PregnancyCOGEMNCT07408973
Prospective Twin Pregnancy Cohort at Montpellier University Hospital
An observational study of Pregnancy and Twin, run by University Hospital, Montpellier.
Trial summary
This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Read more about this study
- Who is it for?
- Ages 18 years and older
- What is being tested?
- Biological samples from the mother and Biological samples from the twins
- How many people
- 360 participants
- Where
- No sites listed yet
- Study dates
- Dec 2026to 1 Dec 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Any dichorionic or monochorionic twin pregnancy of more than 25 weeks' gestation, monitored at the University Hospital of Montpellier.
Mother's inclusion Criteria:
- Patient of legal age (≥ 18 years)
- Patient pregnant with a twin pregnancy ≥ 25 weeks of gestation
- Pregnancy initially twin, triplet, or quadruplet, progressing to a twin pregnancy after spontaneous or medical embryo reduction, or after selective termination of pregnancy
- Delivery planned at Montpellier University Hospital
Twins' inclusion Criteria:
- Twins born in a twin pregnancy ≥ 25 weeks of gestation
Mother's exclusion Criteria:
- Pregnant woman with at least one fetus presenting with a chromosomal or genetic abnormality or a polymalformative syndrome, and for whom early postnatal death is anticipated.
- Planned travel preventing the study from being completed
- Failure to obtain informed and written consent from the patient for participation in the study and the collection of biological samples
- Patient unable to read and/or write French
- Patient unable to understand and/or speak French
- Patient not benefiting from a national health insurance scheme
- Person under legal protection, guardianship or curatorship
- Person participating in other interventional research study
Twins' exclusion Criteria:
- Mother's absence from or withdrawal from the study
- Birth in a facility other than Montpellier University Hospital
- One or two children under guardianship
- Lack of informed and written consent from legal representatives
- One of the two fetuses is expected to die
- Lack of informed and written consent from the prospective parent(s) for participation in the study and the collection of biological samples
- Parents unable to read and/or write French
- Parents not understanding and/or speaking French
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Twin Pregnancy Cohort at Montpellier University Hospital for a Study of the Impact of the Exposome: Pilot Study
This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Grounded in the Developmental Origins of Health and Disease (DOHaD) framework, the study focuses on how environmental, biological, and lifestyle exposures during pregnancy and the first year of life influence fetal growth, neonatal health, and early development.
A total of 120 women with monochorionic or dichorionic twin pregnancies and their 240 children will be included. Maternal exposome assessment includes air pollution exposure, lifestyle, diet, medical history, and biological measurements. Neonatal outcomes, including abnormal birth weight, will be evaluated at birth, and children will be followed until one year of age to assess growth, health events, and developmental outcomes. Biological samples collected at different times during the study will allow the assessment of chemical exposures and epigenetic markers. This study aims to generate original French twin pregnancy data and to improve understanding of environmental determinants of early-life health.
Read the detailed description
Introduction:
Over the past two decades, growing epidemiological evidence in humans and experimental studies in animals have supported the concept of the Developmental Origins of Health and Disease (DOHaD), initially proposed by Barker. This hypothesis suggests that environmental and maternal conditions during critical periods of development-particularly the first 1,000 days of life, from conception to early childhood-can induce long-term effects on organogenesis, metabolic pathways, and physiological functions, ultimately influencing physical and mental health throughout life.
In parallel, the concept of the exposome, introduced by Wild in 2005, aims to comprehensively characterize all environmental exposures (chemical, physical, biological, behavioral, and socioeconomic) encountered by an individual from conception onwards. Twin pregnancies represent a particularly valuable model for exposome research, as they allow the study of shared and differential exposures within the same intrauterine environment. Establishing a large French cohort of twin pregnancies is therefore essential to generate national data and to investigate the impact of environmental exposures on pregnancy outcomes, neonatal health, and early childhood development.
Primary Aim:
Assess the impact of maternal exposome during twin pregnancies followed at Montpellier University Hospital on the occurrence of abnormal neonatal birth weight (small for gestational age) at birth.
Secondary Aims:
- Evaluate the impact of maternal exposome on neonatal abnormalities at birth and on child health outcomes during the first year of life.
- Assess the association between maternal exposome and the occurrence of obstetric complications.
- Compare outcomes between twins from monochorionic (monozygotic) and dichorionic pregnancies (dizygotic, different-sex twins), focusing on:
The impact of maternal exposome during pregnancy on child health outcomes. The impact of the child's own exposome on health outcomes during the first year of life.
