AromatherapyARTICLENCT07368374
EFFECTS OF CİTRUS AND CLOVE OİL AROMATHERAPY İN OLDER ADULTS
A study testing Intervention Group 1 and Intervention Group 2 in people with Aromatherapy, run by Mersin University.
Trial summary
This study aimed to determine the effects of citrus and clove oil aromatherapy, administered via inhalation (2 drops, 2 minutes, 3 times a week for one month), on fatigue level, sleep quality, and quality of life in older adults. Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aromatherapy
- What is being tested?
- Intervention Group 1 and Intervention Group 2
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 51 participants
- Where
- No sites listed yet
- Study dates
- 1 Feb 2026to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- Individuals who are: • 65 years of age or older
- Registered at the 60+ Refreshment University campus
- Can understand and communicate in Turkish
- Have a score of ≥24 on the Standardized Mini Mental State Examination (SMMT)
- Have a visual similarity scale (VAS-S) score of 4 or higher for sleep problems within the past week
- Have a visual similarity scale (VAS-F) score of 4 or higher for fatigue level within the past week
- Have agreed to participate in the study will be included in the study.
Who cannot join
- Those with a known allergy/sensitivity to citrus or clove oil,
- Those diagnosed with any respiratory disease (asthma, COPD, etc.),
- Those with any health condition that impairs their ability to smell will not be included in the study.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: THE EFFECTS OF CİTRUS AND CLOVE OİL AROMATHERAPY ON FATİGUE LEVEL, SLEEP, AND QUALİTY OF LİFE İN OLDER ADULTS
This study aimed to determine the effects of citrus and clove oil aromatherapy, administered via inhalation (2 drops, 2 minutes, 3 times a week for one month), on fatigue level, sleep quality, and quality of life in older adults.
Research Hypotheses
Read more
H11: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on fatigue level in older adults.
H01: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on fatigue level in older adults.
H12: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on sleep quality in older adults.
H02: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on sleep quality in older adults.
H13: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on quality of life in older adults.
H03: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on quality of life in older adults.
H14: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on fatigue level in older adults.
H04: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on fatigue level in older adults.
H15: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on sleep quality in older adults.
H05: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on sleep quality in older adults.
H16: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on quality of life in older adults.
- Conditions
- Aromatherapy
- Being tested
- Intervention Group 1, Intervention Group 2, Placebo Control Group
- Keywords
- aromatherapy, citrus oil, clove oil, older adults
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Intervention Group 1Other
Intervention 1 (Citrus Oil) Group: This group receives treatment 3 times a week (Mondays, Wednesdays, and Fridays between 13:00 and 14:00), for a total of 12 sessions over one month, with 2 drops of citrus oil applied to a 6x6 cm gauze pad for 2 minutes in each session.
Intervention Group 2Other
This group undergoes a total of 12 sessions over one month, 3 times a week (Mondays, Wednesdays, and Fridays between 13:00 and 14:00), each session involves applying 2 drops of clove oil for 2 minutes, using a 6x6 cm gauze pad in each application.
Placebo Control GroupOther
This group undergoes a treatment three times a week (Mondays, Wednesdays, and Fridays between 13:00 and 14:00), a total of 12 sessions over one month, and in each session, 2 drops of almond oil are applied to a 6x6 cm gauze pad for 2 minutes.
| Study group | Role | What they receive |
|---|---|---|
| Citrus Oil Aromatherapy Arm, | Experimental | Older adults receiving inhalation aromatherapy with 2 drops of pure citrus oil for 2 minutes, 3 times a week, for one month (12 sessions in total). Receives: Other: Intervention Group 1 |
| Clove Oil Aromatherapy Arm | Experimental | Older adults receiving inhalation aromatherapy with 2 drops of pure clove oil for 2 minutes, 3 times a week, for one month (12 sessions in total). Receives: Other: Intervention Group 2 |
| Placebo Control Arm | Placebo comparator | Older adults not receiving any aromatherapy intervention (or receiving standard care only). Receives: Other: Placebo Control Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in fatigue level assessed by the Multidimensional Fatigue Inventory (MFI-20)
Fatigue level will be assessed using the Multidimensional Fatigue Inventory (MFI-20), a validated self-report questionnaire. Prior to the initiation of the aromatherapy intervention, baseline MFI-20 data will be collected through face-to-face interviews conducted by Assessor 1. Following the completion of the four-week intervention period, the MFI-20 will be re-administered through face-to-face interviews by Assessor 2. The primary outcome will be the mean change in total MFI-20 score from baseline to post-intervention. Comparisons will be conducted between the intervention groups and the placebo control group.
