Septoplasty SurgeriesNCT07407751
Disorders of the Lateral Nasal Wall and Nasal Septum in Patients Candidate for Septorhinoplasty
A study testing rhinoplasty and septoplasty in people with Septoplasty Surgeries, run by Sohag University.
Trial summary
Our aim of this study is to provide a detailed description of the lateral nasal wall and nasal septum disorders faced by the surgeon in septorhinoplasty operation and evaluation of therapeutic techniques for their management Read more about this study
- Who is it for?
- Ages 16 to 60 years
- Conditions the study is for
- Septoplasty Surgeries
- What is being tested?
- rhinoplasty and septoplasty
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 25 participants
- Where
- No sites listed yet
- Study dates
- 1 Mar 2026to 1 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 to 60 years
- All sexes
- No healthy volunteers
- Child, Adult
Who may be able to join
- All sept rhinoplasty patients aged between 16-60 years
Who cannot join
- participants who had a history of major craniofacial trauma or surgeries
- conditions such as acromegaly or gigantism
- fungal infections in the paranasal sinuses
- craniofacial malignancies
- chronic rhinosinusitis
- congenital anomalies like cleft lip or cleft palate.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Our aim of this study is to provide a detailed description of the lateral nasal wall and nasal septum disorders faced by the surgeon in septorhinoplasty operation and evaluation of therapeutic techniques for their management
Read the detailed description
Septorhinoplasty is among the most frequently performed plastic surgeries and a common surgical procedure in the field of head and neck. A minor modification of 1 mm can significantly affect the surgical result, necessitating an in-depth understanding of nasal anatomy and adjacent structures on the part of the surgery. The surgical goal for these patients is to address both aesthetic and functional issues, ultimately enhancing their quality of life.
Advancements in understanding the anatomy and physiological characteristics of the nose have paralleled the evolution of surgical remedies for obstructive and aesthetic nasal issues.
The nasal septum carries out several functions, such as splitting the nasal passage into two distinct compartments, maintaining the shape of the nasal dorsum, columella, and nasal tip. Disruptions, be it from injury or innate malformations, in the septum can result in substantial nasal obstruction and visible nasal deformities. The architecture of the nasal septum is composed of distinct osseous and cartilaginous elements, which encompass the perpendicular plate of the ethmoid bone, the vomer bone, and the septal cartilage.
A flawless, undeviated septum ensures that incoming air is humidified, warmed, cleansed, and made appropriate for gas exchanges in the lung alveoli. However, a deviated septum can create various degrees of nasal blockage and modifications in nasal respiration. Disruptions in the airflow can result in olfactory impairment, impairment in the purification and humidification of respiratory air, and diminished oxygen intake. Additionally, anatomical aberrations in the septum can cause epistaxis (nosebleeds), chronic sinusitis, and commonly manifest as visible alterations in the nose's exterior appearance. Septum deviation indicates a departure from the midline, whether of the bone or cartilage, or both.
Common deformities associated with the septum include the subluxation of the rectangular cartilage from the maxillary ridge, or its deviations, which block the nasal floor and distort laminar airflow. Also, Deviation of the caudal portion of the nasal septum may result in nasal obstruction, a crooked nose, and columellar irregularities. The correction of a severely deviated caudal septum is one of the most difficult challenges for the otolaryngologist.
One potential cause of treatment failure may be misidentification of other comorbid causes of nasal obstruction, specifically nasal valve collapse (NVC). Nasal valve collapse not only affects function but also shape of the nose, concurrent NVC is often viewed as an important feature to identify prior to a septorhinoplasty to prevent need for revision surgery .
On each lateral wall of the nasal cavity, there are three bony projections known as nasal turbinates. Disorders in the lateral wall can affect the function of the nose. In a condition known as concha bullosa, the turbinate has a double layer of bone instead of a single layer.