Methods:
This is a prospective observational cohort study including women with twin pregnancies (monochorionic or dichorionic) of at least 25 weeks of gestation, followed and delivering at University Hospital of Montpellier (France). A total of 120 pregnant women and their 240 twin children will be enrolled.
Maternal data will be collected during pregnancy through electronic questionnaires and medical records, including sociodemographic characteristics, medical and obstetric history, lifestyle, diet, and environmental exposures. Maternal exposome assessment includes long-term exposure to ambient air pollutants from two years before pregnancy and throughout gestation, as well as biological measurements such as urinary lead levels at 25 weeks of gestation.
At delivery, biological samples will be collected from the mother, placenta, and umbilical cord (blood and tissue). Neonatal data will include anthropometric measurements and clinical outcomes at birth. The child exposome will be assessed through environmental exposure data during pregnancy and the first year of life, questionnaires on lifestyle and environment, and biological analyses including exposure to PFAS, heavy metals, and genomic/epigenetic markers from cord blood and tissue samples.
- Being tested
- Biological samples from the mother, Biological samples from the twins
- Keywords
- Exposome, Air Pollutants, Lead, Diet, Food, and Nutrition, Healthy Lifestyle, Obstetric Labor Complications, Children Health
- Medical subject headings
- Obstetric Labor Complications
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Biological samples from the motherOther
During pregnancy, the research team collects:
- 15 ml of urine from the expectant mother.
Immediately after delivery, the research team collects:
- 10 ml of peripheral blood from the mother
- One or two 2 cm x 2 cm pieces of placenta, depending on the type of pregnancy
- 12 ml of cord blood for each twin
- A 5 cm fragment of cord tissue for each twin
Biological samples from the twinsOther
The day after delivery, the reserch team collects:
- A meconium sample from each twin
At 6 months and 1 year of age, the parents collect:
- A stool sample from each twin
| Study group | Role | What they receive |
|---|---|---|
| Women pregnant with twins | Not described Receives: Other: Biological samples from the mother | |
| Twins newborns | Not described Receives: Other: Biological samples from the twins |
What is being measured
The primary outcome is the main question the study is designed to answer.
Maternal extern exposome
Exposure to air pollutants (NO₂, PM₂.₅, O₃, VOCs) during the two years prior to and during pregnancy: these values will be derived from the Chimera model, and an area under the exposure curve will be calculated.
The level of exposure will be calculated based on the mother's home addresses during the two years prior to inclusion, at the time of inclusion, and based on her work addresses during pregnancy if she worked for more than four months during pregnancy.
These data will be assessed individually and incorporated into a statistical model.
Data from the patient follow-up log, data from questionnaires:
- Environment, general health, lifestyle, and diet.
- Obstetric, medical, and surgical history, current pregnancy. These data will be assessed individually and incorporated into a statistical model.
Measured: From two years before pregnancy until delivery
Maternal intern exposome
Amount of lead in urine at 25 weeks of gestation. Lead will be measured by Montpellier University Hospital in a urine sample taken during the sixth month of pregnancy (inclusion) using ICP-Ms.
These data will be assessed individually and incorporated into a statistical model.
Measured: From two years before pregnancy until delivery
Abnormal newborn weight
Growth retardation: Abnormal birth weight (in kg) for at least one of the two children (< 3rd percentile according to the Olsen curve).
Measured: At childbirth
Secondary outcomes (5)
Abnormalities in children
- Occurrence of one or more altered anthropometric characteristics (outside reference values) at birth: fetal macrosomia, abnormal height, abnormal head circumference.
- Occurrence of one or more altered anthropometric characteristics (outside reference values) at D+15, 1, 3, 6, 8, 10 months and 1 year: abnormal weight (<3rd or >97th percentile, Olsen curve), abnormal height (<5th or >95th percentile), abnormal head circumference (<5th or >95th percentile).
- Occurrence of a serious health problem at birth or during the first year of life.
- Knowledge of occurrence of one or more of the following conditions during the first year: ENT, respiratory, gastroenterological, dermatological conditions, recognized atopy/allergies, early neurodevelopmental disorder.
All these data will be assessed individually and incorporated into a statistical model.
Measured: From childbirth to the twins' first birthday
Obstetric complications
Occurrence of at least one of the obstetric complications listed in the patient follow-up record.
Measured: At childbirth
Comparison of the Twins
- Type of pregnancy from which the twins originate: monochorionic (monoamniotic or biamniotic) or dichorionic.
