Pain, AcuteNCT07411417
Combined Acupressure Effects on Post-Thoracotomy Pain and Lung Volume
A study testing Acupressure group in people with Pain, Acute and Breathing, Mouth, run by Özgül Aydemir at 1 site in Turkey (Türkiye).
Trial summary
Pain is a subjective, sensory and emotionally unpleasant experience resulting from real or hidden injuries in tissues. The pain experience is a subjective and unique experience in physiological and psychological terms and is the first negative sensory experience of the patient after the surgical procedure. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Pain, Acute, Breathing, Mouth, Relaxation; Diaphragm
- What is being tested?
- Acupressure group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 6 Jan 2025to 6 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Underwent thoracotomy
- Undergoing thoracic surgery for the first time
- Classified as ASA (American Society of Anesthesiology) physical status I, II and III
- Presence of a drain upon admission to the intensive care unit
- Conscious, oriented, and cooperative
- Provided verbal and written informed consent after receiving information about the study
Who cannot join
- Intubated
- Persistent anxiety before the surgery
- Diagnosed with panic disorder
- Chemotherapy within the last 6 months
- Diagnosed psychiatric illness or mental health problems
- Presence of edema
Show all 10Show fewer
- Intraoperative or postoperative complications
- Non-Turkish speaking, or presence of hearing or visual impairment
- Body mass index (BMI) greater than 30
- Participation in another clinical trial during the study period
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Özgül Aydemir
Istanbul, 34067
Özgül Aydemir, Doctor, +905435326567, ozgul6761@gmail.com
Öykü Kara, Specialist, +905546669614, oyku.kara@iuc.edu.tr
About this study
Official title: The Effects of Acupressure Combination on Post-Thoracotomy Pain and Lung Volume During Rest, Breathing-Coughing Exercises: A Randomized Controlled Study
Pain is a subjective, sensory and emotionally unpleasant experience resulting from real or hidden injuries in tissues. The pain experience is a subjective and unique experience in physiological and psychological terms and is the first negative sensory experience of the patient after the surgical procedure. Thoracotomy is an invasive surgical incision that causes severe postoperative pain due to the negative effect on the ribs, muscles and peripheral nerves. During thoracic surgery, anatomical lung resection is performed through posterolateral thoracotomy. Surgical incision during thoracotomy surgery is the most severe cause of postoperative pain. Epidural analgesia, peripheral nerve block and systematic treatment methods are used in post-thoracotomy pain management. Opioid use is frequently preferred in post-thoracotomy pain management. Although thoracotomy pain can mostly be controlled with opioid analgesics, excessive use of opioids may lead to respiratory suppression, constipation, suppression of cough, nausea, vomiting and many other possible side effects. Ineffective postoperative pain management may lead to postoperative complications such as increased cardiac workload, prolonged pulmonary rehabilitation and delayed wound healing. The use of holistic non-drug pain relief methods is vital in reducing the need for opioid analgesics and the risk of possible side effects in early postoperative pain management.
