Traumatic Brain InjuryReSTARTNCT07332299
Remote Stimulation and Training to Advance Recovery From TBI in Seniors
A study testing Active tDCS and Cognitive Training Intervention in people with Traumatic Brain Injury and Aging Related Cognitive Decline, run by Minneapolis Veterans Affairs Medical Center at 1 site in United States.
Trial summary
The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI). Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Traumatic Brain Injury, Aging Related Cognitive Decline
- What is being tested?
- Active tDCS and Cognitive Training Intervention
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Jan 2026to Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Who may be able to join
- Veterans age 65 and older.
- History of mild TBI (as defined by the DOD/VA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months prior to enrollment.
- Self-reported or medically documented attention and/or concentration difficulties.
- Stable dose of all prescription and non-prescription medications that may impact cognition or brain chemistry (except for PRN medication) for at least 3 weeks prior to the baseline session (Visit 1), in the medical opinion of the principal investigator.
- Capable and willing to provide voluntary informed consent, in the medical opinion of the principal investigator.
Who cannot join
- Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the principal investigator: (a) may pose a significant risk to the participant, (b) raises the possibility that the participant is unlikely to successfully complete all the requirements of the study according to the study protocol, or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of brain tumor near the stimulation site, brain surgery, stroke with current sequalae, epilepsy, multiple sclerosis, Huntington's Disease, ALS, ataxia, aphasia, Alzheimer's Disease, and dementia.
- Moderate to severe cognitive impairment with MoCA score (assessed upon enrollment) less than 15.
- Prior treatment with ECT or neuromodulation in the last 12 months.
- Current severe alcohol or substance use disorder with evidence of withdrawal or tolerance within the past 6 months, based on psychiatric history and/or a review of available medical records.
- Psychosis or mania within 30 days of enrollment, as determined by the principal investigator, based on psychiatric history and/or a review of available medical records.
- Contraindications for tDCS (e.g., metallic cranial plates/screws or implanted device, eczema or skin lesions on scalp near electrode site, etc.).
- No or limited internet connection in their home.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Minneapolis VA Health Care System
Minneapolis, Minnesota, 55417
Casey S Gilmore, PhD, 612-629-7466, casey.gilmore2@va.gov
Laura Hemmy, PhD, 612-467-2323, laura.hemmy@va.gov
About this study
The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI).
The main questions are:
Read more
- Does transcranial direct current stimulation (tDCS) make cognitive training more effective for improving attention, memory, and decision-making?
- Is this type of home-based program feasible and acceptable for older adults with TBI?
Researchers will compare two groups: one group will receive active tDCS during cognitive training, and the other group will receive sham (placebo) tDCS during cognitive training.
Participants will:
- Complete computer-based cognitive training exercises (BrainHQ) to practice attention, memory, and decision-making.
- Receive either active or sham tDCS during training sessions.
- Complete assessments before and after the program to measure changes in thinking and daily functioning.
Read the detailed description
Traumatic brain injury (TBI) is a major public health issue among older adults. Each year, thousands of seniors sustain TBIs, most often from falls. Even when the injury is classified as "mild," it can lead to long-term problems with memory, attention, decision-making, and self-control. These difficulties can make it harder to live independently, maintain social relationships, and manage everyday responsibilities. Older adults with a history of TBI are also at greater risk of experiencing faster cognitive decline as they age. Unfortunately, there are few effective treatments available to improve thinking skills in this group.
This study is designed to test a new approach that combines computer-based cognitive training with transcranial direct current stimulation (tDCS), a safe, non-invasive form of brain stimulation. The goal is to determine whether this combined treatment can improve attention, memory, and decision-making in older adults with TBI, and whether the program is practical for participants to complete at home with remote supervision.
About the Interventions
- Cognitive training (BrainHQ): Participants will complete computerized exercises that provide structured practice in skills such as attention, working memory, and decision-making. These exercises adapt to each individual's performance, gradually increasing in difficulty as skills improve.
