Knee OsteoarthristisNCT07402408
Blood Flow Restriction Training in Knee Osteoarthritic Patients
A study testing Blood flow restriction training with Floss band and Blood flow restriction training with pneumatic cuff in people with Knee Osteoarthristis, run by Riphah International University at 1 site in Pakistan.
Trial summary
The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Knee Osteoarthristis
- What is being tested?
- Blood flow restriction training with Floss band and Blood flow restriction training with pneumatic cuff
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 46 participants
- Where
- 1 sitePakistan
- Study dates
- 30 Jun 2026to 30 Oct 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age 40-60 years
- Pain more than or equal to 3 on NPRS
- Range of motion ≤ 100-degree flexion and ≤ 0-degree extension
- Those who have knee osteoarthritis, according to KL (Grade 1 and 2)
- Genders: Male and Female
Who cannot join
- Cardiovascular condition e.g., hypertension, thromboembolism, lymphatic diseases etc.
- Muscle/tendon/ ligament injuries
- Any surgery, skin infection, trauma, pregnancy, fracture and fall
- Patient with intra articular steroidal therapy with in last 6 months
- Patient unwilling to participate and comply with the study session
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Pakistan Institute of Medical Sciences (P.I.M.S.)
Islamabad, Federal, 44000
About this study
Official title: Comparison of Band Tissue Flossing Method and Traditional Cuff Method for Blood Flow Restriction Training in Patients With Knee Osteoarthritis
The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Symptoms of this condition limit patient's ability to perform high load strengthening. Blood flow restraining training allows strengthening with lower loads. 46 subjects will be divided in two groups, 23 subjects in each group. knee extension and knee press exercises will be performed. In group A floss band was tied on thigh and in group B pneumatic cuff was applied on thigh. 40-60 years individual with knee osteoarthritis will be included. outcome measures will be assessed at baseline, after 1st session, after 2nd week and after 4th week.
- Conditions
- Knee Osteoarthristis
- Being tested
- Blood flow restriction training with Floss band, Blood flow restriction training with pneumatic cuff
- Keywords
- Blood flow restriction therapy, Knee Osteoarthritis, Range of Motion
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Blood flow restriction training with Floss bandOther
seated knee extension exercise and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Floss band was tied at proximal thigh with 50% stretch in proximal to distal direction starting from above the patella and moving towards groin.
Blood flow restriction training with pneumatic cuffOther
seated knee extension exercises and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Clinical cuff was tied at proximal thigh with 40% of limb occlusion pressure.
| Study group | Role | What they receive |
|---|---|---|
| Blood flow restriction with Floss band (group A) | Experimental | seated knee extension and knee press while floss band is tied at proximal thigh. Receives: Other: Blood flow restriction training with Floss band |
| Blood flow restriction with pneumatic cuff (group B) | Experimental | seated knee extension and knee press exercises with pneumatic cuff tied at proximal thigh Receives: Other: Blood flow restriction training with pneumatic cuff |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale (NPRS)
Changes from baseline will be assessed using NPRS scale. It is a one-dimensional measure of pain severity in adults including those suffering from chronic pain. Scale has ratings of 0 to 10, with higher points indicating higher levels of pain severity. it is a valid tool for assessing pain in knee OA patients.
Measured: 4th week
Secondary outcomes (6)
Knee Flexion Range of motion
Changes in knee flexion range of motion from baseline will be assessed using universal goniometer. Goniometer is the most common instrument utilized for measuring available range of motion. Universal Goniometer Comes in two variations one is short arm whereas one is long arm. The one with short arm is used for smaller joints like the wrist, elbow, or ankle. On the other hand, long arm goniometers provide greater accuracy for knee and hip joints which have long bones acting as levers
Measured: 4th week
Knee Extension Range of Motion
Changes from baseline in knee extension range of motion will be assessed with goniometer. It is the most common instrument utilized for measuring available range of motion. Universal Goniometer Comes in two variations one is short arm whereas one is long arm. The one with short arm is used for smaller joints like the wrist, elbow, or ankle. On the other hand, long arm goniometers provide greater accuracy for knee and hip joints which have long bones acting as levers
Measured: 4th week
Quadriceps strength (dynamometer)
Quadriceps muscle strength changes from baseline will be assessed using crane scale dynamometer. Participant sits in chair with hips and knees flexed to 90 degrees. The hook of dynamometer is secured to the ankle with a strap, while from behind the dynamometer is fixed to leg of chair to provide a stable anchor. As the participant performs knee extension the force generated is recorded in newtons or kilograms. It is a valid and reliable tool for assessing strength of knee extensors.
Measured: 4th week
Western Ontario and McMaster Universities (WOMAC) index
WOMAC index was developed in order to fill the need for an outcome instrument that could be responsive to change in OA-related symptoms following a clinical trial. It includes five questions about pain, two about stiffness, and seventeen on degree of disability of activities of daily living. total score is converted to percentage. higher scores mean severe symptoms.
