RecoveryNCT07342634
Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise
A study testing BFR-80%, BFR-60% and BFR-10mmHg in people with Recovery and Recovery Time, run by Paulista University at 1 site in Brazil.
Trial summary
Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Recovery, Recovery Time
- What is being tested?
- BFR-80%, BFR-60% and BFR-10mmHg
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 80 participants
- Where
- 1 siteBrazil
- Study dates
- 1 Feb 2026to 1 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Individuals exhibiting one or more of the following characteristics will not be included:
- (1) diabetes and hypertension;
- (2) inflammatory rheumatological, psychiatric, cardiovascular and/or respiratory disease;
- (3) pre-existing injury restricting their ability to perform vigorous physical activities;
- (4) having one or more predisposing risk factors for thromboembolism.
Who cannot join
- Participants will be excluded from the study if they:
- (1) have a health problem that does not allow them to continue;
- (2) wish to leave the study;
- (3) use medications, electrotherapy, or other therapeutic methods during the study period that could interfere with any results;
- (4) not sign the consent form.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Brazil1 site, 1 recruiting
- Recruiting
Franciele Marques Vanderlei
Presidente Prudente, São Paulo, 19060-900
Franciele M Vanderlei, +55 (18) 3229-5824, franmvanderlei@gmail.com
About this study
Official title: Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise: a Controlled Clinical Trial
Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Among the accessible techniques, blood flow restriction (BFR) has shown promise for its potential to accelerate muscle recovery.
Read the detailed description
A randomized clinical trial will be conducted with 40 men and 40 women allocated to one of four groups: i) BFR using 80% of total occlusion pressure (TOP) [BFR-80%]; ii) BFR using 60% of total occlusion pressure (TOP) [BFR-60%]; iii) BFR using 10 mmHg (BFR-10 mmHg); and iv) control (CON). All groups will undergo initial assessments, followed by the muscle stress protocol, and all outcomes will be collected again. Subsequently, the intervention to which they were previously randomized will be performed, and finally, subsequent assessments will be conducted immediately, 24, 48, and 72 hours after exercise. The outcomes assessed will be, in order: pain using the Numerical Rating Scale (NRS), perception of recovery and discomfort using the Likert scale, and perception of effort using the Borg scale (CR-10), cellular integrity vectors using bioelectrical impedance analysis (BIA), pain threshold using a pressure algometer, muscle tone, stiffness, and elasticity using myotonometry, quadriceps muscle strength test using a digital dynamometer, muscle power test using the Squat Jump test, and a single-leg jump functional test.
Participants will be duly informed about the procedures and objectives of this study, and after agreeing, will sign a free and informed consent form, thus becoming effectively part of it. In the consent form, participants will be asked if they agree to the use of their data should they choose to withdraw from the study. Participants will also be asked for permission for the research team to share relevant data with people from the universities participating in the research or regulatory authorities, when relevant, while preserving the participant's identity. The study will be submitted for review and approval to the Research Ethics Committee of FCT/UNESP, Presidente Prudente, SP, Brazil and will be registered on ClinicalTrials.gov.
- Conditions
- Recovery, Recovery Time
- Being tested
- BFR-80%, BFR-60%, BFR-10mmHg
- Keywords
- Resistance training, physiological stress, post-exercise recovery, blood flow restriction therapy, functional physical performance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
BFR-80%Device
Will perform the intervention with BFR using 80% of the total occlusion pressure (TOP) continuously for 20 minutes.
BFR-60%Device
Will perform the intervention with BFR using 60% of the total occlusion pressure (TOP) continuously for 20 minutes.
BFR-10mmHgOther
Will perform the intervention with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes.
| Study group | Role | What they receive |
|---|---|---|
| Blood flow restriction with 80% occlusion | Experimental | Will perform an BFR intervention using 80% of the total occlusion pressure (TOP) continuously for 20 minutes. Receives: Device: BFR-80% |
| Blood flow restriction with 60% occlusion | Experimental | Will perform an BFR intervention using 60% of the total occlusion pressure (TOP) continuously for 20 minutes. Receives: Device: BFR-60% |
| Blood flow restriction with 10 mmHg of occlusion pressure | Placebo comparator | The intervention will be performed with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes. Receives: Other: BFR-10mmHg |
| Control | No intervention | It will remain at rest for 20 minutes without using BFR. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Lower limb muscle power
Muscle power will be assessed through the Squat Jump test using a contact platform (Multisprint). Participants will begin in a 90° knee flexion position (verified with a goniometer), with hands on hips, and will perform a vertical jump without countermovement. Variables to be analyzed will include jump height, modified reactive strength index, jump power, and take-off moment.
Measured: Change from baseline at 72 hours after exercise
Lower limb muscle function
Muscle function will be assessed through the single leg hop functional test sing a measuring tape in centimeters. The participant will be positioned standing on a flat surface, barefoot, and with their hands on their waist. They will be asked to perform a horizontal jump with the greatest possible reach using only one lower limb (test performed unilaterally). The contralateral limb will remain flexed without touching the ground during the execution. After the jump, the participant must maintain balance for at least two seconds without losing stability or moving the landing foot. The jump distance will be measured in centimeters from the toe of the supporting foot (before the jump) to the heel at the moment of landing, using a measuring tape.
