Postoperative DepressionNCT07359170
Delivery Mode Impact on Postoperative Depression
An observational study of Postoperative Depression, run by Jingping Wang, MD, Ph.D..
Trial summary
The goal of this observational retrospective cohort study is to examine the association between mode of delivery and early postpartum depressive symptoms in adult women who delivered at Massachusetts General Hospital. Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Postoperative Depression
- How many people
- 4,000 participants
- Where
- No sites listed yet
- Study dates
- 15 Oct 2026to 28 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: adult patients (≥18 years old) who underwent cesarean delivery or vaginal delivery
Who may be able to join
- Underwent cesarean delivery (elective or emergency) or vaginal delivery during the study period
- Age 18 years or older
- Completed at least one Edinburgh Postnatal Depression Scale (EPDS) assessment at 6-8 weeks postpartum
- Have complete perioperative data available
Who cannot join
- Missing 6-8 week postpartum EPDS scores
- Pregnancy with fetal demise, severe obstetric complications, or atypical maternal conditions
- History of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder), when identifiable
- Incomplete perioperative medical records
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Impact of Elective Versus Emergency Cesarean Delivery on Early Postpartum Depression: a Retrospective Study
The goal of this observational retrospective cohort study is to examine the association between mode of delivery and early postpartum depressive symptoms in adult women who delivered at Massachusetts General Hospital. Specifically, the study evaluates whether the urgency of cesarean delivery (elective versus emergency) is associated with differences in Edinburgh Postnatal Depression Scale (EPDS) scores at 6-8 weeks postpartum, compared with elective cesarean delivery and vaginal delivery. The EPDS is a validated 10-item self-report questionnaire with scores ranging from 0 to 30, where higher scores indicate more severe depressive symptoms.
The primary questions are whether EPDS scores differ among women undergoing emergency cesarean delivery, elective cesarean delivery, and vaginal delivery, and whether perioperative and obstetric factors are associated with postpartum depressive symptoms.
This study involves retrospective analysis of de-identified electronic health record data. Participants will not undergo any study-specific interventions.
- Conditions
- Postoperative Depression
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| elective cesarean | patients who undergone elective cesarean | |
| urgent cesarean | patients undergone urgent cesarean | |
| vaginal delivery | patients who delivered by vaginal pass |
What is being measured
The primary outcome is the main question the study is designed to answer.
Edinburgh Postnatal Depression Scale (EPDS) scores, a 10-item self-reported screening tool for postpartum depression (range: 0-30, with higher scores indicating more severe depressive symptoms)
Measured: 6-8 weeks postpartum
Secondary outcomes (1)
Prevalence of postpartum depression
Prevalence of postpartum depression (EPDS ≥ threshold) across delivery groups.
Measured: 6-8weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start15 Oct 2026 (estimated)
- Primary completion28 Oct 2027 (estimated)
- Study completion28 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative DepressionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 4,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Jingping Wang, MD, Ph.D.
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Jingping Wang, MD, Ph.D., Massachusetts General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07359170
- Sponsor's protocol ID
- 2025P002461
- Status last verified
- Jan 2026
- First submitted
- 14 Jan 2026
- Last updated
- 9 Jun 2026
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Elective Versus Emergency Cesarean Delivery on Early Postpartum Depression: a Retrospective Study
- ClinicalTrials.gov ID
- NCT07359170
- Acronym / sponsor ID
- 2025P002461
- Conditions
- Postoperative Depression
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 4,000 participants (estimated)
- Lead sponsor
- Jingping Wang, MD, Ph.D.University, hospital or other
- Study start
- 15 Oct 2026 (estimated)
- Primary completion
- 28 Oct 2027 (estimated)
- Study completion
- 28 Dec 2027 (estimated)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational retrospective cohort study is to examine the association between mode of delivery and early postpartum depressive symptoms in adult women who delivered at Massachusetts General Hospital. Specifically, the study evaluates whether the urgency of cesarean delivery (elective versus emergency) is associated with differences in Edinburgh Postnatal Depression Scale (EPDS) scores at 6-8 weeks postpartum, compared with elective cesarean delivery and vaginal delivery. The EPDS is a validated 10-item self-report questionnaire with scores ranging from 0 to 30, where higher scores indicate more severe depressive symptoms.
The primary questions are whether EPDS scores differ among women undergoing emergency cesarean delivery, elective cesarean delivery, and vaginal delivery, and whether perioperative and obstetric factors are associated with postpartum depressive symptoms.
This study involves retrospective analysis of de-identified electronic health record data. Participants will not undergo any study-specific interventions.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| elective cesarean | – | –patients who undergone elective cesarean |
| urgent cesarean | – | –patients undergone urgent cesarean |
| vaginal delivery | – | –patients who delivered by vaginal pass |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- adult patients (≥18 years old) who underwent cesarean delivery or vaginal delivery
Key inclusion criteria (4 listed)
- Underwent cesarean delivery (elective or emergency) or vaginal delivery during the study period
- Age 18 years or older
- Completed at least one Edinburgh Postnatal Depression Scale (EPDS) assessment at 6-8 weeks postpartum
- Have complete perioperative data available
Key exclusion criteria (4 listed)
- Missing 6-8 week postpartum EPDS scores
- Pregnancy with fetal demise, severe obstetric complications, or atypical maternal conditions
- History of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder), when identifiable
- Incomplete perioperative medical records
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Edinburgh Postnatal Depression Scale (EPDS) scores, a 10-item self-reported screening tool for postpartum depression (range: 0-30, with higher scores indicating more severe depressive symptoms)
Time frame: 6-8 weeks postpartum
1 secondary outcome
Prevalence of postpartum depression
Time frame: 6-8weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Postoperative Depression, run by Jingping Wang, MD, Ph.D..
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jingping Wang, MD PhD (6179369136, jwang23@mgh.harvard.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Edinburgh Postnatal Depression Scale (EPDS) scores, a 10-item self-reported screening tool for postpartum depression (range: 0-30, with higher scores indicating more severe depressive symptoms) (time frame: 6-8 weeks postpartum). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jun 2026.