Read the detailed description
Many non-drug applications such as music therapy, transcutaneous electrical nerve stimulation, cryotherapy, acupuncture, electroacupuncture are used in pain management after thoracic surgery and to reduce analgesic use. Acupuncture is an application that provides the balance of energy flow (Qi) on meridians with thin needles placed at certain points of the body, which has been widely applied in China for more than 4000 years. Factors such as trauma and surgical incision disrupt the energy flow between meridians and cause problems in organ groups where meridians are effective. Acupuncture is accepted as an application that helps to balance this energy flow. Acupressure application, which is included in nursing practices, is a holistic non-pharmaceutical application based on acupuncture. Acupressure is a holistic treatment method that includes manual and noninvasive methods that provide stimulation to acupuncture points with pressure instead of needle stimulation. The point where acupressure will be applied is selected among the acupuncture points on the relevant meridian according to the problem existing in the individual. In acupressure application, pressure can be applied to a single point or more than one point consecutively.In acupressure application, it is reported that pressure can be applied to a single point, as well as stimulating multiple points consecutively will increase the desired effect. As the preferred acupuncture key points on the meridians, points on the hand, finger, wrist, palm, elbow, knee, and feet are often preferred. Acupressure tactilely reduces the sensation of pain by stimulating Aβ nerve fibres; increases the pain threshold by supporting the release of endogenous opioids; regulates the transmission of pain signals by secreting serotonin and norepinephrine, which are neurotransmitters responsible for the regulation of pain. In a randomised controlled study, the efficacy of acupressure in the treatment of postoperative pain in patients undergoing thoracoscopic surgery was examined. The participants in the experimental group were acupressured three times a day for two days at LI11, LU7, LU9, LU5, LU1, LU2, TE5, TE6, PC4, PC6 and LI4 acupressure points. In the control group, routine treatment of the clinic was applied and acupressure was not applied. After acupressure application, the pain score of the experimental group was found to be lower compared to the control group (p < 0.001). Similarly, it is reported in the literature that the use of acupressure is one of the best options for the relief of postoperative pain. It is also reported in the literature that acupressure can effectively improve lung function, dyspnoea and quality of life of patients with pneumonia.
Non-drug applications planned for the expected pain in the early postthoracotomy period are important in terms of reducing respiratory complications, improving the quality of pain management and supporting patients. When the literature is examined, there is no study examining the effect of acupressure on pain and lung volume during deep breathing and cough exercises, which have an important role in maintaining and improving lung volume after thoracotomy.
- Conditions
- Pain, Acute, Breathing, Mouth, Relaxation; Diaphragm, Cough, Lung Volume
- Being tested
- Acupressure group
- Keywords
- Thoracotomy after Pain, Acupressure, Pain, Lung Volume
- Medical subject headings
- Acute Pain, Mouth Breathing, Cough, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Acupressure groupOther
A series of acupressure applications
| Study group | Role | What they receive |
|---|---|---|
| Acupressure group | Experimental | Patients meeting the research criteria were included in the experimental group according to the randomisation table. The acupressure combination will be applied to the LI11, LU7, LU9, LU5, LU1, LU2, TE5, TE6,PC4, PC6 and LI4 points 2, 6 and 24 hours after surgery.
Applications will last 1 minute for each point. Applications will last 1 minute for each point. Patients in this group will continue to receive routine clinical treatment and care. The patients' pain level during rest, breathing, coughing and mobilisation before surgery and 2, 6 and 24 hours after surgery, blood pressure, respiratory rate, respiratory count, SpO2 values, and lung volume before surgery and 24 hours after surgery will be measured and recorded using triflow.
Additionally, the individuals' breathing and coughing exercise status will be assessed within the first 24 hours after surgery. These stages will also be carried out in a similar manner in the control group without any intervention. Receives: Other: Acupressure group |
| Control group | No intervention | Patients meeting the study criteria were included in the control group according to the randomisation table. Patients in this group will continue to receive routine clinical treatment and care. The patients' pain level during rest, breathing, coughing and mobilisation before surgery and 2, 6 and 24 hours after surgery, blood pressure, respiratory rate, respiratory count, SpO2 values, and lung volume before surgery and 24 hours after surgery will be measured and recorded using triflow. Additionally, individuals' breathing and coughing exercise status will be assessed within the first 24 hours after surgery. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain after thoracotomy
Pain after thoracotomy
Measured: The patient's visual analogue scale pain score (VAS) at 2, 6, and 24 hours post-surgery,
Secondary outcomes (1)
Pain during rest
Pain during rest
Measured: The patient's visual analogue scale pain score (VAS) at 2, 6, and 24 hours post-surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2026
- Study start6 Jan 2025
- Primary completion6 Jun 2026 (estimated)
