InflammationNCT07344727
Impact of Haskap Berries on Recovery From High Intensity Resistance Training
A study testing Haskap berry smoothie in people with Inflammation and Oxidative Stress, run by Montana State University at 1 site in United States.
Trial summary
The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Inflammation, Oxidative Stress, Resistance Exercise
- What is being tested?
- Haskap berry smoothie
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 21 Oct 2025to May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- 2+ years of barbell squat experience
- Currently squatting at least once a week
Who cannot join
- BMI <18 or > 40 kg/m^2
- potential allergy to Haskap or placebo ingredients
- anti-inflammatory, weight loss, anabolic steroids, testosterone, or other drugs that may interfere with the measures of the study or any other medications that may interfere with study measures
- pregnant or lactating woman
- diagnosis with type 1 or type 2 diabetes, hypo-/hyperthyroidism or any other condition that may interfere with study measures
- smoke cigarettes
Show all 9Show fewer
- lower extremity injury within the last year
- currently following a special diet including vegan, vegetarian, low carbohydrate, or ketogenic.
- currently consuming any of the following products: tart cherry juice, pomegranate juice, or 1 or more cups of acai or other berries per day.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Montana State University
Bozeman, Montana, 59715
Mary P Miles, 406-994-6678, mmiles@montana.edu
Bryce Peterson, 4066975460
About this study
The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following:
- Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults?
- Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults?
- The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses.
Read more
Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance.
- Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet
- Participants will perform an intense resistance workout
- Participants will have their blood drawn before and after the workout
- Performance will be analyzed at 24, 48 and 72 hours after the workout
Read the detailed description
The main goal of the clinical trial is to learn more about how the haskap berry impacts the recovery process form intense resistance training. Haskap berries are very high in several compounds that function as antioxidants, such as polyphenols and vitamin C, which have many health promoting effects. For example, antioxidants lower inflammation and oxidative stress, which is known to cause damage to cells, proteins, and DNA. Oxidative stress is a result of excess free radicals, which are unstable molecules that can be created, along with inflammation, during intense exercise. This combination of excessive harmful byproducts in the body can cause soreness and decrease muscle performance experienced after a workout. However, the antioxidants in foods have the ability to neutralize free radicals that are produced and may reduce the time to recover from exercise.
To do this, a parallel, randomized, double blind, placebo controlled clinical trial of Haskap versus a placebo on resistance trained individuals will be completed. Participants will complete an intense workout consisting of barbell back squats and leg extension. Participants will drink either Haskap juice or placebo and follow a low polyphenolic diet for a total of 11 days. Participants will have their blood drawn before supplementation, before, immediately after and 8, 24, 48, and 72 hours after the workout to track recovery of blood markers. Performance will be analyzed via vertical jumps on force plates, maximal voluntary contraction of the quadriceps on a biodex, and speed of the squat at 24, 48, and 72 hours post workout.
- Conditions
- Inflammation, Oxidative Stress, Resistance Exercise, Recovery, Exercise Performance Recovery
- Being tested
- Haskap berry smoothie, Placebo Comparator
- Keywords
- exercise performance, resistance exercise, recovery, oxidative stress, inflammation
- Medical subject headings
- Inflammation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Haskap berry smoothieDietary supplement
A smoothie blend of berries and water
Placebo ComparatorDietary supplement
A smoothie with no polyphenolic content and matched in carbohydrate composition to the experimental haskap smoothie
| Study group | Role | What they receive |
|---|---|---|
| Placebo Control | Placebo comparator | The placebo supplement will have no polyphenol content and will be carbohydrate-matched to the experimental group. A twice daily dose (10-12 hours apart) will be consumed for 11 days. Receives: Dietary Supplement: Placebo Comparator |
| Haskap | Experimental | The haskap supplement will consist of a haskap berry smoothie. A twice daily dose (10-12) hours apart will be consumed for 11 days. Receives: Dietary Supplement: Haskap berry smoothie |
What is being measured
The primary outcome is the main question the study is designed to answer.
Force Production
Maximal Voluntary Contraction (MVC) to assess force production of knee extensors at 60 degrees.
Measured: 72 hours
Barbell Velocity
Barbell velocity will be measure to determine how squat velocity recovers over the course of the study.
Measured: 72 hours
Vertical Jump
Force plates will be used to evaluate vertical jump height.
Measured: 72 hours
Inflammation (pg/mL)
Serum interleukin (IL) IL-6, IL-10, IL-1ra, tumor necrosis factor alpha (TNF-alpha),
Measured: 11 days
Lipid peroxidation
Plasma Malondialdehyde (MDA)
Measured: 11 days
Creatine Kinase
Plasma
Measured: 11 days
C-Reactive Protein
Plasma
Measured: 11 days
Protein Carbonyls
Plasma
Measured: 11 days
Secondary outcomes (3)
Soreness
Soreness will be evaluated objectively by participants drawing a line on a scale of 0-10 of how sore their legs are. 0 represents no soreness at all and 10 represents the most muscular soreness the participant has felt. A lower number could indicate less inflammation and muscular damage.
Measured: 72 hours
Acute Diet
24-hour dietary recall using the Automated Self-Administered 24-hour Dietary. Assessment Tool (ASA24). Outcome is macronutrient and micronutrient composition of food entry.
Measured: 9 days
Sleep Questionnaire
Participants report information on the previous night's sleep. What time they went to sleep, how long it took them to fall asleep, how many hours they slept, whether these were normal sleep and wake times and how restful they perceive their sleep to be on a scale of 1 to 10. 1 indicates their sleep was not restful at all and 10 indicates their sleep was as restful as possible.
