Thyroid DiseaseNCT07354048
Impact Of Thyroid Dysfunction on Liver Function Tests
An observational study of Thyroid Disease, run by Sohag University at 1 site in Egypt.
Trial summary
This study aims to evaluate the effect of thyroid dysfunction on liver function tests. Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Thyroid Disease
- What is being tested?
- Patients with hypothyroidism or hyperthyroidism that are firstly discovered
- How many people
- 100 participants
- Where
- 1 siteEgypt
- Study dates
- 14 Jul 2025to 30 Jan 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Study population: All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
Who may be able to join
- All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
- Euthyroid controls (clinically healthy control subjects were recruited from the general population with the same socio-economic status with the subjects.)
Who cannot join
- Patients aged < 20 years old.
- Patients With Liver Disease.
- Pregnant and lactating women.
- Patients with severe infections or sepsis.
- Patients with Heart Disease.
- Patients who on drugs that can affect liver function such as phenothiazine, phenylbutazone, methyldopa, among others.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Usama M Abdel-Aal, Professor contact
Egypt1 site, 1 recruiting
- Recruiting
Sohag University Hospital
Sohag
Magdy M Amin, Professor, 01090801900
About this study
Official title: Impact Of Thyroid Dysfunction on Liver Function Tests In Sohag University Hospital
This study aims to evaluate the effect of thyroid dysfunction on liver function tests.
- Conditions
- Thyroid Disease
- Being tested
- Control group, Patients with hypothyroidism or hyperthyroidism that are controlled on treatment, Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment, Patients with hypothyroidism or hyperthyroidism that are firstly discovered
- Medical subject headings
- Thyroid Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Control groupOther
Healthy people
Patients with hypothyroidism or hyperthyroidism that are controlled on treatmentOther
This group includes patients with hypothyroidism or hyperthyroidism that are controlled on treatment
Patients with hypothyroidism or hyperthyroidism that are not controlled on treatmentOther
This group includes patients with hypothyroidism or hyperthyroidism that are not controlled on treatment
Patients with hypothyroidism or hyperthyroidism that are firstly discoveredOther
This group includes patients with hypothyroidism or hyperthyroidism that are firstly discovered
| Study group | Role | What they receive |
|---|---|---|
| Control group | Not described Receives: Other: Control group | |
| Patients with hypothyroidism or hyperthyroidism that are controlled on treatment | Not described Receives: Other: Patients with hypothyroidism or hyperthyroidism that are controlled on treatment | |
| Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment | Not described Receives: Other: Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment | |
| Patients with hypothyroidism or hyperthyroidism that are firstly discovered | Not described Receives: Other: Patients with hypothyroidism or hyperthyroidism that are firstly discovered |
What is being measured
The primary outcome is the main question the study is designed to answer.
Measuring total bilirubin level in patients with thyroid dysfunction diseases
Collecting blood samples from the patients
Measured: 1 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Jan 2026
- Study start14 Jul 2025
- Primary completion30 Jan 2026 (estimated)
- Study completion30 Jan 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Thyroid DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Omnia Ahmed Mohamed Aref, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07354048
- Sponsor's protocol ID
- Soh-Med--25-7-9MS
- Status last verified
- Jan 2026
- First submitted
- 30 Sep 2025
- Last updated
- 21 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J Endocrinol. 2005 Oct;187(1):1-15. doi: 10.1677/joe.1.06131.
PubMed 16214936Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM. 2002 Sep;95(9):559-69. doi: 10.1093/qjmed/95.9.559.
PubMed 12205333Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb;23(1):38-89. doi: 10.1210/edrv.23.1.0455.
PubMed 11844744
Study at a glance
From the registry record, last updated by the sponsor on 21 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact Of Thyroid Dysfunction on Liver Function Tests In Sohag University Hospital
- ClinicalTrials.gov ID
- NCT07354048
- Acronym / sponsor ID
- Soh-Med--25-7-9MS
- Conditions
- Thyroid Disease
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 14 Jul 2025 (actual)
- Primary completion
- 30 Jan 2026 (estimated)
- Study completion
- 30 Jan 2026 (estimated)
- First posted
- 21 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate the effect of thyroid dysfunction on liver function tests.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Control group | – | Other: Control group |
| Patients with hypothyroidism or hyperthyroidism that are controlled on treatment | – | Other: Patients with hypothyroidism or hyperthyroidism that are controlled on treatment |
| Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment | – | Other: Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment |
| Patients with hypothyroidism or hyperthyroidism that are firstly discovered | – | Other: Patients with hypothyroidism or hyperthyroidism that are firstly discovered |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
Key inclusion criteria (2 listed)
- All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
- Euthyroid controls (clinically healthy control subjects were recruited from the general population with the same socio-economic status with the subjects.)
Key exclusion criteria (6 listed)
- Patients aged < 20 years old.
- Patients With Liver Disease.
- Pregnant and lactating women.
- Patients with severe infections or sepsis.
- Patients with Heart Disease.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Control groupHealthy people | Other | Control group |
| Patients with hypothyroidism or hyperthyroidism that are controlled on treatmentThis group includes patients with hypothyroidism or hyperthyroidism that are controlled on treatment | Other | Patients with hypothyroidism or hyperthyroidism that are controlled on treatment |
| Patients with hypothyroidism or hyperthyroidism that are not controlled on treatmentThis group includes patients with hypothyroidism or hyperthyroidism that are not controlled on treatment | Other | Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment |
| Patients with hypothyroidism or hyperthyroidism that are firstly discoveredThis group includes patients with hypothyroidism or hyperthyroidism that are firstly discovered | Other | Patients with hypothyroidism or hyperthyroidism that are firstly discovered |
Primary outcome
Measuring total bilirubin level in patients with thyroid dysfunction diseases
Time frame: 1 months
Collecting blood samples from the patients
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jan 2026.
- Background: PubMed 16214936Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J Endocrinol. 2005 Oct;187(1):1-15. doi: 10.1677/joe.1.06131.
- Background: PubMed 12205333Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM. 2002 Sep;95(9):559-69. doi: 10.1093/qjmed/95.9.559.
- Background: PubMed 11844744Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb;23(1):38-89. doi: 10.1210/edrv.23.1.0455.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Usama M Abdel-Aal, Professor contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Thyroid Disease, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Omnia A Mohamed, Resident (01285252564, omnia_ahmed_post@med.sohag.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Measuring total bilirubin level in patients with thyroid dysfunction diseases (time frame: 1 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07354048, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jan 2026.