Measured: Change from baseline at 72 hours after exercise
Isometric strenght of quadriceps and hamstring muscle
The isometric peak torque of the quadriceps and hamstring will be measured using a digital handheld dynamometer (DD-300, Instrutherm). For the quadriceps strength assessment, the participant will be seated in a chair with their knee bent at 90° and instructed to push maximally against the dynamometer. To measure hamstring strength, the participant will be positioned in a prone position with their knee flexed at 90º and will be instructed to push maximally against the dynamometer. Three attempts will be performed with a 1-minute rest interval. The highest value will be used for analysis.
Measured: Change from baseline at 72 hours after exercise
Muscle soreness and pain threshold
Muscle soreness will be assessed using a Numeric Pain Rating Scale (0-10). Pain threshold will be measured with a pressure algometer (FPX 50/220; Wagner) at four sites: biceps femoris and rectus femoris. Measurements will be recorded in kgf and will not exceed 2.55 kgf.
Measured: Change from baseline at 72 hours after exercise
Perceived exertion, recovery, and discomfort
Perceived exertion, recovery, and discomfort will be measured using the Borg CR-10 scale (0-10). Participants will rate: (1) exertion as whole-body effort, (2) discomfort as muscular sensations in the lower limbs, and (3) recovery as general physical and psychological recovery. Values will be individually recorded at each time point.
Measured: Change from baseline at 72 hours after exercise
Myotonometry
Muscle tone, stiffness, and elasticity will be measured using the MyotonPRO device. The probe will be positioned perpendicularly over the following sites: biceps femoris and rectus femoris. The device will apply a 0.18 N pre-load and a 0.40 N impulse to induce tissue oscillation for measurement.
Measured: Change from baseline at 72 hours after exercise
Bioelectrical impedance analysis
Bioimpedance will be measured using a tetrapolar device (BIA Analyzer, 50 kHz, 800 µA). Electrodes will be positioned on the biceps femoris and rectus femoris. Analyzed variables will include resistance (R), reactance (Xc), phase angle (PhA), and tolerance ellipse, via Bioscan software.
Measured: Change from baseline at 72 hours after exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Jan 2026
- Study start1 Feb 2026
- Primary completion1 Dec 2026 (estimated)
- Study completion1 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for RecoveryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Paulista University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Franciele Marques Vanderle, Paulista University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07342634
- Sponsor's protocol ID
- 91529125.6.0000.5402
- Status last verified
- Dec 2025
- First submitted
- 15 Dec 2025
- Last updated
- 16 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise: a Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07342634
- Acronym / sponsor ID
- 91529125.6.0000.5402
- Conditions
- Recovery, Recovery Time
- Keywords
- Resistance training, physiological stress, post-exercise recovery, blood flow restriction therapy, functional physical performance
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Paulista UniversityUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 1 Dec 2026 (estimated)
- Study completion
- 1 Dec 2027 (estimated)
- First posted
- 15 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Among the accessible techniques, blood flow restriction (BFR) has shown promise for its potential to accelerate muscle recovery.
Detailed description
A randomized clinical trial will be conducted with 40 men and 40 women allocated to one of four groups: i) BFR using 80% of total occlusion pressure (TOP) [BFR-80%]; ii) BFR using 60% of total occlusion pressure (TOP) [BFR-60%]; iii) BFR using 10 mmHg (BFR-10 mmHg); and iv) control (CON). All groups will undergo initial assessments, followed by the muscle stress protocol, and all outcomes will be collected again. Subsequently, the intervention to which they were previously randomized will be performed, and finally, subsequent assessments will be conducted immediately, 24, 48, and 72 hours after exercise. The outcomes assessed will be, in order: pain using the Numerical Rating Scale (NRS), perception of recovery and discomfort using the Likert scale, and perception of effort using the Borg scale (CR-10), cellular integrity vectors using bioelectrical impedance analysis (BIA), pain threshold using a pressure algometer, muscle tone, stiffness, and elasticity using myotonometry, quadriceps muscle strength test using a digital dynamometer, muscle power test using the Squat Jump test, and a single-leg jump functional test.