- Sex of twins: 2 girls, or 2 boys, or 1 girl and 1 boy
Measured: At childbirth
Children's extern exposome
Exposure to air pollutants (NO2, PM2.5, O3, VOCs) throughout pregnancy and during the first year of life: these values will be derived from the Chimera model, and an area under the exposure curve will be calculated.
The level of exposure will be determined based on the mother's personal and professional addresses during pregnancy and the first year of the children's lives.
These data will be assessed individually and incorporated into a statistical model.
Data from the patient follow-up log, data from questionnaires:
- Environment, lifestyle, diet, treatments received, games and care. These data will be assessed individually and incorporated into a statistical model.
Measured: From childbirth to the twins' first birthday
Children's intern exposome
- Exposure to PFAS (per- and polyfluoroalkyl substances) substances can be measured using a piece of umbilical cord taken at birth. The measurement of PFAS in a piece of umbilical cord will be outsourced to a competent laboratory. The PFAS will be extracted from the tissue, then separated and finally quantified using a highly accurate analytical technique.
These data will be assessed individually and incorporated into a statistical model.
- Exposure to heavy metals can be measured using a sample of umbilical cord blood taken at birth. The measurement of heavy metals will be entrusted to a competent laboratory. The elements (lead, manganese, copper, zinc, mercury, cadmium, arsenic, selenium) present in the blood are measured by inductively coupled plasma mass spectrometry (ICP-MSMS) after being mineralised (internal method ESS_ANA_PT_641).
These data will be assessed individually and incorporated into a statistical model.
Measured: From childbirth to the twins' first birthday
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2026
- Study startDec 2026 (estimated)
- Primary completion1 Mar 2030 (estimated)
- Study completion1 Dec 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (19)Papers the sponsor has linked to this study.
- Other trials for PregnancyStudies of the same condition, open and under way.
- More trials run by University Hospital, MontpellierThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 360 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Montpellier
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Florent FUCHS, MD, PhD, Principal investigator, University Hopistal of Montpellier
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07408973
- Sponsor's protocol ID
- RECHMPL23_0476
- Other IDs
- 2024-A02160-47
- Acronym
- COGEM
- Status last verified
- Jun 2026
- First submitted
- 22 Jan 2026
- Last updated
- 18 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: NC
Publications
Robinson R. The fetal origins of adult disease. BMJ. 2001 Feb 17;322(7283):375-6. doi: 10.1136/bmj.322.7283.375. No abstract available.
PubMed 11179140Kozyrskyj AL, Bahreinian S, Azad MB. Early life exposures: impact on asthma and allergic disease. Curr Opin Allergy Clin Immunol. 2011 Oct;11(5):400-6. doi: 10.1097/ACI.0b013e328349b166.
PubMed 21772139Wild CP. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50. doi: 10.1158/1055-9965.EPI-05-0456. No abstract available.
PubMed 16103423Gordon H, Blad W, Trier Moller F, Orchard T, Steel A, Trevelyan G, Ng S, Harbord M. UK IBD Twin Registry: Concordance and Environmental Risk Factors of Twins with IBD. Dig Dis Sci. 2022 Jun;67(6):2444-2450. doi: 10.1007/s10620-021-07080-5. Epub 2021 Jun 7.
PubMed 34097167Southwest Thames Obstetric Research Collaborative (STORK). Prospective risk of late stillbirth in monochorionic twins: a regional cohort study. Ultrasound Obstet Gynecol. 2012 May;39(5):500-4. doi: 10.1002/uog.11110. Epub 2012 Mar 7.
PubMed 22302586Garne E, Andersen HJ. The impact of multiple pregnancies and malformations on perinatal mortality. J Perinat Med. 2004;32(3):215-9. doi: 10.1515/JPM.2004.040.
PubMed 15188793Bricker L. Optimal antenatal care for twin and triplet pregnancy: the evidence base. Best Pract Res Clin Obstet Gynaecol. 2014 Feb;28(2):305-17. doi: 10.1016/j.bpobgyn.2013.12.006. Epub 2013 Dec 17.
PubMed 24412490Campbell DM, MacGillivray I. Preeclampsia in twin pregnancies: incidence and outcome. Hypertens Pregnancy. 1999;18(3):197-207. doi: 10.3109/10641959909016193.
PubMed 10586523Schwartz DB, Daoud Y, Zazula P, Goyert G, Bronsteen R, Wright D, Copes J. Gestational diabetes mellitus: metabolic and blood glucose parameters in singleton versus twin pregnancies. Am J Obstet Gynecol. 1999 Oct;181(4):912-4. doi: 10.1016/s0002-9378(99)70324-8.
