history of UC symptoms for more than 8 years
- Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators). Participants with inadequate response to vedolizumab are excluded
- Must meet contraception requirements
Who cannot join
- Have a current diagnosis of
- Crohn's disease
- Inflammatory Bowel Disease (IBD unclassified) (formerly known as indeterminate colitis), or
- primary sclerosing cholangitis
- Have an inherited immunodeficiency syndrome or known monogenic cause of UC-like colonic inflammation
- Have had or will need bowel resection or intestinal or intra-abdominal surgery
Show all 9Show fewer
- Have evidence of toxic megacolon, intra-abdominal abscess, or stricture or stenosis within small bowel or colon that cannot be traversed by a colonoscope or that are symptomatic
- Have any prior or current evidence of cancer gastrointestinal (GI) tract, or specified lesions with increased risk of GI malignancies
- Have a diagnosis or history of malignant disease within 5 years prior to randomization
Trial locations and contacts
258 sites in 28 countries. Contact the study team or a site near you to ask about taking part.
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact
Physicians interested in becoming principal investigators please contact contact
258 sites in 28 countries
United States52 sites, 51 recruiting
- Recruiting
Clinnova Research
Anaheim, California, 92805
Amit Bhanvadia
- Recruiting
Treasure Valley Medical Research
Boise, Idaho, 83706
208-813-6505
Neetu Talreja
- Not yet recruiting
Medical University of South Carolina
Charleston, South Carolina, 29425
843-792-3710
Erin Forster
- Not yet recruiting
Northwestern University
Chicago, Illinois, 60611
312-695-4077
Keith Summa
- Not yet recruiting
Rush University Medical Center
Chicago, Illinois, 60612
Atsushi Sakuraba
- Recruiting
Peak Gastroenterology Associates
Colorado Springs, Colorado, 80907
719-310-6719
Bhaktasharan Patel
- Recruiting
K2 Medical Research - Daytona Beach
Daytona Beach, Florida, 32114
Esteban Olivera
- Suspended
Advanced Research Institute - Denver
Denver, Colorado, 80218
- Recruiting
Midwest Digestive Health & Nutrition
Des Plaines, Illinois, 60016
312-767-3244
Amar Naik
- Recruiting
GMC Clinical Research
Folsom, California, 95630
Nazir Rahim
- Recruiting
GI Alliance - Fort Worth
Fort Worth, Texas, 76104
817-612-5575
Kumar Gutta
- Recruiting
GI Alliance - Garland
Garland, Texas, 75044
972-265-8201
Harry Sarles
- Recruiting
Carolina Digestive Diseases and Endoscopy Center
Greenville, North Carolina, 27834
252-758-8181
Phillip Goldstein
- Not yet recruiting
Medical Research Center of Connecticut
Hamden, Connecticut, 06518
Paul Feuerstadt
- Not yet recruiting
Ohio State University
Hilliard, Ohio, 43026
Jacob Skeans
- Recruiting
Integrity Advanced Therapeutics
Houston, Texas, 77090
281-453-2005
Howard Hamat
- Recruiting
Grand Teton Research Group
Idaho Falls, Idaho, 83404
208-528-4256
Todd Williams
- Recruiting
Skyline Gastroenterology of West Tennessee
Jackson, Tennessee, 38301
731-280-0157
Brittain Little
- Recruiting
Clinical Research of Osceola
Kissimmee, Florida, 34741
407-954-4016
Basher Atiquzzaman
- Recruiting
Rocky Mountain Gastroenterology Associates - Lakewood
Lakewood, Colorado, 80228
Rajesh Jain
- Recruiting
Florida Research Institute
Lakewood Rch, Florida, 34211
941-727-7772
Manuel Rodriguez
- Recruiting
Digestive Disease Specialists - Las Vegas - Crimson Canyon Drive
Las Vegas, Nevada, 89128
Michael Zimmerman
- Recruiting
Gastroenterology Health Partners
