AzTrials
AzTrials

ObesityPhase 3ENLIGHTEN-1NCT07321886

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

A Phase 3 study testing Eloralintide in people with Obesity and Overweight, run by Eli Lilly and Company at 158 sites in 15 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Obesity, Overweight
What is being tested?
Eloralintide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
1,980 participants
Where
158 sitesin 15 countries
Study dates
6 Feb 2026to Jul 2030
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Have Body Mass Index (BMI) at screening of the following:
  • 30 kilogram per square meter (kg/m2) OR
  • 27 kg/m2 with at least one of the following weight-related health conditions at screening:
  • high blood pressure
  • dyslipidemia
  • obstructive sleep apnea, or
Show all 9Show fewer
  • heart disease
  • Have a stable body weight (<5% body weight change) for 90 days prior to screening.
  • Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight

Who cannot join

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes or type 2 diabetes
  • Have had within 90 days prior to screening:
  • heart attack
  • stroke
Show all 11Show fewer
  • coronary artery revascularization
  • unstable angina, or
  • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Trial locations and contacts

158 sites in 15 countries. Contact the study team or a site near you to ask about taking part.

Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact

1-317-615-4559

LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact contact

clinical_inquiry_hub@lilly.com

158 sites in 15 countries

United States41 sites, 41 recruiting

  • Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico, 87102

    505-224-7407

    Satkirin Khalsa

    Recruiting

  • JEM Research Institute

    Atlantis, Florida, 33462

    561-968-2933

    David Halpert

    Recruiting

  • MedStar Good Samaritan Hospital

    Baltimore, Maryland, 21239

    443-444-6275

    Adline Ghazi

    Recruiting

  • The University of Texas Health Science Center at Houston

    Bellaire, Texas, 77401

    713-486-1350

    Deborah Horn

    Recruiting

  • Velocity Clinical Research, Dallas

    Dallas, Texas, 75230

    Dan Lender

    Recruiting

  • UT Southwestern Medical Center

    Dallas, Texas, 75390-9302

    Amy Shah

    Recruiting

  • Teak Research Consults - Dunwoody

    Dunwoody, Georgia, 30338

    470-403-4755

    Aakar Thaker

    Recruiting

  • Neighborhood Healthcare Institute of Health

    Escondido, California, 92025

    760-737-6984

    James Schultz

    Recruiting

  • Ark Clinical Research - Fountain Valley

    Fountain Valley, California, 92708

    714-988-2021

    Mark Leibowitz

    Recruiting

  • Tribe Clinical Research, LLC

    Greenville, South Carolina, 29607

    864-334-0141

    Ronald Mayfield

    Recruiting

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814

    808-531-6886

    Cindy Pau

    Recruiting

  • MedStar Health Research Institute (MedStar Physician Based Research Network)

    Hyattsville, Maryland, 20782

    443-444-5663

    Jean Park

    Recruiting

  • Care Access - Lake Charles (Bayou Pines)

    Lake Charles, Louisiana, 70601

    337-602-6642

    William Nabours

    Recruiting

  • AMR Clinical

    Las Vegas, Nevada, 89119

    702-597-9825

    Michael Jacobs

    Recruiting

  • Teak Research Consults

    Lawrenceville, Georgia, 30043

    Kamar Alabi

    Recruiting

  • BioMed Research & Medical Center

    Miami, Florida, 33156

    786-238-7110

    Liliam Hernandez

    Recruiting

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112

    704-283-7359

    Awawu Igbinadolor

    Recruiting

  • Adult Medicine of Lake County, Inc.