PubMed 10521752Tang HHF, Teo SM, Sly PD, Holt PG, Inouye M. The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges. J Allergy Clin Immunol. 2021 Mar;147(3):781-793. doi: 10.1016/j.jaci.2020.08.026.
PubMed 33678251Delvert R, Ghozal M, Adel-Patient K, Kadawathagedara M, Heude B, Charles MA, Annesi-Maesano I, Tafflet M, Leynaert B, Varraso R, de Lauzon-Guillain B, Bedard A. Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother-Child Cohort. Nutrients. 2022 Dec 28;15(1):146. doi: 10.3390/nu15010146.
PubMed 36615802Mensink-Bout SM, van Meel ER, de Jongste JC, Annesi-Maesano I, Aubert AM, Bernard JY, Chen LW, Cooper C, Crozier SR, Hanke W, Harvey NC, Hebert JR, Heude B, Jerzynska J, Kelleher CC, Mehegan J, McAuliffe FM, Phillips CM, Polanska K, Relton CL, Shivappa N, Suderman M, Jaddoe VWV, Duijts L. Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children. Eur Respir J. 2022 Apr 21;59(4):2101315. doi: 10.1183/13993003.01315-2021. Print 2022 Apr.
PubMed 34503987Collado-Soler R, Alferez-Pastor M, Torres FL, Trigueros R, Aguilar-Parra JM, Navarro N. A Systematic Review of Healthy Nutrition Intervention Programs in Kindergarten and Primary Education. Nutrients. 2023 Jan 20;15(3):541. doi: 10.3390/nu15030541.
PubMed 36771248Rani P, Dhok A. Effects of Pollution on Pregnancy and Infants. Cureus. 2023 Jan 18;15(1):e33906. doi: 10.7759/cureus.33906. eCollection 2023 Jan.
PubMed 36819435Olutola BG, Phoobane P. A Bibliometric Analysis of Literature on Prenatal Exposure to Air Pollution: 1994-2022. Int J Environ Res Public Health. 2023 Feb 9;20(4):3076. doi: 10.3390/ijerph20043076.
PubMed 36833768
Study at a glance
From the registry record, last updated by the sponsor on 18 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Twin Pregnancy Cohort at Montpellier University Hospital for a Study of the Impact of the Exposome: Pilot Study
- ClinicalTrials.gov ID
- NCT07408973
- Acronym / sponsor ID
- COGEM / RECHMPL23_0476
- Keywords
- Exposome, Air Pollutants, Lead, Diet, Food, and Nutrition, Healthy Lifestyle, Obstetric Labor Complications, Children Health
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 360 participants (estimated)
- Lead sponsor
- University Hospital, MontpellierUniversity, hospital or other
- Collaborators
- Institut National de la Santé Et de la Recherche Médicale, France
- Study start
- Dec 2026 (estimated)
- Primary completion
- 1 Mar 2030 (estimated)
- Study completion
- 1 Dec 2030 (estimated)
- First posted
- 13 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational cohort study aims to investigate the impact of the maternal and early-life exposome on neonatal and early childhood health outcomes in twin pregnancies followed at University Hospital of Montpellier (France). Grounded in the Developmental Origins of Health and Disease (DOHaD) framework, the study focuses on how environmental, biological, and lifestyle exposures during pregnancy and the first year of life influence fetal growth, neonatal health, and early development.
A total of 120 women with monochorionic or dichorionic twin pregnancies and their 240 children will be included. Maternal exposome assessment includes air pollution exposure, lifestyle, diet, medical history, and biological measurements. Neonatal outcomes, including abnormal birth weight, will be evaluated at birth, and children will be followed until one year of age to assess growth, health events, and developmental outcomes. Biological samples collected at different times during the study will allow the assessment of chemical exposures and epigenetic markers. This study aims to generate original French twin pregnancy data and to improve understanding of environmental determinants of early-life health.
Detailed description
Introduction:
Over the past two decades, growing epidemiological evidence in humans and experimental studies in animals have supported the concept of the Developmental Origins of Health and Disease (DOHaD), initially proposed by Barker. This hypothesis suggests that environmental and maternal conditions during critical periods of development-particularly the first 1,000 days of life, from conception to early childhood-can induce long-term effects on organogenesis, metabolic pathways, and physiological functions, ultimately influencing physical and mental health throughout life.