- tDCS: During some of the training sessions, participants will wear a device with electrodes placed on the scalp. The device delivers a very low level of electrical current (2 milliamps) that helps "tune" brain networks to make them more responsive to training. tDCS is non-invasive, painless for most people, and has been tested safely in thousands of participants in research studies worldwide.
Study Design
This is a randomized controlled trial. All participants will complete the same set of cognitive training exercises, but they will be randomly assigned to one of two groups:
- Active group: Receives active tDCS during training.
- Sham group: Receives sham (placebo) tDCS during training. Sham stimulation mimics the feeling of tDCS at the start of the session but does not deliver active current.
This design allows researchers to determine whether adding tDCS produces greater improvements than cognitive training alone.
Study Procedures
Participants will:
- Complete baseline assessments of cognitive function, daily living skills, and quality of life.
- Take part in multiple sessions of computer-based cognitive training at home, while supervised remotely through secure telehealth connections.
- Receive either active or sham tDCS during the training sessions.
- Complete follow-up assessments after the intervention to measure changes in thinking, decision-making, and daily functioning.
Key Questions
The study is designed to answer three main questions:
- Does tDCS enhance the effects of cognitive training? Specifically, do participants who receive active tDCS show greater gains in attention, memory, and decision-making compared to those who receive sham stimulation?
- Is the program feasible and acceptable? Can older adults with TBI successfully complete the home-based training and stimulation sessions, and do they find the program easy to use and worthwhile?
- Do improvements transfer to everyday life? Beyond test scores, does the program help participants function better in their daily lives, maintain independence, and improve quality of life?
Importance of the Study
Older adults with TBI are at particularly high risk for poor outcomes, but they are often underrepresented in research. This study is innovative in several ways:
- It focuses specifically on older adults with TBI, a group that has historically been overlooked in clinical trials.
- It uses a home-based and remotely supervised model, which increases accessibility for people living in rural areas, those with mobility limitations, or those who cannot easily attend clinic visits.
- It builds on strong preliminary evidence from prior studies in Veterans and other populations showing that combining brain stimulation with cognitive training can reduce impulsivity and improve cognitive control.
- It addresses a critical gap in treatment by testing a scalable rehabilitation approach that could be delivered widely if proven effective.
Potential Impact
If successful, this research could provide the foundation for a new, effective treatment option for older adults with TBI. The intervention is low-risk, non-invasive, and can be delivered in the home setting with minimal equipment. It could help participants improve cognitive functioning, maintain independence longer, and enhance quality of life. At a broader level, the study could reduce the burden of TBI-related cognitive decline on families, caregivers, and healthcare systems.
- Being tested
- Active tDCS and Cognitive Training Intervention, Sham tDCS and Cognitive Training Intervention
- Keywords
- Aging, Cognitive Training, Transcranial Direct Current Stimulation, Traumatic Brain Injury
- Medical subject headings
- Brain Injuries, Traumatic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Active tDCS and Cognitive Training InterventionCombination product
Also called tDCS
Forty-five minutes of cognitive training concurrent with 2 mAmps of anodal stimulation applied to the left frontal cortex for the first 20 minutes of the session.
Sham tDCS and Cognitive Training InterventionCombination product
Also called sham tDCS
Forty-five minutes of cognitive training concurrent with sham tDCS (30 secs ramp up/ramp down of current at beginning and end of session).
| Study group | Role | What they receive |
|---|---|---|
| Active tDCS with cognitive training | Experimental | Participants will receive 10 sessions of cognitive training concurrent with transcranial direct current stimulation (45 minutes of cognitive training with tDCS applied for first 20 minutes of session; tDCS: 2mA, 30s ramp up/down, anode at F3, cathode at F4). Receives: Combination Product: Active tDCS and Cognitive Training Intervention |
| Sham tDCS with cognitive training | Sham comparator | Participants will receive 10 sessions of cognitive training concurrent with sham transcranial direct current stimulation (45 minutes of cognitive training with sham tDCS: 2mA current will be ramped down immediately after the initial 30s ramp up period and then at 20 minutes ramped up and down as done at the beginning, anode at F3, cathode at F4). Receives: Combination Product: Sham tDCS and Cognitive Training Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Total Scale Score
The RBANS is a commonly-used, psychometrically-sound measure of cognitive function across the lifespan. The primary outcome measure is the Total Scale score, which is a standard score (mean 100, SD 15) across five cognitive domains (Immediate/Delayed Memory, Visuospatial, Attention, Language).
