Exercise-Induced Muscle DamageNCT07352319
DOES LOWER BODY PLYOMETRICS CAUSE RHABDOMYOLYSIS IN FEMALE VOLLEYBALL PLAYERS-AN EXPERIMENTAL STUDY
A study testing plyometric program in people with Exercise-Induced Muscle Damage and Rhabdomyolysis, run by Cairo University at 1 site in Saudi Arabia.
Trial summary
Eight-week interventional study to evaluate whether lower-body plyometric training alters serum creatine phosphokinase (CPK) and creatinine levels in female collegiate volleyball players. Sixty participants were randomized to experimental (plyometrics twice weekly) or control (routine volleyball) groups. Read more about this study
- Who is it for?
- Ages 18 to 25 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Exercise-Induced Muscle Damage, Rhabdomyolysis, Athletes
- What is being tested?
- plyometric program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 12 Jan 2022to 25 Oct 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Active collegiate female volleyball players
- consent to participate
- no prior plyometric training program.
Who cannot join
- Neuromuscular impairments
- recent injuries.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Lower Body Plyometric Training on Serum CPK and Creatinine Levels in Collegiate Female Volleyball Players: An Experimental Study
Eight-week interventional study to evaluate whether lower-body plyometric training alters serum creatine phosphokinase (CPK) and creatinine levels in female collegiate volleyball players. Sixty participants were randomized to experimental (plyometrics twice weekly) or control (routine volleyball) groups. Blood sampling occurred at baseline; days 2, 4, and 6; and weeks 1, 2, 4, 6, and 8.
Read the detailed description
Intervention adapted from James \& Robert (2015). Experimental group completed progressive lower-body plyometrics twice weekly (Monday/Wednesday) over eight weeks with warm-up and cool-down. Exercises included squat jump; jump to box (30 cm); tuck jump; split squat jump; lateral hurdle jump (50 cm); zigzag jump; single-leg tuck jump; and depth jump (80 cm). Control group continued routine volleyball activities and did not perform low/medium/high-intensity plyometrics. Primary biomarker (serum CPK) assessed via CK-NAC optimized IFCC method; serum creatinine by modified Jaffe's method. Two-way ANOVA with Bonferroni post hoc used. Findings: CPK increased from day 2, peaked day 4, stabilized to week 2, then declined toward baseline by week 8; creatinine remained stable.
- Conditions
- Exercise-Induced Muscle Damage, Rhabdomyolysis, Athletes
- Being tested
- plyometric program
- Medical subject headings
- Rhabdomyolysis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
plyometric programOther
Also called Lower-body plyometric training
Twice-weekly sessions (Mon/Wed) for 8 weeks; exercise menu and dosing per Table 1 (intensity, rest, and jumps/set).
| Study group | Role | What they receive |
|---|---|---|
| Lower-body plyometric training | Experimental | Progressive plyometric program, twice weekly for eight weeks. Receives: Other: plyometric program |
| Control | Active comparator | Routine volleyball practice; no plyometric exercises. Receives: Other: plyometric program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Serum CPK (U/L)
change from baseline at day 2, day 4, week 1, week 2, week 4, week 6, week 8
Measured: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks
Secondary outcomes (1)
Serum creatinine (mg/dL)
change from baseline over same time points
Measured: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start12 Jan 2022
- Primary completion15 May 2022
- Study completion25 Oct 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise-Induced Muscle DamageStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mariam Elsayed Mohamed Abd Alaal, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07352319
- Sponsor's protocol ID
- BMC VP
- Status last verified
- Jan 2026
- First submitted
- 11 Jan 2026
- Last updated
- 20 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared because this study does not include a data-sharing plan and is limited to internal analysis only.
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Lower Body Plyometric Training on Serum CPK and Creatinine Levels in Collegiate Female Volleyball Players: An Experimental Study
- ClinicalTrials.gov ID
- NCT07352319
- Acronym / sponsor ID
- BMC VP
- Conditions
- Exercise-Induced Muscle Damage, Rhabdomyolysis, Athletes
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 12 Jan 2022 (actual)
- Primary completion
- 15 May 2022 (actual)
- Study completion
- 25 Oct 2022 (actual)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Eight-week interventional study to evaluate whether lower-body plyometric training alters serum creatine phosphokinase (CPK) and creatinine levels in female collegiate volleyball players. Sixty participants were randomized to experimental (plyometrics twice weekly) or control (routine volleyball) groups. Blood sampling occurred at baseline; days 2, 4, and 6; and weeks 1, 2, 4, 6, and 8.
Detailed description
Intervention adapted from James \& Robert (2015). Experimental group completed progressive lower-body plyometrics twice weekly (Monday/Wednesday) over eight weeks with warm-up and cool-down. Exercises included squat jump; jump to box (30 cm); tuck jump; split squat jump; lateral hurdle jump (50 cm); zigzag jump; single-leg tuck jump; and depth jump (80 cm). Control group continued routine volleyball activities and did not perform low/medium/high-intensity plyometrics. Primary biomarker (serum CPK) assessed via CK-NAC optimized IFCC method; serum creatinine by modified Jaffe's method. Two-way ANOVA with Bonferroni post hoc used. Findings: CPK increased from day 2, peaked day 4, stabilized to week 2, then declined toward baseline by week 8; creatinine remained stable.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Lower-body plyometric training | Experimental | Other: plyometric programProgressive plyometric program, twice weekly for eight weeks. |
| Control | Active comparator | Other: plyometric programRoutine volleyball practice; no plyometric exercises. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Active collegiate female volleyball players
- consent to participate
- no prior plyometric training program.
Key exclusion criteria (2 listed)
- Neuromuscular impairments
- recent injuries.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| plyometric programAlso: Lower-body plyometric trainingTwice-weekly sessions (Mon/Wed) for 8 weeks; exercise menu and dosing per Table 1 (intensity, rest, and jumps/set). | Other | Control, Lower-body plyometric training |
Primary outcome
Serum CPK (U/L)
Time frame: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks
change from baseline at day 2, day 4, week 1, week 2, week 4, week 6, week 8
1 secondary outcome
Serum creatinine (mg/dL)
Time frame: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared because this study does not include a data-sharing plan and is limited to internal analysis only.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing plyometric program in people with Exercise-Induced Muscle Damage and Rhabdomyolysis, run by Cairo University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Serum CPK (U/L) (time frame: Baseline; 2, 4, 6 days; 1, 2, 4, 6, 8 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.