Temporomandibular Joint DisordersNCT07359131
Postoperative Assessment of Platelet-Rich Plasma and Platelet-Rich Fibrin in Temporomandibular Joint Surgery
An observational study of Temporomandibular Joint Disorders, run by Jingping Wang, MD, Ph.D. at 1 site in United States.
Trial summary
The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Temporomandibular Joint Disorders
- Type of treatment
- Injection or infusion
- How many people
- 700 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Nov 2026to 5 Dec 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult patients aged 18 to 75 years who underwent unilateral or bilateral temporomandibular joint arthroscopy at a single institution. All patients received intraoperative intra-articular injection of platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) as part of routine clinical care. This is a retrospective observational study based on review of existing medical records, with no prospective recruitment or intervention.
Who may be able to join
- Patients aged 18 to 75 years (inclusive)
- Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy
- Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy
Who cannot join
- Age younger than 18 years or older than 75 years
- Did not undergo TMJ arthroscopy
- Did not receive intraoperative PRP or PRF injection
- Incomplete clinical or follow-up data
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Postoperative Assessment in TMJ Surgery: A Comparison of the Efficacy of Intraoperative Platelet-Rich Plasma and Platelet-Rich Fibrin Injections
The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders.
The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are:
Read more
Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery.
Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms.
If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms.
Participants will:
Have their existing medical records reviewed retrospectively.
Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.
- Conditions
- Temporomandibular Joint Disorders
- Medical subject headings
- Temporomandibular Joint Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Group 1 - Platelet-Rich Plasma injection therapy group | Patients who received Platelet-Rich Plasma injections during surgery. | |
| Group 2 - Platelet-Rich Fibrin injection therapy group | Patients who are receiving Platelet-Rich Fibrin injections during surgery. | |
| Group 3 - non injection therapy group | Patients who are not receiving Platelet-Rich Plasma nor Platelet-Rich Fibrin injections during surgery. |
What is being measured
The primary outcome is the main question the study is designed to answer.
pain intensity
The primary endpoint of the study is the change in pain intensity from baseline to 6 months post-surgery.
Measured: from baseline to 6 months post-surgery.
Secondary outcomes (1)
maximum unassisted opening (MMO)
collect data about maximum unassisted opening (MMO)
Measured: baseline and various follow-up times in 6 months.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start15 Nov 2026 (estimated)
- Primary completion31 Oct 2027 (estimated)
- Study completion5 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Temporomandibular Joint DisordersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 700 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Jingping Wang, MD, Ph.D.
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Jingping Wang, MD, Ph.D., Massachusetts General Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07359131
- Sponsor's protocol ID
- 2024P003298
- Status last verified
- Jan 2026
- First submitted
- 14 Jan 2026
- Last updated
- 9 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 9 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Postoperative Assessment in TMJ Surgery: A Comparison of the Efficacy of Intraoperative Platelet-Rich Plasma and Platelet-Rich Fibrin Injections
- ClinicalTrials.gov ID
- NCT07359131
- Acronym / sponsor ID
- 2024P003298
- Conditions
- Temporomandibular Joint Disorders
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 700 participants (estimated)
- Lead sponsor
- Jingping Wang, MD, Ph.D.University, hospital or other
- Study start
- 15 Nov 2026 (estimated)
- Primary completion
- 31 Oct 2027 (estimated)
- Study completion
- 5 Dec 2027 (estimated)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to evaluate postoperative outcomes following temporomandibular joint (TMJ) surgery and to compare the effectiveness of intraoperative platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) injections in patients with temporomandibular joint disorders.
The study includes adult patients who underwent TMJ surgery and received either PRP or PRF intraoperatively. The main questions this study aims to answer are:
Whether intraoperative PRP or PRF injection is associated with differences in postoperative pain intensity and recovery.
Whether PRP and PRF differ in their effects on postoperative jaw function, including maximum mouth opening and joint symptoms.
If there is a comparison group: Researchers will compare patients who received intraoperative PRP with those who received intraoperative PRF to assess differences in postoperative pain, functional outcomes, and joint-related symptoms.
Participants will:
Have their existing medical records reviewed retrospectively.
Provide postoperative outcome data derived from routine clinical follow-up, with no prospective recruitment or intervention.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group 1 - Platelet-Rich Plasma injection therapy group | – | –Patients who received Platelet-Rich Plasma injections during surgery. |
| Group 2 - Platelet-Rich Fibrin injection therapy group | – | –Patients who are receiving Platelet-Rich Fibrin injections during surgery. |
| Group 3 - non injection therapy group | – | –Patients who are not receiving Platelet-Rich Plasma nor Platelet-Rich Fibrin injections during surgery. |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult patients aged 18 to 75 years who underwent unilateral or bilateral temporomandibular joint arthroscopy at a single institution. All patients received intraoperative intra-articular injection of platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) as part of routine clinical care. This is a retrospective observational study based on review of existing medical records, with no prospective recruitment or intervention.
Key inclusion criteria (3 listed)
- Patients aged 18 to 75 years (inclusive)
- Underwent unilateral or bilateral temporomandibular joint (TMJ) arthroscopy
- Received intraoperative platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injection during TMJ arthroscopy
Key exclusion criteria (4 listed)
- Age younger than 18 years or older than 75 years
- Did not undergo TMJ arthroscopy
- Did not receive intraoperative PRP or PRF injection
- Incomplete clinical or follow-up data
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
pain intensity
Time frame: from baseline to 6 months post-surgery.
The primary endpoint of the study is the change in pain intensity from baseline to 6 months post-surgery.
1 secondary outcome
maximum unassisted opening (MMO)
Time frame: baseline and various follow-up times in 6 months.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Temporomandibular Joint Disorders, run by Jingping Wang, MD, Ph.D. at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jingping Wang, MD PhD (6179369136, jwang23@mgh.harvard.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
pain intensity (time frame: from baseline to 6 months post-surgery.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jun 2026.