Louisville, Kentucky, 40218
502-888-1988
Michael Krease
- Recruiting
GI Alliance - Gastro Group and Endocenter - Mandeville
Mandeville, Louisiana, 70471
985-323-4003
Brandon Brousse
- Recruiting
GI Alliance: Mansfield
Mansfield, Texas, 76063
817-417-9664
MOUSTAFA YOUSSEF
- Not yet recruiting
Virtua Health & Wellness Center - Moorestown
Moorestown, New Jersey, 08057
Sanket Patel
- Recruiting
Gastroenterology Health Partners
New Albany, Indiana, 47150
812-206-1702
Jonathan Obert
- Recruiting
Saint Peter's University Hospital
New Brunswick, New Jersey, 08901
Arkady Broder
- Recruiting
Eximia Research-VA, LLC
Norfolk, Virginia, 23502
John Smith
- Not yet recruiting
AdventHealth Orlando
Orlando, Florida, 32803
407-303-9921
Jennifer Seminerio Diehl
- Recruiting
Valleywise Health Medical Center
Phoenix, Arizona, 85008
602-344-5194
Indu Srinivasan
- Recruiting
The Oregon Clinic
Portland, Oregon, 97220
Phillip Kiyasu
- Not yet recruiting
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, 55905
Amanda Johnson
- Recruiting
Southern Star Research Institute
San Antonio, Texas, 78229
210-581-2812
Jeff Bullock
- Recruiting
GI Alliance - San Marcos
San Marcos, Texas, 78666
512-878-1100
Thomas Kepczyk
- Not yet recruiting
One of a Kind Clinical Research Center
Scottsdale, Arizona, 85258
602-820-6906
Florin Gaidici
- Not yet recruiting
Swedish Medical Center
Seattle, Washington, 98104
Jason Harper
- Recruiting
Sanford USD Medical Center
Sioux Falls, South Dakota, 57105
Ahmed Kurdi
- Recruiting
Principle Research Solutions
Spokane, Washington, 99202
590-474-1107
Harold Preiksaitis
- Not yet recruiting
Providence Sacred Heart Medical Center & Children's Hospital
Spokane, Washington, 99208
509-489-2600
Eashen Liu
- Recruiting
DSI Research, LLC d/b/a ObjectiveHealth Clinical Research - Springboro
Springboro, Ohio, 45066
Anjali Morey
- Recruiting
Springfield Clinic - First
Springfield, Illinois, 62702
217-528-7541
Rajan Kochar
- Recruiting
KAD Clinical Research
St Louis, Missouri, 63123
314-254-3168
Adrian Di Bisceglie
- Recruiting
Specialists in Gastroenterology
St Louis, Missouri, 63141
Benjamin Root
- Not yet recruiting
Stony Brook University
Stony Brook, New York, 11794
Lasha Gogokhia
- Recruiting
Washington Gastroenterology - Tacoma
Tacoma, Washington, 98405
253-272-5127
William Holderman
- Recruiting
Om Research LLC
Temple City, California, 91780
661-388-2239
Ken Nguyen
- Recruiting
Tyler Research Institute
Tyler, Texas, 75701
903-630-6211
George DuVall
- Recruiting
Om Research LLC
Victorville, California, 92395
661-388-2239
Nikhil Gupta
- Recruiting
Gastro Intestinal Research Institute of Northern Ohio, LLC
Westlake, Ohio, 44145
440-250-7630
Mohamed Naem
- Recruiting
Wilmington Health, PLLC
Wilmington, North Carolina, 28401
Ashok Shiani
- Recruiting
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
Wyoming, Michigan, 49519
Allan Coates
China22 sites, 22 recruiting
- Recruiting
Binzhou Medical University Hospital
Binzhou, 256603
Chengxia Liu
- Recruiting
Changzhou Second People's Hospital
Changzhou, 213000
Wenjia LIU
- Recruiting
Sichuan Provincial People's Hospital
Chengdu, 610072
18981838298
Xue Yang
- Recruiting
Chongqing General Hospital
Chongqing, 401121
86-13508389768
Hong Guo
- Recruiting
The First People's Hospital of Foshan
Foshan, 528041
Zhaotao Li
- Recruiting
The Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, 510655
Xiang Gao
- Recruiting
Heilongjiang Provincial Hospital
Harbin, 150036
Xiaomei Sun
- Recruiting
The First Affiliated Hospital of Anhui Medical University