In parallel, the concept of the exposome, introduced by Wild in 2005, aims to comprehensively characterize all environmental exposures (chemical, physical, biological, behavioral, and socioeconomic) encountered by an individual from conception onwards. Twin pregnancies represent a particularly valuable model for exposome research, as they allow the study of shared and differential exposures within the same intrauterine environment. Establishing a large French cohort of twin pregnancies is therefore essential to generate national data and to investigate the impact of environmental exposures on pregnancy outcomes, neonatal health, and early childhood development.
Primary Aim:
Assess the impact of maternal exposome during twin pregnancies followed at Montpellier University Hospital on the occurrence of abnormal neonatal birth weight (small for gestational age) at birth.
Secondary Aims:
- Evaluate the impact of maternal exposome on neonatal abnormalities at birth and on child health outcomes during the first year of life.
- Assess the association between maternal exposome and the occurrence of obstetric complications.
- Compare outcomes between twins from monochorionic (monozygotic) and dichorionic pregnancies (dizygotic, different-sex twins), focusing on:
The impact of maternal exposome during pregnancy on child health outcomes. The impact of the child's own exposome on health outcomes during the first year of life.
Methods:
This is a prospective observational cohort study including women with twin pregnancies (monochorionic or dichorionic) of at least 25 weeks of gestation, followed and delivering at University Hospital of Montpellier (France). A total of 120 pregnant women and their 240 twin children will be enrolled.
Maternal data will be collected during pregnancy through electronic questionnaires and medical records, including sociodemographic characteristics, medical and obstetric history, lifestyle, diet, and environmental exposures. Maternal exposome assessment includes long-term exposure to ambient air pollutants from two years before pregnancy and throughout gestation, as well as biological measurements such as urinary lead levels at 25 weeks of gestation.
At delivery, biological samples will be collected from the mother, placenta, and umbilical cord (blood and tissue). Neonatal data will include anthropometric measurements and clinical outcomes at birth. The child exposome will be assessed through environmental exposure data during pregnancy and the first year of life, questionnaires on lifestyle and environment, and biological analyses including exposure to PFAS, heavy metals, and genomic/epigenetic markers from cord blood and tissue samples.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Women pregnant with twins | – | Other: Biological samples from the mother |
| Twins newborns | – | Other: Biological samples from the twins |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Any dichorionic or monochorionic twin pregnancy of more than 25 weeks' gestation, monitored at the University Hospital of Montpellier.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Biological samples from the motherDuring pregnancy, the research team collects: - 15 ml of urine from the expectant mother. Immediately after delivery, the research team collects: * 10 ml of peripheral blood from the mother * One or two 2 cm x 2 cm pieces of placenta, depending on the type of pregnancy * 12 ml of cord blood for each twin * A 5 cm fragment of cord tissue for each twin | Other | Women pregnant with twins |
| Biological samples from the twinsThe day after delivery, the reserch team collects: - A meconium sample from each twin At 6 months and 1 year of age, the parents collect: - A stool sample from each twin | Other | Twins newborns |
Primary outcome
Maternal extern exposome
Time frame: From two years before pregnancy until delivery
Exposure to air pollutants (NO₂, PM₂.₅, O₃, VOCs) during the two years prior to and during pregnancy: these values will be derived from the Chimera model, and an area under the exposure curve will be calculated. The level of exposure will be calculated based on the mother's home addresses during the two years prior to inclusion, at the time of inclusion, and based on her work addresses during pregnancy if she worked for more than four months during pregnancy. These data will be assessed individually and incorporated into a statistical model. Data from the patient follow-up log, data from questionnaires: * Environment, general health, lifestyle, and diet. * Obstetric, medical, and surgical history, current pregnancy. These data will be assessed individually and incorporated into a statistical model.
Maternal intern exposome
Time frame: From two years before pregnancy until delivery
Amount of lead in urine at 25 weeks of gestation. Lead will be measured by Montpellier University Hospital in a urine sample taken during the sixth month of pregnancy (inclusion) using ICP-Ms. These data will be assessed individually and incorporated into a statistical model.
Abnormal newborn weight
Time frame: At childbirth
Growth retardation: Abnormal birth weight (in kg) for at least one of the two children (< 3rd percentile according to the Olsen curve).
5 secondary outcomes
Abnormalities in children
Time frame: From childbirth to the twins' first birthday
Obstetric complications
Time frame: At childbirth
Comparison of the Twins
Time frame: At childbirth
Children's extern exposome
Time frame: From childbirth to the twins' first birthday
Children's intern exposome
Time frame: From childbirth to the twins' first birthday
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Jun 2026.