    Mt. Dora, Florida, 32757

    352-383-8222

    Shirley Nagel

    Recruiting

  • Accellacare - Mt Pleasant

    Mt. Pleasant, South Carolina, 29464

    843-849-1880

    Richard Mills

    Recruiting

  • AMR Clinical

    Nashville, Tennessee, 37203

    630-491-1900

    Harvey Bowles

    Recruiting

  • AMR Clinical

    Norfolk, Virginia, 23502

    757-627-7446

    Mary Bailey

    Recruiting

  • Desert Oasis Healthcare Medical Group

    Palm Springs, California, 92262

    760-320-9505

    Michael Jardula

    Recruiting

  • American Research Centers of Florida

    Pembroke Pines, Florida, 33027

    954-237-3799

    Luis del Prado Rodriguez

    Recruiting

  • AHF Pensacola

    Pensacola, Florida, 32503

    850-476-3131 x53026

    Mitchell Whitehead

    Recruiting

  • Care Access - Quincy

    Quincy, Massachusetts, 02169

    877-791-0656

    Chih Chao Yang

    Recruiting

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609

    585-288-0890

    Leigh Schirmer

    Recruiting

  • Peninsula Research Associates

    Rolling Hills Estates, California, 90274

    310-265-1623

    David Guzman

    Recruiting

  • Care Access - Sacramento

    Sacramento, California, 95831

    925-734-2331

    Francisco Garcia

    Recruiting

  • IMA Clinical Research San Antonio

    San Antonio, Texas, 78229

    210-692-7157

    Priscilla Thomas

    Recruiting

  • Southern California Clinical Research

    Santa Ana, California, 92701

    714-474-2173

    Wayne Ho

    Recruiting

  • Headlands Research - Scottsdale

    Scottsdale, Arizona, 85260

    480-725-8708

    Benjamin Clark

    Recruiting

  • IMA Clinical Research St. Petersburg

    St. Petersburg, Florida, 33704

    727-521-9137

    Howard Chipman

    Recruiting

  • Clinical Research Atlanta

    Stockbridge, Georgia, 30281

    770-507-6867

    Jason Agran

    Recruiting

  • Cotton O'Neil Clinical Research Center

    Topeka, Kansas, 66606

    785-354-9591

    Katherine Willingham

    Recruiting

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098

    248-312-0025

    Neil Fraser

    Recruiting

  • MFA Clinical Research

    Tuscaloosa, Alabama, 35405

    205-331-4963

    Mohammad Aryanpure

    Recruiting

  • University Clinical Investigators, Inc.