Hefei, 230022
Juan Wu
- Recruiting
Huizhou Central People's Hospital
Huizhou, 516001
Huixin Chen
- Recruiting
First Affiliated Hospital of Kunming Medical University
Kunming, 650032
Jiarong Miao
- Recruiting
Liaocheng People's Hospital
Liaocheng, 252000
Cuicui Lang
- Recruiting
Meihekou Central Hospital
Meihekou, 135000
Zhongwei Pan
- Recruiting
The Affiliated Hospital of Qingdao University
Qingdao, 266003
Xueli Ding
- Recruiting
Shanghai Tenth People's Hospital
Shanghai, 200072
Xiaolei Wang
- Recruiting
Shanghai Pudong New District Zhoupu Hospital
Shanghai, 201318
Zhihua Ran
- Recruiting
Yuebei People's Hospital Guangdong
Shaoguan, 512026
Manran Zhu
- Recruiting
Peking University Shenzhen Hospital
Shenzhen, 518036
Wenke Chen
- Recruiting
The First Affiliated Hospital of Soochow University
Suzhou, 215006
Weichang Chen
- Recruiting
Taian City Central Hospital
Taian, 271000
13375387610
Haipeng Yuan
- Recruiting
Wuhan Union Hospital
Wuhan, 430022
Xiaohua Hou
- Not yet recruiting
Renmin Hospital of Wuhan University
Wuhan, 430060
Ping An
- Recruiting
Zunyi Medical College - No.1 Affiliated Hospital
Zunyi, 563003
Murong Liu
India15 sites, 15 recruiting
- Not yet recruiting
Motilal Nehru Medical College Hospital
Allahabād, 211002
Sandeep Prajapati
- Recruiting
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, 590010
Santosh Hajare
- Not yet recruiting
Belagavi Institute of Medical Sciences - Belagavi
Belgavi, 590019
Ganesh Koppad
- Not yet recruiting
Mahavir Hospital & Research Centre - Hyderabad
Hyderabad, 500004
Rupender Prasad
- Recruiting
SR Kalla Memorial Gastro & General Hospital
Jaipur, 302001
0141-4039432
Mukesh Kalla
- Recruiting
Lakeshore Hospital
Kochi, 682040
04842154754
Abraham Koshy
- Not yet recruiting
Dr. Ram Manohar Lohia Institute of Medical Sciences
Lucknow, 226010
Piyush Upadhyay
- Not yet recruiting
Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
Mumbai, 400008
Shubham Jain
- Recruiting
Midas Multispeciality Hospital Pvt.Ltd.
Nagpur, 440010
Shrikant Mukewar
- Not yet recruiting
Orbit Multispeciality Hospital
Nagpur, 440024
Pankaj Nawghare
- Not yet recruiting
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, 441108
8475000331
Rutwik Loya
- Not yet recruiting
All India Institute of Medical Sciences
New Delhi, 110029
09867932836
Vineet Ahuja
- Not yet recruiting
Yatharth Super Speciality Hospital - Noida Extension
Noida, 201306
Rakesh Kumar Jagdish
- Recruiting
Gastrohub Hospital
Pune, 411027
Mahesh Mahadik
- Recruiting
Lifepoint Multispeciality Hospital
Pune, 411057
Amol Dahale
Japan15 sites, 15 recruiting
- Recruiting
Asahikawa Medical University Hospital
Asahikawa, 078-8510
81120023812
Mikihiro Fujiya
- Recruiting
Juntendo University Hospital
Bunkyō City, 113-8431
81120023812
Dai Ishikawa
- Recruiting
Sai Gastroenterology/Proctology Clinic
Fujiidera, 583-0027
81120023812
Souken Sai
- Recruiting
Fukuoka University Hospital
Fukuoka, 814-0180
81120023812
Fumihito Hirai
- Recruiting
National Hospital Organization Hirosaki General Medical Center
Hirosaki, 036-8545
81120023812
Yoh Ishiguro
- Recruiting
Sameshima Hospital
Kagoshima, 892-0846
81120023812
nobuaki nishimata
- Recruiting
Tsujinaka Hospital - Kashiwanoha
Kashiwa, 273-0011
81120023812
Ken Takeuchi
- Recruiting
Kyorin University Hospital
Mitaka, 181-8611
81120023812
TADAKAZU HISAMATSU
- Recruiting
Saiseikai Niigata Hospital
Niigata, 950-1104
81120023812
Junji Yokoyama
- Recruiting
Hyogo Medical University Hospital
Nishinomiya, 663-8501
81120023812
Shinichiro Shinzaki