- Conditions
- Septoplasty Surgeries
- Being tested
- rhinoplasty, septoplasty
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
rhinoplastyProcedure or surgery
in case inferior turbinate hypertrophy we will do turbinoplasty in case middle turbinate hypertrophy and concha bullosa we will do excision of the medial half of the turbinate in case nasal valve collpase we will manage it using spreader and or batten graft
septoplastyProcedure or surgery
in severe deviated septum we will do submucous resection of the septum in caudal septum dislocation we will refix the septum to the anterior septal angle in fracture cartilagenous septum we will do septoplasty in maxillary crest deviation we will excise it using ostetomies in spurred vomer we will excise it by bone nippler
| Study group | Role | What they receive |
|---|---|---|
| patients with lateral nasal wall disorders | Other | patients with latersl nasal wall disorders such as (middle turbinate hypertrophy, inferior turbinate hypertrophy, concha bullosa, nasal valve collapse) in case inferior turbinate hypertrophy we will do turbinoplasty in case middle turbinate hypertrophy and concha bullosa we will do excision of the medial half of the turbinate in case nasal valve collpase we will manage it using spreader and or batten graft Receives: Procedure: rhinoplasty |
| patients with nasal septum disorders | Other | patients with nasal septum disoreders such as ( severe deviated septum either C or S shaped, caudal septum dislocation, fracture cartilagenous septum, maxillary crest deviations, spurred vomer) in severe deviated septum we will do submucous resection of the septum in caudal septum dislocation we will refix the septum to the anterior septal angle in fracture cartilagenous septum we will do septoplasty in maxillary crest deviation we will excise it using ostetomies in spurred vomer we will excise it by bone nippler Receives: Procedure: septoplasty |
What is being measured
The primary outcome is the main question the study is designed to answer.
straight nose
A straight good looking external nasal framework with straight dorsal nose without nasal valve collapse Postoperative standardized frontal and lateral 2D photographs will be rated by 2 independent blinded experts Patient satisfaction will be assessed using FACE-Q rhinoplasty module
Measured: 2 months
Secondary outcomes (1)
Nasal Airway Patency
A straight nasal septum without any deviations or deformities and patent nasal airway without turbinate hypertrophy by endoscopic assessment Airway patency will be assessed by NOSE Score
Measured: 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Feb 2026
- Study start1 Mar 2026 (estimated)
- Primary completion1 Feb 2027 (estimated)
- Study completion1 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Septoplasty SurgeriesStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Ahmed Mahmoud Mohamed, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07407751
- Sponsor's protocol ID
- Soh-Med--25-12-6MD
- Status last verified
- Feb 2026
- First submitted
- 16 Jan 2026
- Last updated
- 12 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
1. Eugene Tardy M, Regan Thomas J. Cummings Otolaryngology- Head and Neck Surgery, 5th ed. Mosby: 2015.chapter 36; P.544-508. 2. Aziz T, Ansari K, Lagravere MO, Major MP, Flores- Mir C. Effect of non- surgical maxillary expansion on thenasal septum deviation: a systematic review. Prog Orthod. 2015;16:15. [DOI:10.1186/s40510-015-0084-y] [PMID] [PMCID]. 3. Samrid R, Chaisiwamongkol K, Thanaviratananich S, Sukhorum W, Yimdee J, Iamsaard S. The anatomical study of the nasal septum in north- east Thai Cadavers. Srinagarind Med J. 2013;28(4):279-81. 4. Kenyon G. Nasal Anatomy and Analysis. Otolaryngol Clin An Int J. 2013;5(1):34-42. [DOI:10.5005/aijoc-5-1-12] 5. Bailey BJ, Johnson JT, Newlands SD. (editors). Head & neck surgery-otolaryngology, 4th ed. Philadelphia, Lippincott Williams & Wilkins;2006. 6. Brennan HG, Parkes ML. Septal surgery: the high septal transfixion. Int J Surg. 1973;58(10):732. 7. D'Ascanio L, Manzini M. Quick septoplasty: surgical technique and learning curve. Aesthetic Plast Surg. 2009;33(6):814-8. [DOI:10.1007/s00266-009-9388-y] [PMID] 8. Baumann I, Baumann H. A new classification of septal deviations. Rhinology. 2007;45(3):220-3. 9. Byrd HS, Constantian MB, Guyuron B, Pastorek N. Revision rhinoplasty. Aesthet Surg J. 2007.27(2):175-87. [DOI:10.1016/j.asj.2007.02.001] [PMID] 10. Hong SD, Lee NJ, Cho HJ, Jang MS, Jung TY, Kim HY, Chung SK, Dhong HJ. Predictive factors of subjective outcomes after septoplasty with and without turbinoplasty: can individual perceptual differences of the air passage be a main factor? Int Forum Allergy Rhinol. 2015;5(7):616-21. 11. Becker SS, Dobratz EJ, Stowell N, Barker D, Park SS. Revision septoplasty: review of sources of persistent nasal obstruction. Am J Rhinol. 2008;22(4):440-4.