    Tustin, California, 92780

    714-734-7944

    John Kim

    Recruiting

  • Preferred Primary Care Physicians

    Uniontown, Pennsylvania, 15401

    724-912-0033

    Paul Hartley

    Recruiting

  • IMA Clinical Research Warren

    Warren Township, New Jersey, 07059

    Nancy Phillips

    Recruiting

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708

    203-437-6856

    Jenna Langello

    Recruiting

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa, 50266

    Amy Keller

    Recruiting

Other trials in United States

China14 sites, 14 recruiting

  • Luhe Hospital

    Beijing, 1001199

    Dong Zhao

    Recruiting

  • Beijing Pinggu District Hospital

    Beijing, 101200

    13911080328

    yufeng li

    Recruiting

  • Sichuan Provincial People's Hospital

    Chengdu, 610072

    Limin Tian

    Recruiting

  • West China Hospital Sichuan University

    Chengdu, 610041

    18980601658

    zhenmei an

    Recruiting

  • Zhujiang Hospital

    Guangzhou, 510280

    Jia Sun

    Recruiting

  • The Second People's Hospital of Hefei

    Hefei, 230011

    86-13956099720

    Jun Ye

    Recruiting

  • Jinan Central Hospital

    Jinan, 250013

    15318816218

    Xiaolin Dong

    Recruiting

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003

    13653880139

    Hongwei Jiang

    Recruiting

  • Jiangxi Provincial People's Hospital

    Nanchang, 330038

    13767035719

    Zongyou Cheng

    Recruiting

  • Nanjing First Hospital

    Nanjing, 210000

    Qian Li

    Recruiting

  • Jiangsu Province Official Hospital

    Nanjing, 210008

    Wei Tang

    Recruiting

  • Zhongda Hospital Southeast University

    Nanjing, 210009

    Ling Li

    Recruiting

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210011

    18951762960

    Yibing Lu

    Recruiting

  • Shanghai Sixth People's Hospital

    Shanghai

    Jian Zhou

    Recruiting

Other trials in China

Germany12 sites

  • Zentrum fur klinische Forschung - Köln

    Cologne, 51069

    Active, not recruiting

  • Universitaetsklinikum Carl Gustav Carus Dresden

    Dresden, 01307

    Active, not recruiting

  • StudyPoint Duisburg

    Duisburg, 47269

    Active, not recruiting

  • InnoDiab Forschung Gmbh

    Essen, 45136

    Active, not recruiting

  • Medizentrum Essen Borbeck

    Essen, 45355

    Active, not recruiting

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109

    Active, not recruiting

  • AmBeNet GmbH

    Leipzig, 04107

    Active, not recruiting

  • Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz

    Lingen, 49808

    Active, not recruiting

  • BAG Drs. Med. Quist PartG

    Mainz, 55128

    Active, not recruiting

  • CRS Clinical Research Services Mannheim

    Mannheim, 68167

    Active, not recruiting

  • RED-Institut GmbH

    Oldenburg, 23758

    Active, not recruiting

  • Praxis Sauter & Sauter & Vorbach

    Wangen, 88239

    Active, not recruiting

Other trials in Germany

Australia11 sites, 11 recruiting

  • Emeritus Research

    Botany, 2019

    Paul Bird

    Recruiting

  • Core Research Group

    Brisbane, 4064

    61738765688

    David Colquhoun

    Recruiting

  • Emeritus Research

    Camberwell, 3124

    Sam Francis

    Recruiting

  • Life Clinical Research

    Ipswich, 4305

    0734490036

    Cameron Booth

    Recruiting

  • Paratus Clinical Research Central Coast

    Kanwal, 2259

    Ian Forsyth

    Recruiting

  • University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook

    Meadowbrook, 4131

    Ivan Lim

    Recruiting

  • Momentum Sunshine

    Melbourne, 3021

    0395096166

    King Cheung

    Recruiting

  • Paratus Clinical Research - Melbourne

    Melbourne, 3070

    Kianoosh Noori Samie

    Recruiting

  • AIM Research

    Merewether, 2291

    +61 2 4963 2323

    Claire Morbey

    Recruiting

  • Fusion Clinical Research

    Norwood, 5067

    Thomas Polasek

    Recruiting

  • USC Clinical Trials Sunshine Coast

    Sippy Downs, 4556

    Robert Scott

    Recruiting

Other trials in Australia

Argentina10 sites, 10 recruiting

  • CONEXA Investigacion Clinica S.A.

    Buenos Aires, 1012

    5491169680411

    María Scioscia

    Not yet recruiting

  • Cicemo Srl

    Buenos Aires, 1424

    5491157417654

    Pablo Costanzo

    Not yet recruiting

  • Cardiología Palermo

    Buenos Aires, 1425

    5491140306347

    Paula Perez Terns

    Not yet recruiting

  • Glenny Corp. S.A.