- Recruiting
Okayama University Hospital
Okayama, 700-8558
81120023812
Toshihiro Inokuchi
- Recruiting
Tokitokai Tokito Clinic Coloproctology Center
Saitama, 336-0963
81120023812
Satoki Tokito
- Recruiting
Sapporo Higashi Tokushukai Hospital
Sapporo, 065-0033
81120023812
Atsuo Maemoto
- Recruiting
The University of Osaka Hospital
Suita, 565-0871
81120023812
Takeo Yoshihara
- Recruiting
Tokyo Yamate Medical Center
Tokyo, 169-0073
81120023812
Masayuki Fukata
Poland15 sites, 15 recruiting
- Recruiting
M2M Med
Chorzów, 41-500
+48 518 424 470
Magdalena Wloch-Targonska
- Recruiting
Gyncentrum sp. z o.o. NZOZ Holsamed - oddział Libero
Katowice, 40-600
Marek Olakowski
- Recruiting
Polimedica PTG Kielce
Kielce, 25-355
Dariusz Solowiej
- Recruiting
Centrum Medyczne Oslomed
Krakow, 31-228
Anna Drozdz
- Recruiting
Santa Familia PTG Lodz
Lodz, 90-302
Aleksandra Sobolewska-Wlodarczyk
- Not yet recruiting
Centrum Badawcze Panaceum Agnieszka Brzezicka Magdalena Lenkiewicz Sp. z o. o
Malbork, 82-200
Krzysztof Groszewski
- Recruiting
Allmedica
Nowy Targ, 34-400
Mikolaj Krzyzanowski
- Recruiting
Twoja Przychodnia PCM
Poznan, 60-324
+48 724 444 299
Ewa Furmanowska-Ladorska
- Recruiting
ETG Siedlce
Siedlce, 08-110
Anna Lewandowska
- Recruiting
Twoja Przychodnia SCM
Szczecin, 71-434
48 91 433 29 19
Beata Gawdis-Wojnarska
- Recruiting
Sonomed Sp. z o. o.
Szczecin, 71-685
Anna Wiechowska-Kozlowska
- Not yet recruiting
H-T Centrum Medyczne Endoterapia
Tychy, 43-100
48515342221
Tomasz Romanczyk
- Not yet recruiting
Clinical Best Solutions
Warsaw, 00-710
Michal Lawinski
- Recruiting
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
Warsaw, 04-501
500111648
Jaroslaw Kierkus
- Recruiting
ETG Zamość
Zamość, 22-400
48606930022
Katarzyna Wojcik
South Korea14 sites, 14 recruiting
- Recruiting
Dong-A University Hospital
Busan, 49201
Jonghun Lee
- Recruiting
Pusan National University Yangsan Hospital
Busan, 50612
Su Bum Park
- Recruiting
Kyungpook National University Hospital
Daegu, 41944
Eunsoo Kim
- Recruiting
The Catholic University of Korea, Daejeon St. Mary's Hospital
Daejeon, 34943
82422209501
Sang-Bum Kang
- Recruiting
Chosun University Hospital
Gwangju, 61453
Jun Lee
- Recruiting
Yeungnam Univeristy Medical Center
Gyeongsan-si, 42415
82-53-620-3830
BYUNGIK JANG
- Recruiting
Inje University Haeundae Paik Hospital
Pusan, 48108
82-51-797-0220
Tae Oh Kim
- Not yet recruiting
Kyung Hee University Hospital
Seoul, 02447
Chang Kyun Lee
- Recruiting
Seoul National University Hospital
Seoul, 03080
027408112
Seongjoon Koh
- Recruiting
Kangbuk Samsung Hospital
Seoul, 03181
Dong Il Park
- Recruiting
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Seoul, 03312
Sung Hoon Jung
- Recruiting
Severance Hospital, Yonsei University Health System
Seoul, 03722
Jae Hee Cheon
- Recruiting
Samsung Medical Center
Seoul, 06351
YoungHo Kim
- Recruiting
Wonju Severance Christian Hospital
Wŏnju, 26426
Hyun Soo Kim
Mexico12 sites, 12 recruiting
- Not yet recruiting
Scientia Investigacion Clinica S.C.
Chihuahua City, 31207
CHRISTIAN NAVARRO GERRARD
- Not yet recruiting
Scientia Investigacion Clinica Tj
Ciudad de Tijuana, 22105
Luis Lopez
- Not yet recruiting
Clinica de Investigacion en Reumatologia y Obesidad S. C.
Guadalajara, 44650
Hector Martinez Torres
- Not yet recruiting
Private Practice - Dr. Adriana Sánchez
Guadalajara, 44670
Aranzazu Perez
- Not yet recruiting
Proactive CR México SA de CV
Irapuato, 36520
Andrés Mendoza Sanchez
- Not yet recruiting
Centro de Investigación y Gastroenterología - S.C.
