AppendicectomyNCT07351253
Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block for Open Abendectomy Surgery
A study testing Erector Spinae Plane Block and Transversus abdominis plane (TAP) block in people with Appendicectomy and Postoperative Analgesia, run by Cairo University at 1 site in Egypt.
Trial summary
this aim of this study is to compare the analgesic effect of Erector spinae plane (ESP) block and lateral transversus abdominis plan (TAP) block in patients undergoing open appendectomy. Read more about this study
- Who is it for?
- Ages 21 years and older
- Conditions the study is for
- Appendicectomy, Postoperative Analgesia, Regional Anaesthesia
- What is being tested?
- Erector Spinae Plane Block and Transversus abdominis plane (TAP) block
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 1 siteEgypt
- Study dates
- 25 Jan 2026to May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- adult patients, undergoing open appendectomy.
Who cannot join
- American society of anesthesiologist-physical status >III,
- allergy to any of the study drugs,
- coagulopathy
- local infection,
- history of chronic pain or regular opioid use;
- inability to comprehend the Numeric Rating Scale (NRS),
- pregnant or lactating women.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Cairo University
Cairo, Cairo Governorate
ahmed Shash, Professor, +201001033999
About this study
Official title: Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial
this aim of this study is to compare the analgesic effect of Erector spinae plane (ESP) block and lateral transversus abdominis plan (TAP) block in patients undergoing open appendectomy.
Read the detailed description
regional technique according to randomization will be given after induction of general anesthesia Fentanyl boluses of 1 mcg/kg will be given in case of inadequate analgesia. Inadequate analgesia identified by 20% increase in the heart rate and/or systolic blood pressure from baseline measurement.
postoperative analgesia: regular paracetamol 1 g/6 hours (intravenously at first then orally once the oral feeding is resumed) and 75 mg diclofenac (intramuscularly at first then orally once the oral feeding is resumed).
If Numeric rating scale (NRS) is > 3 intravenous titration of 2 mg morphine is given slowly to be repeated after 30 minutes if pain persisted
- Being tested
- Erector Spinae Plane Block, Transversus abdominis plane (TAP) block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Erector Spinae Plane BlockOther
Patients will receive the ESP block at the level of the 10th thoracic (T10) transverse process using a linear 6-13 MHz ultrasound transducer. A 20 mL of 0.25% bupivacaine will be injected below the muscle
Transversus abdominis plane (TAP) blockOther
Patient will received TAP block using the lateral approach while in supine position. A 20 mL of 0.25% bupivacaine will be injected after negative aspiration.
| Study group | Role | What they receive |
|---|---|---|
| ESP group | Active comparator | Not described Receives: Other: Erector Spinae Plane Block |
| TAP group | Active comparator | Not described Receives: Other: Transversus abdominis plane (TAP) block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Total morphine consumption
mg
Measured: from extubation until 24 hours postoperative
Secondary outcomes (2)
numeric rating scale
a scale of 0-10, where 0 means "no pain" and 10 means "worst imaginable pain"
Measured: AT 0.5, 2, 6, 12, and 24 hours postoperative.
quality of recovery
assessed using Quality of recovery-15 (QOR-15); Consists of 15 items evaluating five dimensions of health: physical comfort, physical independence, psychological support, emotional state, and pain.
Scoring Range: Each item is rated on an 11-point numerical scale (0 to 10). The total score ranges from 0 (extremely poor recovery) to 150 (excellent recovery).
Measured: 24 hours after suregry
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Jan 2026
- Study start25 Jan 2026
- Primary completionMay 2026 (estimated)
- Study completionMay 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AppendicectomyStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 68 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Hasanin, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07351253
- Sponsor's protocol ID
- MD-320-2024
- Status last verified
- Jan 2026
- First submitted
- 10 Jan 2026
- Last updated
- 17 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: data regarding this research will be available upon reasonable request from the PI
Study at a glance
From the registry record, last updated by the sponsor on 17 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07351253
- Acronym / sponsor ID
- MD-320-2024
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 68 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 25 Jan 2026 (actual)
- Primary completion
- May 2026 (estimated)
- Study completion
- May 2026 (estimated)
- First posted
- 20 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
this aim of this study is to compare the analgesic effect of Erector spinae plane (ESP) block and lateral transversus abdominis plan (TAP) block in patients undergoing open appendectomy.
Detailed description
regional technique according to randomization will be given after induction of general anesthesia Fentanyl boluses of 1 mcg/kg will be given in case of inadequate analgesia. Inadequate analgesia identified by 20% increase in the heart rate and/or systolic blood pressure from baseline measurement.
postoperative analgesia: regular paracetamol 1 g/6 hours (intravenously at first then orally once the oral feeding is resumed) and 75 mg diclofenac (intramuscularly at first then orally once the oral feeding is resumed).
If Numeric rating scale (NRS) is > 3 intravenous titration of 2 mg morphine is given slowly to be repeated after 30 minutes if pain persisted
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ESP group | Active comparator | Other: Erector Spinae Plane Block |
| TAP group | Active comparator | Other: Transversus abdominis plane (TAP) block |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- adult patients, undergoing open appendectomy.
Key exclusion criteria (7 listed)
- American society of anesthesiologist-physical status >III,
- allergy to any of the study drugs,
- coagulopathy
- local infection,
- history of chronic pain or regular opioid use;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Erector Spinae Plane BlockPatients will receive the ESP block at the level of the 10th thoracic (T10) transverse process using a linear 6-13 MHz ultrasound transducer. A 20 mL of 0.25% bupivacaine will be injected below the muscle | Other | ESP group |
| Transversus abdominis plane (TAP) blockPatient will received TAP block using the lateral approach while in supine position. A 20 mL of 0.25% bupivacaine will be injected after negative aspiration. | Other | TAP group |
Primary outcome
Total morphine consumption
Time frame: from extubation until 24 hours postoperative
mg
2 secondary outcomes
numeric rating scale
Time frame: AT 0.5, 2, 6, 12, and 24 hours postoperative.
quality of recovery
Time frame: 24 hours after suregry
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Mar 2026.
- Individual participant dataSharing planned: No. data regarding this research will be available upon reasonable request from the PI
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Erector Spinae Plane Block and Transversus abdominis plane (TAP) block in people with Appendicectomy and Postoperative Analgesia, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Maha Mostafa, MD (+201000365115, maha.mostafa@cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Total morphine consumption (time frame: from extubation until 24 hours postoperative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Mar 2026.