- Study completion6 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pain, AcuteStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Parallel Assignment Randomised controlled experimental
- Masking
- Single blind
- Who is masked
- Care provider
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Özgül Aydemir
- Sponsor type
- University, hospital or other
- Collaborators
- Istanbul University - Cerrahpasa, Dogus Universitesi, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Yeditepe University Hospital
- Responsible party
- Sponsor-investigator, Özgül Aydemir, Dogus Universitesi
- Investigators
- İlhan Öztekin, Professör, Study director, Yeditepe UniversitySeher Deniz Öztekin, Professör, Study director, Doğuş University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07411417
- Sponsor's protocol ID
- E-95961207-202.3.02-5421
- Status last verified
- Feb 2026
- First submitted
- 31 Mar 2025
- Last updated
- 13 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Acupressure Combination on Post-Thoracotomy Pain and Lung Volume During Rest, Breathing-Coughing Exercises: A Randomized Controlled Study
- ClinicalTrials.gov ID
- NCT07411417
- Acronym / sponsor ID
- E-95961207-202.3.02-5421
- Conditions
- Pain, Acute, Breathing, Mouth, Relaxation; Diaphragm, Cough, Lung Volume
- Keywords
- Thoracotomy after Pain, Acupressure, Pain, Lung Volume
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Özgül AydemirUniversity, hospital or other
- Collaborators
- Istanbul University - Cerrahpasa, Dogus Universitesi, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Yeditepe University Hospital
- Study start
- 6 Jan 2025 (actual)
- Primary completion
- 6 Jun 2026 (estimated)
- Study completion
- 6 Jan 2027 (estimated)
- First posted
- 13 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Pain is a subjective, sensory and emotionally unpleasant experience resulting from real or hidden injuries in tissues. The pain experience is a subjective and unique experience in physiological and psychological terms and is the first negative sensory experience of the patient after the surgical procedure. Thoracotomy is an invasive surgical incision that causes severe postoperative pain due to the negative effect on the ribs, muscles and peripheral nerves. During thoracic surgery, anatomical lung resection is performed through posterolateral thoracotomy. Surgical incision during thoracotomy surgery is the most severe cause of postoperative pain. Epidural analgesia, peripheral nerve block and systematic treatment methods are used in post-thoracotomy pain management. Opioid use is frequently preferred in post-thoracotomy pain management. Although thoracotomy pain can mostly be controlled with opioid analgesics, excessive use of opioids may lead to respiratory suppression, constipation, suppression of cough, nausea, vomiting and many other possible side effects. Ineffective postoperative pain management may lead to postoperative complications such as increased cardiac workload, prolonged pulmonary rehabilitation and delayed wound healing. The use of holistic non-drug pain relief methods is vital in reducing the need for opioid analgesics and the risk of possible side effects in early postoperative pain management.
Detailed description
Many non-drug applications such as music therapy, transcutaneous electrical nerve stimulation, cryotherapy, acupuncture, electroacupuncture are used in pain management after thoracic surgery and to reduce analgesic use. Acupuncture is an application that provides the balance of energy flow (Qi) on meridians with thin needles placed at certain points of the body, which has been widely applied in China for more than 4000 years. Factors such as trauma and surgical incision disrupt the energy flow between meridians and cause problems in organ groups where meridians are effective. Acupuncture is accepted as an application that helps to balance this energy flow. Acupressure application, which is included in nursing practices, is a holistic non-pharmaceutical application based on acupuncture. Acupressure is a holistic treatment method that includes manual and noninvasive methods that provide stimulation to acupuncture points with pressure instead of needle stimulation. The point where acupressure will be applied is selected among the acupuncture points on the relevant meridian according to the problem existing in the individual. In acupressure application, pressure can be applied to a single point or more than one point consecutively.In acupressure application, it is reported that pressure can be applied to a single point, as well as stimulating multiple points consecutively will increase the desired effect. As the preferred acupuncture key points on the meridians, points on the hand, finger, wrist, palm, elbow, knee, and feet are often preferred. Acupressure tactilely reduces the sensation of pain by stimulating Aβ nerve fibres; increases the pain threshold by supporting the release of endogenous opioids; regulates the transmission of pain signals by secreting serotonin and norepinephrine, which are neurotransmitters responsible for the regulation of pain. In a randomised controlled study, the efficacy of acupressure in the treatment of postoperative pain in patients undergoing thoracoscopic surgery was examined. The participants in the experimental group were acupressured three times a day for two days at LI11, LU7, LU9, LU5, LU1, LU2, TE5, TE6, PC4, PC6 and LI4 acupressure points. In the control group, routine treatment of the clinic was applied and acupressure was not applied. After acupressure application, the pain score of the experimental group was found to be lower compared to the control group (p < 0.001). Similarly, it is reported in the literature that the use of acupressure is one of the best options for the relief of postoperative pain. It is also reported in the literature that acupressure can effectively improve lung function, dyspnoea and quality of life of patients with pneumonia.