Mexico City, 03330
5510546591
Alma Ladron de Guevara Cetina
- Not yet recruiting
Centro de Investigación Clinica Chapultepec
Mexico City, 04100
Elda Rodriguez Negrete
- Not yet recruiting
Keystone Clinical Trials
Mexico City, 06100
5526187995
Karina Olvera
- Not yet recruiting
Hospital Juarez de Mexico
Mexico City, 07760
Eumir Juarez-Valdes
- Not yet recruiting
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, 14080
JESUS YAMAMOTO-FURUSHO
- Not yet recruiting
Servicios de Oncología Médica Integral - Monterrey
Monterrey, 66220
Manuel Martinez Vazquez
- Not yet recruiting
Centro de Investigacion Clinica Chapultepec
Querétaro, 76088
RAUL CHAVEZ AYALA
Brazil10 sites, 10 recruiting
- Recruiting
Loema Instituto de Pesquisa Clinica
Campinas, 13092-133
19 3252-5611
Joaquim Simoes Neto
- Not yet recruiting
Fundação Universidade de Caxias do Sul (FUCS)
Caxias do Sul, 95070-560
Eduardo Brambilla
- Recruiting
HNSG
Curitiba
+55 41 99968-0290
HEDA MARIA AMARANTE
- Not yet recruiting
Centro de Oncologia Leonardo Da Vinci - ATO Terapias
Fortaleza, 60140-025
Caio Freire
- Recruiting
Hospital Ernesto Dornelles
Porto Alegre, 90160-092
+5551999624012
Cristina Flores
- Not yet recruiting
Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador
Salvador, 41920-900
55 71 2108-5600
Raymundo Parana
- Recruiting
Irmandade da Santa Casa da Misericórdia de Santos
Santos, 11075-900
+5513997113072
Jose Eduardo Vasconcelos Fernandes
- Not yet recruiting
BR Trials - Ensaios Clinicos e Consultoria
São Paulo, 01236030
Roberto da Silva
- Recruiting
Clínica Hepatogastro JK
São Paulo, 04543-011
5511999158070
Rodrigo Andrey Rocco
- Recruiting
BRA - Clínica Médica e Terapia Assistida
Tajaí, 88301-220
Munique Kurtz de Mello
Ukraine10 sites, 10 recruiting
- Recruiting
Chernivtsi Regional Clinical Hospital
Chernivtsi, 58000
+380503741659
Oleksandr Fediv
- Recruiting
Medical Center of Limited Liability Company "Medical Center "Consilium Medical"
Kiev, 04050
+380979132763
Oksana Gerasymenko
- Recruiting
Edelweiss Medics
Kyiv, 02002
+380445949200
Oleksandra Tymofeieva
- Recruiting
Medical Center Ok!Clinic+
Kyiv, 02091
+380937694807
Nataliia Tsarynna
- Recruiting
Medbud Clinic
Kyiv, 03037
380445947078
Dmytro Donets
- Not yet recruiting
Municipal Nonprofit Enterprise of Kyiv Region Council "Kyiv Regional Clinical Hospital"
Kyiv, 04106
+380506381700
Svitlana Danyliuk
- Recruiting
Center of Family Medicine Plus
Kyiv, 04210
+380972094524
Liudmyla Chupryna
- Recruiting
Progastro Clinic
Lviv, 79019
0933825853
Olha Ivanishyn
- Not yet recruiting
Transcarpathian Regional Hospital im.Andriya Novak
Uzhhorod, 88018
+380997279631
Yaroslava Rishko
- Not yet recruiting
Communal Non-Commercial Enterprise "Vinnytsia City Clinical Hospital #1"
Vinnytsia, 21029
+380676222307
Nataliia Pentiuk
Argentina9 sites, 9 recruiting
- Recruiting
Stat Research S.A.
