HealthyNCT07364149
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
A study testing Resistance Training and Resistance training + Static Stretching in people with Healthy and Healthy Participants, run by University of Palermo at 1 site in Italy.
Trial summary
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition. Read more about this study
- Who is it for?
- Ages 18 to 55 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy, Healthy Participants, Healthy Subjects (HS)
- What is being tested?
- Resistance Training and Resistance training + Static Stretching
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 27 participants
- Where
- 1 siteItaly
- Study dates
- 15 Dec 2025to 10 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- healthy male participants ≥ 18 years old
Who cannot join
- orthopedic disorders
- neurological disorders
- metabolic disorders
- cardovascular disorders
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Effects of Structured Physical Exercise and Static Passive Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation: A Randomized Crossover Study
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition. Participants are allocated to one of three groups (control, resistance training, resistance training plus static stretching) and assessed at baseline, immediately after the session, and 30 minutes post-exercise. Primary outcomes include blood pressure and other hemodynamic or functional measures, in order to explore the short-term impact of these exercise modalities on cardiovascular regulation.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation, Static Stretching, Stretch
- Being tested
- Resistance Training, Resistance training + Static Stretching
- Keywords
- stretching, static stretching, Resistance training, Resistance exercise, tissue stiffness, blood pressure, Flow Mediated Dilation, heart rate variability, Oxygenation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance TrainingOther
Participants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 80% of the individual's 1-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-30 minutes and does not include any additional static stretching beyond the standardized warm-up.
Resistance training + Static StretchingOther
Participants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 80% of the individual's 1-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-25 minutes .Immediately after the resistance exercises, they will complete a structured static stretching protocol targeting the trained muscle groups (pectoralis and elbow flexors), with each stretch held for about 30 seconds and repeated for several sets. The additional stretching lasts 12 minutes, for a total session duration of about 35-40 minutes.
| Study group | Role | What they receive |
|---|---|---|
| RT | Experimental | Resistance Training Receives: Other: Resistance Training |
| RT+SS | Experimental | Resistance training + Static stretching Receives: Other: Resistance training + Static Stretching |
| CC | No intervention | Control Condition --> participants sat silently on a chair without performing any train |
What is being measured
The primary outcome is the main question the study is designed to answer.
Flow Mediated Dilation(FMD%)
Brachial artery flow-mediated dilation (FMD) will be assessed using high-resolution B-mode ultrasound (Esaote MyLab X1 GO, linear transducer) during a standardized forearm cuff occlusion protocol. Baseline diameter will be recorded for 60 seconds prior to cuff deflation. Reactive hyperemia will be induced by 5-minutes arterial occlusion followed by cuff release, with continuous diameter recording for 3 minutes post-deflation to identify peak diameter.
Measured: 3 times (Baseline, immediately after intervantion and 30 minutes after intervention) for each condition (CC, RT, RT+ST)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Jan 2026
- Study start15 Dec 2025
- Primary completion10 Mar 2026
- Study completion10 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 27 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Palermo
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ewan Thomas, University of Palermo
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07364149
- Sponsor's protocol ID
- 353/2025
- Status last verified
- Apr 2026
- First submitted
- 24 Dec 2025
- Last updated
- 28 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Structured Physical Exercise and Static Passive Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation: A Randomized Crossover Study
- ClinicalTrials.gov ID
- NCT07364149
- Acronym / sponsor ID
- 353/2025
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation, Static Stretching, Stretch
- Keywords
- stretching, static stretching, Resistance training, Resistance exercise, tissue stiffness, blood pressure, Flow Mediated Dilation, heart rate variability
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 27 participants (actual)
- Lead sponsor
- University of PalermoUniversity, hospital or other
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- 10 Mar 2026 (actual)
- Study completion
- 10 Mar 2026 (actual)
- First posted
- 23 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition. Participants are allocated to one of three groups (control, resistance training, resistance training plus static stretching) and assessed at baseline, immediately after the session, and 30 minutes post-exercise. Primary outcomes include blood pressure and other hemodynamic or functional measures, in order to explore the short-term impact of these exercise modalities on cardiovascular regulation.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| RT | Experimental | Other: Resistance TrainingResistance Training |
| RT+SS | Experimental | Other: Resistance training + Static StretchingResistance training + Static stretching |
| CC | No intervention | –Control Condition --> participants sat silently on a chair without performing any train |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- healthy male participants ≥ 18 years old
Key exclusion criteria (4 listed)
- orthopedic disorders
- neurological disorders
- metabolic disorders
- cardovascular disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance TrainingParticipants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 80% of the individual's 1-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-30 minutes and does not include any additional static stretching beyond the standardized warm-up. | Other | RT |
| Resistance training + Static StretchingParticipants assigned to this group will complete a single supervised upper body resistance training session. The protocol includes bench presses and bicep curls performed at 80% of the individual's 1-rep max, for 4 sets of 8 reps, with standardized rest intervals between sets of 2 minutes. The total duration of the session is approximately 20-25 minutes .Immediately after the resistance exercises, they will complete a structured static stretching protocol targeting the trained muscle groups (pectoralis and elbow flexors), with each stretch held for about 30 seconds and repeated for several sets. The additional stretching lasts 12 minutes, for a total session duration of about 35-40 minutes. | Other | RT+SS |
Primary outcome
Flow Mediated Dilation(FMD%)
Time frame: 3 times (Baseline, immediately after intervantion and 30 minutes after intervention) for each condition (CC, RT, RT+ST)
Brachial artery flow-mediated dilation (FMD) will be assessed using high-resolution B-mode ultrasound (Esaote MyLab X1 GO, linear transducer) during a standardized forearm cuff occlusion protocol. Baseline diameter will be recorded for 60 seconds prior to cuff deflation. Reactive hyperemia will be induced by 5-minutes arterial occlusion followed by cuff release, with continuous diameter recording for 3 minutes post-deflation to identify peak diameter.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance Training and Resistance training + Static Stretching in people with Healthy and Healthy Participants, run by University of Palermo at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Flow Mediated Dilation(FMD%) (time frame: 3 times (Baseline, immediately after intervantion and 30 minutes after intervention) for each condition (CC, RT, RT+ST)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Apr 2026.