Resistance TrainingNCT07412600
High- and Low-Load Resistance Training
A study testing Low-load resistance training (30% 1RM) and High-load resistance training (75% 1RM) in people with Resistance Training and Muscle Hypertrophy, run by Akdeniz University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to learn whether low-load resistance training performed to muscle failure can produce similar increases in muscle size and strength as high-load resistance training in healthy untrained young adult males. Read more about this study
- Who is it for?
- Ages 18 to 28 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Resistance Training, Muscle Hypertrophy
- What is being tested?
- Low-load resistance training (30% 1RM) and High-load resistance training (75% 1RM)
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 22 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 18 Dec 2021to 2 Jul 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 28 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male sex
- Age between 18 and 28 years
- Healthy status as determined by self-report health screening
- No participation in structured resistance training or lower-limb power training within the previous 12 months
- Engaging only in recreational physical activity (no systematic lower-body resistance training)
- Willingness to maintain usual daily routines throughout the study period
- Agreement to refrain from any structured lower-body resistance training during the 6-week intervention
- Provision of written informed consent
Who cannot join
- Any current or recent musculoskeletal injury affecting lower-limb function
- History or presence of cardiovascular disease
- History or presence of metabolic disorders
- Resting hypertension (≥140/90 mmHg)
- Regular tobacco use
- Use of medications known to affect neuromuscular performance
- Inability or unwillingness to comply with the training protocol
Trial locations and contacts
1 site in 1 country.
About this study
Official title: High- and Low-Load Resistance Training to Failure Result in Similar Muscular Adaptations in Untrained Young Males
The goal of this clinical trial is to learn whether low-load resistance training performed to muscle failure can produce similar increases in muscle size and strength as high-load resistance training in healthy untrained young adult males.
The main questions it aims to answer are:
Read more
Does low-load resistance training (30% of one-repetition maximum) performed to failure increase muscle strength and muscle size to a similar extent as high-load resistance training (75% of one-repetition maximum)?
Are there differences in total training volume between low-load and high-load resistance training programs performed to failure?
Researchers will compare a low-load resistance training group to a high-load resistance training group to determine whether the magnitude of changes in muscle strength and hypertrophy differs between the two approaches.
Participants will:
Be randomly assigned to either a low-load (30% 1RM) or high-load (75% 1RM) resistance training group
Perform supervised leg extension exercises to the point of voluntary muscle fatigue three times per week for 6 weeks
Complete muscle strength testing (one-repetition maximum) before and after the training period
Undergo ultrasound measurements to assess muscle thickness and cross-sectional area of thigh muscles before and after the intervention
- Conditions
- Resistance Training, Muscle Hypertrophy
- Being tested
- Low-load resistance training (30% 1RM), High-load resistance training (75% 1RM)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low-load resistance training (30% 1RM)Other
Participants perform unilateral or bilateral leg extension exercise at 30% of their individually determined one-repetition maximum (1RM). Each training session consists of sets performed to volitional muscular failure. Training is conducted three times per week for 6 weeks under direct supervision. Load is adjusted if necessary to maintain the target relative intensity. All repetitions are performed using a controlled movement tempo.
High-load resistance training (75% 1RM)Other
Participants perform the same leg extension exercise at 75% of their individually determined one-repetition maximum (1RM). As in the LLRT group, sets are performed to volitional muscular failure. Training frequency (three sessions per week), duration (6 weeks), supervision, exercise selection, and movement tempo are identical to the LLRT group.
| Study group | Role | What they receive |
|---|---|---|
| LLRT | Experimental | Not described Receives: Other: Low-load resistance training (30% 1RM) |
| HLRT | Experimental | Not described Receives: Other: High-load resistance training (75% 1RM) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maximal Dynamic Strength - Estimated One-Repetition Maximum (1RM) Using Submaximal Prediction and Epley Equation
Maximal strength will be estimated using a submaximal 1RM prediction protocol (8-10 repetitions) following a standardized warm-up. The highest load completed within the target repetition range will be used to calculate 1RM using the Epley equation (1RM = Load × [1 + 0.033 × repetitions]). Results will be expressed in kilograms (kg), with higher values indicating greater strength. Assessed at baseline and Week 4.
Measured: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)
Muscle Thickness (MT) and Cross-Sectional Area (CSA) - Assessed by B-Mode Ultrasonography (LOGIQ S8, GE Healthcare)
Muscle thickness (cm) and cross-sectional area (cm²) of the rectus femoris and vastus intermedius will be assessed using B-mode ultrasonography (LOGIQ S8, GE Healthcare, 2-8 MHz linear probe). Three images per site will be averaged for analysis. Higher values indicate greater muscle hypertrophy. Measurements performed at baseline and post-intervention by a blinded assessor.
Measured: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)
Secondary outcomes (1)
Muscular Endurance - Repetitions to Volitional Failure at 50% of Estimated 1RM
Muscular endurance will be assessed by performing repetitions to volitional failure at 50% of baseline 1RM. The total number of completed repetitions will be recorded. Results expressed as repetition count, with higher values indicating greater endurance. Assessed at baseline and post-intervention.
