Neutrophil-to-Lymphocyte RatioNCT07353138
Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty
An observational study of Neutrophil-to-Lymphocyte Ratio and Septorhinoplasty, run by Istinye University.
Trial summary
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Neutrophil-to-Lymphocyte Ratio, Septorhinoplasty
- What is being tested?
- Observational Study
- How many people
- 110 participants
- Where
- No sites listed yet
- Study dates
- 1 Jan 2026to 31 Mar 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult patients aged 18-65 years who undergo elective septorhinoplasty under general anesthesia. All participants are managed according to standard clinical practice and are admitted to the Post-Anesthesia Care Unit (PACU) postoperatively, where early pain assessments and routine clinical monitoring are performed. Eligible patients have a complete preoperative hemogram obtained within 30 days prior to surgery and comprehensive postoperative records, including pain scores and vital signs. Patients with conditions or treatments that could significantly affect inflammatory markers or pain perception are excluded to ensure a homogeneous study population
Who may be able to join
- Adult patients aged 18-65 years
- Patients undergoing elective septorhinoplasty
- Surgery performed under general anesthesia
- Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)
- Preoperative complete blood count (hemogram) performed within 30 days prior to surgery
- Clinical records and hospital information system data that are complete, accessible, and adequate for analysis
Who cannot join
- Patients undergoing emergency surgery
- Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)
- Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure
- Chronic opioid use or regular analgesic medication use in the preoperative period
- History of significant clinical events between the preoperative hemogram and surgery that could alter inflammatory status (e.g., infection, hospitalization, additional surgery)
- Incomplete or missing data regarding preoperative hemogram parameters or PACU pain scores
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: The Relationship Between Preoperative Neutrophil-to-Lymphocyte Ratio and Hemogram Parameters and Early Postoperative Pain Scores in Patients Undergoing Septorhinoplasty
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid/albumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.
- Conditions
- Neutrophil-to-Lymphocyte Ratio, Septorhinoplasty
- Being tested
- Observational Study
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Observational StudyOther
Not applicable. This is a prospective observational study. No intervention or alteration to standard treatment protocols will be performed. Clinical and laboratory data obtained during routine care, including preoperative hemogram parameters and early postoperative pain scores, will be recorded and analyzed without influencing patient management.
What is being measured
The primary outcome is the main question the study is designed to answer.
Early Postoperative Pain Severity
early postoperative pain severity, as measured using the Visual Analog Scale (VAS). 0: no pain, 10 worst pain
Measured: Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start1 Jan 2026 (estimated)
- Primary completion15 Mar 2026 (estimated)
- Study completion31 Mar 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Neutrophil-to-Lymphocyte RatioStudies of the same condition, open and under way.
- More trials run by Istinye UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 110 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Istinye University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, İlke Dolgun, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07353138
- Sponsor's protocol ID
- 323-2025
- Status last verified
- Jan 2026
- First submitted
- 7 Jan 2026
- Last updated
- 20 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Sachidananda R, Malipatil A, Joshi V, Hosamani A, Haranagatti A, Kurugodiyavar MD. Relationship between neutrophil-lymphocyte ratio and postoperative pain in cesarean section patients done under subarachnoid block: A prospective observational study. J Anaesthesiol Clin Pharmacol. 2025 Jul-Sep;41(3):464-469. doi: 10.4103/joacp.joacp_213_24. Epub 2024 Dec 16.
PubMed 40635819Yildiz Altun A, Demirel I, Bolat E, Ozcan S, Altun S, Aksu A, Bestas A. The Relationship Between the Preoperative Neutrophil-to-Lymphocyte Ratio and Postoperative Nausea and Vomiting in Patients Undergoing Septorhinoplasty Surgery. Aesthetic Plast Surg. 2019 Jun;43(3):861-865. doi: 10.1007/s00266-019-01325-5. Epub 2019 Feb 14.
PubMed 30767038
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Relationship Between Preoperative Neutrophil-to-Lymphocyte Ratio and Hemogram Parameters and Early Postoperative Pain Scores in Patients Undergoing Septorhinoplasty
- ClinicalTrials.gov ID
- NCT07353138
- Acronym / sponsor ID
- 323-2025
- Conditions
- Neutrophil-to-Lymphocyte Ratio, Septorhinoplasty
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 110 participants (estimated)
- Lead sponsor
- Istinye UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (estimated)
- Primary completion
- 15 Mar 2026 (estimated)
- Study completion
- 31 Mar 2026 (estimated)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid/albumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult patients aged 18-65 years who undergo elective septorhinoplasty under general anesthesia. All participants are managed according to standard clinical practice and are admitted to the Post-Anesthesia Care Unit (PACU) postoperatively, where early pain assessments and routine clinical monitoring are performed. Eligible patients have a complete preoperative hemogram obtained within 30 days prior to surgery and comprehensive postoperative records, including pain scores and vital signs. Patients with conditions or treatments that could significantly affect inflammatory markers or pain perception are excluded to ensure a homogeneous study population
Key inclusion criteria (6 listed)
- Adult patients aged 18-65 years
- Patients undergoing elective septorhinoplasty
- Surgery performed under general anesthesia
- Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)
- Preoperative complete blood count (hemogram) performed within 30 days prior to surgery
Key exclusion criteria (6 listed)
- Patients undergoing emergency surgery
- Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)
- Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure
- Chronic opioid use or regular analgesic medication use in the preoperative period
- History of significant clinical events between the preoperative hemogram and surgery that could alter inflammatory status (e.g., infection, hospitalization, additional surgery)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Observational StudyNot applicable. This is a prospective observational study. No intervention or alteration to standard treatment protocols will be performed. Clinical and laboratory data obtained during routine care, including preoperative hemogram parameters and early postoperative pain scores, will be recorded and analyzed without influencing patient management. | Other | – |
Primary outcome
Early Postoperative Pain Severity
Time frame: Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).
early postoperative pain severity, as measured using the Visual Analog Scale (VAS). 0: no pain, 10 worst pain
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- Background: PubMed 40635819Sachidananda R, Malipatil A, Joshi V, Hosamani A, Haranagatti A, Kurugodiyavar MD. Relationship between neutrophil-lymphocyte ratio and postoperative pain in cesarean section patients done under subarachnoid block: A prospective observational study. J Anaesthesiol Clin Pharmacol. 2025 Jul-Sep;41(3):464-469. doi: 10.4103/joacp.joacp_213_24. Epub 2024 Dec 16.
- Background: PubMed 30767038Yildiz Altun A, Demirel I, Bolat E, Ozcan S, Altun S, Aksu A, Bestas A. The Relationship Between the Preoperative Neutrophil-to-Lymphocyte Ratio and Postoperative Nausea and Vomiting in Patients Undergoing Septorhinoplasty Surgery. Aesthetic Plast Surg. 2019 Jun;43(3):861-865. doi: 10.1007/s00266-019-01325-5. Epub 2019 Feb 14.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Neutrophil-to-Lymphocyte Ratio and Septorhinoplasty, run by Istinye University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact İLKE DOLĞUN (+905555485632, ilkeser2004@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Early Postoperative Pain Severity (time frame: Within the first 60 minutes after admission to the Post-Anesthesia Care Unit (PACU).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07353138, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.