    Buenos Aires, 1430

    01145445522

    Martin Koretzky

    Not yet recruiting

  • CARDIAMET Investigaciones Médicas

    Buenos Aires, C1014ACP

    5491165496764

    Angela Romero Zarante

    Not yet recruiting

  • Centro Médico Viamonte

    Buenos Aires, C1120AAC

    54 1149635650

    Diego Aizenberg

    Not yet recruiting

  • Fundación Respirar

    Buenos Aires, C1426ABP

    5411 7078 1548

    Marina Uhrig

    Not yet recruiting

  • Instituto de Investigaciones Clínicas Córdoba

    Córdoba, 5000

    03515102154

    Mauro Pautasso

    Not yet recruiting

  • INECO Neurociencias Oroño

    Rosario, 2000

    (0341) 425 8695

    María Cappiello

    Not yet recruiting

  • Centro Modelo de Cardiología

    San Miguel de Tucumán, 4000

    3814444500

    GUILLERMO MERCAU

    Not yet recruiting

Other trials in Argentina

India10 sites, 10 recruiting

  • Endolife Speciality Hospitals

    Guntur, 522001

    9849945577

    Kongara Srikanth

    Recruiting

  • Gauhati Medical College and Hospital

    Guwahati, 781032

    9954658926

    Anjan Talukdar

    Recruiting

  • Care Hospitals Hyderabad- Banjara Hills

    Hyderabad, 500034

    91 8008646165

    Bipin Sethi

    Recruiting

  • Mandya Institute Of Medical Sciences

    Mandya, 571401

    GV Anikethana

    Recruiting

  • Topiwala National Medical College & B. Y. L. Nair Charitable Hospital

    Mumbai, 400008

    9819893087

    Jugal Gada

    Recruiting

  • Mysore Medical College

    Mysore, 570001

    7760218464

    Sumaiya Anjum

    Recruiting

  • All India Institute of Medical Sciences (AIIMS) - Nagpur

    Nagpur, 441108

    9930805548

    Udit Narang

    Recruiting

  • Supe Heart & Diabetes Hospital and Research Centre

    Nashik, 422002

    Pravin Supe

    Recruiting

  • Lifepoint Multispeciality Hospital

    Pune, 411057

    09730475068

    Amol Dange

    Recruiting

  • Prabhu Diabetes Multi-Speciality Centre

    Trichy, 620001

    Venkatesan Ravindranath

    Recruiting

Other trials in India

Canada9 sites, 9 recruiting

  • Aggarwal and Associates Limited

    Brampton, L6T 0G1

    9054589033

    Naresh Aggarwal

    Recruiting

  • Med Trust Research

    Courtice, L1E 2J5

    905-728-7915 ext. 5

    Anojan Kathirkamanayagan

    Recruiting

  • Dawson Clinical Research Inc.

    Guelph, N1H 1B1

    519-222-8251

    Garry Wallace

    Recruiting

  • The Wharton Medical Clinic Clinical Trials Inc

    Hamilton, L8L 5G8

    9055238134 x 274

    Mateen Akhtar

    Recruiting

  • Alpha Recherche Clinique

    Québec, G2J 0C4

    418-704-1112

    Anne-Marie Beaulieu

    Recruiting

  • ALPHA Recherche Clinique

    Québec, G3K 2P8

    418-847-1112

    Maggie Lévesque

    Recruiting

  • Bluewater Clinical Research Group Inc.

    Sarnia, N7T 4X3

    1 (519) 344-6612

    John O'Mahony

    Recruiting

  • Winterberry Research Inc.

