Gingival HyperpigmentationNCT07357883
Effect of Topical Argan Oil on Healing After Laser Depigmentation.
A study testing Laser Depigmentation in people with Gingival Hyperpigmentation and Laser Depigmentation, run by Ghada Adayil at 1 site in Egypt.
Trial summary
Effect of Argan oil vs placebo on healing after laser depigmentation Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Gingival Hyperpigmentation, Laser Depigmentation, Topical Argan Oil
- What is being tested?
- Laser Depigmentation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 29 Oct 2025to 10 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients aged 18-40 with moderate/severe physiological gingival pigmentation
- Good general and periodontal health.
Who cannot join
- Systemic diseases affecting healing (e.g., uncontrolled diabetes).
- Smokers or tobacco chewers.
- Pregnant/lactating women.
- Previous depigmentation procedures in the last 2 years.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Evaluation of Argan Oil as a Post-Operative Agent Versus Placebo Following Laser Gingival Depigmentation: A Randomized Controlled Clinical Trial
Effect of Argan oil vs placebo on healing after laser depigmentation
Read the detailed description
Evaluate the effect of Argan oil vs. placebo on post-operative healing after laser depigmentation. as well as Compare pain levels (VAS score), gingival pigmentation recurrence, and patient satisfaction between groups at predetermined follow-up intervals.
- Conditions
- Gingival Hyperpigmentation, Laser Depigmentation, Topical Argan Oil, Postoperative Gingival Healing
- Being tested
- Laser Depigmentation
- Keywords
- Laser depigmentation, postoperative healing, topical argan oil
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Laser DepigmentationProcedure or surgery
Laser protocol:
Diode laser, wavelength 810-980 nm, continuous mode, initiated fiber tip 400 µm, power 1.5-2 W.
| Study group | Role | What they receive |
|---|---|---|
| Topical Argan Oil | Experimental | Applied post-laser depigmentation Receives: Procedure: Laser Depigmentation |
| Reference placebo | Placebo comparator | Identical placebo formulation Receives: Procedure: Laser Depigmentation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effect of Argan oil
Evaluate the effect of Argan oil vs. placebo on post-operative Gingival healing
Measured: 14 days
Secondary outcomes (1)
Visual Analog Scale (VAS)
Compare pain levels (VAS score) , gingival pigmentation recurrence, and patient satisfaction between groups.
Measured: 14 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Jan 2026
- Study start29 Oct 2025
- Primary completion22 Dec 2025
- Study completion10 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Gingival HyperpigmentationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ghada Adayil
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ghada Adayil, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07357883
- Sponsor's protocol ID
- 28-10-2025
- Status last verified
- Jan 2026
- First submitted
- 14 Jan 2026
- Last updated
- 22 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Evaluation of Argan Oil as a Post-Operative Agent Versus Placebo Following Laser Gingival Depigmentation: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07357883
- Acronym / sponsor ID
- 28-10-2025
- Conditions
- Gingival Hyperpigmentation, Laser Depigmentation, Topical Argan Oil, Postoperative Gingival Healing
- Keywords
- Laser depigmentation, postoperative healing, topical argan oil
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Ghada AdayilUniversity, hospital or other
- Study start
- 29 Oct 2025 (actual)
- Primary completion
- 22 Dec 2025 (actual)
- Study completion
- 10 Jan 2026 (actual)
- First posted
- 22 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Effect of Argan oil vs placebo on healing after laser depigmentation
Detailed description
Evaluate the effect of Argan oil vs. placebo on post-operative healing after laser depigmentation. as well as Compare pain levels (VAS score), gingival pigmentation recurrence, and patient satisfaction between groups at predetermined follow-up intervals.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Topical Argan Oil | Experimental | Procedure: Laser DepigmentationApplied post-laser depigmentation |
| Reference placebo | Placebo comparator | Procedure: Laser DepigmentationIdentical placebo formulation |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Patients aged 18-40 with moderate/severe physiological gingival pigmentation
- Good general and periodontal health.
Key exclusion criteria (4 listed)
- Systemic diseases affecting healing (e.g., uncontrolled diabetes).
- Smokers or tobacco chewers.
- Pregnant/lactating women.
- Previous depigmentation procedures in the last 2 years.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Laser DepigmentationLaser protocol: Diode laser, wavelength 810-980 nm, continuous mode, initiated fiber tip 400 µm, power 1.5-2 W. | Procedure or surgery | Reference placebo, Topical Argan Oil |
Primary outcome
Effect of Argan oil
Time frame: 14 days
Evaluate the effect of Argan oil vs. placebo on post-operative Gingival healing
1 secondary outcome
Visual Analog Scale (VAS)
Time frame: 14 days
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Laser Depigmentation in people with Gingival Hyperpigmentation and Laser Depigmentation, run by Ghada Adayil at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Effect of Argan oil (time frame: 14 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jan 2026.