- Background: PubMed 11179140Robinson R. The fetal origins of adult disease. BMJ. 2001 Feb 17;322(7283):375-6. doi: 10.1136/bmj.322.7283.375. No abstract available.
- Background: PubMed 21772139Kozyrskyj AL, Bahreinian S, Azad MB. Early life exposures: impact on asthma and allergic disease. Curr Opin Allergy Clin Immunol. 2011 Oct;11(5):400-6. doi: 10.1097/ACI.0b013e328349b166.
- Background: PubMed 16103423Wild CP. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50. doi: 10.1158/1055-9965.EPI-05-0456. No abstract available.
- Background: PubMed 34097167Gordon H, Blad W, Trier Moller F, Orchard T, Steel A, Trevelyan G, Ng S, Harbord M. UK IBD Twin Registry: Concordance and Environmental Risk Factors of Twins with IBD. Dig Dis Sci. 2022 Jun;67(6):2444-2450. doi: 10.1007/s10620-021-07080-5. Epub 2021 Jun 7.
- Background: PubMed 22302586Southwest Thames Obstetric Research Collaborative (STORK). Prospective risk of late stillbirth in monochorionic twins: a regional cohort study. Ultrasound Obstet Gynecol. 2012 May;39(5):500-4. doi: 10.1002/uog.11110. Epub 2012 Mar 7.
- Background: PubMed 15188793Garne E, Andersen HJ. The impact of multiple pregnancies and malformations on perinatal mortality. J Perinat Med. 2004;32(3):215-9. doi: 10.1515/JPM.2004.040.
- Background: PubMed 24412490Bricker L. Optimal antenatal care for twin and triplet pregnancy: the evidence base. Best Pract Res Clin Obstet Gynaecol. 2014 Feb;28(2):305-17. doi: 10.1016/j.bpobgyn.2013.12.006. Epub 2013 Dec 17.
- Background: PubMed 10586523Campbell DM, MacGillivray I. Preeclampsia in twin pregnancies: incidence and outcome. Hypertens Pregnancy. 1999;18(3):197-207. doi: 10.3109/10641959909016193.
- Background: PubMed 10521752Schwartz DB, Daoud Y, Zazula P, Goyert G, Bronsteen R, Wright D, Copes J. Gestational diabetes mellitus: metabolic and blood glucose parameters in singleton versus twin pregnancies. Am J Obstet Gynecol. 1999 Oct;181(4):912-4. doi: 10.1016/s0002-9378(99)70324-8.
- Background: PubMed 33678251Tang HHF, Teo SM, Sly PD, Holt PG, Inouye M. The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges. J Allergy Clin Immunol. 2021 Mar;147(3):781-793. doi: 10.1016/j.jaci.2020.08.026.
- Background: PubMed 36615802Delvert R, Ghozal M, Adel-Patient K, Kadawathagedara M, Heude B, Charles MA, Annesi-Maesano I, Tafflet M, Leynaert B, Varraso R, de Lauzon-Guillain B, Bedard A. Maternal Diet Quality during Pregnancy and Allergic and Respiratory Multimorbidity Clusters in Children from the EDEN Mother-Child Cohort. Nutrients. 2022 Dec 28;15(1):146. doi: 10.3390/nu15010146.
- Background: PubMed 34503987Mensink-Bout SM, van Meel ER, de Jongste JC, Annesi-Maesano I, Aubert AM, Bernard JY, Chen LW, Cooper C, Crozier SR, Hanke W, Harvey NC, Hebert JR, Heude B, Jerzynska J, Kelleher CC, Mehegan J, McAuliffe FM, Phillips CM, Polanska K, Relton CL, Shivappa N, Suderman M, Jaddoe VWV, Duijts L. Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children. Eur Respir J. 2022 Apr 21;59(4):2101315. doi: 10.1183/13993003.01315-2021. Print 2022 Apr.
- French perinatal survey 2021Link provided by the sponsor.
- Individual participant dataSharing planned: Undecided. NC
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Florent FUCHS, MD, PhD principal investigator
University Hopistal of Montpellier
Questions about this trial
What is this clinical trial studying?
An observational study of Pregnancy and Twin, run by University Hospital, Montpellier.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Florent FUCHS, MD, PhD (+334 67 33 09 80, f-fuchs@chu-montpellier.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Maternal extern exposome (time frame: From two years before pregnancy until delivery). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07408973, which also lists 19 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Jun 2026.