Neuraxial BlocksNCT07367386
Impact of Increasing BMI on the Success of Neuraxial Blocks in Class III Obese Parturients
An observational study of Neuraxial Blocks, run by Mariah Arif at 1 site in Qatar.
Trial summary
This study seeks to compare the success rates, feto-maternal outcomes, and complications associated with different neuraxial blocks in Class III obese parturient undergoing cesarean section Read more about this study
- Who is it for?
- Ages 18 years and older, women onlyHealthy volunteers can take part
- Conditions the study is for
- Neuraxial Blocks
- What is being tested?
- Neuraxial anesthesia
- Type of treatment
- Surgery or procedure
- How many people
- 1,917 participants
- Where
- 1 siteQatar
- Study dates
- 2 Feb 2025to 1 Jan 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Study population: Class III Obese parturients undergoing C-section under neuraxial blocks in the operating rooms of Women's Wellness and Research Center from 1 January 2025 to 1 December 2024.
Who may be able to join
- Age > or equal to 18 years
- BMI ≥ 45 kg/m²
- Gestational age ≥ 28 weeks
Who cannot join
- Age < 18 years
- BMI < 45 kg/m²
- History of venous thromboembolism or arterial disease (e.g., DVT, PE, angina, MI, or stroke)
- Severe active lung, cardiovascular, renal, or liver disorders; autoimmune disease; or hemoglobinopathies
- Hereditary or acquired thrombophilia (e.g., Factor V Leiden mutation or antithrombin deficiency)
- In utero fetal demise (IUFD)
Show all 12Show fewer
- Failed operative vaginal delivery
- Cesarean for the second twin or multiple pregnancies (triplets or higher)
- IVF pregnancy
- Intraoperative bleeding>1500mL
- Emergency cesarean section (Category I)
- Presence of large uterine fibroid ≥10 cm
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluating the Impact of Increasing BMI on the Success of Neuraxial Blocks in Class III Obese Parturients: A Retrospective Cohort Study
This study seeks to compare the success rates, feto-maternal outcomes, and complications associated with different neuraxial blocks in Class III obese parturient undergoing cesarean section
Read the detailed description
This was a retrospective cohort study. The data was obtained from electronic medical records of the eligible participants.
- Conditions
- Neuraxial Blocks
- Being tested
- Neuraxial anesthesia
- Keywords
- Neuraxial blocks, Obesity, Parturient, Cesarean
- Medical subject headings
- Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neuraxial anesthesiaProcedure or surgery
Single-shot spinal anesthesia
Neuraxial anesthesiaProcedure or surgery
Epidural anesthesia
Neuraxial anesthesiaProcedure or surgery
Combined spinal-epidural anesthesia
| Study group | Role | What they receive |
|---|---|---|
| Class III obese parturient | Class III obese parturient undergoing cesarean section under neuraxial block Receives: Procedure: Neuraxial anesthesia |
What is being measured
The primary outcome is the main question the study is designed to answer.
Failed neuraxial block
Determine the occurrence of the conversion to general anesthesia
Measured: From onset of block until surgery completion
Secondary outcomes (2)
Maternal adverse events
Determine the incidence of maternal hypotension, bradycardia, high-spinal (above T1 level), level of blockade higher than T4, post-dural puncture headache
Measured: From onset of blockade until surgery completion
Fetal outcomes
Apgar score
Measured: At one and five minutes after birth
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Jan 2026
- Study start2 Feb 2025
- Primary completion31 Dec 2025
- Study completion1 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neuraxial BlocksStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 1,917 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mariah Arif
- Sponsor type
- Other government
- Responsible party
- Sponsor-investigator, Mariah Arif, Hamad General Hospital
- Investigators
- Ayten Saracoglu, Principal investigator, University of Florida, UF Health, Jacksonville, FL 32209, USA
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07367386
- Sponsor's protocol ID
- MRC-01-24-905
- Status last verified
- Jan 2026
- First submitted
- 16 Jan 2026
- Last updated
- 27 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluating the Impact of Increasing BMI on the Success of Neuraxial Blocks in Class III Obese Parturients: A Retrospective Cohort Study
- ClinicalTrials.gov ID
- NCT07367386
- Acronym / sponsor ID
- MRC-01-24-905
- Conditions
- Neuraxial Blocks
- Keywords
- Neuraxial blocks, Obesity, Parturient, Cesarean
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 1,917 participants (actual)
- Lead sponsor
- Mariah ArifOther government
- Study start
- 2 Feb 2025 (actual)
- Primary completion
- 31 Dec 2025 (actual)
- Study completion
- 1 Jan 2026 (actual)
- First posted
- 26 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study seeks to compare the success rates, feto-maternal outcomes, and complications associated with different neuraxial blocks in Class III obese parturient undergoing cesarean section
Detailed description
This was a retrospective cohort study. The data was obtained from electronic medical records of the eligible participants.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Class III obese parturient | – | Procedure: Neuraxial anesthesiaClass III obese parturient undergoing cesarean section under neuraxial block |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Class III Obese parturients undergoing C-section under neuraxial blocks in the operating rooms of Women's Wellness and Research Center from 1 January 2025 to 1 December 2024.
Key inclusion criteria (3 listed)
- Age > or equal to 18 years
- BMI ≥ 45 kg/m²
- Gestational age ≥ 28 weeks
Key exclusion criteria (12 listed)
- Age < 18 years
- BMI < 45 kg/m²
- History of venous thromboembolism or arterial disease (e.g., DVT, PE, angina, MI, or stroke)
- Severe active lung, cardiovascular, renal, or liver disorders; autoimmune disease; or hemoglobinopathies
- Hereditary or acquired thrombophilia (e.g., Factor V Leiden mutation or antithrombin deficiency)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neuraxial anesthesiaSingle-shot spinal anesthesia | Procedure or surgery | Class III obese parturient |
| Neuraxial anesthesiaEpidural anesthesia | Procedure or surgery | Class III obese parturient |
| Neuraxial anesthesiaCombined spinal-epidural anesthesia | Procedure or surgery | Class III obese parturient |
Primary outcome
Failed neuraxial block
Time frame: From onset of block until surgery completion
Determine the occurrence of the conversion to general anesthesia
2 secondary outcomes
Maternal adverse events
Time frame: From onset of blockade until surgery completion
Fetal outcomes
Time frame: At one and five minutes after birth
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jan 2026.
- Individual participant dataSharing planned: No
Related trials for Neuraxial Blocks
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Comparing Spinal, Epidural, and Dural Puncture Epidural Anesthesia for Cesarean Delivery: Hemodynamics and Block Quality
Hypotension After Neuraxial Anesthesia, Cesarean Section
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Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section
Pregnancy, Cesarean Section
Enrolling by invitationObservational study
A Study to Evaluate Virtual Reality As Adjunct to Anesthesia During Orthopedic Surgery
Knee Arthropathy, Hip Injuries
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Impact of Ultrasound Guidance on Central Neuraxial Block Success in Patients With Non-Palpable Vertebral Anatomy
Epidural Analgesia, Ultrasound Assistance
Active, not recruitingPhase 1
Long Acting Neuraxial Peri-prostatic Block in Cancer
Prostate Cancer
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ayten Saracoglu principal investigator
University of Florida, UF Health, Jacksonville, FL 32209, USA
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Neuraxial Blocks, run by Mariah Arif at 1 site in Qatar.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Qatar. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Failed neuraxial block (time frame: From onset of block until surgery completion). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2026.