OverweightNCT07368777
Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
A study testing Genotype-Based Dietary Counseling and Standard Dietary Counseling in people with Overweight and Overweight and Obesity, run by Metropolitan College at 1 site in Greece.
Trial summary
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Read more about this study
- Who is it for?
- Ages 18 to 65 yearsHealthy volunteers can take part
- Conditions the study is for
- Overweight, Overweight and Obesity, Adiposity
- What is being tested?
- Genotype-Based Dietary Counseling and Standard Dietary Counseling
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 88 participants
- Where
- 1 siteGreece
- Study dates
- 15 Dec 2025to Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged ≥18 years
- Body mass index (BMI) ≥25 kg/m²
- Greek-speaking (able to read and understand Greek and provide informed consent)
- Willing and able to participate in dietary counseling and study assessments for the duration of the study
Who cannot join
- Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
- Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
- Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
- Pregnancy or lactation
- Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Greece1 site, 1 recruiting
- Recruiting
Dietetics Department, School of Health Sciences, Metropolitan College
Marousi, 151 25
Angeliki Kapellou, PhD, +30 21 3333 0300, akapellou@mitropolitiko.edu.gr
About this study
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.
- Conditions
- Overweight, Overweight and Obesity, Adiposity
- Being tested
- Genotype-Based Dietary Counseling, Standard Dietary Counseling
- Keywords
- genotype-based nutrition, dietary counseling, weight loss, nutrigenetics
- Medical subject headings
- Overweight, Obesity, Weight Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Genotype-Based Dietary CounselingBehavioural
Also called Nutrigenetic dietary counseling
This intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period.
Standard Dietary CounselingBehavioural
Also called General dietary recommendations
This intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information.
| Study group | Role | What they receive |
|---|---|---|
| Genotype-Based Dietary Counseling | Experimental | Participants in this arm will receive dietary counseling tailored according to their genetic profile. Dietary recommendations will be provided by qualified nutrition professionals and will be based on individual genetic information in combination with standard nutritional principles. The counseling will be delivered over the course of the intervention period. Receives: Behavioral: Genotype-Based Dietary Counseling |
| Standard Dietary Counseling | Active comparator | Participants in this arm will receive dietary counseling based on general dietary guidelines and standard nutritional recommendations. Counseling will be provided by qualified nutrition professionals over the course of the intervention period, without the use of genetic information. Receives: Behavioral: Standard Dietary Counseling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Fat Mass (%)
Change in whole-body fat mass percentage from baseline to end of the intervention
Measured: baseline to end of intervention (12 months)
Secondary outcomes (2)
Change in Body Weight
Change in body weight from baseline to end of the intervention
Measured: baseline to end of intervention (12 months)
Change in Lipid Profile
Change in fasting lipid profile parameters (e.g., total cholesterol, LDL-C, HDL-C, triglycerides) from baseline to end of the intervention.
Measured: baseline to end of intervention (12 months)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jan 2026
- Study start15 Dec 2025
- Primary completionJan 2027 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OverweightStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 88 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Metropolitan College
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Angeliki Kapellou, Metropolitan College
- Investigators
- Angeliki Kapellou, PhD, Principal investigator, Dietetics Department, School of Health Sciences, Metropolitan College
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07368777
- Sponsor's protocol ID
- 001
- Status last verified
- Jan 2026
- First submitted
- 20 Jan 2026
- Last updated
- 28 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared outside the research team.
Study at a glance
From the registry record, last updated by the sponsor on 28 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
- ClinicalTrials.gov ID
- NCT07368777
- Acronym / sponsor ID
- 001
- Conditions
- Overweight, Overweight and Obesity, Adiposity
- Keywords
- genotype-based nutrition, dietary counseling, weight loss, nutrigenetics
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 88 participants (estimated)
- Lead sponsor
- Metropolitan CollegeUniversity, hospital or other
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- Jan 2027 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 27 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Genotype-Based Dietary Counseling | Experimental | Behavioral: Genotype-Based Dietary CounselingParticipants in this arm will receive dietary counseling tailored according to their genetic profile. Dietary recommendations will be provided by qualified nutrition professionals and will be based on individual genetic information in combination with standard nutritional principles. The counseling will be delivered over the course of the intervention period. |
| Standard Dietary Counseling | Active comparator | Behavioral: Standard Dietary CounselingParticipants in this arm will receive dietary counseling based on general dietary guidelines and standard nutritional recommendations. Counseling will be provided by qualified nutrition professionals over the course of the intervention period, without the use of genetic information. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults aged ≥18 years
- Body mass index (BMI) ≥25 kg/m²
- Greek-speaking (able to read and understand Greek and provide informed consent)
- Willing and able to participate in dietary counseling and study assessments for the duration of the study
Key exclusion criteria (5 listed)
- Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
- Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
- Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
- Pregnancy or lactation
- Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Genotype-Based Dietary CounselingAlso: Nutrigenetic dietary counselingThis intervention consists of dietary counseling informed by individual genetic information. Nutrition guidance is provided by qualified nutrition professionals and aims to support weight management and reduction of body fat over the intervention period. | Behavioural | Genotype-Based Dietary Counseling |
| Standard Dietary CounselingAlso: General dietary recommendationsThis intervention consists of dietary counseling based on general dietary guidelines and standard nutrition recommendations. Counseling is delivered by qualified nutrition professionals without the use of genetic information. | Behavioural | Standard Dietary Counseling |
Primary outcome
Change in Fat Mass (%)
Time frame: baseline to end of intervention (12 months)
Change in whole-body fat mass percentage from baseline to end of the intervention
2 secondary outcomes
Change in Body Weight
Time frame: baseline to end of intervention (12 months)
Change in Lipid Profile
Time frame: baseline to end of intervention (12 months)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jan 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared outside the research team.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Angeliki Kapellou, PhD principal investigator
Dietetics Department, School of Health Sciences, Metropolitan College
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Genotype-Based Dietary Counseling and Standard Dietary Counseling in people with Overweight and Overweight and Obesity, run by Metropolitan College at 1 site in Greece.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Greece. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Angeliki Kapellou, PhD (+30 6938406218, akapellou@mitropolitiko.edu.gr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Fat Mass (%) (time frame: baseline to end of intervention (12 months)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jan 2026.