Chronic Kidney Disease (Mild to Moderate)NCT07370662
Effect of Resistance Exercises and Relaxation Therapy on Physical Function and Quality Of Life in Patients With Chronic Kidney Disease
A study testing Resistance exercises: and Relaxation exercise in people with Chronic Kidney Disease (Mild to Moderate), run by Rashid Latif Medical College at 1 site in Pakistan.
Trial summary
The significance of this study to compare the effect of resistance exercises and relaxation therapy to find out which technique is more effective for improving physical function and quality of life in chronic kidney disease patient. Read more about this study
- Who is it for?
- Ages 30 to 65 years
- Conditions the study is for
- Chronic Kidney Disease (Mild to Moderate)
- What is being tested?
- Resistance exercises: and Relaxation exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 sitePakistan
- Study dates
- 12 Aug 2024to 15 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age (30-65years).
- Both Male and female.
- Patient able to stand and walk independently.
- Patient with mild to moderate stage of chronic kidney disease.
Who cannot join
- Physical disability.
- Acute Myocardial infarction.
- Kidney transplant.
- Pregnant women.
Trial locations and contacts
1 site in 1 country.
Pakistan1 site
Arif memorial teaching hospital
Lahore, Punjab Province, 54000
About this study
The significance of this study to compare the effect of resistance exercises and relaxation therapy to find out which technique is more effective for improving physical function and quality of life in chronic kidney disease patient.
The study was aimed to determine the effect of resistance exercises and relaxation therapy on physical function and quality of life in patients with chronic kidney disease.
We hypothesized if there was significant effect of resistance exercises and relaxation therapy on physical function and quality of life in patients with chronic kidney disease.
Group A: Relaxation therapy and Resistance exercises. Group B: Resistance exercises.
Read the detailed description
Chronic kidney disease (CKD) is a pathophysiological process, where the kidneys experience a slow, progressive and irreversible decline in function where the body's ability fail in maintaining metabolism and fluid and electrolyte balance causes the occurrence of uremia.
Individuals of all ages and both sexes benefit from moderate-intensity physical activity, with diminished risk of cardiovascular diseases, maintenance of muscle strength, fewer symptoms of depression and anxiety and improved quality of life. Resistance exercises, alone and in combination with other exercises have shown beneficial outcomes in improving physical fitness, walking capacity, cardiovascular outcomes, and health-related quality of life (HRQoL). However, relaxation techniques are considered successful in improving the condition of patients. Deep breathing relaxation techniques can reduce oxidative stress, increase cellular energy, increase elasticity of blood vessels and improve circulation, so that the final result can reduce and even overcome fatigue. The technique is easy to do, easy to learn, does not harm and a less costs is the advantage of deep breathing relaxation techniques. Resistance training has been successfully recommended as a method of gaining lean mass, strength and physical functioning in frail elderly persons and those with chronic diseases, including patients with cardiovascular and kidney diseases
- Being tested
- Resistance exercises:, Relaxation exercise
- Keywords
- Chronic Kidney Disease, Physical Function, Quality of Life, Resistance Exercises., Relaxation Therapy
- Medical subject headings
- Renal Insufficiency, Chronic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance exercises:Other
The researcher taught patients this exercise and encouraged them to do it daily each once about 20 to 30 minutes. The exercise started with moderate intensity of no more than 10 minutes then time of practice increased gradually to 30 minutes. Resistance exercise included the following: Knee and hip flexion and extension, elbow extension. The repetition was be 15-20 times
Relaxation exerciseOther
Relaxation exercise (diaphragmatic breathing, pursed lip breathing) Diaphragmatic breathing is intended to help patient use the diaphragm correctly while breathing to strengthen the diaphragm and decrease the work of breathing. Patient was instructed to sit comfortably with the knees bent and the shoulders, head and neck relaxed. Breathe in slowly through the nose so that the stomach moves out against the hand. Then exhaled through pursed lib technique so that stomach moves in again. Patients was instructed to place one hand on the upper chest and the other just below the rib cage. This was allowing patient to feel the diaphragm move as he or she breathe. Patients was instructed to practice this exercise 5-10 minutes about 3-4 times per day.