Measured: Baseline, 1-week post, & 6-weeks post intervention
Electroencephalogram (EEG) - Resting State Theta Band Functional Connectivity
Resting State EEG will be collected to assess neural dynamics or functional connectivity and spectral power of delta,theta, alpha, beta, and gamma frequency bands. The primary outcome measure will be change in prefrontal-parietal functional connectivity in the theta frequency band.
Measured: Baseline, 1-week post, & 6-weeks post intervention
Secondary outcomes (5)
Neurobehavioral Symptom Inventory (NSI) Total Score
A 22-item measure that assesses post-concussive symptoms for those with a TBI.
Measured: Baseline, 1-week post, & 6-weeks post intervention
Insomnia Severity Index (ISI) Total Score
A 7-item measure of the severity of nighttime and daytime components of insomnia.
Measured: Baseline, 1-week post, & 6-weeks post intervention
Patient Health Questionnaire-8 (PHQ-8) Total Score
An 8-item measure of depressive symptoms.
Measured: Baseline, 1-week post, & 6-weeks post intervention
Groton Maze Learning Task (GMLT) Completion Time
A computer cognitive test of spatial working memory and error monitoring.
Measured: Baseline, 1-week post, & 6-weeks post intervention
NIH Toolbox Quality of Life Assessment (NeuroQoL)
Questionnaire to assess quality of life with regard to cognitive, social, emotional, and behavioral abilities.
Measured: Baseline, 1-week post, & 6-weeks post intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Jan 2026
- Study start15 Jan 2026 (estimated)
- Primary completionSep 2027 (estimated)
- Study completionSep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Traumatic Brain InjuryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Minneapolis Veterans Affairs Medical Center
- Sponsor type
- US federal agency
- Collaborators
- Center for Veterans Research and Education
- Responsible party
- Principal investigator, Casey Gilmore, PhD, Minneapolis Veterans Affairs Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07332299
- Sponsor's protocol ID
- 1893132
- Other IDs
- SCI-TBI-2025-00025
- Acronym
- ReSTART
- Status last verified
- Jan 2026
- First submitted
- 17 Sep 2025
- Last updated
- 12 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Remote Stimulation and Training to Advance Recovery From TBI in Seniors
- ClinicalTrials.gov ID
- NCT07332299
- Acronym / sponsor ID
- ReSTART / 1893132
- Keywords
- Aging, Cognitive Training, Transcranial Direct Current Stimulation, Traumatic Brain Injury
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Minneapolis Veterans Affairs Medical CenterUS federal agency
- Collaborators
- Center for Veterans Research and Education
- Study start
- 15 Jan 2026 (estimated)
- Primary completion
- Sep 2027 (estimated)
- Study completion
- Sep 2027 (estimated)
- First posted
- 12 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if combining brain stimulation with cognitive training can improve thinking skills in older adults who have had a traumatic brain injury (TBI).
The main questions are:
- Does transcranial direct current stimulation (tDCS) make cognitive training more effective for improving attention, memory, and decision-making?
- Is this type of home-based program feasible and acceptable for older adults with TBI?
Researchers will compare two groups: one group will receive active tDCS during cognitive training, and the other group will receive sham (placebo) tDCS during cognitive training.
Participants will:
- Complete computer-based cognitive training exercises (BrainHQ) to practice attention, memory, and decision-making.
- Receive either active or sham tDCS during training sessions.
- Complete assessments before and after the program to measure changes in thinking and daily functioning.
Detailed description
Traumatic brain injury (TBI) is a major public health issue among older adults. Each year, thousands of seniors sustain TBIs, most often from falls. Even when the injury is classified as "mild," it can lead to long-term problems with memory, attention, decision-making, and self-control. These difficulties can make it harder to live independently, maintain social relationships, and manage everyday responsibilities. Older adults with a history of TBI are also at greater risk of experiencing faster cognitive decline as they age. Unfortunately, there are few effective treatments available to improve thinking skills in this group.