Buenos Aires, C1023AAB
54111550120614
Maria Linares
- Recruiting
Mautalen Salud e Investigación
Buenos Aires, C1128AAF
+541145143408
Emiliano Tron
- Recruiting
GEDYT
Buenos Aires, C1425BGC
54 11 5288 6107
Silvina Goncalves
- Not yet recruiting
Sanatorio Maipú
Mendoza, 5515
01121919736
PAMELA DAFFRA
- Recruiting
CER medical Institute
Quilmes, 1878
EDGARDO DANIEL GIMENEZ
- Recruiting
INECO Neurociencias Oroño
Rosario, 2000
+54 9 3416 18-5727
Sebastian Ferretti
- Recruiting
Hospital Provincial del Centenario
Rosario, 2002
5493415329980
JOAQUIN MONTERO
- Recruiting
Instituto Médico de Alta Complejidad San Isidro Sa
San Isidro, 1642
EDGARDO SMECUOL
- Recruiting
C.I.C.E. 9 de Julio
San Miguel de Tucumán, 4000
5493816299018
Abel Novillo
Czechia9 sites, 8 recruiting
- Recruiting
Hepato-Gastroenterologie HK
Hradec Králové, 500 12
Miroslava Volfova
- Recruiting
Nemocnice Pardubického kraje
Pardubice, 532 03
+420466014229
Petr Vyhnalek
- Recruiting
Clinoxus
Prague, 140 00
Petr Hrabak
- Recruiting
MEDICON
Prague, 140 00
+420 222 501 720
David Kamenar
- Recruiting
ISCARE klinické centrum
Prague, 19000
+420 725 505 279
Milan Lukas
- Recruiting
Nemocnice Slany
Slaný, 274 01
+ 420 606 661 523
Martin Peterka
- Suspended
Nemocnice AGEL Šternberk
Sternberk, 785 01
- Recruiting
Clinical Trials Service s.r.o.
Uherské Hradiště, 686 01
Vladimir Cech
- Recruiting
Gastro-nell
Vsetín, 755 01
+420 775 316 692
Vladimir Vaculin
Turkey (Türkiye)8 sites, 8 recruiting
- Not yet recruiting
Bakent University, Adana Clinic & Research Ctr.
Adana, 01250
+905325467187
Birol Ozer
- Not yet recruiting
Hacettepe Universite Hastaneleri
Ankara, 06230
Muhammed Durak
- Not yet recruiting
Antalya Egitim ve Arastırma Hastanesi
Antalya, 07100
Ayhan Hilmi Cekin
- Not yet recruiting
Ege Universitesi Hastanesi
Bornova, 35100
+90 505 782 38 08
Nalan Unal
- Not yet recruiting
Mustafa Kemal Universitesi
Hatay, 31030
Mehmet Demir
- Not yet recruiting
Bezmialem Vakf Üniversitesi
Istanbul, 34093
Metin Basaranoglu
- Not yet recruiting
Kocaeli University Medical Faculty Hospital
İzmit, 41380
Ali Duman
- Not yet recruiting
Mersin University
Mersin, 33110
905326145276
Engin Altintas
Italy7 sites, 7 recruiting
- Not yet recruiting
IRCCS Policlinico San Donato
Milan, 20097
39 0252774951
Vito Annese
- Not yet recruiting
Ospedale San Raffaele
Milan, 20132
Silvio Danese
- Recruiting
Ospedale Di Circolo
Rho, 20017
02 99430.3264
Simone Saibeni
- Not yet recruiting
Fondazione Policlinico Tor Vergata
Rome, 00133
Irene Marafini
- Not yet recruiting
Azienda Ospedaliera San Camillo Forlanini
Rome, 00152
Rita Monterubbianesi
- Not yet recruiting
Ospedale Isola Tiberina - Gemelli Isola
Rome, 00186
+390668370271
Daniela Pugliese
- Not yet recruiting
Humanitas
Rozzano, 20089
0282243263
Alessandro Armuzzi
Israel6 sites, 6 recruiting
- Recruiting
Assuta Ashdod Medical Center
Ashdod, 7747629
+9720723398277
Adi Lahat-Zok
- Recruiting
Barzilai Medical Center
Ashkelon, 7830604
+97286745244
Ofer Ben-Bassat
- Recruiting
Rambam Health Care Campus
Haifa, 3109601
972-4-7772850
Roni Weisshof
- Recruiting
Clalit Health Services - Lev Talpiot Clinic
Jerusalem, 9362410
+97225457100
Nadav Ilani
- Recruiting
Meir Medical Center
Kfar Saba, 4428164
+97297471017
Michal Openhaim
- Recruiting
Yitzhak Shamir Medical Center
Ẕerifin, 7033001
9728779720
Leore Mendel
Colombia5 sites, 5 recruiting
- Not yet recruiting
Clinica de la Costa S.A.S.
Barranquilla, 080020
Leonardo Brochado
- Not yet recruiting
Fundacion Santa Fe de Bogota
Bogotá, 110111
3212108418
GUSTAVO REYES
- Not yet recruiting
Hospital Universitario Mayor Méderi
Bogotá, 111411
Carlos Figueroa
- Not yet recruiting
Hospital Universitario San Ignacio
Bogotá
Ana Leguizamo
- Not yet recruiting
Hospital Pablo Tobon Uribe
Medellín, 050034
Jhon Carvajal Gutierrez
Slovakia5 sites, 5 recruiting
- Recruiting
Cliniq s.r.o.