| Study group | Role | What they receive |
|---|---|---|
| Resistance exercises | Active comparator | Resistance exercise (knee and hip flexion and extension ,and elbow extension) Receives: Other: Resistance exercises: |
| Relaxation exercise | Experimental | Diaphragmatic Breathing + Pursed Lip Breathing Receives: Other: Resistance exercises:; Other: Relaxation exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
SF 36 (Quality of Life)
To assess patients Quality of life SF-36 was used. It provides information on 8 scales, scoring from0(worst health) to100(best health), and on the physical component scale (PCS) and the mental component scale (MCS), normalized scores representing overall physical and mental functioning
Measured: Pre-test (Baseline) and Post-test (08 Weeks)
Secondary outcomes (2)
Sit-to-Stand test
The STS 10 consisted of measuring the seconds employed by the patient to stand up from the sitting position, and to sit down for 10 consecutive times as quickly as possible. STS-10 is proved to be a feasible measure to detect changes resulting from an exercise intervention [ After 5 minutes for recuperation, the patient performed the STS 60 consisting of standing-up from a chair and sitting-down again as many times as possible during a 60 second time period.
Measured: Pre-test (Baseline) and Post-test (08 Weeks)
6-minute walk test
It was used as an indicator of patients' exercise capacity. The total distance covered by subjects during 6 minutes on a walk of 20 meters in length along an internal corridor of the HD unit was recorded
Measured: Pre-test (Baseline) and Post-test (08 Weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jan 2026
- Study start12 Aug 2024
- Primary completion15 Mar 2025
- Study completion15 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Chronic Kidney Disease (Mild to Moderate)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Group A: Resistance exercises and relaxation therapy Group B: Resistance exercises, where Resistance exercise (knee and hip flexion and extension, and elbow extension)
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rashid Latif Medical College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Tahir Mahmood, Rashid Latif Medical College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07370662
- Sponsor's protocol ID
- IRB/2024/159
- Status last verified
- Aug 2025
- First submitted
- 19 Jan 2026
- Last updated
- 27 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The data will be shared on reasonable request
Publications
Segura-Orti E, Kouidi E, Lison JF. Effect of resistance exercise during hemodialysis on physical function and quality of life: randomized controlled trial. Clin Nephrol. 2009 May;71(5):527-37. doi: 10.5414/cnp71527.
PubMed 19473613Barcellos FC, Santos IS, Mielke GI, del Vecchio FB, Hallal PC. Effects of exercise on kidney function among non-diabetic patients with hypertension and renal disease: randomized controlled trial. BMC Nephrol. 2012 Aug 28;13:90. doi: 10.1186/1471-2369-13-90.
PubMed 22928872Abd Elbaky M, Zaki S, Amin N, Ali R. Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients. American Journal of Nursing. 2018;6(5):263-72
Study at a glance
From the registry record, last updated by the sponsor on 27 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Resistance Exercises and Relaxation Therapy on Physical Function and Quality Of Life in Patients With Chronic Kidney Disease
- ClinicalTrials.gov ID
- NCT07370662
- Acronym / sponsor ID
- IRB/2024/159
- Keywords
- Chronic Kidney Disease, Physical Function, Quality of Life, Resistance Exercises., Relaxation Therapy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Rashid Latif Medical CollegeUniversity, hospital or other
- Study start
- 12 Aug 2024 (actual)
- Primary completion
- 15 Mar 2025 (actual)
- Study completion
- 15 Mar 2025 (actual)
- First posted
- 27 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The significance of this study to compare the effect of resistance exercises and relaxation therapy to find out which technique is more effective for improving physical function and quality of life in chronic kidney disease patient.
The study was aimed to determine the effect of resistance exercises and relaxation therapy on physical function and quality of life in patients with chronic kidney disease.
We hypothesized if there was significant effect of resistance exercises and relaxation therapy on physical function and quality of life in patients with chronic kidney disease.
Group A: Relaxation therapy and Resistance exercises. Group B: Resistance exercises.
Detailed description
Chronic kidney disease (CKD) is a pathophysiological process, where the kidneys experience a slow, progressive and irreversible decline in function where the body's ability fail in maintaining metabolism and fluid and electrolyte balance causes the occurrence of uremia.