Measured: 11 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jan 2026
- Study start21 Oct 2025
- Primary completionMar 2026 (estimated)
- Study completionMay 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for InflammationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Montana State University
- Sponsor type
- University, hospital or other
- Collaborators
- Montana State Agricultural Experiment Station
- Responsible party
- Sponsor
- Investigators
- Mary P Miles, Principal investigator, Montana State University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07344727
- Sponsor's protocol ID
- 2025-2138
- Status last verified
- Jan 2026
- First submitted
- 7 Jan 2026
- Last updated
- 21 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Haskap Berries on Recovery From High Intensity Resistance Training
- ClinicalTrials.gov ID
- NCT07344727
- Acronym / sponsor ID
- 2025-2138
- Conditions
- Inflammation, Oxidative Stress, Resistance Exercise, Recovery, Exercise Performance Recovery
- Keywords
- exercise performance, resistance exercise, recovery, oxidative stress, inflammation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Montana State UniversityUniversity, hospital or other
- Collaborators
- Montana State Agricultural Experiment Station
- Study start
- 21 Oct 2025 (actual)
- Primary completion
- Mar 2026 (estimated)
- Study completion
- May 2026 (estimated)
- First posted
- 15 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following:
- Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults?
- Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults?
- The data collected in this investigation may also be used to ask additional questions not yet identified. For example, the investigators may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses.
Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance.
- Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet
- Participants will perform an intense resistance workout
- Participants will have their blood drawn before and after the workout
- Performance will be analyzed at 24, 48 and 72 hours after the workout
Detailed description
The main goal of the clinical trial is to learn more about how the haskap berry impacts the recovery process form intense resistance training. Haskap berries are very high in several compounds that function as antioxidants, such as polyphenols and vitamin C, which have many health promoting effects. For example, antioxidants lower inflammation and oxidative stress, which is known to cause damage to cells, proteins, and DNA. Oxidative stress is a result of excess free radicals, which are unstable molecules that can be created, along with inflammation, during intense exercise. This combination of excessive harmful byproducts in the body can cause soreness and decrease muscle performance experienced after a workout. However, the antioxidants in foods have the ability to neutralize free radicals that are produced and may reduce the time to recover from exercise.
To do this, a parallel, randomized, double blind, placebo controlled clinical trial of Haskap versus a placebo on resistance trained individuals will be completed. Participants will complete an intense workout consisting of barbell back squats and leg extension. Participants will drink either Haskap juice or placebo and follow a low polyphenolic diet for a total of 11 days. Participants will have their blood drawn before supplementation, before, immediately after and 8, 24, 48, and 72 hours after the workout to track recovery of blood markers. Performance will be analyzed via vertical jumps on force plates, maximal voluntary contraction of the quadriceps on a biodex, and speed of the squat at 24, 48, and 72 hours post workout.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Placebo Control | Placebo comparator | Dietary Supplement: Placebo ComparatorThe placebo supplement will have no polyphenol content and will be carbohydrate-matched to the experimental group. A twice daily dose (10-12 hours apart) will be consumed for 11 days. |
| Haskap | Experimental | Dietary Supplement: Haskap berry smoothieThe haskap supplement will consist of a haskap berry smoothie. A twice daily dose (10-12) hours apart will be consumed for 11 days. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- 2+ years of barbell squat experience
- Currently squatting at least once a week
Key exclusion criteria (9 listed)
- BMI <18 or > 40 kg/m^2
- potential allergy to Haskap or placebo ingredients
- anti-inflammatory, weight loss, anabolic steroids, testosterone, or other drugs that may interfere with the measures of the study or any other medications that may interfere with study measures
- pregnant or lactating woman
- diagnosis with type 1 or type 2 diabetes, hypo-/hyperthyroidism or any other condition that may interfere with study measures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Haskap berry smoothieA smoothie blend of berries and water | Dietary supplement | Haskap |
| Placebo ComparatorA smoothie with no polyphenolic content and matched in carbohydrate composition to the experimental haskap smoothie | Dietary supplement | Placebo Control |
Primary outcome
Force Production
Time frame: 72 hours
Maximal Voluntary Contraction (MVC) to assess force production of knee extensors at 60 degrees.
Barbell Velocity
Time frame: 72 hours
Barbell velocity will be measure to determine how squat velocity recovers over the course of the study.
Vertical Jump
Time frame: 72 hours
Force plates will be used to evaluate vertical jump height.
Inflammation (pg/mL)
Time frame: 11 days
Serum interleukin (IL) IL-6, IL-10, IL-1ra, tumor necrosis factor alpha (TNF-alpha),
Lipid peroxidation
Time frame: 11 days
Plasma Malondialdehyde (MDA)
Creatine Kinase
Time frame: 11 days
Plasma
C-Reactive Protein
Time frame: 11 days
Plasma
Protein Carbonyls
Time frame: 11 days
Plasma
3 secondary outcomes
Soreness
Time frame: 72 hours
Acute Diet
Time frame: 9 days
Sleep Questionnaire
Time frame: 11 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mary P Miles principal investigator
Montana State University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Haskap berry smoothie in people with Inflammation and Oxidative Stress, run by Montana State University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Bryce Peterson (40666975460, brycepeterson@montana.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Force Production (time frame: 72 hours). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Jan 2026.