Measured: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2026
- Study start18 Dec 2021
- Primary completion20 Jun 2022
- Study completion2 Jul 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Resistance TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 22 participants (actual)
Sponsor and investigators
- Lead sponsor
- Akdeniz University
- Sponsor type
- University, hospital or other
- Collaborators
- Selcuk University
- Responsible party
- Principal investigator, Abdullah Kayhan, Akdeniz University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07412600
- Sponsor's protocol ID
- 21202139
- Status last verified
- Feb 2026
- First submitted
- 9 Feb 2026
- Last updated
- 18 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- High- and Low-Load Resistance Training to Failure Result in Similar Muscular Adaptations in Untrained Young Males
- ClinicalTrials.gov ID
- NCT07412600
- Acronym / sponsor ID
- 21202139
- Conditions
- Resistance Training, Muscle Hypertrophy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 22 participants (actual)
- Lead sponsor
- Akdeniz UniversityUniversity, hospital or other
- Collaborators
- Selcuk University
- Study start
- 18 Dec 2021 (actual)
- Primary completion
- 20 Jun 2022 (actual)
- Study completion
- 2 Jul 2022 (actual)
- First posted
- 17 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn whether low-load resistance training performed to muscle failure can produce similar increases in muscle size and strength as high-load resistance training in healthy untrained young adult males.
The main questions it aims to answer are:
Does low-load resistance training (30% of one-repetition maximum) performed to failure increase muscle strength and muscle size to a similar extent as high-load resistance training (75% of one-repetition maximum)?
Are there differences in total training volume between low-load and high-load resistance training programs performed to failure?
Researchers will compare a low-load resistance training group to a high-load resistance training group to determine whether the magnitude of changes in muscle strength and hypertrophy differs between the two approaches.
Participants will:
Be randomly assigned to either a low-load (30% 1RM) or high-load (75% 1RM) resistance training group
Perform supervised leg extension exercises to the point of voluntary muscle fatigue three times per week for 6 weeks
Complete muscle strength testing (one-repetition maximum) before and after the training period
Undergo ultrasound measurements to assess muscle thickness and cross-sectional area of thigh muscles before and after the intervention
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| LLRT | Experimental | Other: Low-load resistance training (30% 1RM) |
| HLRT | Experimental | Other: High-load resistance training (75% 1RM) |
Who may qualify
- Ages
- 18 to 28 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Male sex
- Age between 18 and 28 years
- Healthy status as determined by self-report health screening
- No participation in structured resistance training or lower-limb power training within the previous 12 months
- Engaging only in recreational physical activity (no systematic lower-body resistance training)
Key exclusion criteria (7 listed)
- Any current or recent musculoskeletal injury affecting lower-limb function
- History or presence of cardiovascular disease
- History or presence of metabolic disorders
- Resting hypertension (≥140/90 mmHg)
- Regular tobacco use
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low-load resistance training (30% 1RM)Participants perform unilateral or bilateral leg extension exercise at 30% of their individually determined one-repetition maximum (1RM). Each training session consists of sets performed to volitional muscular failure. Training is conducted three times per week for 6 weeks under direct supervision. Load is adjusted if necessary to maintain the target relative intensity. All repetitions are performed using a controlled movement tempo. | Other | LLRT |
| High-load resistance training (75% 1RM)Participants perform the same leg extension exercise at 75% of their individually determined one-repetition maximum (1RM). As in the LLRT group, sets are performed to volitional muscular failure. Training frequency (three sessions per week), duration (6 weeks), supervision, exercise selection, and movement tempo are identical to the LLRT group. | Other | HLRT |
Primary outcome
Maximal Dynamic Strength - Estimated One-Repetition Maximum (1RM) Using Submaximal Prediction and Epley Equation
Time frame: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)
Maximal strength will be estimated using a submaximal 1RM prediction protocol (8-10 repetitions) following a standardized warm-up. The highest load completed within the target repetition range will be used to calculate 1RM using the Epley equation (1RM = Load × [1 + 0.033 × repetitions]). Results will be expressed in kilograms (kg), with higher values indicating greater strength. Assessed at baseline and Week 4.
Muscle Thickness (MT) and Cross-Sectional Area (CSA) - Assessed by B-Mode Ultrasonography (LOGIQ S8, GE Healthcare)
Time frame: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)
Muscle thickness (cm) and cross-sectional area (cm²) of the rectus femoris and vastus intermedius will be assessed using B-mode ultrasonography (LOGIQ S8, GE Healthcare, 2-8 MHz linear probe). Three images per site will be averaged for analysis. Higher values indicate greater muscle hypertrophy. Measurements performed at baseline and post-intervention by a blinded assessor.
1 secondary outcome
Muscular Endurance - Repetitions to Volitional Failure at 50% of Estimated 1RM
Time frame: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low-load resistance training (30% 1RM) and High-load resistance training (75% 1RM) in people with Resistance Training and Muscle Hypertrophy, run by Akdeniz University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maximal Dynamic Strength - Estimated One-Repetition Maximum (1RM) Using Submaximal Prediction and Epley Equation (time frame: Baseline (Week 0) and immediately after completion of the 6-week intervention (Week 6)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2026.