Individuals of all ages and both sexes benefit from moderate-intensity physical activity, with diminished risk of cardiovascular diseases, maintenance of muscle strength, fewer symptoms of depression and anxiety and improved quality of life. Resistance exercises, alone and in combination with other exercises have shown beneficial outcomes in improving physical fitness, walking capacity, cardiovascular outcomes, and health-related quality of life (HRQoL). However, relaxation techniques are considered successful in improving the condition of patients. Deep breathing relaxation techniques can reduce oxidative stress, increase cellular energy, increase elasticity of blood vessels and improve circulation, so that the final result can reduce and even overcome fatigue. The technique is easy to do, easy to learn, does not harm and a less costs is the advantage of deep breathing relaxation techniques. Resistance training has been successfully recommended as a method of gaining lean mass, strength and physical functioning in frail elderly persons and those with chronic diseases, including patients with cardiovascular and kidney diseases
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Group A: Resistance exercises and relaxation therapy Group B: Resistance exercises, where Resistance exercise (knee and hip flexion and extension, and elbow extension)
| Arm | Type | Receives |
|---|---|---|
| Resistance exercises | Active comparator | Other: Resistance exercises:Resistance exercise (knee and hip flexion and extension ,and elbow extension) |
| Relaxation exercise | Experimental | Other: Resistance exercises:, Other: Relaxation exerciseDiaphragmatic Breathing + Pursed Lip Breathing |
Who may qualify
- Ages
- 30 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age (30-65years).
- Both Male and female.
- Patient able to stand and walk independently.
- Patient with mild to moderate stage of chronic kidney disease.
Key exclusion criteria (4 listed)
- Physical disability.
- Acute Myocardial infarction.
- Kidney transplant.
- Pregnant women.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance exercises:The researcher taught patients this exercise and encouraged them to do it daily each once about 20 to 30 minutes. The exercise started with moderate intensity of no more than 10 minutes then time of practice increased gradually to 30 minutes. Resistance exercise included the following: Knee and hip flexion and extension, elbow extension. The repetition was be 15-20 times | Other | Relaxation exercise, Resistance exercises |
| Relaxation exerciseRelaxation exercise (diaphragmatic breathing, pursed lip breathing) Diaphragmatic breathing is intended to help patient use the diaphragm correctly while breathing to strengthen the diaphragm and decrease the work of breathing. Patient was instructed to sit comfortably with the knees bent and the shoulders, head and neck relaxed. Breathe in slowly through the nose so that the stomach moves out against the hand. Then exhaled through pursed lib technique so that stomach moves in again. Patients was instructed to place one hand on the upper chest and the other just below the rib cage. This was allowing patient to feel the diaphragm move as he or she breathe. Patients was instructed to practice this exercise 5-10 minutes about 3-4 times per day. | Other | Relaxation exercise |
Primary outcome
SF 36 (Quality of Life)
Time frame: Pre-test (Baseline) and Post-test (08 Weeks)
To assess patients Quality of life SF-36 was used. It provides information on 8 scales, scoring from0(worst health) to100(best health), and on the physical component scale (PCS) and the mental component scale (MCS), normalized scores representing overall physical and mental functioning
2 secondary outcomes
Sit-to-Stand test
Time frame: Pre-test (Baseline) and Post-test (08 Weeks)
6-minute walk test
Time frame: Pre-test (Baseline) and Post-test (08 Weeks)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jan 2026.
- Background: PubMed 19473613Segura-Orti E, Kouidi E, Lison JF. Effect of resistance exercise during hemodialysis on physical function and quality of life: randomized controlled trial. Clin Nephrol. 2009 May;71(5):527-37. doi: 10.5414/cnp71527.
- Background: PubMed 22928872Barcellos FC, Santos IS, Mielke GI, del Vecchio FB, Hallal PC. Effects of exercise on kidney function among non-diabetic patients with hypertension and renal disease: randomized controlled trial. BMC Nephrol. 2012 Aug 28;13:90. doi: 10.1186/1471-2369-13-90.
- BackgroundAbd Elbaky M, Zaki S, Amin N, Ali R. Impact of Intradialytic Rehabilitation Program on General Health of Chronic Kidney Disease Patients. American Journal of Nursing. 2018;6(5):263-72
- Individual participant dataSharing planned: No. The data will be shared on reasonable request
Related trials for Chronic Kidney Disease (Mild to Moderate)
RecruitingPhase 4
Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Adolescents With Early Stages of Chronic Kidney Disease
Chronic Kidney Disease (Mild to Moderate), Albuminuria
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance exercises: and Relaxation exercise in people with Chronic Kidney Disease (Mild to Moderate), run by Rashid Latif Medical College at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
SF 36 (Quality of Life) (time frame: Pre-test (Baseline) and Post-test (08 Weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07370662, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2026.