    Stoney Creek, L8J 0B6

    365-366-6267

    Steven Zizzo

    Recruiting

  • Diex Recherche Inc. Division Trois-Rivieres

    Trois-Rivières, G9A 4P3

    Jean-francois Naud

    Recruiting

Other trials in Canada

Japan9 sites, 9 recruiting

  • Adachi Kyosai Hospital

    Adachi-ku, 120-0022

    81120023812

    Manabu Yamamoto

    Recruiting

  • Nihonbashi Sakura Clinic

    Chūōku, 103-0025

    81120023812

    Kumie Ito

    Recruiting

  • Medical Corporation Chiseikai Tokyo Center Clinic

    Chūōku, 103-0027

    81120023812

    Aki Tsuji

    Recruiting

  • Tokyo-Eki Center-building Clinic

    Chūōku, 103-0027

    81120023812

    Arihiro Kiyosue

    Recruiting

  • Boocs Clinic Fukuoka

    Fukuoka, 812-0025

    81120023812

    Minoru Fujino

    Recruiting

  • Patient First Clinic Ginza-Shimbashi

    Minato, 105-0004

    81120023812

    Kimihiro Hayashi

    Recruiting

  • Kanno Naika

    Mitaka, 181-0013

    81120023812

    Kazuo Kanno

    Recruiting

  • Medical Corporation Heishinkai OCROM Clinic

    Suita-shi, 565-0853

    81120023812

    Yuko Soma

    Recruiting

  • Higashi Shinjuku Clinic

    Tokyo, 169-0072

    81120023812

    Hiroaki Kondo

    Recruiting

Other trials in Japan

Poland9 sites, 9 recruiting

  • Zdrowie Osteo-Medic

    Bialystok, 15-351

    48504055959

    Katarzyna Wasilewska

    Recruiting

  • Legeartis - Poradnie Specjalistyczne

    Bialystok, 15-404

    48 507 18 11 18

    Anna Modzelewska

    Recruiting

  • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

    Krakow, 31-261

    48126237122

    Joanna Mirocka

    Recruiting

  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, 90-338

    607536360

    Malgorzata Jozefowska

    Recruiting

  • Gabinety TERPA

    Lublin, 20-333

    48814427272

    Beata Matyjaszek-Matuszek

    Recruiting

  • Ekamed

    Lublin, 20-718

    48603787884

    Ewa Skokowska

    Recruiting

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznan, 60-589

    48662023004

    Pawel Bogdanski

    Recruiting

  • Pracownia Badań Klinicznych Salus

    Wroclaw, 53-034

    607424301

    Katarzyna Madziarska

    Recruiting

  • Samodzielny Publiczny Szpital Kliniczny nr 1 SUM

    Zabrze, 41-800

    48 32 271 25 11

    Janusz Gumprecht

    Recruiting

Other trials in Poland

United Kingdom9 sites, 9 recruiting

  • Layton Medical Centre

    Blackpool, FY3 7EN

    441253951943

    Rebecca Clark

    Recruiting

  • Bradford on Avon Health Centre

    Bradford on Avon, BA15 1DQ

    01225866611

    Nell Wyatt

    Recruiting

  • Ashton Medical Group - Chapel House

    Lancashire, OL6 6EW

    Omair Razzaq

    Recruiting

  • Royal Lancaster Infirmary

    Lancaster, LA1 4RP

    Mohamed Elnaggar

    Recruiting

  • Altnagelvin Area Hospital

    Londonderry, BT47 6SB

    Alex Miras

    Recruiting

  • Bodyline Clinic - Openshaw

    Manchester, M11 1AA

    Sandra Connell

    Recruiting

  • Wansford Research Limited

    Peterborough, PE8 6PL

    Matthew Davies

    Recruiting

  • Abbeywell Surgery

    Romsey, SO51 7QN

    01794 512218

    Nicola Lester

    Recruiting

  • Rame Group Practice

    Torpoint, PL11 2TB

    01752 817900

    Georgina Hatton

    Recruiting

Other trials in United Kingdom

Brazil8 sites, 7 recruiting

  • Chronos Pesquisa Clínica

    Brasília, 72145-450

    Maira Polcheira

    Not yet recruiting

  • Instituto de Pesquisa clinica de Campinas

    Campinas, 13060-080

    55 19 3267 0023

    Sylka Rodovalho

    Not yet recruiting

  • Private Practice - Dr.Miguel N. Hissa

    Fortaleza, 60430-350

    Suspended

  • Centro de Pesquisa Clínica de Marília - CPCLIM

    Marília, 17504-072

    55 14 21051477

    José Sgarbi

    Not yet recruiting

  • Núcleo de Pesquisa Clínica do Rio Grande do Sul

    Porto Alegre, 90430-001

    555137796400

    Luis Henrique Canani

    Not yet recruiting

  • IBPClin - Instituto Brasil de Pesquisa Clínica

    Rio de Janeiro, 20241-180

    552125277979

    Renata Alexandra Pinheiro

    Not yet recruiting

  • Ruschel Medicina e Pesquisa Clínica

    Rio de Janeiro, 22270-060

    552135979708

    Luiza Siffert

    Not yet recruiting

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, 04266-010

    551122713450

    Breno Balabem Alves

    Not yet recruiting

Other trials in Brazil

South Korea5 sites, 5 recruiting

  • Gachon University Gil Medical Center

    Namdong-gu, 21565

    +82-32-458-2778

    Kyoung-Kon Kim

    Recruiting

  • Konyang University Hospital

    Seogu, 35365

    Jee Hyun Kang

    Recruiting

  • Seoul National University Bundang Hospital

    Seongnam, 13620

    Kiheon Lee

    Recruiting

  • Seoul National University Hospital

    Seoul, 03080

    82220723497

    Minseon Park

    Recruiting

  • Pusan National University Yangsan Hospital

    Yangsan, 50612

    82-55-360-2860

    Sang Yeoup Lee

    Recruiting

Other trials in South Korea

Taiwan5 sites, 5 recruiting

  • Chiayi Christian Hospital

    Chiayi City, 600

    886-5-2765041

    Chu-Kuang Chou

    Recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

    886-7-3121101 ext 7741

    Tsung-Hsien Lin

    Recruiting

  • Chang Gung Memorial Hospital at Kaohsiung

    Kaohsiung Niao Sung Dist, 83301

    886 975056106

    Chih-Yuan Fang

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    0223123456

    Chih-Yuan Wang

    Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217

    Kang-Ling Wang

    Recruiting

Other trials in Taiwan

Belgium4 sites, 4 recruiting

  • ANIMA Research

    Diepenbeek, 3590

    +32 11 94 91 15

    Hilde Bollen

    Recruiting

  • Jessa Ziekenhuis

    Hasselt, 3500

    011337030

    Guido Claessen

    Recruiting

  • Kormont

    Kluisbergen, 9690

    32 496 376259

    Klaas Vercruysse

    Recruiting

  • Gezondheidshuis De Gloed

    Machelen, 9870

    32 496 376259

    Klaas Vercruysse

    Recruiting

Other trials in Belgium

Puerto Rico2 sites, 2 recruiting

  • Puerto Rico Health and Wellness Institute

    Dorado, 00646

    7877961049

    Elham Ghorbani

    Recruiting

  • Wellness clinical Research Vega Baja

    Vega Baja, 00693

    787-654-9444

    Gustavo Albizu Angulo

    Recruiting

Other trials in Puerto Rico

About this study

Official title: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase.

Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

Conditions
Obesity, Overweight
Being tested
Eloralintide, Placebo
Medical subject headings
Obesity, Overweight

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • EloralintideDrug

    Also called LY3841136

    Administered SC

  • PlaceboDrug

    Administered SC

Study groups in NCT07321886
Study groupRoleWhat they receive
Eloralintide Dose 1ExperimentalParticipants will receive eloralintide subcutaneously (SC)
Receives: Drug: Eloralintide
Eloralintide Dose 2ExperimentalParticipants will receive eloralintide SC
Receives: Drug: Eloralintide
Eloralintide Dose 3ExperimentalParticipants will receive eloralintide SC
Receives: Drug: Eloralintide
Eloralintide Dose 4ExperimentalParticipants will receive eloralintide SC
Receives: Drug: Eloralintide
PlaceboPlacebo comparatorParticipants will receive placebo SC
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percent Change from Baseline in Body Weight

    Measured: Baseline, Week 64

Secondary outcomes (18)

  1. Percent Change from Baseline in Total Body Fat Mass

    Measured: Baseline, Week 64

  2. Change from Baseline in Waist Circumference

    Measured: Baseline, Week 64

  3. Percent Change from Baseline in Triglycerides

    Measured: Baseline, Week 64

  4. Change from Baseline in Systolic Blood Pressure (SBP)

    Measured: Baseline, Week 64

  5. Time to Onset of Type 2 Diabetes (T2D)

    Time to Onset of Type 2 Diabetes (T2D) in Participants with Prediabetes at Randomization

    Measured: Baseline to Week 168 and Week 191

  6. Change from Baseline in Body Mass Index (BMI)

    Measured: Baseline, Week 64

  7. Change from Baseline in Hemoglobin A1c (HbA1c)

    Measured: Baseline, Week 64

  8. Percent Change from Baseline in Fasting Insulin

    Measured: Baseline, Week 64

  9. Percent Change from Baseline in High-Sensitivity C-Reactive Protein (hsCRP)

    Measured: Baseline, Week 64

  10. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)

    Measured: Baseline, Week 64

  11. Change from Baseline in Short Form-36 Version 2 (SF-36 v2) Score

    Measured: Baseline, Week 64

  12. Change from Baseline in EQ-5D-5L

    Measured: Baseline, Week 64

  13. Change from Baseline in Control of Eating Questionnaire (CoEQ) Score

    Measured: Baseline, Week 64

  14. Achievement of Improved Categorical Shift in Patient Global Improvement of Status (PGIS) Physical Function Weight

    Measured: Baseline, Week 64

  15. Change in Medication Use

    Measured: Baseline through Week 64

  16. Percent Change from Baseline in Body Weight in Participants with Prediabetes at Randomization

    Measured: Baseline, Week 168

  17. Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss)

    Measured: Baseline through Week 64

  18. PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss)

    Measured: Baseline through Week 64

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted7 Jan 2026
  2. Study start6 Feb 2026
  3. Primary completionMar 2028 (estimated)
  4. Study completionJul 2030 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
1,980 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07321886
Sponsor's protocol ID
27742
Other IDs
J3R-MC-YDAG, 2025-523657-34-00, 2025
Acronym
ENLIGHTEN-1
Status last verified
Sep 2026
First submitted
5 Jan 2026
Last updated
22 Sep 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Eloralintide in people with Obesity and Overweight, run by Eli Lilly and Company at 158 sites in 15 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 9 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 158 sites in United States, China, Germany, Australia, Argentina and 10 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or (1-317-615-4559, LillyTrials@Lilly.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percent Change from Baseline in Body Weight (time frame: Baseline, Week 64). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07321886.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.

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