Study at a glance
From the registry record, last updated by the sponsor on 12 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Disorders of the Lateral Nasal Wall and Nasal Septum in Patients Candidate for Septorhinoplasty
- ClinicalTrials.gov ID
- NCT07407751
- Acronym / sponsor ID
- Soh-Med--25-12-6MD
- Conditions
- Septoplasty Surgeries
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 1 Mar 2026 (estimated)
- Primary completion
- 1 Feb 2027 (estimated)
- Study completion
- 1 Mar 2027 (estimated)
- First posted
- 12 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Our aim of this study is to provide a detailed description of the lateral nasal wall and nasal septum disorders faced by the surgeon in septorhinoplasty operation and evaluation of therapeutic techniques for their management
Detailed description
Septorhinoplasty is among the most frequently performed plastic surgeries and a common surgical procedure in the field of head and neck. A minor modification of 1 mm can significantly affect the surgical result, necessitating an in-depth understanding of nasal anatomy and adjacent structures on the part of the surgery. The surgical goal for these patients is to address both aesthetic and functional issues, ultimately enhancing their quality of life.
Advancements in understanding the anatomy and physiological characteristics of the nose have paralleled the evolution of surgical remedies for obstructive and aesthetic nasal issues.
The nasal septum carries out several functions, such as splitting the nasal passage into two distinct compartments, maintaining the shape of the nasal dorsum, columella, and nasal tip. Disruptions, be it from injury or innate malformations, in the septum can result in substantial nasal obstruction and visible nasal deformities. The architecture of the nasal septum is composed of distinct osseous and cartilaginous elements, which encompass the perpendicular plate of the ethmoid bone, the vomer bone, and the septal cartilage.
A flawless, undeviated septum ensures that incoming air is humidified, warmed, cleansed, and made appropriate for gas exchanges in the lung alveoli. However, a deviated septum can create various degrees of nasal blockage and modifications in nasal respiration. Disruptions in the airflow can result in olfactory impairment, impairment in the purification and humidification of respiratory air, and diminished oxygen intake. Additionally, anatomical aberrations in the septum can cause epistaxis (nosebleeds), chronic sinusitis, and commonly manifest as visible alterations in the nose's exterior appearance. Septum deviation indicates a departure from the midline, whether of the bone or cartilage, or both.
Common deformities associated with the septum include the subluxation of the rectangular cartilage from the maxillary ridge, or its deviations, which block the nasal floor and distort laminar airflow. Also, Deviation of the caudal portion of the nasal septum may result in nasal obstruction, a crooked nose, and columellar irregularities. The correction of a severely deviated caudal septum is one of the most difficult challenges for the otolaryngologist.
One potential cause of treatment failure may be misidentification of other comorbid causes of nasal obstruction, specifically nasal valve collapse (NVC). Nasal valve collapse not only affects function but also shape of the nose, concurrent NVC is often viewed as an important feature to identify prior to a septorhinoplasty to prevent need for revision surgery .