Bratislava, 81109
+421917752297
Tibor Hlavaty
- Recruiting
Gastroentero s.r.o.
Bratislava, 821 01
+421907798994
Vladimir Klinovsky
- Recruiting
Gastro I., s.r.o.
Prešov, 080 01
+421903607349
Bohus Bunganic
- Recruiting
Vseobecna nemocnica Rimavska Sobota
Rimavská Sobota, 979 01
+421 905 218 417
Jan Zachar
- Recruiting
Accout Center
Šahy, 936 01
+421 918 477 281
Frantisek Horvath
South Africa5 sites, 5 recruiting
- Not yet recruiting
Iatros International
Bloemfontein, 9301
Wayne Simmonds
- Not yet recruiting
Spoke Research
Cape Town, 7405
+27832844682
Malgorzata George
- Not yet recruiting
Mediclinic Panorama
Cape Town, 7500
+27219300923
Maarten Prins
- Not yet recruiting
Lenasia Clinical Trial Centre - Johannesburg
Johannesburg, 1821
Nazeer Chopdat
- Not yet recruiting
Clinresco Centres
Kempton Park, 1619
Jennifer Rosa
Taiwan5 sites, 5 recruiting
- Recruiting
Changhua Christian Hospital
Changhua, 50006
Hsu-Heng Yen
- Recruiting
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807
Deng-Chyang Wu
- Recruiting
China Medical University Hospital
Taichung, 404332
Jen-Wei Chou
- Recruiting
National Taiwan University Hospital
Taipei, 10002
Shu-Chen Wei
- Recruiting
Tri-Service General Hospital
Taipei, 114
Tien-Yu Huang
Croatia4 sites, 4 recruiting
- Not yet recruiting
Opća bolnica Bjelovar
Bjelovar, 43000
Marinko Lukic
- Recruiting
Poliklinika Borzan
Osijek, 31000
Vladimir Borzan
- Not yet recruiting
Klinički Bolnički Centar Split
Split, 21000
Zeljko Puljiz
- Not yet recruiting
Klinički bolnički centar Zagreb
Zagreb, 10000
Zeljko Krznaric
France4 sites, 4 recruiting
- Not yet recruiting
Centres Médico Chirurgicaux - Clinique Ambroise Paré
Neuilly-sur-Seine, 92200
01 41 43 05 73
Xavier Treton
- Recruiting
CHU Bordeaux Haut-Leveque
Pessac, 33600
Pauline RIVIERE
- Recruiting
Centre Hospitalier Lyon Sud
Pierre-Bénite, 69310
Gilles BOSCHETTI
- Recruiting
CHU Rangueil
Toulouse, 31059
cyrielle Gilletta
Greece4 sites, 4 recruiting
- Recruiting
Evangelismos General Hospital of Athens
Athens, 106 76
NIKOLAOS VIAZIS
- Recruiting
Thoracic General Hospital of Athens "I Sotiria"
Athens, 115 27
+306976062713
Giorgos Bamias
- Recruiting
University General Hospital of Heraklion
Heraklion, 711 10
2810392037
Ioannis Koutroubakis
- Not yet recruiting
Ippokrateio General Hospital of Thessaloniki
Thessaloniki, 54642
OLGA GIOULEME
Hungary4 sites, 4 recruiting
- Recruiting
Óbudai Egészségügyi Centrum
Budapest, 1036
06309399575
Tamás Toth
- Recruiting
Semmelweis University
Budapest, 1083
Akos Ilias
- Recruiting
Clinexpert Gyöngyös
Gyöngyös, 3200
+36209650290
Gyula Horvat
- Recruiting
Komarom-Esztergom Varmegyei Szent Borbala Korhaz
Tatabánya, 2800
36309578269
András Káfony
Portugal4 sites, 4 recruiting
- Recruiting
2Ca Braga
Braga, 4710-243
Bruno Arroja
- Not yet recruiting
Hospital da Luz Lisboa
Lisbon, 1500-650
Lidia Ramos
- Recruiting
Centro Hospitalar Universitário Lisboa Norte, E.P.E. - Hospital de Santa Maria
Lisbon, 1649-035
Samuel Fernandes
- Not yet recruiting
Unidade Local de Saúde Entre o Douro e Voga
Santa Maria da Feira, 4520-211
351256379733
Rute Cerqueira
Serbia4 sites, 4 recruiting
- Not yet recruiting
MSB General Hospital
Belgrade, 11000
Dragan Tomic
- Not yet recruiting
Leskovac General Hospital
Leskovac, 16000
Tomislav Tasic
- Not yet recruiting
Sremska Mitrovica Health Centre
Sremska Mitrovica, 22000
RADOVAN ZEC
- Not yet recruiting
General Hospital "Djordje Joanovic"
Zrenjanin, 23000
Tatjana Latinovic Radakovic
Canada3 sites, 3 recruiting
- Recruiting
Health Sciences North
Greater Sudbury, P3E 5J1
Anas Eddin
- Not yet recruiting
QEII Health Sciences Centre - Victoria General Site
Halifax, B3H 2Y9
Jennifer Jones
- Not yet recruiting
London Digestive Disease Institute
London, N6K 1M6