This study is designed to test a new approach that combines computer-based cognitive training with transcranial direct current stimulation (tDCS), a safe, non-invasive form of brain stimulation. The goal is to determine whether this combined treatment can improve attention, memory, and decision-making in older adults with TBI, and whether the program is practical for participants to complete at home with remote supervision.
About the Interventions
- Cognitive training (BrainHQ): Participants will complete computerized exercises that provide structured practice in skills such as attention, working memory, and decision-making. These exercises adapt to each individual's performance, gradually increasing in difficulty as skills improve.
- tDCS: During some of the training sessions, participants will wear a device with electrodes placed on the scalp. The device delivers a very low level of electrical current (2 milliamps) that helps "tune" brain networks to make them more responsive to training. tDCS is non-invasive, painless for most people, and has been tested safely in thousands of participants in research studies worldwide.
Study Design
This is a randomized controlled trial. All participants will complete the same set of cognitive training exercises, but they will be randomly assigned to one of two groups:
- Active group: Receives active tDCS during training.
- Sham group: Receives sham (placebo) tDCS during training. Sham stimulation mimics the feeling of tDCS at the start of the session but does not deliver active current.
This design allows researchers to determine whether adding tDCS produces greater improvements than cognitive training alone.
Study Procedures
Participants will:
- Complete baseline assessments of cognitive function, daily living skills, and quality of life.
- Take part in multiple sessions of computer-based cognitive training at home, while supervised remotely through secure telehealth connections.
- Receive either active or sham tDCS during the training sessions.
- Complete follow-up assessments after the intervention to measure changes in thinking, decision-making, and daily functioning.
Key Questions
The study is designed to answer three main questions:
- Does tDCS enhance the effects of cognitive training? Specifically, do participants who receive active tDCS show greater gains in attention, memory, and decision-making compared to those who receive sham stimulation?
- Is the program feasible and acceptable? Can older adults with TBI successfully complete the home-based training and stimulation sessions, and do they find the program easy to use and worthwhile?
- Do improvements transfer to everyday life? Beyond test scores, does the program help participants function better in their daily lives, maintain independence, and improve quality of life?
Importance of the Study
Older adults with TBI are at particularly high risk for poor outcomes, but they are often underrepresented in research. This study is innovative in several ways:
- It focuses specifically on older adults with TBI, a group that has historically been overlooked in clinical trials.
- It uses a home-based and remotely supervised model, which increases accessibility for people living in rural areas, those with mobility limitations, or those who cannot easily attend clinic visits.
- It builds on strong preliminary evidence from prior studies in Veterans and other populations showing that combining brain stimulation with cognitive training can reduce impulsivity and improve cognitive control.
- It addresses a critical gap in treatment by testing a scalable rehabilitation approach that could be delivered widely if proven effective.
Potential Impact
If successful, this research could provide the foundation for a new, effective treatment option for older adults with TBI. The intervention is low-risk, non-invasive, and can be delivered in the home setting with minimal equipment. It could help participants improve cognitive functioning, maintain independence longer, and enhance quality of life. At a broader level, the study could reduce the burden of TBI-related cognitive decline on families, caregivers, and healthcare systems.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Active tDCS with cognitive training | Experimental | Combination Product: Active tDCS and Cognitive Training InterventionParticipants will receive 10 sessions of cognitive training concurrent with transcranial direct current stimulation (45 minutes of cognitive training with tDCS applied for first 20 minutes of session; tDCS: 2mA, 30s ramp up/down, anode at F3, cathode at F4). |
| Sham tDCS with cognitive training | Sham comparator | Combination Product: Sham tDCS and Cognitive Training InterventionParticipants will receive 10 sessions of cognitive training concurrent with sham transcranial direct current stimulation (45 minutes of cognitive training with sham tDCS: 2mA current will be ramped down immediately after the initial 30s ramp up period and then at 20 minutes ramped up and down as done at the beginning, anode at F3, cathode at F4). |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
Key inclusion criteria (5 listed)
- Veterans age 65 and older.