Non-drug applications planned for the expected pain in the early postthoracotomy period are important in terms of reducing respiratory complications, improving the quality of pain management and supporting patients. When the literature is examined, there is no study examining the effect of acupressure on pain and lung volume during deep breathing and cough exercises, which have an important role in maintaining and improving lung volume after thoracotomy.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (care provider)
- Number of arms
- 2
- Model description
- Parallel Assignment Randomised controlled experimental
| Arm | Type | Receives |
|---|---|---|
| Acupressure group | Experimental | Other: Acupressure groupPatients meeting the research criteria were included in the experimental group according to the randomisation table. The acupressure combination will be applied to the LI11, LU7, LU9, LU5, LU1, LU2, TE5, TE6,PC4, PC6 and LI4 points 2, 6 and 24 hours after surgery. Applications will last 1 minute for each point. Applications will last 1 minute for each point. Patients in this group will continue to receive routine clinical treatment and care. The patients' pain level during rest, breathing, coughing and mobilisation before surgery and 2, 6 and 24 hours after surgery, blood pressure, respiratory rate, respiratory count, SpO2 values, and lung volume before surgery and 24 hours after surgery will be measured and recorded using triflow. Additionally, the individuals' breathing and coughing exercise status will be assessed within the first 24 hours after surgery. These stages will also be carried out in a similar manner in the control group without any intervention. |
| Control group | No intervention | –Patients meeting the study criteria were included in the control group according to the randomisation table. Patients in this group will continue to receive routine clinical treatment and care. The patients' pain level during rest, breathing, coughing and mobilisation before surgery and 2, 6 and 24 hours after surgery, blood pressure, respiratory rate, respiratory count, SpO2 values, and lung volume before surgery and 24 hours after surgery will be measured and recorded using triflow. Additionally, individuals' breathing and coughing exercise status will be assessed within the first 24 hours after surgery. |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (6 listed)
- Underwent thoracotomy
- Undergoing thoracic surgery for the first time
- Classified as ASA (American Society of Anesthesiology) physical status I, II and III
- Presence of a drain upon admission to the intensive care unit
- Conscious, oriented, and cooperative
Key exclusion criteria (10 listed)
- Intubated
- Persistent anxiety before the surgery
- Diagnosed with panic disorder
- Chemotherapy within the last 6 months
- Diagnosed psychiatric illness or mental health problems
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Acupressure groupA series of acupressure applications | Other | Acupressure group |
Primary outcome
Pain after thoracotomy
Time frame: The patient's visual analogue scale pain score (VAS) at 2, 6, and 24 hours post-surgery,
Pain after thoracotomy
1 secondary outcome
Pain during rest
Time frame: The patient's visual analogue scale pain score (VAS) at 2, 6, and 24 hours post-surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
İlhan Öztekin, Professör study director
Yeditepe University
Seher Deniz Öztekin, Professör study director
Doğuş University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Acupressure group in people with Pain, Acute and Breathing, Mouth, run by Özgül Aydemir at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Özgül Aydemir, Doctor (+905435326567, ozgul6761@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain after thoracotomy (time frame: The patient's visual analogue scale pain score (VAS) at 2, 6, and 24 hours post-surgery,). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Feb 2026; AzTrials last refreshed its copy on 7 Nov 2026.