Measured: 4th week
30 Second Sit to Stand Test (STS)
The 30 Second Sit to Stand Test (STS) is also known as 30 Second Chair Stand Test (30CST), was initially designed for testing leg strength and endurance in older adults. It is used for adults of 18-64 years, older adults (65 years and above), and people with osteoarthritis. A person stands up and sits down five times as quickly and safely as possible, with their arms folded across their chest, A longer time indicates weaker leg strength and a greater risk of falls. It records the number of times a person can sit and stand within 30 seconds
Measured: 4th week
Timed Up and Go Test (TUG)
This test is for assessing ambulatory transition in knee OA patients. For this test participant stands from armed chair, walks with comfortable pace to a line 3 m away, at end point turns, and returns to sitting position in chair. Participant can't use walking aid during task. Time is recorded in which task is done.
Measured: 4th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Feb 2026
- Study start30 Jun 2026
- Primary completion30 Oct 2026
- Study completion30 Oct 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthristisStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 46 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Muhammad Affan Iqbal, PhD*, Principal investigator, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07402408
- Sponsor's protocol ID
- Riphah/RCRAHS/REC/MS-PT/02171
- Status last verified
- Nov 2026
- First submitted
- 4 Feb 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Band Tissue Flossing Method and Traditional Cuff Method for Blood Flow Restriction Training in Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07402408
- Acronym / sponsor ID
- Riphah/RCRAHS/REC/MS-PT/02171
- Conditions
- Knee Osteoarthristis
- Keywords
- Blood flow restriction therapy, Knee Osteoarthritis, Range of Motion
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 46 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 30 Jun 2026 (actual)
- Primary completion
- 30 Oct 2026 (actual)
- Study completion
- 30 Oct 2026 (actual)
- First posted
- 11 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to compare the effect of band tissue flossing method and traditional cuff method for blood flow restriction training on pain, range of motion, muscle strength and functional status in patients with knee osteoarthritis. Symptoms of this condition limit patient's ability to perform high load strengthening. Blood flow restraining training allows strengthening with lower loads. 46 subjects will be divided in two groups, 23 subjects in each group. knee extension and knee press exercises will be performed. In group A floss band was tied on thigh and in group B pneumatic cuff was applied on thigh. 40-60 years individual with knee osteoarthritis will be included. outcome measures will be assessed at baseline, after 1st session, after 2nd week and after 4th week.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Blood flow restriction with Floss band (group A) | Experimental | Other: Blood flow restriction training with Floss bandseated knee extension and knee press while floss band is tied at proximal thigh. |
| Blood flow restriction with pneumatic cuff (group B) | Experimental | Other: Blood flow restriction training with pneumatic cuffseated knee extension and knee press exercises with pneumatic cuff tied at proximal thigh |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Age 40-60 years
- Pain more than or equal to 3 on NPRS
- Range of motion ≤ 100-degree flexion and ≤ 0-degree extension
- Those who have knee osteoarthritis, according to KL (Grade 1 and 2)
- Genders: Male and Female
Key exclusion criteria (5 listed)
- Cardiovascular condition e.g., hypertension, thromboembolism, lymphatic diseases etc.
- Muscle/tendon/ ligament injuries
- Any surgery, skin infection, trauma, pregnancy, fracture and fall
- Patient with intra articular steroidal therapy with in last 6 months
- Patient unwilling to participate and comply with the study session
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Blood flow restriction training with Floss bandseated knee extension exercise and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Floss band was tied at proximal thigh with 50% stretch in proximal to distal direction starting from above the patella and moving towards groin. | Other | Blood flow restriction with Floss band (group A) |
| Blood flow restriction training with pneumatic cuffseated knee extension exercises and knee press exercises (4 sets; repetitions: 30,15,15,15) performed for four weeks with three sessions per week. Exercises performed with 20% of one repetition maximum. Clinical cuff was tied at proximal thigh with 40% of limb occlusion pressure. | Other | Blood flow restriction with pneumatic cuff (group B) |
Primary outcome
Numeric Pain Rating Scale (NPRS)
Time frame: 4th week
Changes from baseline will be assessed using NPRS scale. It is a one-dimensional measure of pain severity in adults including those suffering from chronic pain. Scale has ratings of 0 to 10, with higher points indicating higher levels of pain severity. it is a valid tool for assessing pain in knee OA patients.
6 secondary outcomes
Knee Flexion Range of motion
Time frame: 4th week
Knee Extension Range of Motion
Time frame: 4th week
Quadriceps strength (dynamometer)
Time frame: 4th week
Western Ontario and McMaster Universities (WOMAC) index
Time frame: 4th week
30 Second Sit to Stand Test (STS)
Time frame: 4th week
Timed Up and Go Test (TUG)
Time frame: 4th week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: No
Related trials for Knee Osteoarthristis
Recruiting
Aquatic Exercise in Patients With Knee Osteoarthritis
Central Sensitization, Knee Osteoarthristis
Recruiting
Study NRPT Feasibility in Knee Osteoarthritis
Knee Osteoarthristis
Not yet recruitingEarly Phase 1
Medication vs. Meditation for Chronic Knee Osteoarthritis
Knee Osteoarthristis
Not yet recruiting
Wearable Device Guided Exercise for Patients on Total Knee Arthroplasty Wait-list
Knee Osteoarthristis
Not yet recruiting
Application of Perinatal Derivatives in Total Knee Arthroplasty
Total Knee Arthroplasty, Knee Osteoarthristis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Muhammad Affan Iqbal, PhD* principal investigator
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Blood flow restriction training with Floss band and Blood flow restriction training with pneumatic cuff in people with Knee Osteoarthristis, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (NPRS) (time frame: 4th week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.