Measured: Baseline and at the end of the 4-week intervention period
Change in insomnia complaints and sleep quality assessed by the Basic Insomnia and Sleep Quality Scale (BaSIQS)
Insomnia complaints and sleep quality will be assessed using the Basic Insomnia and Sleep Quality Scale (BaSIQS), a validated self-report questionnaire. Baseline measurements will be collected through face-to-face interviews conducted by Assessor 1 prior to the initiation of the aromatherapy intervention. Following the completion of the four-week intervention period, the BaSIQS will be re-administered through face-to-face interviews by Assessor 2. The primary outcome will be the mean change in total BaSIQS score from baseline to post-intervention. Comparisons will be made between the aromatherapy intervention groups and the placebo control group.
Measured: Baseline and at the end of the 4-week intervention period
Secondary outcomes (1)
Change in quality of life assessed by the Older People's Quality of Life Questionnaire-Brief (OPQOL-Brief)
Quality of life will be assessed using the Older People's Quality of Life Questionnaire-Brief (OPQOL-Brief), a validated self-report instrument. Baseline measurements will be collected through face-to-face interviews conducted by Assessor 1 prior to the initiation of the aromatherapy intervention. Following the completion of the four-week intervention period, the OPQOL-Brief will be re-administered through face-to-face interviews by Assessor 2. The primary outcome will be the mean change in total OPQOL-Brief score from baseline to post-intervention. Comparisons will be made between the aromatherapy intervention groups and the placebo control group.
Measured: Baseline and at the end of the 4-week intervention period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jan 2026
- Study start1 Feb 2026 (estimated)
- Primary completion30 Jun 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AromatherapyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This research is a mixed-pattern study.
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Investigator
- Enrolment
- 51 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mersin University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, İbrahim Duman, Mersin University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07368374
- Sponsor's protocol ID
- ERU-SBF-ID-01
- Acronym
- ARTICLE
- Status last verified
- Jan 2026
- First submitted
- 23 Sep 2025
- Last updated
- 26 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD), even if anonymized, will not be shared with researchers outside the primary study team. The collected individual-level data will be used solely for the purposes of this study and will be protected in accordance with ethical approval and informed consent procedures. Study findings will be reported only in aggregate form, and no external access to individual participant data will be provided.
Study at a glance
From the registry record, last updated by the sponsor on 26 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- THE EFFECTS OF CİTRUS AND CLOVE OİL AROMATHERAPY ON FATİGUE LEVEL, SLEEP, AND QUALİTY OF LİFE İN OLDER ADULTS
- ClinicalTrials.gov ID
- NCT07368374
- Acronym / sponsor ID
- ARTICLE / ERU-SBF-ID-01
- Conditions
- Aromatherapy
- Keywords
- aromatherapy, citrus oil, clove oil, older adults
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 51 participants (estimated)
- Lead sponsor
- Mersin UniversityUniversity, hospital or other
- Study start
- 1 Feb 2026 (estimated)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 26 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to determine the effects of citrus and clove oil aromatherapy, administered via inhalation (2 drops, 2 minutes, 3 times a week for one month), on fatigue level, sleep quality, and quality of life in older adults.
Research Hypotheses
H11: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on fatigue level in older adults.
H01: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on fatigue level in older adults.
H12: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on sleep quality in older adults.
H02: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on sleep quality in older adults.
H13: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on quality of life in older adults.
H03: Inhalation aromatherapy with 2 drops of pure citrus oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on quality of life in older adults.
H14: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on fatigue level in older adults.
H04: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on fatigue level in older adults.
H15: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on sleep quality in older adults.
H05: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is not effective on sleep quality in older adults.