Vipul Jairath
Lithuania3 sites, 3 recruiting
- Recruiting
Hospital of Lithuanian University of Health Sciences Kauno klinikos
Kaunas, LT-50161
Gediminas Kiudelis
- Not yet recruiting
Klaipeda University Hospital
Klaipėda, 92288
Aiste Puriene
- Recruiting
Viesoji Istaiga Klaipedos Miesto Poliklinika
Klaipėda, 93200
+37046345968
Giedrius Simulionis
Latvia2 sites, 2 recruiting
- Not yet recruiting
Pauls Stradins Clinical Univeristy Hospital
Riga, LV-1002
Aldis Pukitis
- Not yet recruiting
VCA poliklīnika Aura
Riga, LV-1035
Aleksejs Derovs
Puerto Rico2 sites, 2 recruiting
- Recruiting
Pan American Center for Oncology Trials - Ciudadela
San Juan, 00909
787-407-3333
Juan Marques Lespier
- Recruiting
Adult University Hospital
San Juan, 00935
787-7540101x5420
Esther Torres
About this study
Official title: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Development Program to Evaluate the Efficacy and Safety of LY4268989 (MORF-057) for the Treatment of Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC). The study drug will be administered orally.
The study will last up to approximately 108 weeks, excluding screening.
- Conditions
- Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe
- Being tested
- LY4268989, Placebo
- Medical subject headings
- Colitis, Ulcerative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
LY4268989Drug
Also called MORF-057, zotemtegrast
Administered orally
PlaceboDrug
Administered orally
| Study group | Role | What they receive |
|---|---|---|
| LY4268989 Study Dose 1 | Experimental | LY4268989 administered orally Receives: Drug: LY4268989 |
| LY4268989 Study Dose 2 | Experimental | LY4268989 administered orally Receives: Drug: LY4268989 |
| Placebo Study Dose | Placebo comparator | Placebo administered orally Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Percentage of Participants Who Achieve Clinical Remission with Modified Mayo Score (mMS)
Measured: Week 10
Percentage of Participants Who Achieve Clinical Remission with mMS Among Participants Who Achieved Clinical Response with LY4268989 at Week 10
Measured: Week 52
Secondary outcomes (6)
Percentage of Participants Who Achieve Clinical Response with mMS
Measured: Week 10
Percentage of Participants Who Achieve Clinical Response with mMS Among Participants Who Achieved Clinical Response with LY4268989 at Week 10
Measured: Week 10 Up to Week 52
Percentage of Participants Who Achieve Symptomatic Response
Measured: Baseline Up to Week 8
Percentage of Participants Who Achieve Symptomatic Response Among Participants Who Achieved Clinical Response with LY4268989 at Week 10
Measured: Week 10 Up to Week 52
Pharmacokinetics (PK): Plasma Concentrations of LY4268989
Measured: Baseline Up to Approximately Week 52
Percentage of Participants Who Achieve Clinical Remission Among Participants Who Achieved Clinical Remission with LY4268989 at Week 10
Measured: Week 52
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2026
- Study start26 Mar 2026
- Primary completionJun 2030 (estimated)
- Study completionJul 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ulcerative Colitis (UC)Studies of the same condition, open and under way.
- More trials run by Eli Lilly and CompanyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Care provider
- Enrolment
- 1,431 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Eli Lilly and Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Study director, Eli Lilly and Company
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07415044
- Sponsor's protocol ID
- 27589
- Other IDs
- J6E-MC-KWAM, EU Trial (CTIS) Number
- Acronym
- EMERALD-3
- Status last verified
- Oct 2026
- First submitted
- 6 Feb 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.