Kidney StonesNCT07389226
The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults
A study testing Apple Cider Vinegar in people with Kidney Stones and Urine Specimen Collection, run by University of Chicago at 1 site in United States.
Trial summary
This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Kidney Stones, Urine Specimen Collection
- What is being tested?
- Apple Cider Vinegar
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- Dec 2026to Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Controls: Adults above the age of 18.
- Kidney stone patients: Adults above the age of 18.
- History of majority (>50%) calcium oxalate kidney stones
Who cannot join
- Anyone with a history of calcium phosphate stones (>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (<30 days), or recurrent urinary tract infections.
- Any individual who has had ACV outside of normal consumption in the prior month will be excluded.
- Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.
- Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
The University of Chicago
Chicago, Illinois, 60637
Luke Reynolds, 713-792-6105, lukereynolds@bsd.uchicago.edu
About this study
This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Read the detailed description
The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.
- Conditions
- Kidney Stones, Urine Specimen Collection
- Being tested
- Apple Cider Vinegar
- Keywords
- urine specimen collection, kidney stones
- Medical subject headings
- Kidney Calculi
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Apple Cider VinegarDietary supplement
Goli Apple Cider Vinegar gummies
| Study group | Role | What they receive |
|---|---|---|
| kidney stone patients and healthy participants | Experimental | Each participant will be asked to complete a basic metabolic panel prior to initiating the study to ensure that no baseline metabolic derangements exist. On day 1, participants will complete a 24-hour urine collection and 48-hour food diary at home. Participants will then consume an ACV gummy containing 60 meq daily for 14 consecutive days. Receives: Dietary Supplement: Apple Cider Vinegar |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measure changes in citrate in urine.
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measured: From Enrollment to 2 weeks
Measure changes in Urine PH
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measured: From enrollment to 2 weeks
Measure changes in calcium in urine.
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measured: from enrollment to 2 weeks
Measure changes in calcium oxalate in urine
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measured: From Enrollment to 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2026
- Study startDec 2026 (estimated)
- Primary completionJan 2028 (estimated)
- Study completionFeb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Kidney StonesStudies of the same condition, open and under way.
- More trials run by University of ChicagoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Chicago
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Luke Reynolds, Principal investigator, The University of Chicago Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07389226
- Sponsor's protocol ID
- IRB25-0715
- Status last verified
- Jul 2026
- First submitted
- 27 Jan 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults
- ClinicalTrials.gov ID
- NCT07389226
- Acronym / sponsor ID
- IRB25-0715
- Conditions
- Kidney Stones, Urine Specimen Collection
- Keywords
- urine specimen collection, kidney stones
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of ChicagoUniversity, hospital or other
- Study start
- Dec 2026 (estimated)
- Primary completion
- Jan 2028 (estimated)
- Study completion
- Feb 2028 (estimated)
- First posted
- 5 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Detailed description
The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| kidney stone patients and healthy participants | Experimental | Dietary Supplement: Apple Cider VinegarEach participant will be asked to complete a basic metabolic panel prior to initiating the study to ensure that no baseline metabolic derangements exist. On day 1, participants will complete a 24-hour urine collection and 48-hour food diary at home. Participants will then consume an ACV gummy containing 60 meq daily for 14 consecutive days. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Controls: Adults above the age of 18.
- Kidney stone patients: Adults above the age of 18.
- History of majority (>50%) calcium oxalate kidney stones
Key exclusion criteria (4 listed)
- Anyone with a history of calcium phosphate stones (>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (<30 days), or recurrent urinary tract infections.
- Any individual who has had ACV outside of normal consumption in the prior month will be excluded.
- Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.
- Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Apple Cider VinegarGoli Apple Cider Vinegar gummies | Dietary supplement | kidney stone patients and healthy participants |
Primary outcome
Measure changes in citrate in urine.
Time frame: From Enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measure changes in Urine PH
Time frame: From enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measure changes in calcium in urine.
Time frame: from enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Measure changes in calcium oxalate in urine
Time frame: From Enrollment to 2 weeks
to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Luke Reynolds principal investigator
The University of Chicago Medical Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Apple Cider Vinegar in people with Kidney Stones and Urine Specimen Collection, run by University of Chicago at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Luke Reynolds (7137926105, lukereynolds@bsd.uchicago.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Measure changes in citrate in urine. (time frame: From Enrollment to 2 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.