On each lateral wall of the nasal cavity, there are three bony projections known as nasal turbinates. Disorders in the lateral wall can affect the function of the nose. In a condition known as concha bullosa, the turbinate has a double layer of bone instead of a single layer.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| patients with lateral nasal wall disorders | Other | Procedure: rhinoplastypatients with latersl nasal wall disorders such as (middle turbinate hypertrophy, inferior turbinate hypertrophy, concha bullosa, nasal valve collapse) in case inferior turbinate hypertrophy we will do turbinoplasty in case middle turbinate hypertrophy and concha bullosa we will do excision of the medial half of the turbinate in case nasal valve collpase we will manage it using spreader and or batten graft |
| patients with nasal septum disorders | Other | Procedure: septoplastypatients with nasal septum disoreders such as ( severe deviated septum either C or S shaped, caudal septum dislocation, fracture cartilagenous septum, maxillary crest deviations, spurred vomer) in severe deviated septum we will do submucous resection of the septum in caudal septum dislocation we will refix the septum to the anterior septal angle in fracture cartilagenous septum we will do septoplasty in maxillary crest deviation we will excise it using ostetomies in spurred vomer we will excise it by bone nippler |
Who may qualify
- Ages
- 16 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- All sept rhinoplasty patients aged between 16-60 years
Key exclusion criteria (6 listed)
- participants who had a history of major craniofacial trauma or surgeries
- conditions such as acromegaly or gigantism
- fungal infections in the paranasal sinuses
- craniofacial malignancies
- chronic rhinosinusitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| rhinoplastyin case inferior turbinate hypertrophy we will do turbinoplasty in case middle turbinate hypertrophy and concha bullosa we will do excision of the medial half of the turbinate in case nasal valve collpase we will manage it using spreader and or batten graft | Procedure or surgery | patients with lateral nasal wall disorders |
| septoplastyin severe deviated septum we will do submucous resection of the septum in caudal septum dislocation we will refix the septum to the anterior septal angle in fracture cartilagenous septum we will do septoplasty in maxillary crest deviation we will excise it using ostetomies in spurred vomer we will excise it by bone nippler | Procedure or surgery | patients with nasal septum disorders |
Primary outcome
straight nose
Time frame: 2 months
A straight good looking external nasal framework with straight dorsal nose without nasal valve collapse Postoperative standardized frontal and lateral 2D photographs will be rated by 2 independent blinded experts Patient satisfaction will be assessed using FACE-Q rhinoplasty module
1 secondary outcome
Nasal Airway Patency
Time frame: 1 month
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Feb 2026.
- Background1. Eugene Tardy M, Regan Thomas J. Cummings Otolaryngology- Head and Neck Surgery, 5th ed. Mosby: 2015.chapter 36; P.544-508. 2. Aziz T, Ansari K, Lagravere MO, Major MP, Flores- Mir C. Effect of non- surgical maxillary expansion on thenasal septum deviation: a systematic review. Prog Orthod. 2015;16:15. [DOI:10.1186/s40510-015-0084-y] [PMID] [PMCID]. 3. Samrid R, Chaisiwamongkol K, Thanaviratananich S, Sukhorum W, Yimdee J, Iamsaard S. The anatomical study of the nasal septum in north- east Thai Cadavers. Srinagarind Med J. 2013;28(4):279-81. 4. Kenyon G. Nasal Anatomy and Analysis. Otolaryngol Clin An Int J. 2013;5(1):34-42. [DOI:10.5005/aijoc-5-1-12] 5. Bailey BJ, Johnson JT, Newlands SD. (editors). Head & neck surgery-otolaryngology, 4th ed. Philadelphia, Lippincott Williams & Wilkins;2006. 6. Brennan HG, Parkes ML. Septal surgery: the high septal transfixion. Int J Surg. 1973;58(10):732. 7. D'Ascanio L, Manzini M. Quick septoplasty: surgical technique and learning curve. Aesthetic Plast Surg. 2009;33(6):814-8. [DOI:10.1007/s00266-009-9388-y] [PMID] 8. Baumann I, Baumann H. A new classification of septal deviations. Rhinology. 2007;45(3):220-3. 9. Byrd HS, Constantian MB, Guyuron B, Pastorek N. Revision rhinoplasty. Aesthet Surg J. 2007.27(2):175-87. [DOI:10.1016/j.asj.2007.02.001] [PMID] 10. Hong SD, Lee NJ, Cho HJ, Jang MS, Jung TY, Kim HY, Chung SK, Dhong HJ. Predictive factors of subjective outcomes after septoplasty with and without turbinoplasty: can individual perceptual differences of the air passage be a main factor? Int Forum Allergy Rhinol. 2015;5(7):616-21. 11. Becker SS, Dobratz EJ, Stowell N, Barker D, Park SS. Revision septoplasty: review of sources of persistent nasal obstruction. Am J Rhinol. 2008;22(4):440-4.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing rhinoplasty and septoplasty in people with Septoplasty Surgeries, run by Sohag University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 12 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact mohamed ahmed mahmoud (+1002956860, mohamed.ahmed8@med.sohag.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
straight nose (time frame: 2 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07407751, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Feb 2026.