H16: Inhalation aromatherapy with 2 drops of pure clove oil administered for 2 minutes, 3 times a week, for a total of 12 sessions over one month is effective on quality of life in older adults.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, investigator)
- Number of arms
- 3
- Model description
- This research is a mixed-pattern study.
| Arm | Type | Receives |
|---|---|---|
| Citrus Oil Aromatherapy Arm, | Experimental | Other: Intervention Group 1Older adults receiving inhalation aromatherapy with 2 drops of pure citrus oil for 2 minutes, 3 times a week, for one month (12 sessions in total). |
| Clove Oil Aromatherapy Arm | Experimental | Other: Intervention Group 2Older adults receiving inhalation aromatherapy with 2 drops of pure clove oil for 2 minutes, 3 times a week, for one month (12 sessions in total). |
| Placebo Control Arm | Placebo comparator | Other: Placebo Control GroupOlder adults not receiving any aromatherapy intervention (or receiving standard care only). |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (7 listed)
- Individuals who are: • 65 years of age or older
Key exclusion criteria (3 listed)
- Those with a known allergy/sensitivity to citrus or clove oil,
- Those diagnosed with any respiratory disease (asthma, COPD, etc.),
- Those with any health condition that impairs their ability to smell will not be included in the study.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Intervention Group 1Intervention 1 (Citrus Oil) Group: This group receives treatment 3 times a week (Mondays, Wednesdays, and Fridays between 13:00 and 14:00), for a total of 12 sessions over one month, with 2 drops of citrus oil applied to a 6x6 cm gauze pad for 2 minutes in each session. | Other | Citrus Oil Aromatherapy Arm, |
| Intervention Group 2This group undergoes a total of 12 sessions over one month, 3 times a week (Mondays, Wednesdays, and Fridays between 13:00 and 14:00), each session involves applying 2 drops of clove oil for 2 minutes, using a 6x6 cm gauze pad in each application. | Other | Clove Oil Aromatherapy Arm |
| Placebo Control GroupThis group undergoes a treatment three times a week (Mondays, Wednesdays, and Fridays between 13:00 and 14:00), a total of 12 sessions over one month, and in each session, 2 drops of almond oil are applied to a 6x6 cm gauze pad for 2 minutes. | Other | Placebo Control Arm |
Primary outcome
Change in fatigue level assessed by the Multidimensional Fatigue Inventory (MFI-20)
Time frame: Baseline and at the end of the 4-week intervention period
Fatigue level will be assessed using the Multidimensional Fatigue Inventory (MFI-20), a validated self-report questionnaire. Prior to the initiation of the aromatherapy intervention, baseline MFI-20 data will be collected through face-to-face interviews conducted by Assessor 1. Following the completion of the four-week intervention period, the MFI-20 will be re-administered through face-to-face interviews by Assessor 2. The primary outcome will be the mean change in total MFI-20 score from baseline to post-intervention. Comparisons will be conducted between the intervention groups and the placebo control group.
Change in insomnia complaints and sleep quality assessed by the Basic Insomnia and Sleep Quality Scale (BaSIQS)
Time frame: Baseline and at the end of the 4-week intervention period
Insomnia complaints and sleep quality will be assessed using the Basic Insomnia and Sleep Quality Scale (BaSIQS), a validated self-report questionnaire. Baseline measurements will be collected through face-to-face interviews conducted by Assessor 1 prior to the initiation of the aromatherapy intervention. Following the completion of the four-week intervention period, the BaSIQS will be re-administered through face-to-face interviews by Assessor 2. The primary outcome will be the mean change in total BaSIQS score from baseline to post-intervention. Comparisons will be made between the aromatherapy intervention groups and the placebo control group.
1 secondary outcome
Change in quality of life assessed by the Older People's Quality of Life Questionnaire-Brief (OPQOL-Brief)
Time frame: Baseline and at the end of the 4-week intervention period
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Jan 2026.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No. Individual participant data (IPD), even if anonymized, will not be shared with researchers outside the primary study team. The collected individual-level data will be used solely for the purposes of this study and will be protected in accordance with ethical approval and informed consent procedures. Study findings will be reported only in aggregate form, and no external access to individual participant data will be provided.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Intervention Group 1 and Intervention Group 2 in people with Aromatherapy, run by Mersin University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact ibrahim Duman (03243610001, ibrahimduman@mersin.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in fatigue level assessed by the Multidimensional Fatigue Inventory (MFI-20) (time frame: Baseline and at the end of the 4-week intervention period). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Jan 2026.