- History of mild TBI (as defined by the DOD/VA criteria used in conjunction with the OSU TBI-ID) sustained at least 3 months prior to enrollment.
- Self-reported or medically documented attention and/or concentration difficulties.
- Stable dose of all prescription and non-prescription medications that may impact cognition or brain chemistry (except for PRN medication) for at least 3 weeks prior to the baseline session (Visit 1), in the medical opinion of the principal investigator.
- Capable and willing to provide voluntary informed consent, in the medical opinion of the principal investigator.
Key exclusion criteria (7 listed)
- Presence of a medical, psychiatric, physical or non-physical disease, disorder, condition, injury, disability or pre-existent history such that study participation, in the opinion of the principal investigator: (a) may pose a significant risk to the participant, (b) raises the possibility that the participant is unlikely to successfully complete all the requirements of the study according to the study protocol, or (c) might adversely impact the integrity of the data or the validity of the study results. Specific conditions include (but are not limited to) a history of brain tumor near the stimulation site, brain surgery, stroke with current sequalae, epilepsy, multiple sclerosis, Huntington's Disease, ALS, ataxia, aphasia, Alzheimer's Disease, and dementia.
- Moderate to severe cognitive impairment with MoCA score (assessed upon enrollment) less than 15.
- Prior treatment with ECT or neuromodulation in the last 12 months.
- Current severe alcohol or substance use disorder with evidence of withdrawal or tolerance within the past 6 months, based on psychiatric history and/or a review of available medical records.
- Psychosis or mania within 30 days of enrollment, as determined by the principal investigator, based on psychiatric history and/or a review of available medical records.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Active tDCS and Cognitive Training InterventionAlso: tDCSForty-five minutes of cognitive training concurrent with 2 mAmps of anodal stimulation applied to the left frontal cortex for the first 20 minutes of the session. | Combination product | Active tDCS with cognitive training |
| Sham tDCS and Cognitive Training InterventionAlso: sham tDCSForty-five minutes of cognitive training concurrent with sham tDCS (30 secs ramp up/ramp down of current at beginning and end of session). | Combination product | Sham tDCS with cognitive training |
Primary outcome
Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Total Scale Score
Time frame: Baseline, 1-week post, & 6-weeks post intervention
The RBANS is a commonly-used, psychometrically-sound measure of cognitive function across the lifespan. The primary outcome measure is the Total Scale score, which is a standard score (mean 100, SD 15) across five cognitive domains (Immediate/Delayed Memory, Visuospatial, Attention, Language).
Electroencephalogram (EEG) - Resting State Theta Band Functional Connectivity
Time frame: Baseline, 1-week post, & 6-weeks post intervention
Resting State EEG will be collected to assess neural dynamics or functional connectivity and spectral power of delta,theta, alpha, beta, and gamma frequency bands. The primary outcome measure will be change in prefrontal-parietal functional connectivity in the theta frequency band.
5 secondary outcomes
Neurobehavioral Symptom Inventory (NSI) Total Score
Time frame: Baseline, 1-week post, & 6-weeks post intervention
Insomnia Severity Index (ISI) Total Score
Time frame: Baseline, 1-week post, & 6-weeks post intervention
Patient Health Questionnaire-8 (PHQ-8) Total Score
Time frame: Baseline, 1-week post, & 6-weeks post intervention
Groton Maze Learning Task (GMLT) Completion Time
Time frame: Baseline, 1-week post, & 6-weeks post intervention
NIH Toolbox Quality of Life Assessment (NeuroQoL)
Time frame: Baseline, 1-week post, & 6-weeks post intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jan 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Active tDCS and Cognitive Training Intervention in people with Traumatic Brain Injury and Aging Related Cognitive Decline, run by Minneapolis Veterans Affairs Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Casey S Gilmore, PhD (612-629-7466, casey.gilmore2@va.gov), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Total Scale Score (time frame: Baseline, 1-week post, & 6-weeks post intervention). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jan 2026.