Participants will be duly informed about the procedures and objectives of this study, and after agreeing, will sign a free and informed consent form, thus becoming effectively part of it. In the consent form, participants will be asked if they agree to the use of their data should they choose to withdraw from the study. Participants will also be asked for permission for the research team to share relevant data with people from the universities participating in the research or regulatory authorities, when relevant, while preserving the participant's identity. The study will be submitted for review and approval to the Research Ethics Committee of FCT/UNESP, Presidente Prudente, SP, Brazil and will be registered on ClinicalTrials.gov.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Blood flow restriction with 80% occlusion | Experimental | Device: BFR-80%Will perform an BFR intervention using 80% of the total occlusion pressure (TOP) continuously for 20 minutes. |
| Blood flow restriction with 60% occlusion | Experimental | Device: BFR-60%Will perform an BFR intervention using 60% of the total occlusion pressure (TOP) continuously for 20 minutes. |
| Blood flow restriction with 10 mmHg of occlusion pressure | Placebo comparator | Other: BFR-10mmHgThe intervention will be performed with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes. |
| Control | No intervention | –It will remain at rest for 20 minutes without using BFR. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Individuals exhibiting one or more of the following characteristics will not be included:
- (1) diabetes and hypertension;
- (2) inflammatory rheumatological, psychiatric, cardiovascular and/or respiratory disease;
- (3) pre-existing injury restricting their ability to perform vigorous physical activities;
- (4) having one or more predisposing risk factors for thromboembolism.
Key exclusion criteria (5 listed)
- Participants will be excluded from the study if they:
- (1) have a health problem that does not allow them to continue;
- (2) wish to leave the study;
- (3) use medications, electrotherapy, or other therapeutic methods during the study period that could interfere with any results;
- (4) not sign the consent form.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| BFR-80%Will perform the intervention with BFR using 80% of the total occlusion pressure (TOP) continuously for 20 minutes. | Device | Blood flow restriction with 80% occlusion |
| BFR-60%Will perform the intervention with BFR using 60% of the total occlusion pressure (TOP) continuously for 20 minutes. | Device | Blood flow restriction with 60% occlusion |
| BFR-10mmHgWill perform the intervention with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes. | Other | Blood flow restriction with 10 mmHg of occlusion pressure |
Primary outcome
Lower limb muscle power
Time frame: Change from baseline at 72 hours after exercise
Muscle power will be assessed through the Squat Jump test using a contact platform (Multisprint). Participants will begin in a 90° knee flexion position (verified with a goniometer), with hands on hips, and will perform a vertical jump without countermovement. Variables to be analyzed will include jump height, modified reactive strength index, jump power, and take-off moment.
Lower limb muscle function
Time frame: Change from baseline at 72 hours after exercise
Muscle function will be assessed through the single leg hop functional test sing a measuring tape in centimeters. The participant will be positioned standing on a flat surface, barefoot, and with their hands on their waist. They will be asked to perform a horizontal jump with the greatest possible reach using only one lower limb (test performed unilaterally). The contralateral limb will remain flexed without touching the ground during the execution. After the jump, the participant must maintain balance for at least two seconds without losing stability or moving the landing foot. The jump distance will be measured in centimeters from the toe of the supporting foot (before the jump) to the heel at the moment of landing, using a measuring tape.
Isometric strenght of quadriceps and hamstring muscle
Time frame: Change from baseline at 72 hours after exercise
The isometric peak torque of the quadriceps and hamstring will be measured using a digital handheld dynamometer (DD-300, Instrutherm). For the quadriceps strength assessment, the participant will be seated in a chair with their knee bent at 90° and instructed to push maximally against the dynamometer. To measure hamstring strength, the participant will be positioned in a prone position with their knee flexed at 90º and will be instructed to push maximally against the dynamometer. Three attempts will be performed with a 1-minute rest interval. The highest value will be used for analysis.
Muscle soreness and pain threshold
Time frame: Change from baseline at 72 hours after exercise
Muscle soreness will be assessed using a Numeric Pain Rating Scale (0-10). Pain threshold will be measured with a pressure algometer (FPX 50/220; Wagner) at four sites: biceps femoris and rectus femoris. Measurements will be recorded in kgf and will not exceed 2.55 kgf.
Perceived exertion, recovery, and discomfort
Time frame: Change from baseline at 72 hours after exercise
Perceived exertion, recovery, and discomfort will be measured using the Borg CR-10 scale (0-10). Participants will rate: (1) exertion as whole-body effort, (2) discomfort as muscular sensations in the lower limbs, and (3) recovery as general physical and psychological recovery. Values will be individually recorded at each time point.
Myotonometry
Time frame: Change from baseline at 72 hours after exercise
Muscle tone, stiffness, and elasticity will be measured using the MyotonPRO device. The probe will be positioned perpendicularly over the following sites: biceps femoris and rectus femoris. The device will apply a 0.18 N pre-load and a 0.40 N impulse to induce tissue oscillation for measurement.
Bioelectrical impedance analysis
Time frame: Change from baseline at 72 hours after exercise
Bioimpedance will be measured using a tetrapolar device (BIA Analyzer, 50 kHz, 800 µA). Electrodes will be positioned on the biceps femoris and rectus femoris. Analyzed variables will include resistance (R), reactance (Xc), phase angle (PhA), and tolerance ellipse, via Bioscan software.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing BFR-80%, BFR-60% and BFR-10mmHg in people with Recovery and Recovery Time, run by Paulista University at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Franciele Marques Vanderlei PhD (+55 (18) 3229-5824, franmvanderlei@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Lower limb muscle power (time frame: Change from baseline at 72 hours after exercise). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Sep 2026.